氧增强放疗对大鼠胶质瘤细胞凋亡相关基因Bcl-2和Bax影响

氧增强放疗对大鼠胶质瘤细胞凋亡相关基因Bcl-2和Bax影
响
胡殿雷;李伯安;王余军;戴如飞;阎超
【期刊名称】《临床神经外科杂志》
【年(卷),期】2011(8)6
【摘要】Objective To investigate the impact of radio-therapy after hyperbaric oxygenation on apoptosis-related gene of Bcl-2 ^ Bax expressions in glioma. Motheds The glioma models were established in 20 SD rats, and were divided into two groups; treatment group(10 rats, treated with radio-therapy combided with hyperbaric oxygenation) , control group (10 rats, treated by common radio-therapy) o When treatment was finished, the expressions of Bcl-2, Bax were detected by immunostaining assay using Streptavidin-Peroxidase( SP) mothed. Results The expression of Bcl-2 protein in treatment group significantly lower than the control group. There were significantly differences between the two groups (P <0. 05 ) ; The expression of Bax protein in treatment group significantly higher than the control group. There were significantly differences between the two groups(P<0. 05 ). Conclusions Rradio-therapy after hyperbaric oxygenation can more effectly inhibit the expression of
the Bcl-2 and increase the expression of the Bax.%目的探讨氧增强放疗对胶
质瘤凋亡相关基因Bcl-2、Bax 影响的差异.方法建立大鼠胶质瘤动物模型,治疗组10 只,高压氧处理后放疗;对照组10 只,常规放疗.免疫组化检测凋亡相关基因Bcl-2、
Bax 的表达.结果治疗组Bcl-2 表达明显低于对照组,组间差异有显著性(P ＜ 0.05);治疗组Bax 的表达明显高于对照组,组间差异有显著性(P ＜0.05).结论氧增强放疗可以更有效地抑制Bcl-2、增加Bax 的表达.
【总页数】2页(P296-297)
【作者】胡殿雷;李伯安;王余军;戴如飞;阎超
【作者单位】221003,徐州医学院附属第三医院神经外科;221003,徐州医学院附属第三医院神经外科;221003,徐州医学院附属第三医院神经外科;徐州医学院附属第二医院神经外科;徐州医学院附属第二医院神经外科
【正文语种】中文
【中图分类】R739.41
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