遗传题库整理Chapter 16
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Chapter 16
D 1 Which of the following statements is false?
A) The primary function of basal transcription factors is to assist in associating RNA polymerase with the promoter element.
B) The Myc transcription factor functions to cause proliferation in specific cell types by associating with Max to form heterodimers.
C) Mutations in the GAL80 gene in yeast result in the continuous expression of the GAL1, GAL7, and GAL10 genes, even in the absence of galactose.
D) The association of DNA with histones to form chromatin increases transcription.
E) A variation that does not involve a change in DNA sequence but can be passed from one generation to another is an epigenetic condition.
Feedback: Review the section "Chromatin Structure and Epigenetic Effects" (pp. 562-568).
B 2 miRNA is involved in:
A) transcriptional silencing
B) RNA interference
C) ubiquitination
D) methylation
E) quenching
Feedback: Review the process of RNA interference (pp. 569-572).
B 3 Protein encoding genes are transcribed by
A) RNA polymerase I
B) RNA polymerase II
C) RNA polymerase III
D) RNA polymerase IV
E) all of the above
Feedback: Review the function of the various RNA polymerases (p. 554).
A 4 Hypercondensation of heterochromatin can result in:
A) transcriptional silencing
B) mRNA editing
C) ubiquitination
D) methylation
E) quenching
Feedback: Review the process of chromatin remodeling (pp. 563-565).
E 5 Alteration of the properties of one transcription factor by another is an example of:
A) transcriptional silencing
B) mRNA editing
C) ubiquitination
D) methylation
E) quenching
Feedback: Review transcriptional silencing (pp. 564-565), mRNA editing (p. 500), ubiquitination (p. 562), methylation (p. 562), and quenching (p. 558).
C 6 Targeting of a protein for degradation is accomplished by:
A) transcriptional silencing
B) mRNA editing
C) ubiquitination
D) methylation
E) quenching
Feedback: Review protein modification after translation (p. 572).
C 7 Gene silencing that is heritable is an example of:
A) basal factors
B) locus control region
C) imprinting
D) iron response element
E) proteasome
Feedback: Review the material on genomic imprinting (pp. 565-568) and Figure 16.23.
B 8 Transcription factors act as _________.
A) cis‐acting regulatory elements
B) trans‐acting regulatory elements
C) promoters
D) enhancers
E) micro‐RNAs
Feedback:
Review the section on trans-acting elements (p. 555) and Figure 16.4.
E 9 SWI‐SN
F proteins are involved in:
A) basal transcription
B) RNA interference
C) repression
D) enhancer inactivation
E) chromatin remodeling
Feedback: Review the material on chromatin remodeling (pp. 563-565) and Figure 16.20.
E 10 DNA binding is mediated by:
A) zinc finger motifs
B) helix‐turn‐helix motifs