第五章《补体系统》练习题
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第五章《补体系统》练习题
一、单项选择题
1.补体激活的经典途径中,其补体成分的激活顺序是·····························()
A、C1→C2→C3→C4→C5→C6→C7→C8→C9
B、C1→C2→C4→C3→C5→C6→C7→C8→C9
C、C1→C4→C5→C2→C3→C6→C7→C8→C9
D、C1→C4→C2→C3→C5→C6→C7→C8→C9
2.下列补体固有成分中含量最高的是··········································()
A、C3
B、C4
C、C1q
D、C2
3.具有调理作用的补体裂解片段是············································()
A、C2b
B、C3b
C、C3a
D、C5b
4.具有过敏毒素作用的补体组分是············································()
A、C3a、C4a、C5a
B、C3a、C4a
C、C2a
D、C3b、C4b 5.构成膜攻击复合物的补体成分是············································()
A、C6b~9
B、C4b2a
C、C5b6789n
D、C3bBb
6.与抗原结合后,可通过经典途径激活补体系统的Ig是··························()
A、IgA、IgG
B、IgM、IgG
C、sIgA、IgD
D、IgA、IgM 7.可以激活补体旁路途径的成分是············································()
A、内毒素
B、抗原抗体复合物
C、IgM
D、MBL
8.关于补体正确的叙述是····················································()
A、补体成分在血液中处于活化状态
B、旁路途径的活化是从C2开始的
C、补体的理化性质稳定
D、补体主要是由肝细胞和巨噬细胞产生的9.三条补体激活途径的共同点是··············································()
A、参与的补体成分
B、C3转化酶的组成
C、激活物质
D、膜攻击复合物的形成及其溶解细胞效应
10.与免疫球蛋白Fc段的补体结合部位相结合的补体分子是······················()
A、C3
B、C1q
C、C1r
D、C1s
11.既对中性粒细胞具有趋化作用又可激发肥大细胞释放组胺的补体裂解产物是·····()
A、C3b
B、C4b
C、C4a
D、C5a
12.某些补体片段能促进吞噬细胞的吞噬作用,是因为吞噬细胞表面存在············()
A、D因子受体
B、C3b受体
C、C5a受体
D、C3a受体13.下列补体活化中形成的转化酶中,不包含补体C3b成分的是····················()
A、经典途径C5转化酶
B、旁路途径C5转化酶
C、经典途径C3转化酶
D、旁路途径C3转化酶
14.下列具有溶细胞作用的补体成分是·········································()
A、C1
B、B因子
C、C3b
D、C5b6789n
15.下列具有趋化中性粒细胞的补体成分是·····································()
A、C1
B、C4b
C、C3b
D、C5a
16.补体激活经典途径的C3转化酶是··········································()
A、C4a2a
B、C4a2b
C、C4b2b
D、C4b2a
17.补体激活经典途径的C5转化酶是··········································()
A、C3bBb
B、C4b2a
C、C3bnBb
D、C4b2a3b
18.补体激活旁路途径的C5转化酶是··········································()
A、C3bBb
B、C4b2a
C、C3bnBb
D、C4b2a3b
19.补体激活旁路途径的C3转化酶是··········································()
A、C3bBb
B、C4b2a
C、C3bnBb
D、C4b2a3b
20.补体激活凝集素途径的C5转化酶是········································()
A、C3bBb
B、C4b2a
C、C3bnBb
D、C4b2a3b
二、填空题
1.补体系统由、及组成。
2.C1由、、三种蛋白组成。
3.补体旁路途径的激活物质是;类和类抗体与抗原结合形成的免疫复合物可经经典途径激活补体。
4.具有趋化因子作用的补体片段是;具有调理作用的补体片段有、和。5.具有炎症介质作用的补体片段有、和;补体攻膜复合物(MAC)的组成是。
三、名词解释
补体补体的调理作用免疫黏附作用MAC
四、简答题
1.简述补体膜攻击复合物(MAC)的组成及其靶细胞溶解的效应机制。
2.简述补体的生物学功能及相应的补体成分。
五、问答题
1.比较补体经典途径和旁路途径的异同点(激活物、参与的补体成分、C3转化酶、C5转化酶及作用等)。