医学免疫学-免疫器官PPT优选课件
合集下载
相关主题
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
cortex
shallow cortex (B cell areas)
paracortex (T cell areas)
medulla
medullary cords 髓索
(T,B,plasma cell and M) medullary sinus 髓窦
*function of thymus
8
thymus
---
胸腺小叶的结构
*structure of thymic lobule outer cortex inner medulla
*contain thymocytes and thymic stromal cells(TSC)
*function of thymus
TSC including: • thymus epithelial cells • macrophage • thymus dendritic cells • fibroblast
2020/10/18
5
2. Immune system (IS)
-
A.Components of immune system B.Functions of immune system
2020/10/18
6
A.Components of IS
immune organs
immune cells
immune molecules
第一课件网网站
医学微生物学 (46)
医学免疫学 (28)
医学寄生虫 (24)
药理学
(12)
2020/10/18
1
2020/10/18
2
Chapter 1,2
1.Major conception
2.Immune system
3.Type of immune response
4.The History of immunology
Immune molecules
secritory molecule (Ig,Complement,Cytokine)
membrane molecules
(TCR,BCR, MHC molecule, CKR ,CD
2020/1m0/18olecule, AM,CR and so on.)
13
B. Function of IS reject
*function
• 执行固有免疫 • 分泌SIgA , 执行局部特异性免疫功能的主要场所 • 参与口服抗原介导的免疫耐受
2020/10/18
12
Immune cells
---所有参与免疫应答或与免疫应答有关的细胞及其前 体,均属于免疫细胞
hematopoietic stem cells(HSC) phagocytes lymphocytes(T,B and NK cells) antigen-presenting cell (APC) other cell
边缘带
中央小动脉 (B cell,T cell)
2020/10/18
第一课件网网站
11
Mucosal immune system(MIS)
(or mucosal-associated lymphoid tissue, MALT)
*consists of unencapsulated subepithelial lymphoid found in the gastrointestinal, respiratory and urogenital tracts
2020/10/18
7
bone marrow *sourse of various blood cells
*site of B cell differentiation and mutulation
*site of developing response mediated by B cell
2020/10/18
2020/10/18
3
1. Major conception
A. Immunity
(immunis)
Classical conception
Biblioteka Baidu
---机体防御病原体侵袭的能力 (或抗感染的防御能力)
Modern conception
免疫是机体识别自己和非己, 并排除 非己抗原, 以维持机体内环境稳定的生理 性防御功能;正常情况下具有保护作用,异 常情况下可损害机体 （双重性）
sites of residence and developing immune
response for T and B cell
filter lymph
take 2020/10/18 part in lymphocyte recirculation
10
spleen 55%---B
35%---T
*structure
site of T cell differentiation and mutulation
induce autoimmune tolerance
take 2020/10/18 part in immunoregulation
9
lymph nodes 75% ---T
25%---B
*structure
2020/10/18
4
B.Antigen, antibody and immune
response
Combine with
Pathogen or toxic product
body
Specific substance
Ag
Ab
Ag→ → →body → → →Ab
(IS)
抗原刺激机体(免疫系统)产生抗体的全过程 称为免疫应答(immune response,IR)
white pulp red pulp
*function
•T,B细胞定居和
产生免疫应答 的 场所
•过滤血液 •合成免疫活性
物质的重要场所
被膜
边缘带
白髓 (淋巴鞘)
生发中心 脾索 (B cell,M,DC)
(淋巴滤泡) 红髓
静脉窦
入脾动脉
小动脉周
围淋巴鞘 (T cell areas)
淋巴小结的
生发中心 (B cell areas)
Immune organs
•central immune organ
---bone marrow and thymus
•peripheric immune organ and tissues
---lymph nodes and spleen
•mucosal-associated lymphoid tissue
shallow cortex (B cell areas)
paracortex (T cell areas)
medulla
medullary cords 髓索
(T,B,plasma cell and M) medullary sinus 髓窦
*function of thymus
8
thymus
---
胸腺小叶的结构
*structure of thymic lobule outer cortex inner medulla
*contain thymocytes and thymic stromal cells(TSC)
*function of thymus
TSC including: • thymus epithelial cells • macrophage • thymus dendritic cells • fibroblast
2020/10/18
5
2. Immune system (IS)
-
A.Components of immune system B.Functions of immune system
2020/10/18
6
A.Components of IS
immune organs
immune cells
immune molecules
第一课件网网站
医学微生物学 (46)
医学免疫学 (28)
医学寄生虫 (24)
药理学
(12)
2020/10/18
1
2020/10/18
2
Chapter 1,2
1.Major conception
2.Immune system
3.Type of immune response
4.The History of immunology
Immune molecules
secritory molecule (Ig,Complement,Cytokine)
membrane molecules
(TCR,BCR, MHC molecule, CKR ,CD
2020/1m0/18olecule, AM,CR and so on.)
13
B. Function of IS reject
*function
• 执行固有免疫 • 分泌SIgA , 执行局部特异性免疫功能的主要场所 • 参与口服抗原介导的免疫耐受
2020/10/18
12
Immune cells
---所有参与免疫应答或与免疫应答有关的细胞及其前 体,均属于免疫细胞
hematopoietic stem cells(HSC) phagocytes lymphocytes(T,B and NK cells) antigen-presenting cell (APC) other cell
边缘带
中央小动脉 (B cell,T cell)
2020/10/18
第一课件网网站
11
Mucosal immune system(MIS)
(or mucosal-associated lymphoid tissue, MALT)
*consists of unencapsulated subepithelial lymphoid found in the gastrointestinal, respiratory and urogenital tracts
2020/10/18
7
bone marrow *sourse of various blood cells
*site of B cell differentiation and mutulation
*site of developing response mediated by B cell
2020/10/18
2020/10/18
3
1. Major conception
A. Immunity
(immunis)
Classical conception
Biblioteka Baidu
---机体防御病原体侵袭的能力 (或抗感染的防御能力)
Modern conception
免疫是机体识别自己和非己, 并排除 非己抗原, 以维持机体内环境稳定的生理 性防御功能;正常情况下具有保护作用,异 常情况下可损害机体 （双重性）
sites of residence and developing immune
response for T and B cell
filter lymph
take 2020/10/18 part in lymphocyte recirculation
10
spleen 55%---B
35%---T
*structure
site of T cell differentiation and mutulation
induce autoimmune tolerance
take 2020/10/18 part in immunoregulation
9
lymph nodes 75% ---T
25%---B
*structure
2020/10/18
4
B.Antigen, antibody and immune
response
Combine with
Pathogen or toxic product
body
Specific substance
Ag
Ab
Ag→ → →body → → →Ab
(IS)
抗原刺激机体(免疫系统)产生抗体的全过程 称为免疫应答(immune response,IR)
white pulp red pulp
*function
•T,B细胞定居和
产生免疫应答 的 场所
•过滤血液 •合成免疫活性
物质的重要场所
被膜
边缘带
白髓 (淋巴鞘)
生发中心 脾索 (B cell,M,DC)
(淋巴滤泡) 红髓
静脉窦
入脾动脉
小动脉周
围淋巴鞘 (T cell areas)
淋巴小结的
生发中心 (B cell areas)
Immune organs
•central immune organ
---bone marrow and thymus
•peripheric immune organ and tissues
---lymph nodes and spleen
•mucosal-associated lymphoid tissue