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work 2008-0528 21:43:04 阅读2529 评论11 字号：大 中小 JX SOT23 BAV170 B dual cc Si diode low Ir JY SOT23 BAV199 dioda-2x JY SOT23 BAV199 D dual series Si diode lowIr JZ SOT23 BAW 156 JZ SOT23 BAW156 A dual ca Si diode low Ir K SCD80 BBY5202W I UHF varicap 1.751.25pF
K15 DTA124G N pnp sw 50V 50mA w. b-e res K1p SOT23 BCW71 N BC107A K1t SOT23 BCW71 N BC107A K1X SOT23 KSC3265 NPN K2 SOT23 BCW72 NPN K2 SOT23 BCW72 N BC107B ZXT300 K2 SOT23 HSMP3832 D dual HP3830 pin diode K24 DTC114G N npn sw 50V 100mA w. b-eres
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左西孟旦联合丹参川芎嗪注射液治疗慢性难治性心衰的临床研究
㊃8863㊃检验医学与临床2023年12月第20卷第24期 L a b M e d C l i n,D e c e m b e r2023,V o l.20,N o.24㊃论著㊃D O I:10.3969/j.i s s n.1672-9455.2023.24.024左西孟旦联合丹参川芎嗪注射液治疗慢性难治性心衰的临床研究孙红周1,王娜2ә1.陕西省西安市北方医院心血管内二科,陕西西安710043;2.陕西省西安市中医医院心血管内科,陕西西安710021摘要:目的探讨左西孟旦注射液联合丹参川芎嗪注射液治疗慢性难治性心力衰竭的疗效及对患者脑钠肽(B N P)㊁心功能㊁微小R N A-423-5P(m i R-423-5P)等的影响㊂方法采用随机数字表法将2018年1月至2020年1月西安市北方医院收治的160例慢性难治性心力衰竭患者分为左西孟旦组和联合组,每组80例㊂左西孟旦组采用左西孟旦注射液治疗,联合组采用左西孟旦注射液联合丹参川芎嗪注射液治疗㊂比较两组治疗后总有效率㊁心功能指标[左室射血分数(L V E F)㊁心脏指数(C I)㊁每搏输出量(S V)㊁左室舒张末期内径(L V E D D)㊁收缩末期内径(L V E S D)㊁舒张早期二尖瓣血流速度/舒张晚期二尖瓣血流速度(E/A)]㊁心力衰竭标志物[B N P㊁微管连接蛋白(N e x i l i n)㊁心型脂肪酸结合蛋白(H-F A B P)]㊁血管内皮功能指标[内皮素-1(E T-1)㊁一氧化氮(N O)]㊁m i R-423-5P m R N A水平及不良反应㊂结果联合组总有效率(95.00%)高于左西孟旦组(83.75%),差异有统计学意义(P<0.05)㊂联合组治疗后L V E F㊁C I㊁S V㊁E/A高于左西孟旦组,L V E D D㊁L V E S D低于左西孟旦组,差异均有统计学意义(P<0.05)㊂联合组治疗后B N P㊁N e x i l i n㊁H-F A B P水平低于左西孟旦组(P<0.05)㊂联合组治疗后E T-1水平低于左西孟旦组,N O水平高于左西孟旦组,差异均有统计学意义(P<0.05)㊂联合组治疗后m i R-423-5P m R N A水平低于左西孟旦组(P<0.05)㊂联合组不良反应发生率(2.50%)与左西孟旦组(5.00%)相比,差异无统计学意义(P>0.05)㊂结论左西孟旦注射液联合丹参川芎嗪注射液治疗慢性难治性心力衰竭,能有效改善患者心功能,保护心肌细胞,缓解内皮功能障碍,安全㊁可靠,其疗效机制可能与下调m i R-423-5P m R N A表达有关㊂关键词:左西孟旦注射液;丹参川芎嗪注射液;慢性难治性心力衰竭;脑钠肽;心功能; m i R-423-5P中图法分类号:R541.6+1文献标志码:A文章编号:1672-9455(2023)24-3688-05C l i n i c a l s t u d y o f l e v o s i m e n d a n c o m b i n e d w i t hD a n s h e n C h u a n x i o n g q i n i n j e c t i o ni n t r e a t m e n t o f c h r o n i c r e f r a c t o r y h e a r t f a i l u r eS U N H o n g z h o u1,WA N G N a2ә1.S e c o n d D e p a r t m e n t o f C a r d i o v a s c u l a r M e d i c i n e,X i'a n M u n i c i p a l N o r t h H o s p i t a l,X i'a n,S h a a n x i710043,C h i n a;2.D e p a r t m e n t o f C a r d i o v a s c u l a r M e d i c i n e,X i'a n M u n i c i p a l H o s p i t a l o fT r a d i t i o n a l C h i n e s e M e d i c i n e,X i'a n,S h a a n x i710021,C h i n aA b s t r a c t:O b j e c t i v e T o i n v e s t i g a t e t h e e f f i c a c y o f l e v o s i m e n d a n i n j e c t i o n c o m b i n e d w i t h D a n s h e n C h u a-n x i o n g q i n i n j e c t i o n i n t h e t r e a t m e n t o f c h r o n i c r e f r a c t o r y h e a r t f a i l u r e a n d i t s e f f e c t s o n b r a i n n a t r i u r e t i c p e p-t i d e(B N P),c a r d i a c f u n c t i o n a n d m i c r o R N A-423-5P(m i R-423-5P)i n t h e p a t i e n t s.M e t h o d s A t o t a l o f160 p a t i e n t s w i t h c h r o n i c r e f r a c t o r y h e a r t f a i l u r e a d m i t t e d a n d t r e a t e d i n t h e X i'a n M u n i c i p a l N o r t h H o s p i t a l f r o m J a n u a r y2018t o J a n u a r y2020w e r e d i v i d e d i n t o t h e l e v o s i m e n d a n g r o u p a n d c o m b i n e d g r o u p b y t h e r a n d o m n u m b e r t a b l e m e t h o d,80c a s e s i n e a c h g r o u p.T h e l e v o n i m e n d a n g r o u p w a s t r e a t e d w i t h l e v o n i m e n d a n i n j e c-t i o n,a n d t h e c o m b i n e d g r o u p w a s t r e a t e d w i t h l e v o n i m e n d a n i n j e c t i o n c o m b i n e d w i t h D a n s h e nC h u a n x i o n g q i n i n j e c t i o n.T h e t o t a l e f f e c t i v e r a t e,c a r d i a c f u n c t i o n i n d i c a t o r s[l e f t v e n t r i c u l a r e j e c t i o n f r a c t i o n(L V E F),h e a r t i n d e x(C I),s t r o k e o u t p u t(S V),l e f t v e n t r i c u l a r e n d-d i a s t o l i c d i a m e t e r(L V ED D),e n d-s y s t o l i c d i a m e t e r (L VE S D),e a r l y d i a s t o l i c m i t r a l v a l v e f l o w v e l o c i t y/l a t e d i a s t o l i c m i t r a l v a l v e f l o w v e l o c i t y(E/A)]a n d h e a r t f a i l u r e[B N P,N e x i l i n,c a r d i a c f a t t y a c i d b i n d i n g p r o t e i n(H-F A B P)],a n d v a s c u l a r e n d o t h e l i a l f u n c t i o n i n d e x e s [e n d o t h e l i n-1(E T-1),n i t r i c o x i d e(N O)],m i R-423-5P m R N A l e v e l a f t e r t r e a t m e n t a n d a d v e r s e r e a c t i o n s w e r e c o m p a r e d b e t w e e n t h e t w o g r o u p s.R e s u l t s T h e t o t a l e f f e c t i v e r a t e o f t h e c o m b i n e d g r o u p w a s h i g h e r t h a n t h a t o f t h e l e v o s i m e n d a n g r o u p,a n d t h e d i f f e r e n c e w a s s t a t i s t i c a l l y s i g n i f i c a n t(95.00%v s.83.75%,作者简介:孙红周,男,副主任医师,主要从事心血管疾病治疗方面的研究㊂ә通信作者,E-m a i l:33764606@q q.c o m㊂P <0.05).A f t e r t r e a t m e n t ,t h e L V E F ,C I ,S V a n d E /A l e v e l s o f t h e c o m b i n e d g r o u p w e r e h i gh e r t h a n t h o s e o f t h e l e v o s i m e n d a n g r o u p ,w h i l e L V E D D a n d L V E S D w e r e l o w e r t h a n t h o s e o f t h e l e v o s i m e n d a n g r o u p,a n d t h e d i f f e r e n c e s w e r e s t a t i s t i c a l s i gn i f i c a n t (P <0.05).A f t e r t r e a t m e n t ,t h e l e v e l s o f B N P ,N e x i l i n a n d H -F A B P i n t h e c o m b i n e d g r o u p w e r e l o w e r t h a n t h o s e i n t h e l e v o s i m e n d a n g r o u p (P <0.05).A f t e r t r e a t m e n t ,t h e E T -1l e v e l i n t h e c o m b i n e d g r o u p w a s l o w e r t h a n t h a t i n t h e l e f t s i m o n d a n g r o u p,a n d t h e N O l e v e l w a s h i g h e r t h a n t h a t i n t h e l e v o s i m e n d a n g r o u p ,a n d t h e d i f f e r e n c e s w e r e s t a t i s t i c a l l y s i gn i f i c a n t (P <0.05).A f t e r t r e a t m e n t ,t h e m i R -423-5P m R N A l e v e l i n t h e c o m b i n e d g r o u p w a s l o w e r t h a n t h a t i n t h e l e v o s i m e n d a n g r o u p(P <0.05).T h e r e w a s n o s t a t i s t i c a l l y s i gn i f i c a n t d i f f e r e n c e i n t h e i n c i d e n c e r a t e o f a d v e r s e r e a c t i o n s b e t w e e n t h e c o m b i n a t i o n g r o u p a n d l e v o s i m e n d a n g r o u p (2.50%v s .5.00%,P >0.05).C o n c l u s i o n L e v o s i m e n d a n i n -j e c t i o n c o m b i n e d w i t h D a n s h e n C h u a n x i o n g q i n i n j e c t i o n c o u l d e f f e c t i v e l y i m p r o v e t h e c a r d i a c f u n c t i o n ,pr o t e c t t h e c a r d i o m y o c y t e s a n d a l l e v i a t e t h e e n d o t h e l i a l d y s f u n c t i o n i n t h e p a t i e n t s w i t h c h r o n i c r e f r a c t o r y he a r tf a i l -u r e ,w h i c h i s s a f e a n d r e l i a b l e ,a n d i t s e f f i c a c y m e c h a n i s m m a y b e r e l a t e d t o t h e d o w n r e gu l a t i o n o f m i R -423-5P m R N A e x pr e s s i o n .K e y w o r d s :l e v o s i m e n d a n i n j e c t i o n ; D a n s h e n C h u a n x i o n g q i n i n j e c t i o n ; c h r o n i c r e f r a c t o r y h e a r t f a i l u r e ; b r a i n n a t r i u r e t i c p e pt i d e ; c a r d i a c f u n c t i o n ; m i R -423-5P 慢性难治性心力衰竭是指通过控制饮食㊁限制活动及应用利尿剂㊁洋地黄等常规治疗措施不能改善患者病情,甚至逐渐加重病情㊂慢性难治性心力衰竭患者对治疗反应性较差,成为临床棘手问题及研究的热点之一[1]㊂左西孟旦注射液是一种新型正性肌力药物,能增强心肌收缩力,减轻心脏负荷,采用其治疗心力衰竭能改善患者心功能[2]㊂丹参川芎嗪注射液是采用丹参㊁川芎制成的制剂,适用于缺血性心脑血管疾病的治疗,但在慢性难治性心力衰竭的应用报道较少,且与左西孟旦注射液联合是否能提高疗效尚不清楚[3]㊂本研究选取160例慢性难治性心力衰竭患者作为研究对象,探讨两种药物联合应用的效果,现报道如下㊂1 资料与方法1.1 一般资料 采用随机数字表法将2018年1月至2020年1月西安市北方医院收治的160例慢性难治性心力衰竭患者分为左西孟旦组和联合组,每组80例㊂患者年龄43~78岁㊂纳入标准:住院接受治疗;符合慢性难治性心力衰竭诊断标准[4];美国纽约心脏病协会(N Y H A )心功能分级Ⅲ㊁Ⅳ级;无心脏手术史;入组前未接受过相关治疗;治疗依从性良好;无恶性心律失常;未安装起搏器;无活动性出血或出血倾向㊂排除标准:不稳定型心绞痛患者;合并癌症患者;先天性心脏病患者;主动脉夹层患者;存在相关药物过敏史患者;存在严重瓣膜狭窄患者;肝肾功能严重障碍患者;入组前4周有急性心肌梗死史患者;缩窄性心包炎患者;近6个月发生急性脑梗死患者;甲状腺功能亢进患者;严重贫血患者;合并感染疾病患者㊂两组一般资料比较,差异无统计学意义(P >0.05),见表1㊂本研究经西安市北方医院医学伦理委员会审批通过㊂所有患者对本研究均知情同意㊂表1 两组一般资料比较资料n年龄(x ʃs ,岁)性别(男/女,n /n )体质量指数(x ʃs ,k g/m 2)病程(x ʃs ,年)合并症[n (%)]冠心病高血压糖尿病高脂血症N Y H A 分级[n (%)]Ⅲ级Ⅳ级联合组8064.07ʃ6.9145/3522.34ʃ1.923.29ʃ0.8816(20.00)8(10.00)15(18.75)12(15.00)45(56.25)35(43.75)左西孟旦组8063.89ʃ7.0139/4122.42ʃ1.893.34ʃ0.9118(22.50)11(13.75)10(12.50)14(17.50)39(48.75)41(51.25)t 或χ20.1640.9020.2660.3530.1490.5381.1850.1840.902P0.8700.3420.7910.7240.6990.4640.2760.6680.3421.2 主要试剂 脑钠肽(B N P )试剂盒(上海岚派生物科技有限公司);微管连接蛋白(N e x i l i n)试剂盒(上海康朗生物科技有限公司);心型脂肪酸结合蛋白(H -F A B P )试剂盒(基蛋生物科技股份有限公司);内皮素-1(E T -1)试剂盒(上海宇淳生物科技有限公司);一氧化氮(N O )试剂盒(青岛捷世康生物科技有限公司);P C R 检测试剂盒(德国Q i a ge n 公司);引物(北京擎科生物科技股份有限公司)㊂1.3 方法1.3.1 常规治疗 嘱两组均保持低盐饮食㊁限制饮水量㊁卧床休息,完善相关检查,尽可能找到发病诱因,针对诱因进行干预治疗,并根据患者实际情况,给予吸氧以及洋地黄类㊁利尿剂㊁β-受体阻滞剂㊁硝酸盐等药物治疗,共治疗2周㊂㊃9863㊃检验医学与临床2023年12月第20卷第24期 L a b M e d C l i n ,D e c e m b e r 2023,V o l .20,N o .241.3.2 左西孟旦组 采用左西孟旦注射液(成都圣诺生物制药有限公司,批准文号:国药准字H 20110104)治疗,首剂负荷量12μg /k g,静脉注射>10m i n ,之后以0.075p g /(k g㊃m i n )持续微量泵入24h ㊂1.3.3 联合组 采用左西孟旦注射液(给药剂量和方法同左西孟旦组)联合丹参川芎嗪注射液(吉林四长制药有限公司,批准文号:国药准字H 22026448)治疗㊂丹参川芎嗪注射液10m L ,与250m L 生理盐水混合后静脉滴注,1次/天,共2周㊂1.3.4 疗效判定 显效:N Y H A 分级达Ⅰ级或改善ȡ2级;有效:N Y H A 分级改善1级;较差:N Y H A 分级未改善或恶化㊂总有效率=(显效例数+有效例数)/总例数ˑ100%㊂1.3.5 各实验室指标检测 采集所有患者肘部静脉血5m L ,3000r /m i n 离心㊂采用酶联免疫吸附试剂盒检测血B N P ㊁N e x i l i n ㊁E T -1水平,采用干式免疫荧光法检测血H -F A B P 水平,采用活性荧光定量法检测血N O 水平,采用q R T -P C R 检测微小R N A -423-5P (m i R -423-5P m R N A )水平㊂1.4 观察指标 (1)比较两组疗效㊂(2)比较两组心功能指标:治疗前后左室射血分数(L V E F )㊁心脏指数(C I )㊁每搏输出量(S V )㊁左室舒张末期内径(L V E D D )㊁收缩末期内径(L V E S D )㊁舒张早期二尖瓣血流速度/舒张晚期二尖瓣血流速度(E /A ),采用彩色多普勒超声诊断仪(美国G E 公司V i v i d 7)检测㊂(3)比较两组治疗前后心力衰竭标志物B N P ㊁N e x i l i n㊁H -F A B P 水平㊂(4)比较两组治疗前后血管内皮功能指标E T -1㊁N O 水平㊂(5)比较两组治疗前后m i R -423-5Pm R N A 水平㊂(6)比较两组不良反应发生情况㊂1.5 统计学处理 采用S P S S 24.0统计软件进行数据处理㊂呈正态分布的计量资料以x ʃs 表示,两组间比较采用独立样本t 检验,组内比较采用配对样本t 检验;计数资料以例数㊁百分率表示,组间比较采用χ2检验㊂以P <0.05为差异有统计学意义㊂2 结 果2.1 两组疗效比较 联合组总有效率(95.00%)高于左西孟旦组(83.75%),差异有统计学意义(P <0.05)㊂见表2㊂表2 两组疗效比较[n (%)]组别n显效有效较差总有效联合组8029(36.25)47(58.75)4(5.00)76(95.00)左西孟旦组8015(18.75)52(65.00)13(16.25)67(83.75)χ25.331P0.0212.2 两组治疗前后心功能指标比较 治疗前两组间L V E F ㊁C I ㊁S V ㊁L V E D D ㊁L V E S D ㊁E /A 比较,差异均无统计学意义(P >0.05);联合组治疗后L V E F ㊁C I㊁S V ㊁E /A 高于左西孟旦组,L V E D D ㊁L V E S D 低于左西孟旦组,差异均有统计学意义(P <0.05)㊂见表3㊂2.3 两组治疗前后心力衰竭标志物水平比较 治疗前两组B N P ㊁N e x i l i n ㊁H -F A B P 水平比较,差异均无统计学意义(P >0.05);联合组治疗后B N P ㊁N e x i l i n㊁H -F A B P 水平低于左西孟旦组(P <0.05)㊂见表4㊂2.4 两组治疗前后血管内皮功能指标水平比较 联合组治疗后E T -1水平低于左西孟旦组,N O 水平高于左西孟旦组,差异均有统计学意义(P <0.05)㊂见表5㊂2.5 两组治疗前后m i R -423-5P m R N A 水平比较 两组治疗前m i R -423-5P m R N A 水平比较,差异无统计学意义(P >0.05);联合组治疗后m i R -423-5P m R -N A 水平低于左西孟旦组(P <0.05)㊂见表6㊂2.6 两组不良反应发生情况比较 联合组不良反应发生率(2.50%)与左西孟旦组(5.00%)相比,差异无统计学意义(P >0.05)㊂见表7㊂表3 两组治疗前后心功能指标比较(x ʃs )组别nL V E F (%)治疗前治疗后C I [L /(m i n㊃m 2)]治疗前治疗后S V (m L /m i n )治疗前治疗后联合组8026.67ʃ5.1145.89ʃ7.451.83ʃ0.222.76ʃ0.3743.01ʃ8.1970.12ʃ6.79左西孟旦组8027.72ʃ5.3639.27ʃ8.361.85ʃ0.242.10ʃ0.4042.94ʃ8.3358.37ʃ9.05t-1.2685.288-0.54910.8340.0549.289P0.207<0.0010.584<0.0010.957<0.001组别nL V E D D (mm )治疗前治疗后L V E S D (mm )治疗前治疗后E /A治疗前治疗后联合组8068.05ʃ8.4558.41ʃ5.0256.81ʃ7.4347.24ʃ6.230.93ʃ0.181.29ʃ0.10左西孟旦组8067.87ʃ7.9263.27ʃ5.3656.49ʃ7.6852.55ʃ7.080.91ʃ1.201.10ʃ0.31t0.139-5.9190.268-5.0360.1472.134P0.890<0.0010.789<0.0010.8830.034㊃0963㊃检验医学与临床2023年12月第20卷第24期 L a b M e d C l i n ,D e c e m b e r 2023,V o l .20,N o .24表4 两组治疗前后心力衰竭标志物水平比较(x ʃs )组别nB N P (n g/L )治疗前治疗后N e x i l i n (n g/m L )治疗前治疗后H -F A B P (n g /m L )治疗前治疗后联合组808965.23ʃ525.493088.05ʃ515.391.47ʃ0.470.61ʃ0.146.91ʃ1.023.34ʃ0.75左西孟旦组808959.75ʃ536.824279.23ʃ620.131.50ʃ0.520.86ʃ0.176.87ʃ1.134.87ʃ0.80t0.065-13.213-0.383-10.1540.235-12.479P0.948<0.0010.702<0.0010.815<0.001表5 两组治疗前后血管内皮功能指标水平比较(x ʃs )组别nN O (μm o l /L )治疗前治疗后E T -1(n g/L )治疗前治疗后联合组8042.46ʃ13.0761.15ʃ15.3858.85ʃ12.4943.32ʃ10.53左西孟旦组8043.28ʃ12.7450.88ʃ14.0459.01ʃ13.3750.66ʃ11.24t -0.4024.411-0.078-4.263P0.688<0.0010.938<0.001表6 两组治疗前后m i R -423-5P m R N A 水平比较(x ʃs )组别n治疗前治疗后t P联合组800.34ʃ0.110.12ʃ0.0317.258<0.001左西孟旦组800.35ʃ0.100.20ʃ0.0512.000<0.001t -0.602-12.271P0.548<0.001表7 两组不良反应发生情况比较[n (%)]组别n低血压失眠胃肠道反应皮疹不良反应发生联合组801(1.25)0(0.00)0(0.00)1(1.25)2(2.50)左西孟旦组802(2.50)1(1.25)1(1.25)0(0.00)4(5.00)χ20.173P0.6773 讨 论慢性难治性心力衰竭诱因复杂,治疗难度大,病死率高,研究其安全㊁有效的疗法对改善病情转归具有现实意义㊂本研究显示,联合组总有效率高于左西孟旦组,治疗后心功能指标优于左西孟旦组,提示左西孟旦注射液联合丹参川芎嗪注射液治疗慢性难治性心力衰竭能改善患者心功能,疗效显著㊂朱宏旭等[5]研究显示,左西孟旦治疗慢性难治性心力衰竭,能提高L V E F ㊁C I ㊁S V ,改善心功能㊂赵春丽等[6]报道,丹参川芎嗪注射液治疗缺血性心肌病心力衰竭能改善患者心功能分级,本研究结果与之相似㊂左西孟旦注射液能结合心肌纤维上的肌钙蛋白氨基酸氨基末端,促进钙离子诱导的心肌收缩必需的心肌纤维蛋白空间构型保持稳定,增强心肌收缩力,是一种钙离子增敏剂,且不增加心肌耗氧,不影响心率,并能扩张外周静脉血管和肺血管,降低心脏前后负荷[7]㊂丹参川芎嗪注射液主要功能为活血化瘀㊁宁心安神㊁止痛排脓等㊂现代医学认为,丹参川芎嗪注射液有加速红细胞流速㊁抗血小板聚集㊁增加冠状动脉血流等作用,并能增加心肌灌注,能增强心肌收缩力,降低心脏外周阻力[8]㊂与左西孟旦注射液联合时,能协同发挥作用,因此应用于慢性难治性心力衰竭能提高治疗效果㊂B N P ㊁N e x i l i n ㊁H -F A B P 均为心力衰竭标志物㊂B N P 主要在心室心肌中合成㊁分泌,生理状态下,在心室中储备很少,当心室受到压力㊁容量超负荷刺激后,心室壁张力增加,可上调B N P 表达,释放入血的B N P 可反映心室功能,尤其是左室功能,并与心力衰竭严重程度呈正相关[9]㊂N e x i l i n 是一种高丰度表达的肌动蛋白结合蛋白㊂H -F A B P 能在心力衰竭时特异性结合㊁转化脂肪酸,对重症心力衰竭预后不良的早期诊断具有一定价值[10]㊂本研究显示,左西孟旦注射液联合丹参川芎嗪注射液能降低B N P ㊁N e x i l i n ㊁H -F A B 水平,提示患者心功能得到改善,这可能与丹参川芎嗪注射液清除机体氧自由基㊁抗炎,保护心肌细胞等作用有关㊂有资料显示,心力衰竭患者存在内皮功能障碍,E T -1具有收缩血管效应,在心力衰竭患者中呈高表达,N O 具有舒张血管的作用,降低E T -1水平㊁升高N O 水平可改善心力衰竭患者内皮功能[11]㊂本研究显示,左西孟旦注射液联合丹参川芎嗪注射液能降低E T -1水平㊁提高N O 水平,改善患者内皮功能障碍,有利于促进患者病情的缓解㊂m i R -423-5P 是一种微小R N A ,能通过神经生长因子及其信号通路参与心力衰竭㊁心室重构,与心源性休克患者3个月死亡高度相关[12]㊂且m i R -423-5P在心力衰竭患者外周血中表达高于非心力衰竭患㊃1963㊃检验医学与临床2023年12月第20卷第24期 L a b M e d C l i n ,D e c e m b e r 2023,V o l .20,N o .24者[13]㊂抑制m i R-423-5p表达能通过激活w n t/β-c a t e n i n信号通路,减轻缺氧/复氧引起的心肌细胞凋亡和线粒体功能障碍,保护心肌细胞,并通过激活磷酸肌醇-3激酶/蛋白激酶B通路抑制心肌细胞凋亡,缓解心力衰竭的恶性进展[14]㊂本研究显示,左西孟旦注射液联合丹参川芎嗪注射液能降低m i R-423-5P m R N A水平,有助于保护心肌,延缓心力衰竭的进展,这可能是两种药物联合发挥抗心力衰竭效果的一个分子水平作用机制㊂同时本研究还发现,两组不良反应发生率相似,提示两种药物联合安全㊁可靠㊂综上所述,左西孟旦注射液联合丹参川芎嗪注射液治疗慢性难治性心力衰竭,能有效改善患者心功能,保护心肌细胞,缓解内皮功能障碍,安全㊁可靠,其疗效机制可能与下调m i R-423-5P m R N A水平有关㊂参考文献[1]N E R S E S I A N G,H E N N I G F,MÜL L E R M,e t a l.T e m p o-r a r y m e c h a n i c a l c i r c u l a t o r y s u p p o r t f o r r e f r a c t o r y h e a r tf a i l u r e:t h e G e r m a n H e a r t C e n t e r B e r l i n e x p e r i e n c e[J].A n n C a r d i o t h o r a c S u r g,2019,8(1):76-83.[2]彭艳玲,王冉冉,黄洁,等.左西孟旦治疗慢性心力衰竭的疗效分析[J].中国急救复苏与灾害医学杂志,2018,13(6):533-535.[3]张德龙,殷莉,姜芳,等.丹参川芎嗪注射液联合单硝酸异山梨酯对冠心病不稳定型心绞痛血脂水平及疗效的影响[J].中华中医药学刊,2019,37(6):1451-1454. [4]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014,42(2):98-122.[5]朱宏旭,宋丽萍,耿学峰.左西孟旦联合多巴胺对顽固性心力衰竭患者心功能及心肌损伤的影响[J].临床和实验医学杂志,2019,18(13):1404-1407.[6]赵春丽,张先位,韦永强,等.丹参川芎嗪注射液联合左卡尼汀治疗缺血性心肌病心力衰竭患者的疗效观察[J].广西医学,2019,41(14):1787-1791.[7]C OMÍN-C O L E T J,MA N I T O N,S E G O V I A-C U B E R O J,e t a l.Ef f i c a c y a n d s a f e t y o f i n t e r m i t t e n t i n t r a v e n o u s o u t-p a t i e n t a d m i n i s t r a t i o n o f l e v o s i m e n d a n i n p a t i e n t s w i t h a d v a n c e d h e a r t f a i l u r e:t h e L I O N-H E A R T m u l t i c e n t r e r a n d o m i s e d t r i a l[J].E u r J H e a r t F a i l,2018,20(7):1128-1136.[8]杨倩,吕莉莉,孙蓉.基于网络药理学的丹参川芎嗪注射液作用机制分析[J].中草药,2018,49(11):2606-2613.[9]WA N G Y,MA X.R e l a t i o n s h i p b e t w e e n c h a n g e s o f e l e c-t r o c a r d i o g r a m i n d e x e s i n c h r o n i c h e a r t f a i l u r e w i t h a r-r h y t h m i a a n d s e r u m PⅢN P a n d B N P[J].E x p T h e r M e d, 2020,19(1):591-596.[10]王锁柱,陈炜,陆非平,等.尿B N P联合血H-F A B P及N e x i l i n水平检测在评估重症心衰患者预后心功能改善情况中的价值研究[J].标记免疫分析与临床,2019,26(7):1088-1092.[11]李敏,李虎,王逵,等.硝普钠联合硝酸甘油治疗急性心力衰竭的疗效及对血浆A n gⅡ,N O,E T-1,C y s-C的影响[J].中西医结合心脑血管病杂志,2018,16(3):330-333.[12]JÄN T T I T,S E G E R S VÄR D H,T O L P P A N E N H,e t a l.C i r c u l a t i n g l e v e l s o f m i c r o R N A423-5p a r e a s s o c i a t e dw i t h90d a y m o r t a l i t y i n c a r d i o g e n i c s h o c k[J].E S C H e a r tF a i l,2019,6(1):98-102.[13]刘小燕,陈文江,王江.m i R N A-423-5p与心力衰竭发病的相关性[J].中国老年学杂志,2018,38(15):36-38.[14]周咏梅,舒燕,唐艺加,等.m i c r o R N A-423-5p调节P I3K/A K T通路在大鼠心力衰竭进展中的作用探究[J].临床和实验医学杂志,2019,18(2):20-25.(收稿日期:2023-02-21修回日期:2023-10-30)(上接第3687页)[9]D E V A L L A,C HU J,B E E S O N L,e t a l.M i f e p r i s t o n e a n dm i s o p r o s t o l v e r s u s p l a c e b o a n d m i s o p r o s t o l f o r r e s o l u t i o n o f m i s c a r r i a g e i n w o m e n d i a g n o s e d w i t h m i s s e d m i s c a r-r i a g e:t h e M i f e M i s o R C T[J].H e a l t h T e c h n o l A s s e s s, 2021,25(68):1-114.[10]C HU J J,D E V A L L A J,B E E S O N L E,e t a l.M i f e p r i s-t o n e a n d m i s o p r o s t o l v e r s u s m i s o p r o s t o l a l o n e f o r t h e m a n a g e m e n t o f m i s s e d m i s c a r r i a g e(M i f e M i s o):a r a n-d o m i se d,d o u b l e-b l i n d,p l a c e b o-c o n t r o l l e d t r i a l[J].L a n-c e t,2020,396(10253):770-778.[11]郑春梅.化瘀生新汤联合米非司酮㊁米索前列醇治疗稽留流产的效果评价[J].中国妇幼保健,2019,34(9):2096-2098.[12]余红娥.桂枝茯苓胶囊联合新生化片对药物流产患者完全流产率的影响[J].江西医药,2022,57(4):380-383.[13]刘方舟,杨阳,李萌,等.基于网络药理学研究陇产当归挥发油类成分多维药理的作用机制[J].世界中医药,2022, 17(16):2258-2262.[14]夏雨,赵昱东,邝高艳,等.基于网络药理学研究桃仁-红花的药效活性成分及其治疗葡萄胎的分子机制研究[J].湖南中医杂志,2020,36(9):165-172.[15]谢晓芳,陈俊仁,李刚敏,等.益母草对子宫的药理作用研究进展[J].世界中医药,2020,15(9):1263-1266. [16]顾爱玲,王小红,繆玲.新生化颗粒联合米非司酮配伍米索前列醇治疗稽留流产效果及对血清H I F-1α㊁V E G F影响[J].中国计划生育学杂志,2019,27(5):616-623.(收稿日期:2023-05-23修回日期:2023-11-08)㊃2963㊃检验医学与临床2023年12月第20卷第24期 L a b M e d C l i n,D e c e m b e r2023,V o l.20,N o.24。
TTC03系列NTC热敏电阻器
H1max. ----5.5
Imax. 3 3 --3
L
d
30~40
弯脚型 外弯型引脚
0.5±0.02
24.5~34.5
40
产品规格与数据若有变更，恕不另行通知
2012.08
负温度系数热敏电阻器：TTC03 系列
温度传感/补偿用 Ф 3mm 芯片型
电气特性
型号 零功率电阻 ＠25°C
10
1
7:TTC3A203□374* 8:TTC3A103□39H* 9:TTC3A682□39H* 10:TTC3A482□395* 11:TTC3A302□39H* 12:TTC3A202□39H* 13:TTC3A901□39D*
1
7:TTC3A123□374* 8:TTC3A103□34D* 9:TTC3A482□39H* 10:TTC3A332□39H*
41
产品规格与数据若有变更，恕不另行通知
2012.08
负温度系数热敏电阻器：TTC03 系列
温度传感/补偿用 Ф 3mm 芯片型
最大功耗减额曲线
TU：工作温度上限(℃) TL：工作温度下限(℃) 例如： 环境温度(Ta) = 55℃ 工作温度上限(Tu) = 125℃ 0 TL 0 25 TU PTa = (Tu-Ta)/(Tu-25)×Pmax = 70% Pmax
温度 (℃)
温度 (℃)
42
产品规格与数据若有变更，恕不另行通知
2012.08
负温度系数热敏电阻器：TTC03 系列
温度传感/补偿用 Ф 3mm 芯片型
TTC3A152□39D*~ TTC3B474□520*
100000
10000
片式NTC热敏电阻器-SDNT系列
● Consumer electronics such as VCR, DVD, CD players, etc
产品型号
PRODUCT IDENTIFICATION
SDNT 1005
用途
● 移动电话，汽车电话，无绳电话等通讯设备
● 打印机，传真机，文字处理机等办公设备 ● 录像机，DVD, CD 等消费类电子设备
APPLICATIONS
● Telecommunication equipments such as cellular phone, automobile phone, cordless phone, etc
SPECIFICATIONS
B constant (25－50℃)
B 常数 K
B25/50 3500 3500 3950 3450 3950 3500 4050 4050 4150 4150 4150 4250 4300 4350 4400 4500 4500
Thermal Time
Rated Electric
SDNT1608 TYPE
Part Number 型号
Units 单位 Symbol 符号 SDNT1608X101□3250◎ SDNT1608X151□3250◎ SDNT1608X221□3450◎ SDNT1608X331□3450◎ SDNT1608X471□3450◎ SDNT1608X681□3450◎ SDNT1608X102□3450◎ SDNT1608X152□3450◎ SDNT1608X152□3950◎ SDNT1608X222□3950◎ SDNT1608X302□3950◎ SDNT1608X332□3950◎
FS FORTH-SYSTEME GmbH Mod520C_2 产品说明书
Mod520C_2P.O. Box 11 03l D-79200 Breisach, Germany Kueferstrasse 8l D-79206 Breisach, Germany (+49 (7667) 908-0 l Fax +49 (7667) 908-200 l e-mail:****************Mod520C_2© Copyright 2004:FS FORTH-SYSTEME GmbHPostfach 1103, D-79200 Breisach a. Rh., GermanyRelease of Document:May 27, 2004Filename:Mod520C_2.docAuthor:Hans-Peter SchneiderAll rights reserved. No part of this document may be copied or reproduced in any form or by any means without the prior written consent of FS FORTH-SYSTEME GmbH.2Mod520C_2 Table of Contents1.Introduction (4)2.Features (5)3.Functional Description (6)3.1.1.CPU AMD ÉlanSC520 (6)3.1.2.SDRAM stage (6)3.1.3.ROM stage (6)3.1.4.SRAM stage (6)3.1.5.32 I/O Ports (7)3.1.6.256 Byte EEPROM for BIOS and Applications on PIO30,31 (7)3.1.7.On-board Power Supply (7)3.1.8.Voltage Supervision, RESET Generation (7)3.1.9.Serial Ports (7)3.1.10.Fast Ethernet Controller Stage (8)3.1.11.Dual CAN Controller Stage (8)3.1.12.GP Bus used for ISA Bus (9)4.Connectors Of MOD520C (10)4.1.System Connector X2 (10)4.2.System Connector X4 (12)5.Application Notes (14)5.1.Power Supply (14)5.2.Important Signals (14)5.2.13.PCICLKRTN PCICLK PCICLKETHER (14)5.2.14.ISA-Bus Signals (14)5.2.15.CAN-Interrupt IRQ11 (15)6.Members of the MOD520C family (16)3Mod520C_21. IntroductionThe module MOD520C with its integrated and optional peripherals, based on the 32 Bit AMD ÉlanSC520 microcontroller, is designed for medium to high performance applications in telecommunication, data communication and information appliances on the general embedded market. It can easily be designed in customized boards.The AMD ÉlanSC520 microcontroller combines a low voltage 586 CPU running on 133 MHz, including FPU (Floating Point Unit) with a set of integrated peripherals: 32 Bit PCI controller, SDRAM controller for up to 256 MByte, GP (General Purpose) bus with programmable timing and ROM/Flash controller. Enhanced PC compatible peripherals like DMA controller, two UARTs and battery buffered RTC and CMOS, watchdog and software timers make this device a very fast system for both real time and PC/AT compatible applications. Insyde Software’s Mobile BIOS is available which offers serial and parallel remote features (video, keyboard, floppy). Furthermore FS FORTH-SYSTEME has adapted Datalight Sockets (TCP/IP Stack), ROM-DOS and the Flash File System FlashFX to this environment.The MOD520C offers the software engineer the possibility to reduce the time-to-market phase even more. FS FORTH-SYSTEME added several features on-board as SDRAM (up to 64 MByte), PCI Fast Ethernet controller to facilitate networking and remote control. A Strata-FLASH for booting and data is included on board. Two CAN Ports are additionally available for communication. 512 Kbyte SRAM is available for battery buffered data. The enhanced JTAG port for low-cost debugging is supported. This allows instruction tracing during execution. FS FORTH-SYSTEME has adapted Windows CE 3.0 to this platform and offers drivers and support. With Ethernet debugging the software designer has powerful means for fast debugging his applications.Due to the 16 MByte FLASH it is possible to build larger, complete systems on this module like Linux, QNX or VxWorks.4Mod520C_252. Features• 16 MByte STRATA-FLASH or 2 MByte AMD FLASH • 64 MByte or 16 MByte SDRAM • 512 KByte battery buffered SRAM• PCI Ethernet controller with EEPROM. Rx and Tx signals are providedon the System Connectors • Two CAN-Buses.• Enhanced JTAG port available on System Connector.• GP-Bus signals available on System Connector • PCI-Bus signals available on System Connector• BIOS for ÉlanSC520 by Insyde Software Inc. Including serial or parallelremote features (Video, Keyboard, Floppy).Mod520C_23. Functional Description3.1.1. CPU AMD ÉlanSC520The CPU AMD ÉlanSC520 is powered with 2.5V (core and analog path) and 3.3V (all other voltages) except VRTC, which is powered with about 3V either from battery or from on-board 3.3V. This voltage is limited to 3.3V, the other 3.3V power planes have a limit of 3.6V.The CPU is clocked with a 32.768 kHz quartz. An internal PLL derives from this frequency the RTC clock and DRAM refresh clock and the clocks for PC/AT compatible PIT (1.1882 MHz) and UARTs (18.432 MHz). All other stages (CPU, PCI, GP bus, GP DMA, ROM, SSI, timers) are fed from the second clock generator driven by a 33.33 MHz clock oscillator. SDRAM is clocked with 66.66 MHz.3.1.2. SDRAM stageThe SDRAM (up to 128 MByte on-board) has its own DRAM bus containing memory addresses MA0..12, memory data MD0..31 and control signals for up to four banks. Due to small load no buffering of clocks and signals is necessary.3.1.3. ROM stageROM or FLASH are driven by the general purpose address bus GPA0..25. It has three programmable chip selects with each up to 64 MByte range. The ROM Data bus is either the 32 bit general purpose bus GPD0..31 or the memory data bus MD0..31. Configuration pins decide, which bus at boot time is used. The bus size is selectable with 8, 16 or 32 bit. The MOD520C has a FLASH IC for up to 16 MByte 16 bit ROM or FLASH selected by BOOTCS# connected to MD0..15. 3.1.4. SRAM stageThe SRAM (512 KByte on-board) is buffered by VBAT. The Memory Location is defined in the System BIOS. ROMCS1# is used to access the SRAM.6Mod520C_23.1.5. 32 I/O PortsThe ÉlanSC520 CPU has 32 I/O ports. They have alternate functions. Most of them are control signals for GP bus (PIO0..26) used as ISA-bus. PIO27 (GPCS0#) is used as a programmable external chip select and PIO28,29 are not connected. PIO30,31 are used to drive a serial parameter EEPROM on-board. 3.1.6. 256 Byte EEPROM for BIOS and Applications on PIO30,31An on-board serial EEPROM with 256 byte and I2C bus is controlled by PIO30 (I2CDAT) and PIO31 (I2CCLK). 128 byte are used for non-volatile BIOS defaults, the remaining range may contain application specific data and parameters. The BIOS contains calls to read and write to this memory (see BIOS documentation).3.1.7. On-board Power SupplyThe 2.5V on-board voltage is generated from +5V.An external battery may be connected to the signal VBATIN. Battery status is controlled by BBATSEN, which sets a power fail bit in a status register for RTC, if BBATSEN is low at power-up.3.1.8. Voltage Supervision, RESET GenerationThree voltages are used on board: +2.5V, +3.3V and +5V. U2 controls +5V and U10 controls +3.3V. LBOUT or PWRGOOD will become low, if these voltages are out of tolerance. An external SRESET# is wired or-ed to U10. It can also be activated from extended JTAG signal SRESET# via X1. The wired OR of 1RESET# and 2RESET# control U10. Its output PWRGOOD is low (not active), if either the signals described above from U10 are low or +5V is out of tolerance. Typical length of PWRGOOD low is longer than 1 sec (minimum 790 msec).3.1.9. Serial PortsThe AMD ÉlanSC520 CPU has two internal asynchronous ports and one synchronous serial port. Both of this ports are available at the System Connectors.7Mod520C_23.1.10. Fast Ethernet Controller StageConnected to the PCI bus device 0 (REQ/GNT0#) of the Élan SC520 CPU, a Fast Ethernet Controller U7 supports 10/100Mbps transfer depending on driver software. X3 is a JST B5B-PH-SM3 5 pin connector. Parameters as physical address and power down modes are stored in a 64X16 bit Serial EEPROM controlled by U7. 2 status LEDs LE1, LE2 show the state of the Ethernet connection. For a more detailed hardware and software description see Intel 82559ER manual.3.1.11. Dual CAN Controller StageThe CAN Controller is selected via ROMCS1# and the Memory location is selectable in the BIOS Setup Screen. The CAN Interrupt provided by 82C900 is inverted by the onboard Lattice CPLD. Since the Interrupt asserted by the 82C900 is only a low active pulse of 0.2µs the CPLD holds the interrupt active until the software accesses the Memory at the location CAN-Base+1xxh. The BIOS routes this interrupt to IRQ11.8Mod520C_2 3.1.12. GP Bus used for ISA BusThe AMD ÉlanSC520 CPU contains an 8/16bit General Purpose Bus (GP bus) with 26 address lines (GPA0..25), 16 data lines (GPD0..15) and different control lines using PIO ports in their alternate GP bus function. Its timing is programmable for speeds up to 33MHz. This bus is to emulate a 16 bit ISA bus (PC/104) running with 8 MHz. ISA bus signal are connected without buffers directly to the lines of the CPU due to the 5V tolerance of the 3.3V signals.8 bit signals SMEMRD# and SMEMWR# (active only at addresses beyond 1 MByte) are not supported (GPMEM_RD# and GPMEM_WR# used).The AMD ÉlanSC520 CPU has only 4 DMA channels on GP bus. DMA channel 2 is used for Super-I/O (U2) on EVAMOD520. All four channels are connected to edge connector X2.Not supported ISA bus signals 0WS#, IOCHK#, IRQ15, REFRESH#, 8MHz and 14.318 MHz clocks, MASTER#.9Mod520C_24. Connectors Of MOD520C4.1. System Connector X2Pin Function I/O Pin Function I/O1+3.3V power2GND power 3+3.3V power4GND power 5GPD0I/O6TDP O7GPD1I/O8TDN O9GPD2I/O10not connected11GPD3I/O12RDP I13GPD4I/O14RDN I15GPD5I/O16not connected17GPD6I/O18DRQ0I19GPD7I/O20DRQ2I21GPD8I/O22DRQ5I23GPD9I/O24DRQ7I25GPD10I/O26DACK0#O27GPD11I/O28DACK2#O29GPD12I/O30DACK5#O31GPD13I/O32DACK7#O33GPD14I/O34GND power 35GPD15I/O36GPRESET O37GND power38GPIORD#O39GPA0O40GPIOWR#O41GPA1O42GPALE O43GPA2O44GPBHE#O45GPA3O46GPRDY I47GPA4O48GPAEN O49GPA5O50GPTC O51GPA6O52GPDBUFOE#O53GPA7O54GPIO_CS16#O55GPA8O56GPMEM_CS16#O57GPA9O58GPCS0#O59GPA10O60GPMEM_RD#O61GPA11O62GPMEM_WR#O63GPA12O64GND power 10Pin Function I/O Pin Function I/O65GPA13O66EXTRES#I67GPA14O68PWRGOOD O69BUFA15O70CLKTEST71BUFA16O72PRG_RESET73BUFA17O74GND power75BUFA18O76GPCS1#O77BUFA19O78GPCS2#O79BUFA20O80GPCS3#O81BUFA21O82GPCS4#O83BUFA22O84GPCS5#O85BUFA23O86GPCS6#O87BUFA24O88GPCS7#O89BUFA25O90VBATIN power91GND power92GND power93IRQ1I94RSTLD0I95IRQ3I96RSTLD1I97IRQ4I98RSTLD2I99IRQ5I100RSTLD3I101IRQ6I102RSTLD4I103IRQ7I104RSTLD5I105IRQ9I106RSTLD6I107IRQ10I108RSTLD7I109CANINT I110DBGDIS I111IRQ12I112INSTRC I113IRQ14I114DBGENTR I115SPEAKER O116not connected117+5V power118GND power119+5V power120GND power114.2. System Connector X4Pin Function I/O Pin Function I/O1PCICLKRTN I2GND power 3PCICLK O4PCICLKETHER I5AD0I/O6CBE0#I/O7AD1I/O8CBE1#I/O9AD2I/O10CBE2#I/O11AD3I/O12CBE3#I/O13AD4I/O14not connected15AD5I/O16not connected17AD6I/O18not connected19AD7I/O20not connected21AD8I/O22GND power 23AD9I/O24RXD1I25AD10I/O26TXD1O27AD11I/O28CTS1#I29AD12I/O30DCD1#I31AD13I/O32DSR1#I33AD14I/O34RIN1#I35AD15I/O36DTR1#O37AD16I/O38RTS1#O39AD17I/O40RXD2I41AD18I/O42TXD2O43AD19I/O44CTS2#I45AD20I/O46DCD2#I47AD21I/O48DSR2#I49AD22I/O50RIN2#I51AD23I/O52DTR2#O53AD24I/O54RTS2#O55AD25I/O56CANH1/TXD157AD26I/O58CANL1/RXD159AD27I/O60CANH2/TXD261AD28I/O62CANL2/RXD263AD29I/O64GND power 12Pin Function I/O Pin Function I/O65AD30I/O66SRESET#I67AD31I/O68GPRESET#O69GND power70TCK O71INTA#I72TMS73INTB#I74TDI I75INTC#I76TDO O77INTD#I78TRST#I79REQ0#I80CMDACK81REQ1#I82BR/TC83REQ2#I84GND Power85REQ3#I86STOP/TX87REQ4#I88TRIG/TRACE89GNT0#O90not connected91GNT1#O92ACTLED#O93GNT2#O94LILED#O95GNT3#O96SPEEDLED#O97GNT4#O98not connected99GND power100GND power101PAR I/O102SSI_CLK O103PERR#I/O104SSI_DO O105SERR#I106SSI_DI I107FRAME#I/O108not connected109TRDY#I/O110ISP_TDI I111IRDY#I/O112ISP_TDO O113STOP#I/O114ISP_TMS115DEVSEL#I/O116ISP_TCK I117RST#O118BSCAN#119GND power120GND power135. Application Notes5.1. Power SupplyThe MOD520C needs +3.3V and 5V power supply.3.3V worst case supply current is 1130 mA5V worst case supply current is 550 mABe sure to design your power supply for this current including large load transients.5.2. Important Signals5.2.13. PCICLKRTN PCICLK PCICLKETHERPCICLK is the clock source for the PCI-Bus. PCICLKETHER is the clock input for the Ethernet Controller. PCICLKRTN is the clock input of the AMD Élan Sc520. This pin is used to synchronize the CPU with the external PCI-Bus. Therefore it is important that all clock traces have the same length to provide each PCI-Target with the clock at the same time. Trace length of each of this clocks is 68mm on the module. If you do not plan to connect an additional PCI-Target on your board you just add a serial resistor 33R between PCICLK and PCICLKRTN and one between PCICLK and PCICLKETHER.5.2.14. ISA-Bus SignalsIf you use the ISA-Bus Signals you have to add some resistors to the following Signals:GPD0 – GPD15 4k7 pull upGPRDY1k pull downIRQ´s10k pull upDRQ´s10k pull down145.2.15. CAN-Interrupt IRQ11IRQ11 is used for the CAN-Controller 82C900 and is not sharable. Since the interrupt provided by 82C900 is a low active pulse with a length of 0.2µs the CPLD inverts this signal and holds it until the software acknowledges the interrupt. To acknowledge this interrupt the software has to access a memory location with the offset 1xxh to the CAN-Base. This memory access is just an access of the system memory, not an access of the CAN-Controller.156. Members of the MOD520C familyNumbe r Variant Flash SDRAM SRAM CAN CAN-DriverTemp.320MOD520C_0_V018M*16, Strata(=16 Mbyte)1*TM014452*4M*16(=16 Mbyte)2*TM01519512k*8Yes Yes0..70°321MOD520C_0_V021M*16, AMD(=2 Mbyte)1*TM015202*4M*16(=16 Mbyte)2*TM01519512k*8Yes Yes0..70°322MOD520C_0_V038M*16, Strata(=16 Mbyte)1*TM014452*16M*16(=64 Mbyte)2*TM01249512k*8Yes Yes0..70°334MOD520C_1_V01MOD520C_2_V018M*16, Strata(=16 Mbyte)1*TM014452*4M*16(=16 Mbyte)2*TM01519512k*8TM0Yes no0..70°335MOD520C_1_V02MOD520C_2_V021M*16, AMD(=2 Mbyte)1*TM015202*4M*16(=16 Mbyte)2*TM01519512k*8TM0Yes no0..70°336MOD520C_1_V03MOD520C_2_V038M*16, Strata(=16 Mbyte)1*TM014452*16M*16(=64 Mbyte)2*TM01249512k*8TM0Yes no0..70°184MOD520C_1_V048M*16, Strata(=16 Mbyte)1*TM014452*4M*16(=16 Mbyte)2*TM01519No No No0..70°16。
NTC 1295 2021 NTC 6476 2021 NTC 3697 2021说明书
M A Y ONTC 1295:2021NTC 6476:2021NTC 3697:2021NTC 5832:2021N O R M AGTC 333:2021A C T U A L I Z A C I ÓN : N U E V A D E S C R I P C I ÓNGuía para el desarrollo de especificaciones para unidades de mampostería no tradicional.N O R M ANTC 1205:2021A C T U A L I Z A C I ÓN : S E X T AVajillería cerámica de uso doméstico.N O R M ANTC 3664:2021A C T U A L I Z A C I ÓN : T E R C E R A D E S C R I P C I ÓNTubos plásticos de polietileno (PE) controlados con base en el diámetro exterior (RDE-PN).N O R M ANTC 3871:2021A C T U A L I Z A C I ÓN : S E X T A D E S C R I P C I ÓNTubos de “fibra de vidrio” (resina termoestable reforzada con fibra devidrio) para uso en sistemas a presión.2N O R M ANTC 4450-2:1998A C T U A L I Z A C IÓN:R E P R OB A D AD E S C R I P C IÓNTuberías termoplásticas para la conducción defluidos. Diámetros exteriores nominales y presionesnominales. Parte 2. Series con base en pulgadas.N O R M ANTC 5832:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNPrácticas estándar para edificios y puentes de acero.N O R M ANTC 916:2021A C T U A L I Z A C IÓN:S E X T AD E S C R I P C IÓNVajillería cerámica de uso institucional.3N O R M ANTC 6507:2021A C T U A L I Z A C I ÓN : N U E V A D E S C R I P C I ÓNRequisitos para la prestación del servicio de guionaje (guianza) turístico.N O R M ANTC 6523:2021A C T U A L I Z A C I ÓN : N U E V A D E S C R I P C I ÓNTurismo de aventura. Buenas prácticas para la sostenibilidad. Requisitos y recomendaciones.N O R M ANTC-ISO 11121:2021A C T U A L I Z A C I ÓN : P R I M E R A D E S C R I P C I ÓNServicios de buceo recreativo. Requisitos para programas introductorios a buceo scubaN O R M ANTC 595:2021A C T U A L I Z A C I ÓN : Q U I N T A D E S C R I P C I ÓNMétodo de ensayo para determinar las propiedades de tracción en plásticos.N O R M ANTC 6528:2021A C T U A L I Z A C I ÓN : N U E V A D E S C R I P C I ÓNMétodos de ensayo para la evaluación del secado o curado durante la formación de la película derecubrimiento orgánico usando registradores mecánicos.4N O R M ANTC 199:2021A C T U A L I Z A C I ÓN : S E P T I M A D E S C R I P C I ÓNGrasas y aceites comestiblesvegetales y animales. Definiciones.N O R M ANTC 2758:2021A C T U A L I Z A C I ÓN : S E G U N D A D E S C R I P C I ÓNCafé. Análisis sensorial. Vocabulario.N O R M ANTC 3697:2021A C T U A L I Z A C I ÓN : P R I M E R A D E S C R I P C I ÓNAlimento para animales.Alimento completo para conejos.N O R M ANTC-ISO 8791-1:1995A C T U A L I Z A C I ÓN : R E P R OB A D A D E SC R I P C I ÓNPapel y cartón. Determinación de la rugosidad/lisura(métodos de salida de aire). Parte 1: Método general.5N O R M ANTC 1759:2021A C T U A L I Z A C I ÓN : C U A R T A D E S C R I P C I ÓNElectrotecnia. Empaques elastoméricos resistentes al aceite para transformadores eléctricos.N O R M ANTC 3531:2021A C T U A L I Z A C I ÓN : Q U I N T A D E S C R I P C I ÓNArtefactos domésticos que emplean gasescombustibles para la producción instantánea de agua caliente. Calentadores de agua de paso continuo.N O R M ANTC 3607:2021A C T U A L I Z A C I ÓN : T E R C E R A D E S C R I P C I ÓNElectrotecnia. Accesorios para transformadorestrifásicos de potencias entre 2 001 kVA y 10 000 kVA.N O R M ANTC 3609:2021A C T U A L I Z A C I ÓN : S E G U N D A D E S C R I P C I ÓNElectrotecnia. Ensayos mecánicos a transformadores de distribución.N O R M ANTC 6079:2021A C T U A L I Z A C I ÓN : S E G U N D A D E S C R I P C I ÓNRequisitos para sistemas de infraestructura de medición avanzada (AMI) en redes de distribución de energía eléctrica.6N O R M ANTC-IEC 60034-5:2021A C T U A L I Z A C IÓN:N U E V AD E S C R I P C IÓNMáquinas eléctricas rotatorias. Parte 5:Grados de protección provistos para eldiseño integral de las máquinas eléctricasrotatorias (código IP). Clasificación.N O R M ANTC 1295:2021A C T U A L I Z A C IÓN:D E C I M O T E R C E R AD E S C R I P C IÓNPetróleo y sus derivados. Aceites lubricantes paracárter en motores de combustión interna a gasolina,a operación dual gasolina/gas natural para vehículos(cuatro tiempos) y diesel (cuatro y dos tiempos).7N O R M ANTC 3988:2021A C T U A L I Z A C I ÓN : P R I M E R A D E S C R I P C I ÓNVehículos automotores. Símbolos para controles, indicadores y testigos.N O R M ANTC 4163:1997A C T U A L I Z A C I ÓN : R E P R OB A D AVehículos de pasajeros. Distribución de masa.N O R M ANTC 6468:2021A C T U A L I Z A C I ÓN : N U E V A D E S C R I P C I ÓNTerminología relacionada con el transporte terrestre de pasajeros.N O R M ANTC 6506:2021A C T U A L I Z A C I ÓN : N U E V A D E S C R I P C I ÓNRequisitos para la prestación del servicio de transporte turístico terrestre automotor.N O R M ANTC-ISO 10088:2021A C T U A L I Z A C I ÓN : N U E V A D E S C R I P C I ÓNEmbarcaciones menores. Sistemas decombustible instalados de forma permanente.8N O R M ANTC-ISO 12103-1:2021A C T U A L I Z A C IÓN:N U E V AD E S C R I P C IÓNVehículos de carretera. Ensayo decontaminantes para la evaluación del filtro.Parte 1. Polvo de ensayo de Arizona.N O R M ANTC-ISO 612:2021A C T U A L I Z A C IÓN:N U E V AD E S C R I P C IÓNVehículos de carretera. Dimensiones delos vehículos a motor y de los vehículos deremolque. Términos y definiciones.N O R M ANTC-ISO 7117:2021A C T U A L I Z A C IÓN:N U E V AD E S C R I P C IÓNMotocicletas. Método de medición paradeterminar la velocidad máxima.N O R M ANTC-ISO 7840:2021A C T U A L I Z A C IÓN:N U E V AD E S C R I P C IÓNEmbarcaciones menores. Mangueras paracombustible resistentes al fuego.N O R M ANTC-ISO 8099-1:2021A C T U A L I Z A C IÓN:N U E V AD E S C R I P C IÓNEmbarcaciones menores. Sistemas de aguas9 negras. Parte 1: Retención de aguas negras.N O R M ANTC 3630:2021A C T U A L I Z A C I ÓN : T E R C E R A D E S C R I P C I ÓNCalidad del agua. Demanda bioquímica de oxígeno (DBO).N O R M ANTC 5403:2021A C T U A L I Z A C I ÓN : S E G U N D ACalidad del suelo. Determinación del carbono orgánico.N O R M ANTC 6469:2021A C T U A L I Z A C I ÓN : P R I M E R A D E S C R I P C I ÓNAcción integral contra minasantipersonal. Liberación de tierras.N O R M ANTC 6470:2021A C T U A L I Z A C I ÓN : P R I M E R A D E S C R I P C I ÓNAcción integral contra minas antipersonal. Estudio no técnico.N O R M ANTC 6471:2021A C T U A L I Z A C I ÓN : P R I M E R A D E S C R I P C I ÓNAcción integral contra minasantipersonal. Estudio técnico.10N O R M ANTC 6472:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. DespejeN O R M ANTC 6473:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Técnica de Despeje Manual (TDM).N O R M ANTC 6474:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Técnica Detección Canina (TDC).N O R M ANTC 6475:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Técnica de Detección Mecánica (TDEM).N O R M ANTC 6476:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Señalización, marcación y organización del sitio de trabajo.N O R M ANTC 6477:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Disposición de artefactos explosivos (EOD)N O R M ANTC 6478:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción Integral contra minas antipersonal. Investigación de incidentes y accidentes de desminado humanitario.N O R M ANTC 6479:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Gestión de Información.N O R M ANTC 6480:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Gestión territorial.11N O R M ANTC 6481:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Educaciónen el riesgo de minas antipersonal, municionessin explosionar y trampas explosivas (ERM).N O R M ANTC 6482:2021A C T U A L I Z A C IÓN:P R I M E R AAcción integral contra minas antipersonal. Acreditaciónde Organizaciones de Desminado Humanitario(ODH) y acreditación de capacidad operacional.N O R M ANTC 6483:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal.Asignación de tareas de desminado humanitario.N O R M ANTC 6484:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Monitoreo.N O R M ANTC 6485:2021A C T U A L I Z A C IÓN:P R I M E R AD E S C R I P C IÓNAcción integral contra minas antipersonal. Glosario. 12N O R M AGTC 47:1997A N U L A D AR E E M P L A Z A D A P O RNTC-IEC 60034-27-3:2021N O R M ANTC-IEC 34-5:2007A N U L A D AR E E M P L A Z A D A P O RNTC-IEC 60034-5:2021I n d u s t r i a (M a q u i n a r i a y e q u i p o s )13Canales de atención al cliente: Bogotá: 607 8888Resto del país: 01 8000 94 9000*******************Para adquirir alguna de nuestras normas ingrese a:Para consultar las normas por sector adquiere nuestros servicios de e-Colllection14。
多种电源管理芯片代换
1200AP40 1200AP60、1203P60200D6、203D6 DAP8A 可互代203D6/1203P6 DAP8A2S0680 2S08803S0680 3S08805S0765 DP104、DP7048S0765C DP704加24V的稳压二极管ACT4060 ZA3020LV/MP1410/MP9141ACT4065 ZA3020/MP1580ACT4070 ZA3030/MP1583/MP1591MP1593/MP1430 ACT6311 LT1937ACT6906 LTC3406/AT1366/MP2104AMC2576 LM2576AMC2596 LM2596AMC3100 LTC3406/AT1366/MP2104AMC34063A AMC34063AMC7660 AJC1564AP8012 VIPer12AAP8022 VIPer22ADAP02 可用SG5841 /SG6841代换DAP02ALSZ SG6841DAP02ALSZ SG6841DAP7A、DP8A 203D6、1203P6DH321、DL321 Q100、DM0265RDM0465R DM/CM0565RDM0465R/DM0565R 用cm0565r代换（取掉4脚的稳压二极管）DP104 5S0765DP704 5S0765DP706 5S0765DP804 DP904FAN7601 LAF0001LD7552 可用SG6841代（改4脚电阻）LD7575PS 203D6改1脚100K电阻为24KOB2268CP OB2269CPOB2268CP SG6841改4脚100K电阻为20-47KOCP1451 TL1451/BA9741/SP9741/AP200OCP2150 LTC3406/AT1366/MP2104OCP2160 LTC3407OCP2576 LM2576OCP3601 MB3800OCP5001 TL5001OMC2596 LM2596/AP1501PT1301 RJ9266PT4101 AJC1648/MP3202PT4102 LT1937/AJC1896/AP1522/RJ9271/MP1540SG5841SZ SG6841DZ/SG6841DSM9621 RJ9621/AJC1642SP1937 LT1937/AJC1896/AP1522/RJ9271/MP1540STR-G5643D STR-G5653D、STR-G8653DTEA1507 TEA1533TEA1530 TEA1532对应引脚功能接入THX202H TFC719THX203H TFC718STOP246Y TOP247YVA7910 MAX1674/75 L6920 AJC1610VIPer12A VIPer22A[audio01]ICE2A165(1A/650V.31W);ICE2A265(2A/650V.52W);ICE2B0565(0.5A/650V.23W):ICE2B165(1A/650V.31W);ICE2B265(2A/650V.52W);ICE2A180(1A/800V.29W);ICE2A280(2A/800.50W).KA5H0365R, KA5M0365R, KA5L0365R, KA5M0365RN# u) t! u1 W1 B) R, PKA5L0365RN, KA5H0380R, KA5M0380R, KA5L0380R1、KA5Q1265RF/RT（大小两种体积）、KA5Q0765、FSCQ1265RT、KACQ1265RF、FSCQ0765RT、FSCQ1565Q这是一类的，这些型号的引脚功能全都一样，只是输出功率不一样。