CIR化妆品原料安全使用指南072018

Quick Reference Table Ingredient Name
4-Nitro-m-Phenylenediamine 5-Amino-4-Chloro-o-Cresol 5-Amino-6-Chloro-o-Cresol 5-Bromo-5-Nitro-1,3-Dioxane
Finding†
as an oxidative hair dye in hair coloring products 0.2% as the free base 0.2% as the free base
in wk.baidu.comair dyes
should not be used in cosmetic products where N-nitroso compounds may be formed should not be used in cosmetic products where N-nitroso compounds may be formed 2% in hair dyes 2% in hair dyes 0.1%; may contribute to endogenous nitrosamine formation; but should not be used under circumstances where its actions with amines or amides can result in the formation of nitrosamines or nitrosamides
JACT 11(4):521-530, 1992 JACT 11(4):521-530, 1992 IJT 24(S5):53-100, 2005
2-Methyl Resorcinol 2-Methyl-5-Hydroxyethylaminophenol 2-Nitro-p-Phenylenediamine 2-oleamido-1,3-Octadecanediol 3-Methylamino-4-Nitrophenoxyethanol 3-Nitro-p-Hydroxyethylaminophenol 4-Amino-2-Hydroxytoluene 4-Amino-2-Nitrophenol 4-Amino-3-Nitrophenol 4-Amino-m-Cresol 4-Chloro-2-Aminophenol 4-Chlororesorcinol 4-Hydroxypropylamino-3-Nitrophenol 4-Methoxy-m- Phenylenediamine 4-Methoxy-m-Phenylenediamine HCl 4-Methoxy-m-Phenylenediamine Sulfate
S SQ S SQ Z UNS Z Z UNS UNS UNS Z UNS S S SQ
IJT 23(S2):1-22, 2004 IJT 23(S2):1-22, 2004 IJT 33(S3):24-35, 2014 IJT 21(S3):1-50, 2002 IJT 24(S3):75-118, 2005 IJT 24(S3):75-118, 2005 IJT 24(S3):75-118, 2005 IJT 24(S3):75-118, 2005 IJT 24(S3):75-118, 2005 IJT 24(S3):75-118, 2005 IJT 24 (S3):75-118, 2005 IJT 24(S3):75-118, 2005 IJT 24(S3):75-118, 2005 IJT 24(S3:75-118, 2005 IJT 24(S3:75-118, 2005 IJT 34(S1): 18-34, 2015; JACT 12(3):225-36, 1993 (original report); IJT 30(S2):73-127, 2011 (re-review) IJT 31(S4): 112-136, 2012 Final report 12/2017 available from CIR IJT 36(Suppl. 1):17-56, 2017 IJT 31(S3):296-341, 2012 IJT 31(S3):296-341, 2012 IJT 36(Suppl. 1):17-56, 2017 IJT 36(Suppl. 1):17-56, 2017 IJT 36(Suppl. 1):17-56, 2017 IJT 36(Suppl. 1):17-56, 2017 IJT 36(Suppl. 1):17-56, 2017 IJT 36(Suppl. 1):17-56, 2017 IJT 21(S2):1-17, 2002 IJT 21(S2):1-17, 2002 IJT 21(S2):1-17, 2002 IJT 21(S2):1-17, 2002 IJT 36(Suppl. 1):17-56, 2017 JEPT 4(4):63-92, 1980 confirmed 02/03 IJT 24(S1):2-10, 2005 JEPT 4(4):63-92, 1980 confirmed 02/03 IJT 24(S1):2-10, 2005 IJT 20(S2):79-84, 2001; IJT 35(Suppl. 3):5-15, 2016 IJT 35(Suppl. 3):5-15, 2016 IJT 35(Suppl. 3):5-15, 2016 IJT 19(S1):1-9, 2000 IJT 20(S3):1-6, 2001; Final report 12/2016 available from CIR IJT 31(S3): 296-341 (2012)
Quick Reference Table Ingredient Name
1,2-Butanediol 1,2-Hexanediol 1,4-Butanediol/Succinic Acid/Adipic Acid/HDI Copolymer 1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate 1-Naphthol 2,3-Naphthalenediol 2,4-Diaminophenol 2,4-Diaminophenol HCl (aka 2,4Diaminophenol Dihydrochloride) 2,4-Diaminophenoxyethanol HCl 2,4-Diaminophenoxyethanol Sulfate 2-Amino-3-Hydroxypyridine 2-Amino-3-Nitrophenol 2-Amino-4-Nitrophenol 2-Amino-4-Nitrophenol Sulfate 2-Amino-4-hydroxyethylaminoanisole 2-Amino-4-hydroxyethylaminoanisole Sulfate 2-Amino-5-Nitrophenol 2-Amino-6-Chloro-4-Nitrophenol 2-Amino-6-Chloro-4-Nitrophenol HCl 2-Bromo-2-Nitropropane-1,3-Diol
2-Chloro-p-Phenylenediamine 2-Chloro-p-Phenylenediamine Sulfate 2-Ethoxy Ethoxy Ethyl Methacrylate
S S SQ
safe in nail enhancement products when skin contact is avoided; products containing this ingredient should be accompanied with directions to avoid skin contact because of the sensitizing potential of methacrylates
Citation‡
JACT 4 (3):161-202, 1985 confirmed 11/03 IJT 25(S2), 2006 IJT 23(S2):1-22, 2004 IJT 23(S2):1-22, 2004 JACT 9(2):279-88, 1990
6-Amino-m-Cresol 6-Amino-o-Cresol 6-Hydroxyindole AMP-Acrylates Copolymer Acacia Catechu Gum Acacia Concinna Fruit Extract Acacia Dealbata Leaf Extract Acacia Dealbata Leaf Wax Acacia Decurrens Extract Acacia Farnesiana Flower Wax Acacia Farnesiana Flower/Stem Extract Acacia Farnesiana Gum Acacia Senegal Extract Acacia Senegal Gum Acacia Senegal Gum Extract Acetamide MEA
JACT 5(3):167- 203, 1986 confirmed 12/06 JACT 9(2):185-202, 1990 confirmed 08/06 JACT 4 (3):161-202, 1985 confirmed 11/03 IJT 25(S2), 2006 Final report 03/2015 available from CIR IJT 27 (S2): 41-51, 2008 IJT 28(S3): 217-251, 2009 JACT 8 (4):569-87, 1989 confirmed 04/06 IJT 28(S3): 217-251, 2009 IJT 28(S3): 217-251, 2009 IJT 23(S2):1-22, 2004 IJT 23(S2):1-22, 2004 JACT 15 (4): 284-94, 1996 IJT 28(S3): 217-251, 2009 JACT 11(4):381-422, 1992 JACT 11(4):381-422, 1992 JACT 11(4):381-422, 1992
S S S SQ
Detail
in oxidative and non-oxidative hair dyes in oxidative and non-oxidative hair dyes 0.1%; but should not be used under circumstances where its actions with amines or amides can result in the formation of nitrosamines or nitrosamides in oxidative and non-oxidative hair dyes safe as used in oxidative hair dyes, but the available data are insufficient to support the safety in non-oxidative hair dyes safe for use when formulated to avoid irritation
S S S S S S S Z S S SQ;Z S S U U U
in oxidative and non-oxidative hair dyes as used in oxidative hair dyesavailable data are insufficient to support the safety in non-oxidative hair dyes in hair dyes in hair dyes carcinogenicity carcinogenicity carcinogenicity
Finding†
S S S S S Z SQ SQ S S S S S S SQ SQ S SQ SQ SQ
Detail
Citation‡
IJT 31(S2):147-168, 2012 IJT 31(S2):147-168, 2012 Final report 06/2016 available from CIR Final report 03/2016 available from CIR JACT 8(4):749-68, 1989 confirmed 12/06 JACT 7(3):353-57, 1988 JACT13(5):330-43, 1994 confirmed 06/09 JACT 13(5):330-43, 1994 confirmed 06/09 Final Amended Report 12/07 Available from CIR JACT 10(1):113-34, 1991 (original report) Final Amended Report 12/07 Available from CIR JACT 10(1):113-34, 1991 (original report) Final report 09/2014 available from CIR IJT 28(S3): 217-251, 2009 IJT 28(S3): 217-251, 2009 IJT 28(S3): 217-251, 2009 IJT 32(S1):25-35, 2013 IJT 32(S1):25-35, 2013 IJT 28(S3): 217-251, 2009 IJT 16(S1):131-43,1997 IJT 16(S1):131-43,1997 JACT 3(3):139-55, 1984 (Addendum) JEPT 4(4):47-61, 1980 (Original report) confirmed 09/03 IJT 25(S2), 2006