奥美拉唑与西咪替丁治疗应激性胃溃疡的疗效观察

奥美拉唑与西咪替丁治疗应激性胃溃疡的疗效观察

Abstract：Objective To observe the clinical effect of Omeprazole and Cimetidine in the treatment of stress gastric ulcer and their effect on the quality of life of patients.Methods 64 patients with stress gastric ulcer from January 2016 to January 2018 were randomly divided into observation group and control group with 32 cases in each group.The control group was treated with Cimetidine and the observation group with Omeprazole.The clinical efficacy，hemostatic time，gastrin level，quality of life score and incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 96.88%，which was higher than that in the control group 78.13%，the difference was statistically significant （P0.05）.After treatment，gastrin levels in the observation group were lower than those in the control group [（95.24 ±2.36）pg/ml vs （112.48 ±2.26）pg/ml]，the difference was statistically significant （P0.05）.The hemostatic time of the patients in the observation group was shorter than that in the control group，and the score of quality of life in the observation group was higher than that in the control group，the difference was statistically significant （P0.05）.The incidence of adverse reactions in the observation group was 3.13%，which was significantly lower than that in the control group 18.75%，the difference was statistically significant （P0.05）.Conclusion The effect of Omeprazole on patients with stress gastric ulcer is better than Cimetidine，and it is more helpful to improve the quality of daily life.

Key words：Stress gastric ulcer；Omeprazole；Cimetidine；Quality of life

應激性胃溃疡（stress gastric ulcer）的患病率呈现逐年增加的趋

势，该疾病属于临床常见的消化内科疾病之一，具有病情危急、进展快速等特点，若治疗不及时，患者可出现胃穿孔、休克等并发症，严重者可致死，对其生命安全构成了严重威胁。因此，对患者实施有效干预十分关键。药物疗法是治疗应激性胃溃疡的有效手段，而如何安全、有效治疗应激性胃溃疡已经成为临床关注的热点问题，其中奥美拉唑、西咪替丁均属于临床治疗应激性胃溃疡的常用药物，但目前临床关于上述2种药物的疗效及安全性依然存在一定争议。为对比奥美拉唑、西咪替丁的临床疗效，我院对应激性胃溃疡患者分别应用奥美拉唑、西咪替丁治疗，现报道如下。

1 资料与方法

1.1一般资料选择2021年1月～2021年1月都昌县人民医院消化内科收治的64例应激性胃溃疡患者，按照随机数字表法分为观察组和对照组，各32例。观察组患者男20例，女12例，年龄23～47岁，平均年龄（3

2.78±6.42）岁；发病原因：术后7例，烧伤5例，中毒10例，颅内出血8例，脑外伤2例。对照组中男19例，女13例，年龄22～46岁，平均年龄（32.69±6.35）岁；发病原因：术后6例，烧伤4例，中毒11例，颅内出血8例，脑外伤3例。两组患者性别、年龄及发病原因等资料比较，差异无统计学意义（P0.05），研究可进行。

1.2纳入和排除标准纳入标准：①患者均经胃镜检查证实为应激性胃溃疡；②年龄20岁；③临床资料齐全，且自愿配合研究者。排除标准：①存在药物过敏史者；②合并胃部大出血者；③既往存在消化道溃疡病史者；④精神异常、肝肾功能异常、妊娠期或哺乳期者。

1.3方法64例应激性胃溃疡患者均进行常规治疗，即给予患者抗感染、止血、补液、使用胃黏膜保护剂等治療。观察组应用奥美拉唑（海南新世通制药有限公司，国药准字H***-*****，规格：40 mg）治疗，0.6～0.8 mg/（kg·d）加入100 ml浓度为0.9%氯化钠注射液静脉滴注，2次/d，治疗1个月。对照组西咪替丁治疗（海南通用同盟药业有限公司，国药准字H***-*****，规格：0.4 g），0.2 mg西咪