Data-dependent accurate mass neutral loss analysis
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
专利名称：Data-dependent accurate mass neutral loss
analysis
发明人：Vladimir Zabrouskov
申请号：US11595023
申请日：20061110
公开号：US07511267B2
公开日：
20090331
专利内容由知识产权出版社提供
专利附图：
摘要：A method is disclosed for data-dependent neutral loss analysis of biomolecules and other materials in a hybrid mass spectrometer. Candidate product ions are selected by identifying peaks in a MS/MS spectrum acquired in a first mass analyzer that exhibit a
specified nominal neutral loss value, which may be representative of the mass of a peptide modification, such as phosphate. High mass accuracy MS and MS/MS spectra acquired at a second mass analyzer, such as an FTICR or Orbitrap, are processed to determine if the mass difference between a candidate product ion and its corresponding precursor matches an accurate neutral loss value. In one embodiment, MSanalysis is performed only on the candidate product ions that satisfy the accurate mass neutral loss value test.
申请人：Vladimir Zabrouskov
地址：Santa Clara CA US
国籍：US
代理人：Charles B. Katz
更多信息请下载全文后查看。