根除幽门螺杆菌后胃溃疡复发非再感染影响因素探讨

根除幽门螺杆菌后胃溃疡复发非再感染影响因素探讨
赵新鲜;张尧;鞠莹
【期刊名称】《胃肠病学》
【年(卷),期】2014(000)011
【摘要】背景：幽门螺杆菌（ Hp）感染是胃溃疡发病的重要因素，虽然根除Hp 有助于胃溃疡愈合，但仍有较高的复发率。

因此，除Hp感染外，仍有诸多胃溃疡致病因素值得关注。

目的：探讨根除Hp后胃溃疡复发的非再感染影响因素。

方法：纳入2011年1月-2012年6月于上海交通大学医学院附属仁济医院就诊的Hp阳性胃溃疡初发患者164例，对其根除Hp并治疗胃溃疡。

对Hp根除成功且溃疡
愈合的患者，于溃疡愈合后的3、6、12个月进行随访，采集可能与胃溃疡复发相关的因素，分析其与溃疡复发的关系。

结果：共123例Hp阴性患者完成12个月的随访，其中18例（14.6%）溃疡复发。

χ2检验显示年龄、性别、吸烟/饮酒、
服用非甾体消炎药（ NSAIDs）、不良情绪、不良饮食习惯与胃溃疡复发相关（ P ＜0.05）；在不良饮食习惯中，饮食不规律、喜食不易消化食物、喜食快餐/碳酸
饮料与胃溃疡复发相关（ P＜0.05）。

结论：胃溃疡患者应改变不良生活习惯、合理用药、调节心理状态以及合理饮食，从而避免胃溃疡复
发。

%BacKground:Helicobacter pylori ( Hp ) infection is an important etioIogicaI factor of gastric uIcer. AIthough eradicating Hp can heIp gastric uIcer heaIing,there is stiII a high recurrence rate of gastric uIcer. Therefore,other factors pIaying a roIe in the pathogenesis of gastric uIcer shouId be in concern. Aims:To investigate the non-reinfectious recurrence factors of gastric uIcer after Hp eradication. Methods:A totaI of 164 newIy
diagnosed gastric uIcer patients with Hp infection from January 2011 to June 2012 at Ren Ji HospitaI,SchooI of Medicine,Shanghai Jiao Tong University were enroIIed. AII patients were given Hp eradication therapy and treatment of gastric uIcer. Patients with successfuI Hp eradication and heaIing of gastric uIcer were foIIowed up at 3,6,12 months after uIcer heaIing. Suspected risk factors of gastric uIcer recurrence were coIIected,and their reIationships with recurrence were anaIyzed. Results:A totaI of 123 patients positive for Hp infection compIeted the 12 months foIIow-up,gastric uIcer recurred in 18(14. 6%)of them. Chi-square test reveaIed that age,gender,smoking/drinking,non-steroidaI anti-infIammatory drugs( NSAIDs ),negative emotions and unheaIthy eating habits were significantIy associated with the recurrence of gastric
uIcer(P<0. 05). Of the unheaIthy eating habits, irreguIar eating, and preference of indigestibIe food and fast food/carbonated drinks were significantIy associated with recurrence of gastric uIcer( P <0. 05 ). Conclusions:Patients with gastric uIcer shouId change their unheaIthy Iiving habits,foIIow rationaI use of drugs,and keep heaIthy mentaI status and eating habits for avoiding the recurrence of gastric uIcer.
【总页数】4页(P661-664)
【作者】赵新鲜;张尧;鞠莹
【作者单位】上海交通大学医学院附属仁济医院消化内科 200127;上海交通大学医学院附属仁济医院消化内科 200127;上海交通大学医学院附属仁济医院消化内科 200127
【正文语种】中文
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