PROCESS FOR THE PRODUCTION OF AN AMYLASE INHIBITOR
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专利名称：PROCESS FOR THE PRODUCTION OF AN AMYLASE INHIBITOR
发明人：FROMMER W,DT,PULS W,DT,SCHMIDT D,DT 申请号：US33668773
申请日：19730228
公开号：US3855066A
公开日：
19741217
专利内容由知识产权出版社提供
摘要：The invention relates to an amylase inhibitor for glycoside-hydrolases derived from a new strain of micro-organism, mutants and variants thereof, of the order Actinomycetales, means for their production comprising cultivation of the new strain of the order Actinomycetales, mutants and variants thereof, in appropriate nutrient solutions under conditions most favorable to growth and production of said amylase inhibitor and recovering an amylase inhibitor from culture broths of said nutrient solutions and said new strain of microorganism, mutants and variants thereof, of the order Actinomycetales as well as the use of said enzyme inhibitor in pharmaceutically acceptable therapeutic compositions suitable for use in the treatment and relief of conditions indicative of obesity, diabetes, pre-diabetes, gastritis, gastric and duodenal ulcers, hyperlipidemia (atheriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes, and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzyme in the presence of a glycoside-hydrolase enzyme inhibitor derived from a new strain, mutants and variants thereof, of the order Actinomycetales. The
invention further contemplates the provision of method for the treatment of indications of the group consisting of obesity, hyperlipidemia (atheriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer and dental caries induced by the action of glycoside-hydrolase enzymes and carbohydrates which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a new strain of microorganism of the order Actinomycetales of the family Actinoplanaceae.
申请人：BAYER AG,DT
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