5’-脱氧-5’-甲基硫代腺苷 组蛋白修饰

Have you heard of 5’-Deoxy-5’-methylthioadenosine (5’-dA)? It’s like the superhero of nucleosides, involved in the methionine salvage pathway and also a key player in the world of epigenetics! Picture this: it’s like adenosine went to a makeover and came back with a cool methylthio group attached to its 5’ carbon, giving birth to the awesome 5’-dA. This modified nucleoside doesn’t just stop there – it can jump into RNA or take a detour into the methionine salvage pathway. But wait, there’s more! 5’-dA is not just some ordinary molecule – it has a knack for gene regulation and might even be involved in causing or preventing diseases. Who knew a tiny nucleoside could have such a big impact? Stay tuned for more exciting updates on the adventures of 5’-dA!
你听说过5 ' 脱氧核糖核酸5 ' 甲基乙二醇（5 ' dA）吗？就像核苷酸的超级英雄，想象一下：这就像阿迪诺辛去改头换面，带着一个冷却的甲基硫酸组附着在它的5 ' 碳上，产下了令人赞叹的5 ' dA。

这个经过修改的核边并不仅仅停留在那里——它可以跳入RNA或绕道进入甲硫磷的救生通道。

但等等， 5 ' dA不仅仅是一些普通分子——它拥有基因调控的诀窍，甚至可能参与导致或预防疾病。

谁知道一个小小的核侧会有这么大的影响？继续寻找更令人兴奋的关于5DA冒险的更新！
In the fascinating world of histone modification, scientists have discovered that 5’-dA, also known as 5’-deoxyadenosine, is like a celebrity for the enzyme ribose 5’-methylthiotransferase (RIMT). RIMT is like a master chef in the cellular kitchen, and it loves to add a special twist to histone proteins, particularly histone H4. This fancy enzyme has the magical power to transfer a methylthio group from its partner, methylthioadenosine (MTA), to the 5’ carbon of the ribose in histone proteins.
Now, this isn't just some ordinary makeover for histones – oh no! This post-translational modification is like giving histones a fabulous new accessory in the form of a 5’-methylthioribose group. And guess what? It's not just for show! This sassy new addition actually plays a crucial role in controlling gene expression and shaping the structure of chromatin.
But wait, it gets even more exciting! Scientists suspect that this modification acts like a secret invitation, drawing in specific chromatin modifiers and remodelingplexes to the party. These VIP guests then work their magic, influencing the epigenetic regulation of gene expression like the fairy godmothers of DNA. So, in the end, it's not just about histones getting a makeover –
it's about throwing an epic epigenetic bash that makes genes dance to a whole new tune!
科学家们发现， 5 ' dA，也称为5 ' deoxyadenosine，就像是酶 5 ' methyliotransase（RIMT）的名人。

RIMT就像蜂窝厨房的主厨一样，它喜欢给整形蛋白，特别是整形H4添加特殊的扭矩。

这种奇异的酶
具有神奇的力量，可以将一个甲基硫酸组从伴侣甲基硫代丁二醇（MTA）转移至肝酮蛋白中的肋骨5的碳。

现在，这不只是一些普通的化妆为他的肌肉—哦不！这种翻译后的
修改就像以5—甲基硫酸盐（5—甲基硫酸盐）组的形式给他一个令人惊叹的新附属物。

你猜怎么着？这不只是为展示！这种令人兴奋的
新添加实际上在控制基因表达和塑造染色体结构方面起着关键作用。

等等，这更刺激了！科学家怀疑这种修改行为就像秘密邀请，在特定
的铬修饰剂中画出，并给进行改造。

这些VIP嘉宾随后运用了他们的
魔法，影响了基因表达的内在调控，如DNA的仙女教母。

归根结底，不只是他的舌头要改头换面——就是扔一个史诗般的史诗般的震撼，
让基因跳到全新的曲调！
The 5’-deoxy-5’-methylthioadenosine modification of histone proteins is like the VIP of the epigenetics world. It's not just a boring old chemical change - it's like a fancy makeover for
the histones that control our genes! This modification is like a bridge between the world of cellular metabolism and the realm of gene expression and chromatin structure. It's like the cool kid at the playground who knows everyone and can make things happen. By digging deeper into the nitty-gritty details of how this modification works, we can unlock the secrets of how our metabolism and our genes are connected, and maybe even find new ways to tackle tricky diseases. It's like a treasure hunt for scientific discoveries - and who doesn't love a good treasure hunt?
蛋白质的5—脱氧基—5—甲基甲氧基乙二醇（英语：deoxy—5—methioadenosine）修饰就像表征世界的要人。

这不仅仅是一个无聊的老化学变化—这就像一个花哨的化妆对于他的骨骼控制我们的基因！这种修饰就像细胞代谢世界与基因表达和染色体结构的范畴之间的桥梁。

就像操场的酷孩子认识每个人，可以让事情发生通过更深入地探索这个修改方法的细微细节，我们可以解开我们的新陈代谢和基因之间通联的秘密，甚至可以找到新的方法来应对棘手的疾病。

这就像为科学发现寻宝——谁不喜欢好寻宝？。