地佐辛超前镇痛用于高血压患者全身麻醉诱导期30例

地佐辛超前镇痛用于高血压患者全身麻醉诱导期30例
邵青
【期刊名称】《中国药业》
【年(卷),期】2014(000)015
【摘要】Objective To investigate the clinical effect of dezocine preemptive analgesia applied in the induction period of general anes-thesia in hypertensive patients. Methods 60 ASA Ⅱ- Ⅲ patients with hypertension undergoing elective operation under general anes-thesia were randomly divided into the dezocine preemptive analgesia group ( group D) and the 0. 9% sodium chloride control group ( group S), 30 cases in each group. The group D was intravenously dripped with dezocine 0. 1 mg / kg at 10 min before induction, while the group S was intravenously dripped with equal amount of 0. 9% normal saline. Two groups took the same general anesthesia induc-tion. The cases of bucking and muscle fibrillation occurred during general anesthesia induction were recorded. The systolic blood pressure (SBP), diastolic blood pressure(DBP), heart rate(HR) were recorded at 5 timepoints of before anesthesia induction (T0 ), instantly before intubation (T1 ), instantly after intubation (T2 ), 1 min after intubation (T3 ), 3 min after intubation (T4 ), 5 min after intubation (T5 ) were recorded. Results The occurrence cases of bucking and muscle fibrillation in the group D were significantly less than those in the group
S( P ﹤ 0. 05). SBP, DBP and HR at T1 in the two groups were decreased
compared with those at T0 ( P ﹤ 0. 05), but there were no signifi-cant differences between the two groups, SBP, DBP and HR at T2, T3 in the two groups were increased, but the ascensional range of the group D was smaller than that of the group S( P ﹤ 0. 05) . There were no statistically significant differences in SBP, DBP, HR at T4, T5 between the two groups. Conclusion Dezocine preemptive analgesia can alleviate the adverse reactions of bucking and muscle fibrillation and offers stable hemodynamics.%目的：观察地佐辛超前镇痛应用在高血压患者全身麻醉诱导期的临床效果。

方法选取60例合并高血压拟行全麻择期手术的患者，美国麻醉医师协会（ASA）分级Ⅱ~Ⅲ级，随机分为地佐辛超前镇痛组（D 组）和0.9%氯化钠注射液对照组（S 组），各30例。

诱导前10 min D 组静脉滴注地佐辛0.1 mg / kg，S 组静脉滴注等量0.9%氯化钠注射液。

两组均采用相同的全麻诱导方式。

记录两组患者在全麻诱导过程中呛咳、肌颤发生例数及诱导前（T0）、插管前即刻（T1）、插管后即刻（T2）、插管后1 min（T3）、插管后3 min（T4）、插管后5 min （T5）5个时间点的收缩压（SBP）、舒张压（DBP）、心率（HR）。

结果 D 组的肌颤、呛咳发生例数明显低于 S 组（ P ﹤0.05）；与 T0比较，两组T1时 SBP，DBP，HR 均降低（ P ﹤0.05），但组间比较，差异无显著性；T2、T3时两组 SBP，DBP，HR 均升高，但 D 组上升幅度小于 S 组（ P ﹤0.05）；T4、T5时两组间 SBP，DBP，HR 比较，差异无统计学意义。

结论地佐辛超前镇痛可减轻高血压患者全麻诱导期呛咳、肌颤等不良反应，提供稳定的血流动力学。

【总页数】3页(P75-76,77)
【作者】邵青
【作者单位】重庆市红十字会医院﹤江北区人民医院﹥，重庆 400020
【正文语种】中文
【中图分类】R969.4;R971+.2
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