146例先天性白内障发生的相关因素分析

146例先天性白内障发生的相关因素分析
罗琪;周炼红;田明星;易贝茜;叶美红;徐永红
【期刊名称】《临床眼科杂志》
【年(卷),期】2014(000)003
【摘要】探讨先天性白内障发生的危险因素，为防治先天性白内障提供依据。

方
法采用病例对照研究设计。

收集2010年1月至2013年4月武汉大学人民医院确诊的先天性白内障患者146例，选取儿科体检的正常儿童584例作为对照组，采
用χ2检验比较先天性白内障白组与对照组在既往史、家族遗传史、个人史及临床表现等方面的差异，采用多因素logistic 回归分析提取主要危险因素。

结果白内障组的平均出生胎龄为（30．58±1.97）周，明显低于对照组（36．56±2．00）周，差异有统计学意义（ t ＝3．90， P ＜0．01）；白内障组的平均出生体重为（1388．89±268．39） g，明显低于对照组平均出生体重为
（2173．91±349．73） g，差异有统计学意义（ t ＝4．45， P＜O．01）；单因素分析提示，早产（χ2＝40．061， P ＜0．05）、低体重（χ2＝26．809，
P ＜0．05）、家族遗传史（χ2＝102.004， P ＜0．05）、持续吸氧（χ2＝31．667， P ＜0．05）、孕期感染（χ2＝6．410， P ＜0．05）与先天性白内
障的发生密切相关。

多因素logistic回归分析表明，出生胎龄（χ2＝8．314，OR 值为1．998， P ＜0．05）、出生体重（χ2＝26．809， OR值为3．375， P
＜0．05）、孕期感染（χ2＝6．410，OR值为2．091， P ＜0．05）、家族遗传（χ2＝97．113，OR值为16.977， P ＜0．05）是先天性白内障的主要危险
因素。

出生体重越低，出生胎龄越小，有孕期感染、家族遗传史，先天性白内障的发生率越高。

结论早产、低体重、家族遗传史、持续吸氧、孕期感染与先天性白内
障的发生密切相关。

早产、低体重、孕期感染、家族遗传是先天性白内障的主要危险因素；先天性白内障患者常合并其他眼部异常。

%Objective To explore the risk factors and clinical characteristics of congenital cataract , and to provide the information for prevention and treatment of congenital cataract .Methods Case control study was conducted in 146 pa-tients with congenital cataract diagnosed between January 2010 and April 2013 and 584 controls.Patients’ data were col-lected from Department of Ophthalmology , People’s H ospital of Wuhan University .Disease history, cataract family histo-ry, personal history , clinical manifestations and complications were reviewed .The difference between these two groups was analyzed.Results The average gestational age at birth for control group was 36.56 ±2.00 weeks, which was significantly larger than average gestational age of the patients (30.58 ±1.97 weeks;t =3.90, P <0.01) ;The average birth weight was 2173.91 ±349.73 g in control group, which is also significantly higher than that i n patients group (1388.89 ±268.89 g;t =4.45, P <0.01).Single factor analysis suggested that preterm birth , family history, low weight, duration of postna-tal oxygen treatment , and infection during pregnancy were independent factors associated with congenital
cataract .Multifac-tor logistic regression analysis revealed that gestational age (χ2 =8.314, OR=1.998, P <0.05), birth weight (χ2 =26.809, OR=3.375, P <0.05), infection during pregnancy (χ2 =11.127, OR=2.638, P <0.05) and family history (χ2 =102.004, OR=16.977, P <0.05) were the main risk factors of congenital cataracts .Conclusion Preterm, low weight , infection during pregnancy and family history were the main risk factors of
congenital cataract .Preterm birth, fami-ly history, low birth weight, duration of postnatal oxygen treatment , and infection during pregnancy were independent fac-tors associated with congenital
cataract .Comorbidity with other ocular anomalies is
【总页数】4页(P230-233)
【作者】罗琪;周炼红;田明星;易贝茜;叶美红;徐永红
【作者单位】430060 武汉大学人民医院眼科;430060 武汉大学人民医院眼
科;430060 武汉大学人民医院眼科;430060 武汉大学人民医院眼科;430060 武汉大学人民医院眼科;430060 武汉大学人民医院眼科
【正文语种】中文
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