医学免疫学精品课件-肿瘤免疫英文课件
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❖ Tumor-specific antigen
Antigen that are expressed on tumor cells but not on normal cells were called tumor- specific antigens; some of these antigens are unique to individual tumors, whereas others are shared among tumors of the same type.
DEPARTMENT OF IMMUNOLOGY
Robin Bush The sister of George W. Bush, die from leukemia, at the age of 4.
Walt Disney This famous animator, producer and co-founder of the corporation known as The Walt Disney Company died at the age of 65 from lung cancer, making him one of the most famous celebrities to have died from smoking.
Immunity to tumors
DEPARTMENT OF IMMUNOLOGY
Content
1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy
❖ The immune system can be activated by external stimuli to effectively kill tumor cells and eradicate tumors.
DEPARTMENT OF IMMUNOLOGY
Tumor Antigen
DEPARTMENT OF IMMUNOLOGY
DEPARTMENT OF IMMUNOLOGY
Tumor Antigen
The earliest classification: ❖ Tumor-specific antigen ❖ Tumor-associated antigen
DEPARTMENT OF IMMUNOLOGY
Tumor Antigen
DEPARTMENT源自文库OF IMMUNOLOGY
Activated immune cell adoptive Transfer for tumor therapy
Steven A. Rosenberg
Steven A. Rosenberg is a leading cancer researcher and surgeon. He is credited with developing the use of IL-2 and immune cells for the treatment of patients with melanoma in a procedure termed adoptive cell transfer.
immune responses.
DEPARTMENT OF IMMUNOLOGY
❖The immune system can be activated by external stimuli to effectively kill tumor cells and eradicate tumors. --- Active immunotherapy; --- Passive immunotherapy.
DEPARTMENT OF IMMUNOLOGY
Cancer is a major health problem worldwide and one of the most important causes of morbidity and mortality in children and adults.
❖ Immune responses frequently fail to prevent the growth of tumors
❖ First, tumor cells are derived from host cells. ❖ Second, the rapid growth and spread of tumors ❖ Third, specialized mechanisms for evading host
Paul Newman Paul Newman was of course a great actor, but was known well for his healthy line of food. He struggled with lung cancer, and passed away on September 26, 2008,at the age of 83.
DEPARTMENT OF IMMUNOLOGY
General Features
❖ Tumor express antigens that are recognized as foreign by the immune system of the tumor-bearing host.
❖ Immune responses frequently fail to prevent the growth of tumors.
LAK TIL IL-2 TCR gene transfer Combination with chemotherapy
DEPARTMENT OF IMMUNOLOGY
DEPARTMENT OF IMMUNOLOGY
Content
1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy
Antigen that are expressed on tumor cells but not on normal cells were called tumor- specific antigens; some of these antigens are unique to individual tumors, whereas others are shared among tumors of the same type.
DEPARTMENT OF IMMUNOLOGY
Robin Bush The sister of George W. Bush, die from leukemia, at the age of 4.
Walt Disney This famous animator, producer and co-founder of the corporation known as The Walt Disney Company died at the age of 65 from lung cancer, making him one of the most famous celebrities to have died from smoking.
Immunity to tumors
DEPARTMENT OF IMMUNOLOGY
Content
1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy
❖ The immune system can be activated by external stimuli to effectively kill tumor cells and eradicate tumors.
DEPARTMENT OF IMMUNOLOGY
Tumor Antigen
DEPARTMENT OF IMMUNOLOGY
DEPARTMENT OF IMMUNOLOGY
Tumor Antigen
The earliest classification: ❖ Tumor-specific antigen ❖ Tumor-associated antigen
DEPARTMENT OF IMMUNOLOGY
Tumor Antigen
DEPARTMENT源自文库OF IMMUNOLOGY
Activated immune cell adoptive Transfer for tumor therapy
Steven A. Rosenberg
Steven A. Rosenberg is a leading cancer researcher and surgeon. He is credited with developing the use of IL-2 and immune cells for the treatment of patients with melanoma in a procedure termed adoptive cell transfer.
immune responses.
DEPARTMENT OF IMMUNOLOGY
❖The immune system can be activated by external stimuli to effectively kill tumor cells and eradicate tumors. --- Active immunotherapy; --- Passive immunotherapy.
DEPARTMENT OF IMMUNOLOGY
Cancer is a major health problem worldwide and one of the most important causes of morbidity and mortality in children and adults.
❖ Immune responses frequently fail to prevent the growth of tumors
❖ First, tumor cells are derived from host cells. ❖ Second, the rapid growth and spread of tumors ❖ Third, specialized mechanisms for evading host
Paul Newman Paul Newman was of course a great actor, but was known well for his healthy line of food. He struggled with lung cancer, and passed away on September 26, 2008,at the age of 83.
DEPARTMENT OF IMMUNOLOGY
General Features
❖ Tumor express antigens that are recognized as foreign by the immune system of the tumor-bearing host.
❖ Immune responses frequently fail to prevent the growth of tumors.
LAK TIL IL-2 TCR gene transfer Combination with chemotherapy
DEPARTMENT OF IMMUNOLOGY
DEPARTMENT OF IMMUNOLOGY
Content
1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy