清肺解毒方对流感病毒感染小鼠的保护作用

清肺解毒方对流感病毒感染小鼠的保护作用
孙国倩;杨静;周喆;王升启
【期刊名称】《国际药学研究杂志》
【年(卷),期】2013(040)001
【摘要】Objective To investigate the protective and treatment effect of Qingfei Jiedu formula on mice infected with influenza virus. Methods The mice were randomly divided into six groups:normal group, model group, positive drug-treated group, Qingfei Jiedu formula-treated groups (3 different concentrations). Intranasal infection with influenza virus was used to establish the model. Treatment was provided once a day for 6 days and the first was at 2 hours after intranasal infection. To observe the protective effect of Qingfei Jiedu formula, the mice were raised and observed for 14 days. The mortality, average of survival time, protection rate of death and rate of prolonging life were determined. To observe the treatment effect of Qingfei Jiedu formulain against influenza virus infection, at the third day and sixth day after virus infection, the lung index, lung virus titer and lung tissue viral load were taken for evaluation. Results Compared with the model group, in 2.5 and 1.25 g/kg Qingfei Jiedu formula treated groups, the mortality significantly reduced, the protection rate of death and the rate of prolonging life increased significantly, and the average survival time prolonged significantly (P <0.01). In addition, the lung index, lung virus titer and lung tissue viral load decreased significantly both at the third day
and sixth day after the model was set up (P < 0.01). Conclusion Qingfei Jiedu formula has a convincing anti - influenza virus activity.%目的研究清肺解毒方对流感病毒感染小鼠的保护作用及对病毒性肺炎的治疗作用.方法小鼠随机分为6组:正常对照组、模型组、阳性对照组,以及清肺解毒方5、2.5和1.25 g/kg 剂量组,采用滴鼻感染流感病毒,造模2h后灌胃给药,连续6d后继续饲养至感染后14 d,统计小鼠死亡率、平均存活时间、死亡保护率和生命延长率,观察清肺解毒方对流感病毒感染小鼠的保护作用；参照以上实验方法于造模后第3天和第6天取肺,以肺指数、肺脏病毒滴度和肺组织病毒载量为评价指标,观察清肺解毒方对病毒性肺炎小鼠的治疗作用.结果与模型组相比,清肺解毒方2.5和1.25 g/kg剂量组死亡率显著降低,死亡保护率明显提高(P＜0.01),存活时间明显延长,生命延长率明显增加(P＜0.01)；造模后第3天和第6天小鼠的肺指数、肺脏病毒滴度及肺脏病毒载量显著降低(P＜0.01).结论清肺解毒方2.5和1.25 g/kg剂量组具有明显的抗流感作用.
【总页数】5页(P53-57)
【作者】孙国倩;杨静;周喆;王升启
【作者单位】450008郑州,河南中医学院;100850北京,军事医学科学院放射与辐射研究所;100850北京,军事医学科学院放射与辐射研究所;100850北京,军事医学科学院放射与辐射研究所
【正文语种】中文
【中图分类】R965.1;R978.7
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