卡比多巴的药物代谢动力学研究(Pharmacokinetic Study of Carbidopa)_计算生物学_科研数据集

卡比多巴的药物代谢动力学研究(Pharmacokinetic
Study of Carbidopa)
数据摘要：
As part of a pharmacokinetic study, 12 healthy male subjects were allocated randomly to a three period crossover design receiving one of three graded doses (25, 50, 100 mg) of Carbidopa q8h in each treatment period. A seven day washout period separated the treatment periods. The pharmacokinetic variables AUC, Cmax, and Tmax were calculated for each subject from plasma concentrations assayed from blood samples taken at 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, and 8 hours postdosing following the second dose of carbidopa on the sixth day of each treatment period.
中文关键词：
药物代谢动力学研究,卡比多巴,健康男性,随机分配,治疗,
英文关键词：
pharmacokinetic study,carbidopa,healthy male,allocate randomly,treatment,
数据格式：
TEXT
数据用途：
The data can be used for computational biology.
数据详细介绍：
Favorite Datasets from Early Phases of Drug Research
Pharmacokinetic Study of Carbidopa
Part 2 - Table 6
Abstract
As part of a pharmacokinetic study, 12 healthy male subjects were allocated randomly to a three period crossover design receiving one of three graded doses (25, 50, 100 mg) of Carbidopa q8h in each treatment period. A seven day washout period separated the treatment periods. The pharmacokinetic variables AUC, Cmax, and Tmax were calculated for each subject from plasma concentrations assayed from blood samples taken at 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, and 8 hours postdosing following the second dose of carbidopa on the sixth day of each treatment period.
Is there a dose response for AUC, Cmax, or Tmax?
∙Can dose proportionality be established?
∙Is there a relationship between AUC, Cmax, and Tmax?
Source:
Bradstreet, T.E. (1992) "Favorite Data Sets from Early Phases of Drug Research - Part 2." Proceedings of the Section on Statistical Education of the American Statistical Association.
数据预览：
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