PF-562271_COA_25707_MedChemExpress
植物病害诊断试剂盒
植物病害诊断试剂盒美国阿格迪agdia 公司是全球最大的植物病害诊断试剂生产商，产品品种最多，可检测项目多达200多个。
包装规格最全,不同的包装规格适合不同规模的实验室。
从中您一定能发现适合您使用的产品。
选购试剂说明，请仔细阅读。
1，kit, 订货号PSAxxxxx/xxxx 或PSPxxxxx/xxxx 为完整的试剂盒包装，包括样品提取缓冲液、包被好抗体的微孔板（可拆分）、酶标记物、稀释液、缓冲液、底物发色剂、阳性质控（如果应该供应）。
特别注明Indirect ELISA 方法的kit 包括未包被的微孔板及联接用的抗体，所含有的其他组分同上。
2， Reagent Set, 订货号SRAxxxxx/xxxx ,XRAxxxxx/xxxx或SRPxxxxx/xxxx 只含有未包被的微孔板、包被需要的抗体或联接用的抗体、酶标记物。
其他试剂如样品提取缓冲液、稀释液、缓冲液、底物发色剂、质控物需另外订购或自己配制。
我公司销售原厂的上述试剂，详见目录。
3， Bacterial Reagent Set, 订货号BRAxxxxx/xxxx 只含有未包被的微孔板、包被需要的抗体或联接用的抗体、酶标记物。
其他试剂如样品提取缓冲液、稀释液、缓冲液、底物发色剂、质控物需另外订购或自己配制。
我公司销售原厂的上述试剂，详见目录。
4， Bacterial ID订货号BIDxxxxx/xxxx 为完整的试剂盒包装，包括样品提取缓冲液、包被好抗体的微孔板（可拆分）、酶标记物、稀释液、缓冲液、底物发色剂、质控（如果应该供应）。
用于鉴定培养基中或有病症植物提取液中的细菌。
操作简便快速。
5， PS A或SR A中的A代表碱性磷酸酶标记；PS P或SR P中的P代表过氧化物酶标记。
6， Immunostrip test, 为检试纸条，操作简单，几分钟内得到结果，非常适合于现场检测。
该试条必须与相应的样品提取缓冲液配套使用。
实验室需要单独购买该样品提取缓冲液，详见目录。
无花果叶中补骨脂素含量测定_0
无花果叶中补骨脂素含量测定目的：建立无花果叶中补骨脂素含量的HPLC测定方法，为无花果叶的开发利用及质量标准的制定提供依据。
方法：色谱柱为hypersil ODS（250mm×4.0mm、5μm）；流动相为乙腈-水（55：45）；流速为1.0mL/min；检测波长290nm；柱温32℃。
结果：补骨脂素在2～10μg范围与峰面积线性关系良好（R2=0.9996），平均回收率为102.2%，RSD=1.80%。
标签：补骨脂素；无花果叶；HPLC；含量测定无花果为桑科榕属植物无花果（Ficus carica L.），为药食兼优的植物。
原产地中海及西南亚，现我国各地均有栽培[1]，主要分布于新疆、江苏、浙江、福建、山东、上海、四川、陕西、甘肃、江西、广东、河南等省，有悠久的栽培历史，是开发应用较广的经济植物。
其果实营养价值高，富含糖、蛋白质、氨基酸、维生素和矿物元素，除食果外，其叶、根又俱含药用成份，为药食同源果品树种[2]。
我国应用其叶、根入药，治疗肠炎，腹泻；外用治痈肿。
现代医学研究证明，无花果叶中含有多种化学成分，包括香豆素、黄酮、挥发油、多糖、微量元素、氨基酸、维生素等[3]，其药理作用包括抗菌、抗病毒、抗肿瘤、降血脂、降血糖、治疗白癜风、痔疮等，药效显著[4]。
无花果叶中所含的补骨脂素经体外抑瘤率活性测试，表明对表皮癌、膀胧癌、肝癌均有显著疗效，并有较好的抗菌活性和降低血糖、血脂的作用。
为进一步开发利用无花果叶，采用高效液相色谱法对无花果叶中补骨脂素的含量进行测定，并对不同提取方法进行了初步探索，为建立无花果叶中有效成分的含量测定方法提供了科学依据。
1仪器与试剂1.1实验仪器高效液相色谱仪（LC-20AT，日本岛津公司），紫外检测器（SPD-20A，日本岛津公司），色谱工作站（CBM-102，日本岛津公司）；无油真空泵（HP-01，天津市恒奥科技发展有限公司）；溶剂过滤器（HL，天津市恒奥科技发展有限公司）；数控超声波清洗器（KQ-500DV，昆山市超声仪器有限公司）；十万分之一天平（梅特勒，Mettler Toledo AB 135-S）；分析天平（BS2242S，北京赛多利斯仪器系统有限公司）；自动双重纯水蒸馏器（SZ-93，上海亚荣生化仪器厂）；电子天平（JJ5000，常熟市双杰测试仪器厂）；粉碎机（FW200，北京中兴伟业仪器有限公司）；循环水式多用真空泵（SHZ-95B，巩义市予华仪器有限责任公司）。
PF-562271_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Aug.-05-2017Print Date:Aug.-05-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :PF-562271Catalog No. :HY-10459CAS No. :717907-75-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:PF562271; PF 562271Formula:C21H20F3N7O3SMolecular Weight:507.49CAS No. :717907-75-04. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
去甲基阿奇霉素羟基选择性保护的研究
去甲基阿奇霉素羟基选择性保护的研究赵伯龙;张萍【摘要】为解决去甲基阿奇霉素活性羟基的反应选择性问题,采用丙酮与邻苯二甲酸酐对去甲基阿奇霉素进行两次邻位保护的方法,得到4"-羟基具有反应活性的保护去甲基阿奇霉素,反应摩尔收率87.9％.本研究产物可直接用于泰拉霉素的合成,实现了对去甲基阿奇霉素的选择性保护.【期刊名称】《中国兽药杂志》【年(卷),期】2015(049)010【总页数】6页(P46-51)【关键词】去甲基阿奇霉素;丙酮;邻苯二甲酸酐;泰拉霉素A【作者】赵伯龙;张萍【作者单位】宁夏泰瑞制药股份有限公司,银川750101;宁夏泰瑞制药股份有限公司,银川750101【正文语种】中文【中图分类】S859.79泰拉菌素[1](结构见图1)是第四代红霉素类抗生素，主要用于治疗放线杆菌、支原体、巴氏杆菌、副嗜血杆菌引起的猪、牛的呼吸系统疾病[2]。
去甲基阿奇霉素(结构见图2)是泰拉菌素的关键合成前体，通过对去甲基阿奇霉素的4”-OH进行氧化并经过一系列修饰，合成泰拉菌素。
4”-OH是去甲基阿奇霉素支链糖上具备反应活性的三个仲羟基之一，有文献报道采用Cbz卞酯保护[1]或者乙酰基[3]对另外两个活性仲羟基12-OH、2’-OH进行保护，但上述方法中卞酯基与乙酰基均为无选择性的单羟基保护，制得的产物需进行层析分离，收率较低。
本研究设计了一套利用活性羟基邻位基团对12-OH、2’-OH进行选择性保护的方法，得到的双保护去甲基阿奇霉素经过corey-kim氧化[4]后脱保护，可以制得较纯净的4”-羰基去甲基阿奇霉素。
1.1 主要试剂 91%去甲基阿奇霉素A,20150201，宁夏泰瑞；丙酮，20141202，天津凯通，分析纯；对甲苯磺酸，20150109，上海国药，分析纯；正辛烷，20141108，天津凯通，分析纯；邻苯二甲酸酐，20150115，上海国药，分析纯；46%氢溴酸，20140801，上海国药，分析纯；乙醇/乙醇钠溶液，20150104，上海紫一；氢氧化锂，20140903，上海国药，分析纯；水合肼，20150102，湖南株洲化工，96%；二氯乙烷，20150114，天津凯通，分析纯；N-氯代琥珀酰亚胺，20141205，上海国药。
高效液相色谱法测定抗癌原料药芳香异羟肟酸二丁基锡
高效液相色谱法测定抗癌原料药芳香异羟肟酸二丁基锡李云兰;王晓剑;杨莉;李青山【期刊名称】《分析试验室》【年(卷),期】2007(26)8【摘要】建立了反相高效液相色谱法测定有机金属抗癌原料药芳香异羟肟酸二丁基锡。
色谱条件：Diamonsil ODS色谱柱（4.6 mmi.d.×200 mm，5μm），以V（甲醇）∶V（水）=35∶65，pH2.5为流动相，流速为1.0 mL/min，紫外检测波长232 nm，柱温25℃。
吲达帕安为内标测定芳香异羟肟酸二丁基锡。
结果表明：线性范围为4.08-102μg/mL，回归方程为f=0.02253ρ-0.005843，r=0.9998（n=7），方法精密度RSD为0.89%（n=6），稳定性的RSD为0.56%（n=9），重复性的RSD为0.90%（n=9），平均回收率为100.5%（n=9，RSD=1.1%）。
方法可用来测定芳香异羟肟酸二丁基锡。
【总页数】4页(P21-24)【关键词】芳香异羟肟酸二丁基锡;反相高效液相色谱法;含量测定【作者】李云兰;王晓剑;杨莉;李青山【作者单位】山西医科大学药学院【正文语种】中文【中图分类】O657.7【相关文献】1.芳香异羟肟酸二烃基锡配合物的合成、表征及其抗癌活性的研究 [J], 杨频;李青山2.二-(4-氯苯甲酰异羟肟酸)二正丁基合锡(DBDCT)对大鼠离体胸主动脉环的舒张作用及机制 [J], 杨彩红;张轩萍;吴博威;李青山3.二-(2,4-二氯苯甲酰异羟肟酸)二苯基合锡大鼠血浆蛋白结合率的测定 [J], 郭璞;李云兰;李青山4.芳香异羟肟酸二丁基锡类抗癌化合物DBDCT和DBDMT在大鼠体内组织分布的比较 [J], 孥云兰;牛晓强;李青山5.毛细管色谱法测定芳香异羟肟酸二丁基锡中有机溶剂残留量 [J], 李云兰;赵晶晶;杨莉;林志华;王晓剑;李青山因版权原因，仅展示原文概要，查看原文内容请购买。