PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
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专利名称：PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
发明人：DELMAR, Mario,TAFFET, Steven, M.
申请号：EP07718080.0
申请日：20070116
公开号：EP1978988A2
公开日：
20081015
专利内容由知识产权出版社提供
摘要：The present invention relates to proteins and polypeptides that (i) have the formula A-[W-A]n where A is a peptide of formula XXXXRXPXXXX where X is any amino acid, R is arginine, and P is proline; W is a linker; and n is any number from 1 through 5; or (ii) consist essentially of the formula XnRXPX3n where each X is any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is between ten and fifteen. Methods using these proteins and polypeptides to: screen for compounds that modulate Cx43CT, measure Cx43CT-binding affinity of a compound that binds to Cx43CT, and identify the location of an RXP-binding domain of Cx43CT, are also disclosed.
申请人：The Research Foundation of State University of New York
地址：35 State Street Albany, NY 12207-2826 US
国籍：US
代理机构：Jones, Stephen Anthony
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