不同剂量131I清甲治疗对分化型甲状腺癌唾液腺功能和生活质量的影响

不同剂量131I清甲治疗对分化型甲状腺癌唾液腺功能和生活
质量的影响
李欢;杜小梅;冯真;冯靖雄
【期刊名称】《解放军医药杂志》
【年(卷),期】2017(029)010
【摘要】目的探讨不同剂量131 I清甲治疗对分化型甲状腺癌(DTC)术后唾液腺功能和生活质量的影响.方法对四川省达州市中心医院2014年1月—2016年1月收治的150例DTC患者的临床资料进行回顾性分析,根据131 I治疗剂量分为A、
B、C组,每组50例.3组均行甲状腺根治术后给予131 I治疗,A组治疗剂量为
1.11~3.7 GBq(30~100 mci),B组治疗剂量为3.7~5.5 GBq(100~150 mci),C组治疗剂量为5.5~7.4 GBq(150~200 mci).观察3组唾液腺定量分析结果,比较治疗前后生活质量评分.结果B组唾液腺功能受损率均低于A、C组,且A组低于C组(P<0.05).治疗后3组生活质量各方面评分均高于治疗前,且B组高于A、C组,A组高于C组(P<0.05).结论DTC术后应用3.7~5.5 GBq(100~150 mci)131I辅助治疗可有效降低唾液腺损伤风险,提高患者生活质量.%Objective To investigate effects of different doses iodine l31 (131I) thyroidectom treatment on sali-vary gland function and life quality of patients with differentiated thyroid carcinoma ( DTC) . Methods Clinical data of 150 patients with DTC admitted during January 2014 and January 2016 was retrospectively analyzed, and the patients were divided into group A, B and C ( n=50 for each group) according to different doses 131 I treatments. 131 I treatments were given for all patients after thyroid radical operation, and
treatment doses were 1. 11-3. 7 GBq (30-100 mci) in group A, 3. 7-5. 5 GBq (100-150 mci) in group B and 5. 5-7. 4 GBq (150 ~200 mci) in group C respectively. Results of sialaden quantitative analysis were observed, and scores of life quality before and after treatment were compare among the three groups. Results Damage rate of salivary gland function in group B was significantly lower than those in group A and C, and the rate in group A was significantly lower than that in group C ( P<0. 05 ) . Scores for all aspects of life quality after treatment were significantly higher than those before treatment in three groups, and the score in group B were significantly higher than those in group A and C, and the score in group A were significantly higher than those in group C (P<0. 05). Conclusion The 8. 25-10. 41GBq 131I in adjunctive treatment of patients with DTC after operation can ef-fectively decrease risk of salivary gland damage and improve life quality.
【总页数】4页(P26-29)
【作者】李欢;杜小梅;冯真;冯靖雄
【作者单位】635000 四川达州,达州市中心医院核医学科;635000 四川达州,达州市中心医院核医学科;635000 四川达州,达州市中心医院核医学科;635000 四川达州,达州市中心医院临床药学科
【正文语种】中文
【中图分类】R736.1
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