转录共激活子 英语

转录共激活子英语
英文回答：
Coactivators are proteins that enhance the transcriptional activity of transcription factors. They do this by interacting with the transcription factor and recruiting other proteins to the transcription initiation complex. This allows the transcription factor to bind to the DNA more tightly and to more effectively promote the formation of the transcription initiation complex.
Coactivators can be divided into two main classes: general coactivators and specific coactivators. General coactivators interact with a wide range of transcription factors, while specific coactivators only interact with a few. Some of the most common general coactivators include Mediator, SWI/SNF, and CBP/p300. Some of the most common specific coactivators include CREB-binding protein (CBP), p300, and SRC-1.
Coactivators play an important role in regulating gene expression. They can help to determine which genes are transcribed and how much of each gene is transcribed. This makes them important targets for therapeutic intervention. For example, drugs that inhibit the activity of coactivators could be used to treat diseases that are caused by the overexpression of genes.
中文回答：
转录共激活因子是增强转录因子转录活性的蛋白质。

它们通过与转录因子相互作用并将其他蛋白质募集到转录起始复合体来实现这一目标。

这使得转录因子可以更紧密地与 DNA 结合，并更有效地促进转录起始复合体的形成。

转录共激活因子可分为两大类，通用共激活因子和特异性共激活因子。

通用共激活因子与广泛的转录因子相互作用，而特异性共激活因子仅与少数转录因子相互作用。

一些最常见的通用共激活因子包括介体、SWI/SNF 和 CBP/p300。

一些最常见的特异性共激活因子包括 CREB 结合蛋白 (CBP)、p300 和 SRC-1。

转录共激活因子在基因表达调控中起着重要作用。

它们可以帮
助确定转录哪些基因以及转录每个基因的量。

这使它们成为治疗干预的重要靶点。

例如，抑制共激活因子活性的药物可用于治疗由基因过度表达引起的疾病。