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C (comparison)
O (outcomes)
關鍵字
比對結果
符合 符合 符合 符合
再次以文獻檢視PICO
文獻標題
第組
PICO
P (patient)
I (intervention)
C (comparison)
O (outcomes)
關鍵字
比對結果
符合 符合 符合 符合
再次以文獻檢視PICO
文獻標題
Resolution at 3 months: ORs of Prdnisolone + antivirals v.s
prednisolone + placebo: 1.24 Prednisolone-based treatment v.s non-Prednisolone-based
treatment ↑ 2-fold chance of recovery (95% CI: 1·55 - 2·42) Prdnisolone + antivirals may lead to slightly higher recovery
therapies for the treatment of Bell's palsy. 23 papers(n=1987) Incomplete recovery at one year: Antivirals v.s placebo:
No significant benefit in the rate of incomplete recovery (n = 1886, RR 0.88, 95% CI 0.65 to 1.18)
搜尋字串 / 限制
(Bell’s palsy) AND (acyclovir OR prednisolone) AND (recovery) eng[LA]
Cochrane
Bell’s palsy
結果
15
7
第組
再次以文獻檢視PICO
文獻標題
第組
PICO
P (patient)
I (intervention)
Antivirals v.s corticosteroids
the outcome with antivirals was significantly worse (n = 768, RR 2.82, 95% CI 1.09 to 7.32)
Antivirals + corticosteroids v.s antivirals + placebo
BMC Neurology 2011, 11:1
Pawin Numthavaj, Ammarin Thakkinstian, Charungthai Dejthevaporn, John Attia
Meta-analysis, Medline and EMBASE, RCT (1a) Six studies (total n = 1805)
臨床問題
問題類型：■預後 □診斷 □傷害 □預防
PICO
第組
P (patient)
I (intervention)
C (comparison)
O (outcomes)
關鍵字 (Keywords)
Bell’s palsy Prednisolone Placebo recovery
搜尋歷程
資料庫
PubMed
The outcome was significantly better 第 組 (n = 658, RR 0.56, 95% CI 0.41 to 0.76)
Corticosteroids for Bell‘s palsy (idiopathic facial paralysis)
The cochrane library Published Online: 17 MAR16 JUN 2010
Rodrigo A Salinas1, Gonzalo Alvarez, Fergus Daly, Joaquim Ferreira
Cochrane Neuromuscular Disease Group Trials Specialized Register, MEDLINE, EMBASE, LILACS
rates compared to treating with prednisone alone
does not quite reach statistical significance
第組
Antiviral treatment for Bell‘s palsy (idiopathic facial paralysis)
第組
PICO
P (patient)
I (intervention)
C (comparison)
O (outcomes)
關鍵字
比對結果
符合 符合 符合 符合
文獻評讀
第組
Corticosteroid and antiviral therapy for Bell's palsy: A network meta-analysis
第組
臨床問題
源自文库
問題類型：■預後 □診斷 □傷害 □預防
PICO
第組
P (patient)
I (intervention)
C (comparison)
O (outcomes)
關鍵字 (Keywords)
Bell’s palsy Acycolvir Acycolvir + prenisolone recovery
101年度 實證醫學競賽報告 第B組
8A 陳明怡 神經外科 劉恆維 NSICU侯俊宇
第組
臨床場景
一位剛剛發生顏面麻痺的病患,傳統上可以給予口服抗 病毒藥物,以及類固醇,據說可以減少日後長久顏面神 經麻痺與產生併發症機會,但病患對使用這兩種藥物有 疑慮:
1.我願意花錢買Acyclovir,但有效嗎? 2.類固醇聽說對身體不好,可以勉強接受,但有效嗎? 3.一定要兩個一起吃嗎?可以只吃Acyclovir嗎?
The cochrane library Published Online: 16 JUN 2010
Pauline Lockhart1, Fergus Daly, Marie Pitkethly, Natalia Comerford, Frank Sullivan1
Meta-analysis RCT of antivirals with and without corticosteroids versus control
O (outcomes)
關鍵字
比對結果
符合 符合 符合 符合
再次以文獻檢視PICO
文獻標題
第組
PICO
P (patient)
I (intervention)
C (comparison)
O (outcomes)
關鍵字
比對結果
符合 符合 符合 符合
再次以文獻檢視PICO
文獻標題
Resolution at 3 months: ORs of Prdnisolone + antivirals v.s
prednisolone + placebo: 1.24 Prednisolone-based treatment v.s non-Prednisolone-based
treatment ↑ 2-fold chance of recovery (95% CI: 1·55 - 2·42) Prdnisolone + antivirals may lead to slightly higher recovery
therapies for the treatment of Bell's palsy. 23 papers(n=1987) Incomplete recovery at one year: Antivirals v.s placebo:
No significant benefit in the rate of incomplete recovery (n = 1886, RR 0.88, 95% CI 0.65 to 1.18)
搜尋字串 / 限制
(Bell’s palsy) AND (acyclovir OR prednisolone) AND (recovery) eng[LA]
Cochrane
Bell’s palsy
結果
15
7
第組
再次以文獻檢視PICO
文獻標題
第組
PICO
P (patient)
I (intervention)
Antivirals v.s corticosteroids
the outcome with antivirals was significantly worse (n = 768, RR 2.82, 95% CI 1.09 to 7.32)
Antivirals + corticosteroids v.s antivirals + placebo
BMC Neurology 2011, 11:1
Pawin Numthavaj, Ammarin Thakkinstian, Charungthai Dejthevaporn, John Attia
Meta-analysis, Medline and EMBASE, RCT (1a) Six studies (total n = 1805)
臨床問題
問題類型：■預後 □診斷 □傷害 □預防
PICO
第組
P (patient)
I (intervention)
C (comparison)
O (outcomes)
關鍵字 (Keywords)
Bell’s palsy Prednisolone Placebo recovery
搜尋歷程
資料庫
PubMed
The outcome was significantly better 第 組 (n = 658, RR 0.56, 95% CI 0.41 to 0.76)
Corticosteroids for Bell‘s palsy (idiopathic facial paralysis)
The cochrane library Published Online: 17 MAR16 JUN 2010
Rodrigo A Salinas1, Gonzalo Alvarez, Fergus Daly, Joaquim Ferreira
Cochrane Neuromuscular Disease Group Trials Specialized Register, MEDLINE, EMBASE, LILACS
rates compared to treating with prednisone alone
does not quite reach statistical significance
第組
Antiviral treatment for Bell‘s palsy (idiopathic facial paralysis)
第組
PICO
P (patient)
I (intervention)
C (comparison)
O (outcomes)
關鍵字
比對結果
符合 符合 符合 符合
文獻評讀
第組
Corticosteroid and antiviral therapy for Bell's palsy: A network meta-analysis
第組
臨床問題
源自文库
問題類型：■預後 □診斷 □傷害 □預防
PICO
第組
P (patient)
I (intervention)
C (comparison)
O (outcomes)
關鍵字 (Keywords)
Bell’s palsy Acycolvir Acycolvir + prenisolone recovery
101年度 實證醫學競賽報告 第B組
8A 陳明怡 神經外科 劉恆維 NSICU侯俊宇
第組
臨床場景
一位剛剛發生顏面麻痺的病患,傳統上可以給予口服抗 病毒藥物,以及類固醇,據說可以減少日後長久顏面神 經麻痺與產生併發症機會,但病患對使用這兩種藥物有 疑慮:
1.我願意花錢買Acyclovir,但有效嗎? 2.類固醇聽說對身體不好,可以勉強接受,但有效嗎? 3.一定要兩個一起吃嗎?可以只吃Acyclovir嗎?
The cochrane library Published Online: 16 JUN 2010
Pauline Lockhart1, Fergus Daly, Marie Pitkethly, Natalia Comerford, Frank Sullivan1
Meta-analysis RCT of antivirals with and without corticosteroids versus control