小剂量阿司匹林联合肝素和地屈孕酮治疗复发性流产的疗效观察

小剂量阿司匹林联合肝素和地屈孕酮治疗复发性流产的疗效观
察
孙梅芳;母华欣
【期刊名称】《中国药物评价》
【年(卷),期】2014(000)006
【摘要】目的：观察小剂量阿司匹林联合肝素、地屈孕酮治疗复发性流产（RSA）的临床疗效。

方法：将258例RSA患者随机分为观察组（122例）和对照组（136例）。

观察组采用小剂量阿司匹林联合肝素和地屈孕酮治疗。

对照组采用
黄体酮和人绒毛膜促性腺激素治疗。

对两组患者的妊娠结局、药品不良反应及妊娠期并发症进行分析比较。

结果：观察组总有效率（足月产＋早产）高于对照组（ P ＜0.05）。

两组药品不良反应发生率差异无统计学意义（ P＞0.05）。

两组妊娠期并发症的发生率差异有统计学意义（ P＜0.05）。

结论：小剂量阿司匹林联合肝素和地屈孕酮治疗RSA能提高妊娠成功率，此方法安全有效，值得临床推
广。

%Objective:To study the clinical efficacy of low-dose aspirin combination with heparin and dydrogesterone in the treatment of recurrent spontaneous abortion(RSA).Methods:258 patients with RSA were randomly divided into observation group (122 cases) and control group (136 cases).The observation group were treated with low-dose aspirin combination with heparin and dydrogesterone.The control group were treated with progesterone and chorionic gonadotropin therapy.We compared the outcome of pregnancy, adverse drug reactions( ADR) ,
blood coagulation index and pregnancy complications of the two
groups.Results:The therapeutic efficacy was sta-tistically significant between observation group and control group( P<0.05).Drug side effects of the two groups had no statistical signifi-cance (P>0.05).pregnancy complications of the two groups had statistical
significance(P<0.05).Conclusion: Low-dose aspirin combined with heparin and dydrogesterone in the treatment of RSA can improve the success rate of pregnancy.This method is safe, and effective, and is worthy of clinical promotion.
【总页数】3页(P333-335)
【作者】孙梅芳;母华欣
【作者单位】丹东市妇女儿童医院妇产科，辽宁丹东118000;丹东市妇女儿童医院妇产科，辽宁丹东118000
【正文语种】中文
【中图分类】R984
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