拉莫三嗪治疗癫痫并抑郁障碍的可行性及安全性

拉莫三嗪治疗癫痫并抑郁障碍的可行性及安全性
高玉娟;潘鹏克
【期刊名称】《中国医药科学》
【年(卷),期】2016(006)021
【摘要】Objective To explore the feasibility and safety study of lamotrigine in treatment of epileptic combined with depression disorder. Methods 194 epileptic combined with depression disorder patients cured in our hospital from July 2011 to April 2016 were selected and divided into control group and observation group according to the parity of ID number. Patients in control group were treated with lamotrigine, and patients in observation group were treated with sodium valproate .The clinical effect, adverse reactions, HAMD-17 and MADRS scores after 8, 16 weekends treatment were compared. Results The HAMD-17 and MADRS scores after 8, 16 weekends treatment in observation group were significantly lower than those of control group (P < 0.05). The effective rate of observation group (85.6%) were significantly better than that of control group (68.0%) (P < 0.05). The adverse reactions rate between the two groups (13.4%VS 16.5%) showed no significant difference (P>0.05). Conclusion The lamotrigine is effective and safe for epileptic patients with depression disorder. It can reduce the epileptic seizure, improve the depression disorder, and it is worth a further application in clinical treatment.%目的：对比分析应用拉莫三嗪治疗癫痫伴有抑郁障碍患者的可行性以及安全性。

方法选取
2011年7月～2016年4月我院收治癫痫伴有抑郁障碍患者194例，按照就诊ID 号奇、偶数区别分为观察组与对照组两组，对照组患者接受丙戊酸钠治疗，观察组患者接受拉莫三嗪治疗，比较两组患者临床疗效、治疗前后HAMD-17量表评分（汉密尔顿抑郁量表）、MADRS量表评分（蒙哥马利抑郁评定量表）以及不良反应发生情况。

结果经过16周治疗后，观察组治疗8周、16周后HAMD-17量表评分和MADRS量表评分较对照组均明显下降，差异显著（P＜0.05）；临床疗效比较，观察组治疗有效率85.6%，优于对照组治疗有效率68.0%，存在统计学差异（P＜0.05）；观察组不良反应发生率13.4%，与对照组16.5%比较无明显差异（P＞0.05）。

结论应用拉莫三嗪治疗癫痫伴有抑郁障碍患者安全可行，可有效降低癫痫发、改善抑郁障碍情况，可在临床治疗中推广应用。

【总页数】3页(P87-89)
【作者】高玉娟;潘鹏克
【作者单位】广西壮族自治区河池市人民医院神经内科，广西河池547000;广西壮族自治区河池市人民医院神经内科，广西河池547000
【正文语种】中文
【中图分类】R742.1
【相关文献】
1.拉莫三嗪治疗癫痫合并抑郁障碍患者的疗效观察 [J], 杨雷;刘莺;付永旺;陈金;云永利
2.拉莫三嗪治疗青少年癫痫合并抑郁障碍的疗效观察 [J], 陈杰;王志坚;李凌恩;许多
3.拉莫三嗪治疗原发性癫痫合并抑郁障碍的疗效及对患者生活质量的影响 [J], 许
贤瑞;涂小平;张庆
4.拉莫三嗪联合丙戊酸钠治疗癫痫合并抑郁障碍的效果及对患者生活质量的影响[J], 陈英歌;黄文斌
5.拉莫三嗪与丙戊酸钠治疗癫痫合并抑郁障碍患者的效果对比分析 [J], 刘丽丹;田新玮;彭颜晖
因版权原因，仅展示原文概要，查看原文内容请购买。