Novel derivatives of peptides therapeutically acti

专利名称：Novel derivatives of peptides
therapeutically active in the cascade
sequence for blood coagulation, process for
their preparation and pharmaceutical
compositions containing same
发明人：JEAN-LUC FAUCHERE,CHRISTOPHE
THURIEAU,TONY VERBEUREN,ALAIN
RUPIN,SERGE SIMONET
申请号：AU7858794
申请日：19941006
公开号：AU680696B2
公开日：
19970807
专利内容由知识产权出版社提供
摘要：The present invention relates to a process for the preparation of cyclopentanone mono - or d - substituted in position 2.... & lt; br / > the method of preparation of the invention is characterized in that it consists in successively carry out the 4 steps (a) to (d) which can be sequenced, if need be, in the same reactor: (a) is a step of the addition of an alkyl acetoacetate on 1,3 - butadiene, optionally substituted in position 2; (b) is a step of deacylation of the addition product formed, followed by alkaline hydrolysis and acidification in order to produce a monocarboxylic acid with 6 carbon atoms in its main chain; (c) is a step of hydroxycarbonylation the monoacid in order to produce an alpha, omega - dicarboxylic acid having 6 carbon atoms in its main chain; and (d) is a step of decarboxylation cyclization of the diacid. & lt; br / > the invention relates more particularly the preparation of 2,2 - dimethylcyclopentanone.
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