Identification of antigen to a particular pathogen

专利名称：Identification of antigen to a particular
pathogen, and a method for manufacturing
the same isolation
发明人：アンドレアス・マインケ,エステル・ナジ,ウ
ヴェ・フォン・アーゼン,クリストフ・クラデ,タ
マシュ・ヘニクス,ヴォルフガング・ツァウナー,
ドゥク・ブイ・ミン,オレスタ・ヴィトヴィツカ,
ヒルデガルト・エッツ,アグニエシュカ・ドリラ,
トーマス・ヴァイヒハルト,マルティン・ハフ
ナー,ブリギッテ・テンペルマイヤー,クレア・エ
ム・フレイザー,スティーブン・ギル
申请号：JP2008152742
申请日：20080611
公开号：JP5053933B2
公开日：
20121024
专利内容由知识产权出版社提供
摘要：Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to autoimmunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: -providing an antibody preparation from a plasma pool of said given type of animal or from a human plasma pool or individual sera with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - providing at least one expression library of said specific pathogen, tumor, allergen or tissue or host prone
to auto-immunity, - screening said at least one expression library with said antibody preparation, - identifying antigens which bind in said screening to antibodies in said antibody preparation, - screening the identified antigens with individual antibody preparations from individual sera from individuals with antibodies against said specific pathogen, tumor, allergen or tissue or host prone to auto-immunity, - identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody preparations from said individual sera and - optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.
申请人：インターツェル・アクチェンゲゼルシャフト
地址：オーストリア、アー－１０３０ヴィエナ、キャンパス・ヴィエナ・バイオセンター６番国籍：AT
代理人：田村 恭生,鮫島 睦,品川 永敏,山中 伸一郎
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