ANTIBODY-COUPLED T CELL RECEPTOR CONSTRUCTS AND TH
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专利名称：ANTIBODY-COUPLED T CELL RECEPTOR CONSTRUCTS AND THERAPEUTIC USES
THEREOF
发明人：Kathleen MCGINNESS,Gregory
MOTZ,Michael FRAY,Birgit SCHULTES,James
HEMPHILL,James KIM,Tooba
CHEEMA,Taylor HICKMAN
申请号：US16481786
申请日：20180130
公开号：US20200181226A1
公开日：
20200611
专利内容由知识产权出版社提供
摘要：Disclosed herein are antibody-coupled T cell receptor (ACTR) polypeptides comprising: a CD16A extracellular domain, a transmembrane domain, one or more co-stimulatory signaling domains, at least one of which is a CD28 co-stimulatory signaling domain, and a CD3z cytoplasmic signaling domain. Also disclosed herein are genetically engineered immune cells, expressing: a first polypeptide which is an antibody-coupled T cell receptor (ACTR); and a second polypeptide that elicits a co-stimulatory signal as well as methods of enhancing antibody-dependent cell cytotoxicity (ADCC) in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a therapeutic antibody and an effective amount of immune cells (e.g., T lymphocytes and/or NK cells) expressing an antibody-coupled T-cell receptor (ACTR) polypeptide.
申请人：UNUM THERAPEUTICS INC.
地址：Cambridge MA US
国籍：US
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