A-867744_1000279-69-5_MSDS_MedChemExpress
钛酸异丙酯产品安全技术说明书（阿拉丁）
GHS02:易燃物; GHS06:急毒性物质钛酸异丙酯Titanium(IV) isopropoxide99.99%CAS No. 546-68-9EC-编号208-909-64急救措施4.1必要的急救措施描述一般的建议请教医生。
向到现场的医生出示此安全技术说明书。
如果吸入如果吸入,请将患者移到新鲜空气处。
如呼吸停止，进行人工呼吸。
请教医生。
在皮肤接触的情况下用肥皂和大量的水冲洗。
请教医生。
在眼睛接触的情况下用大量水彻底冲洗至少15分钟并请教医生。
如果误服禁止催吐。
切勿给失去知觉者喂食任何东西。
用水漱口。
请教医生。
4.2最重要的症状和影响，急性的和滞后的无数据资料4.3及时的医疗处理和所需的特殊处理的说明和指示无数据资料5消防措施5.1灭火介质火灾特征无数据资料灭火方法及灭火剂干粉 干砂不要用水喷射。
5.2源于此物质或混合物的特别的危害无数据资料5.3救火人员的预防如有必要，佩戴自给式呼吸器进行消防作业。
5.4进一步的信息喷水冷却未打开的容器。
6泄露应急处理6.1人员的预防,防护设备和紧急处理程序使用个人防护装备。
避免吸入蒸气、气雾或气体。
保证充分的通风。
消除所有火源。
注意蒸气积累达到可爆炸的浓度，蒸气可蓄积在地面低洼处。
6.2环境预防措施如能确保安全，可采取措施防止进一步的泄漏或溢出。
不要让产品进入下水道。
6.3抑制和清除溢出物的方法和材料围堵溢出物，用非可燃性材料(如砂子、泥土、硅藻土、蛭石)吸收溢出物，将其收集到容器中，根据当地的或国家的规定处理6.4参考其他部分丢弃处理请参阅第13节。
7安全操作与储存7.1安全操作的注意事项避免接触皮肤和眼睛。
避免吸入蒸气或雾滴。
火舌回闪有可能穿过相当长的距离。
容器遇火可能会爆炸切勿靠近火源。
－严禁烟火。
采取措施防止静电积聚。
7.2安全储存的条件,包括任何不兼容性在氩气下操作,避免潮湿。
储存于氩气中 使容器保持密闭，储存在干燥通风处。
雷帕霉素-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Jan.-07-2019Print Date:Jan.-07-20191. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :RapamycinCatalog No. :HY-10219CAS No. :53123-88-91.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Flammable liquids (Category 4), H2272.2 GHS Label elements, including precautionary statementsPictogram No data availableSignal word WarningHazard statement(s)H227 Combustible liquid.Precautionary statement(s)P210 Keep away from heat ⁄sparks ⁄open flames ⁄hot surfaces. - No smoking.P280 Wear protective gloves ⁄ protective clothing ⁄ eye protection ⁄ face protection.P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction.P403 + P235 Store in a well-ventilated place. Keep cool.P501 Dispose of contents ⁄ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:SirolimusFormula:C51H79NO13Molecular Weight:914.17CAS No. :53123-88-94. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 years* The compound is unstable in solutions, freshly prepared is recommended.Shipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2019 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Study_on_the_pharmacological_activities_and_chemic
ReviewStudy on the pharmacological activities and chemicalstructures of Viburnum dilatatumZhiheng Gao, Yufei Xi, Man Wang, Xiaoxiao Huang*, Shaojiang Song*Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research &Development, Liaoning Province, School of Traditional Chinese Materia Medica, ShenyangPharmaceutical University, Shenyang 110016, ChinaAbstractViburnum dilatatum (jiami in Chinese), belonging to the Caprifollaceae family, is widely distributed in Japan and China. Phytochemical investigations of Viburnum dilatatum (V. dilatatum) have resulted in the isolation of triterpenoids, phenolic glycosides essential oil, norisoprenoids, etc. Research results have shown that the chemical constituents of V. dilatatum possess various pharmacological activities, including antihyperglycemic, antioxidant activity and antiulcer effects. This study reviewed the chemical constituents and pharmacological activities of V. dilatatum to provide practical and useful information for further research and development of this plant.Keywords: Viburnum dilatatum; pharmacological activity; chemical structures1 IntroductionViburnum dilatatum (called jiami in Chinese, gamazumi in Japanese and snowball tree in English), beloinging to family Caprifoliaceae, is a deciduous low tree distributed widely in the hills of northern China and Japan [1]. There are many types of chemical constituents in Viburnum dilatatum (V. dilatatum), including triterpenoids, * Author to whom correspondence should be addressed. Address:School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-43520793 (Xiaoxiao Huang); +86-24-43520707 (ShaojiangSong);E-mail:*******************(XiaoxiaoHuang); ****************(ShaojiangSong).Received: 2021-04-16 Accepted: 2022-08-28phenolic glycosides and norisoprenoids [2-4]. The leaves have been utilized as a traditional Chinese medicine, and phenolic compounds have been reported as the main active chemical component of the leaves. Many researchers have analyzed the functions of these medicinal components and found that these components have good antioxidant antihyperglycemic and antiulcer effects. For example, the gamazumi crude extract obtained from the squeezed juice of the fruit prevented oxidative injury in rats [5]. This review described the chemical structures and pharmacological activities of V. dilatatum, so as to help readers understand comprehensively the research progress of V. dilatatum and provide help for the development of V. dilatatum.2 Chemical constituents and structuresPrevious reports have indicated that the main chemical constituents of V. dilatatum are phenolic glycosides and triterpenoids.2.1 Phenolic glycosidesThirteen phenolic glycosides were isolated and identified from V. dilatatum by extensive spectroscopic methods, namely p -hydroxyphenyl-6-O -trans-caffeoyl-β-D -glucoside (1) [6], p -hydroxyphenyl-6-O -trans-caffeoyl-β-D -alloside (2) [6], 4-allyl-2-methoxyphenyl-6-O -β-D -apiosyl(1→6)-β-D -glucoside (3) [6], 1-(4’-hydroxy-3’-methoxypheny1)-2-[2’’-hydroxy-4’’-(3’’’-hydroxypropyl)]-1,3-propanediol-l-O -β-D -glucopyranoside (erythro isomer) (4-7) [7], neochlorogenic acid methyl ester (8-9) [7], cryptochlorogenic acid methyl ester (10-11) [7], cyanidin-3-sambubioside (Cy-3-sam) (12) [8], cyanidin-3-glucoside (Cy-3-glc) (13) [8], 5-O -caffeoyl-4-methoxyl quinic acid (4-MeO-5-CQA) (14) [8], chlorogenic acid (5-CQA) (15) [8], quercetin (16) [8], 2-(glucopyranosyloxy)-benzyl-3-(glucopyranosyloxy)-benzoate (17) [9] and jiamizioside E (18) [10]. These structures are shown in Fig. 1.Fig. 1 Phenolic glycosides isolated from V . dilatatumContinued fig. 12.2 TriterpenoidsThere were about seventeen triterpenoids isolated and characterized from V. dilatatum , such as viburnols A (19) [11], viburnols B (20) [11], viburnols C (21) [11], viburnols D (22) [11], viburnols E (23) [11], viburnols F (24) [12], viburnols G (25) [12], viburnols H (26) [12], viburnols I (27) [12], viburnols J (28) [12],viburnols K (29) [12], viburnudienone B 2methyl ester (30) [13], viburnenone H 2 (31) [13],v i b u r n e n o n e B 2 m e t h y l e s t e r (32) [13], viburnudienone B 1 methyl ester (33) [13], viburnenone H 1 (34) [13], and viburnenone B 2 methyl ester (35) [13]. The structures are shown in Fig. 2.Continued fig. 23 Pharmacological activities3.1 Antioxidant activityOxidative stress caused by free radicals and their derivatives leads to disturbances in redox homeostasis. Reactive oxygen species (ROS) are not only endogenously produced during intracellular metabolic processes but also generated by exogenous stimuli such as UV radiation, pollutants, smoke and drugs. The cell triggers its defense systems or undergoes apoptosis when intracellular oxidative status increases. It influences numerous cellular processes including core signaling pathways, which are associated with development of systematic and chronic disorders, such as aging and cancer. Therefore, it is critical to remove cellular oxidants and restore redox balance.solution of V. dilatatum (GSS) had strong antioxidant activity in vivo and prevent stress-induced oxidative damage by the XYZ-dish method and the澳electron spin resonance (ESR) method [14]. The experimental result showed that the concentrations of lipid peroxide in plasma, liver and stomach in the GSS group were reduced. Furthermore, the activities of plasma lactic dehydrogenase, amylase and creatine phosphokinase are ordinarily increased by stress. However, these activities in the GSS group decreased to that in the control group. It was concluded that gastric ulcer formation, increase of lipid peroxidation in plasma and tissues and elevation of plasma enzymatic activities were confirmed in rats with water immersion restraint stress. It was also found that intake of GSS could protect the stomach and other tissues from oxidative damage.Kim et al. identified and isolated two major anthocyanins by NMR and LC-ESI-MS/MS, namely, cyanidin 3-sambubioside (I) and kuromanin (II) [15]. By the electron spin resonance method, the superoxide anion radical scavenging activities of I and II were evaluated with the IC 50 values of 17.3 and 69.6 µM, and their activities on hydroxyl radicals were evaluated with the IC 50 values of 4.3 and 53.2 mM. As the positive control, the IC 50 values of ascorbic acid were 74.2 µM on superoxide anion radicals and 3.0 mM on hydroxyl radicals, respectively. The above results suggested that these anthocyanins with radical scavenging properties might be the key compounds contributing to the antioxidant activity and physiological effects of V . dilatatum fruits.Woo et al. determined the free radical scavenging capacity of VD (the leaves of V. dilatatum ) [16]. Anti-oxidant activity of the extracts was assessed by the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) or 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals. Butylated hydroxytoluene (BHT), a synthetic antioxidant, or α-tocopherol, was used as the positive control in these assays. The experimental result showed that VD inducedincrease in radical scavenging activity. In addition, lipid peroxidation inhibitory activity was determined via measurement of MDA (Malondialdehyde) levels using mouse liver tissue homogenate treated with various concentrations of the extracts. The concentration-dependent decrease in MDA levels observed was consistent with radical scavenging activities of the extracts. To examine whether VD extracts could protect mam-malian cells from oxidative stress, cultures of a human mammary gland-derived epithelial cell line MCF-7 were treated with each extract prior to challenging them with tBHP. The intracellular ROS (Reactive oxygen species) production was determined with the relative intensity of dichlorofluorescein fluorescence. While intracellular ROS formation was significantly promoted by tBHP treatment, the augmented ROS level was significantly reduced after the treatment with VD extracts.3.2 Antihyperglycemic effectIwai et al. used an oral glucose tolerance test on the diabetic rats [17]. They found that the elevation of plasma glucose level after oral administration of 2 g/kg glucose was suppressed by the repeated administration of the freeze-dried powder of V. dilatatum fruit juice (CEV). The α-glucosidase inhibitory activities of isolated compounds from CEV were also measured. Cyanidin 3-sambubioside and 5-caffeoyl quinic acid A showed inhibitory activity. These results suggested that V. dilatatum fruit had the antihyperglycemic effects.4 ConclusionV. dilatatum is distributed widely in the hills of northern China and Japan. Currently, the studies on V. dilatatum have been conducted at home and abroad, but few studies focus on its chemical components and pharmacological activities. Previousphytochemical investigations showed that the constituents of V. dilatatum included triterpenoids, phenolic glycosides, norisoprenoids and other compounds. This study describes thirteen phenolic glycosides and seventeen triterpenoids and their different degrees of antihyperglycemic, antioxidant activity and antiulcer effects, aiming to provide a reference for further studies on V. dilatatum and pharmaceutical development.References[1] Jeffrey B, Harborne A. Colour atlas of medicinal plantsof Japan. Phytochemistry, 1981, 20: 1467.[2] Miyazawa M, Hashidume S, Takahashi T, et al. Aromaevaluation of gamazumi (Viburnum dilatatum) by aroma extract dilution analysis and odour activity value.Phytochem Anal, 2012, 23: 208-213.[3] Kurihara T, Kikuchi M. Studies on the constituentsof flowers. IV. On the components of the flower of Viburnum dilatatum Thunb. J Health Sci, 1975, 95: 1098-1102.[4] Machida K, Kikuchi M. Norisoprenoids from Viburnumdilatatum. Phytochemistry, 1996, 41: 1333-1336. [5] Iwai K, Onodera A, Matsue H. Mechanism of preventiveaction of Viburnum dilatatum Thunb (gamazumi) crude extract on oxidative damage in rats subjected to stress. J Sci Food Agric, 2010, 83: 1593-1599.[6] Machida K, Nakano Y, Kikuchi M. Phenolic glycosidesfrom Viburnum dilatatum. Phytochemistry, 1991, 30: 2013-2014.[7] Machida K, Kikuchi M. Phenolic compounds fromViburnum dilatatum. Phytochemistry, 1992, 31: 3654-3656.[8] Kim MY, Iwai K, Matsue H. Phenolic compositions ofViburnum dilatatum Thunb. fruits and their antiradical properties. J Food Compos Anal, 2005, 18: 789-802. [9] Lu D, Yao S. Phenolic glycoside from the roots ofViburnum dilatatum. Nat Prod Commun, 2009, 4: 945-946.[10] Wu B, Zeng X, Zhang Y. New metabolite fromViburnum dilatatum. Nat Prod Commun, 2010, 5: 1097-1098.[11] Machida K, Kikuchi M. Viburnols: Novel triterpenoidswith a rearranged dammarane skeleton from Viburnum dilatatum. Tetrahedron Lett, 1996, 37: 4157-4160. [12] Machida K, Kikuchi M. Viburnols: Six noveltriterpenoids from Viburnum dilatatum. Tetrahedron Lett, 1997, 38: 571-574.[13] Machida K, Kikuchi M. Studies on the Constituents ofViburnum Species. XIX. Six New Triterpenoids from Viburnum dilatatum Thunb. Chem Pharm Bull, 1999, 47: 692-694.[14] Iwai K, Onodera A, Matsue H, et al. Antioxidant activityand inhibitory effect of Gamazumi (Viburnum dilatatum THUNB.) on oxidative damage induced by water immersion restraint stress in rats. Int J. Food Sci Nutr, 2001, 52: 443-451.[15] Kim MY, Iwai K, Onodera A, et al. Identification andAntiradical Properties of Anthocyanins in Fruits of Viburnum dilatatum Thunb. J Agric Food Chem, 2003, 51: 6173-6177.[16] Woo YJ, Lee HJ, Jeong YS, et al. Antioxidant Potentialof Selected Korean Edible Plant Extracts. Bio Med Res Int, 2017, 2017: 1-9.[17] Iwai K, Kim MY, Akio O, et al. Alpha-glucosidaseinhibitory and antihyperglycemic effects of polyphenols in the fruit of Viburnum dilatatum Thunb. J Agric Food Chem, 2006, 54: 4588-4592.。
丙酸氟替卡松乳膏体外透皮吸收量测定
丙酸氟替卡松乳膏体外透皮吸收量测定丁水生;肖学成;李金;陈凤;李丹【摘要】Objective To establish a high performance liquid chromatography ( HPLC ) method for quantitative determination of fluticasone propionate in percutaneous solution, and investigate the ability of percutaneous penetration of fluticasone propionate cream. Methods Hypersil ODS C18 column (250 mm×4.6 mm,5 μm) was used. Mobile phase was as follows; methanol-1. 15 g·L-1 ammonium dihydrogen phosphate (adjusted to pH 3.5 )-acetonitrile (55 : 35:15 in volume). The column temperature was set at 55℃. The flow rate was 1.0 mL·min-1. The detection wavelength was 240 nm. Improved Franz type diffusion cells were used in, vitro permeation studies and excised minipig' s skins in vitro were used as a transdermal barrier. The concentration of fluticasone propionate in the receptor solution was determined by HPLC to investigate its cumulative permeation quantities at different time points respectively , which were compared with those of the commercial cream. Results The regression equation of penciclovir was linear in the range of 0. 050 2-1.003 0 μg·mL-1(A=47 709.364 7×C+300. 774 4, r=0. 999 8). The average recovery was 99. 58%. A good linear relationship existed between the cumulative penetration quantities and the time. There was no significant difference in the skin permeation quantities between the self-made cream and commercial cream. Conclusion The method was simple, rapid, and accurate. It is a better method to evaluate the characteristics of permeation for fluticasonepropionate.%目的建立丙酸氟替卡松乳膏中体外透皮接收液的高效液相色谱(HPLC)测定方法,研究丙酸氟替卡松乳膏的透皮能力.方法采用Hypersil ODS C18色谱柱(250 mm×4.6 mm,5μm),流动相:甲醇-0.01 mol·L-1磷酸氢二胺(用磷酸溶液调pH至3.5)-乙腈(55:35:15),柱温为55 ℃；检测波长为240 nm,流速1.0 mL·min-1.体外透皮实验采用改良的Franz扩散池,以体外乳猪皮作为透皮屏障,比较自制乳膏与市售乳膏的透皮结果,分别在不同时间点取样测定透皮接收液中丙酸氟替卡松浓度,计算累积透皮量.结果丙酸氟替卡松在0.0502 ～1.0030μg·mL-1浓度范围内峰面积与浓度之间呈良好的线性关系(r=0.9998),回归方程为A=47 709.364 7×C+300.7744,平均回收率99.58％.自制乳膏与市售乳膏的透皮结果差异无统计学意义.结论该检测方法操作简便,快速准确,是考察丙酸氟替卡松乳膏体外透皮吸收量较理想的方法.【期刊名称】《医药导报》【年(卷),期】2012(031)012【总页数】3页(P1613-1615)【关键词】丙酸氟替卡松乳膏;透皮吸收;色谱法,高效液相【作者】丁水生;肖学成;李金;陈凤;李丹【作者单位】广东省佛山市禅城区南庄医院药剂科,528061;湖北中医药大学药学院,武汉430065;湖北中医药大学药学院,武汉430065;湖北中医药大学药学院,武汉430065;湖北中医药大学药学院,武汉430065【正文语种】中文【中图分类】R986;R927.2丙酸氟替卡松具有很强的抗炎和局部血管收缩作用，主要用于治疗银屑病和白癜风。
洋甘菊提取液MSDS英文版
1. IDENTIFICATION OF THE SUBSTANCE/TREPARATION AND THE COMPANY/UNDERTAKING3.HAZARDS IDENTIFICATION4. FIRST AID MEASURESMATERIAL SAFETY DATA SHEETProduct name:Supplier:Tel:EMERGENCY OVERVIEW: May cause skin irritation and/or dermatitisPrinciple routes of exposure: Inhalation: Ingestion: Skin contact: Eye contact:SkinMay cause irritation of respiratory tract May be harmful if swallowed May cause allergic skin reaction Avoid contact with eyesStatements of hazard MAY CAUSE ALLERGIC SKIN REACTION.Statements of Spill of Leak Label Eliminate all ignition sources. Absorb and/or contain spill with inert materials (e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush spill area. Prevent runoff from entering waterways or sewers.General advice:POSITION/INFORMATION ON INGREDIENTSInhalation:Skin contact:Ingestion:Eye contact:Protection of first – aiders:Medical conditions aggravated by exposure: In the case of accident or if you fell unwell, seek medical advice immediately (show the label where possible).Move to fresh air, call a physician immediately.Rinse immediately with plenty of water and seek medical adviceDo not induce vomiting without medical advice.In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.No information availableNone knownSuitable extinguishing media:Specific hazards:Special protective equipment for firefighters:Flash point:Autoignition temperature:NFPA rating Use dry chemical, CO2, water spray or “alcohol” foam Burning produces irritant fumes.As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gearNot determinedNot determinedNFPA Health: 1 NFPA Flammability: 1 NFPA Reactivity: 0Personal precautions: Environmental precautions: Methods for cleaning up: Use personal protective equipment.Prevent product from entering drains.Sweep up and shovel into suitable containers for disposalStorage:7. HANDLING AND STORAGE5.FIRE-FIGHTING MEASURES6. ACCIDENTAL RELEASE MEASURESRoom temperature Handling:Safe handling advice: Incompatible products:Use only in area provided with appropriate exhaust ventilation.Wear personal protective equipment.Oxidising and spontaneously flammable productsEngineering measures: Respiratory protection: Skin and body protection:Eye protection: Hand protection: Hygiene measures:Ensure adequate ventilation.Breathing apparatus only if aerosol or dust is formed. Usual safety precautions while handling the product will provide adequate protection against this potential effect. Safety glasses with side-shieldsPVC or other plastic material glovesHandle in accordance with good industrial hygiene and safety practice.Melting point/range: Boiling point/range: Density: Vapor pressure: Evaporation rate: Vapor density: Solubility (in water): Flash point:Autoignition temperature:No Data available at this time. No Data available at this time. No data available No data available No data available No data available No data available Not determined Not determinedStability: Stable under recommended storage conditions. Polymerization: None under normal processing.Hazardous decomposition products: Thermal decomposition can lead to release of irritating gases and vapours such as carbon oxides.Materials to avoid: Strong oxidising agents.10. STABILITY AND REACTIVITY9. PHYSICAL AND CHEMICAL PROPERTIES8. EXPOSURE CONTROLS/PERSONAL PROTECTION11. TOXICOLOGICAL INFORMATIONConditions to avoid: Exposure to air or moisture over prolonged periods.Product information Acute toxicityChronic toxicity:Local effects: Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness.Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting.Specific effects:May include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting,headache.Primary irritation: Carcingenic effects: Mutagenic effects: Reproductive toxicity:No data is available on the product itself. No data is available on the product itself. No data is available on the product itself. No data is available on the product itself.Mobility:Bioaccumulation: Ecotoxicity effects: Aquatic toxicity:No data available No data available No data availableMay cause long-term adverse effects in the aquatic environment.12. ECOLOGICAL INFORMATION13. DISPOSAL CONSIDERATIONSWaste from residues/unused products:Contaminated packaging:Waste disposal must be in accordance with appropriate Federal, State and local regulations. This product, if unaltered by use, may be disposed of treatment at a permitted facility or as advised by your local hazardous waste regulatory authority. Residue from fires extinguished with this material may be hazardous.Do not re-use empty containers.UN/Id No:Not regulated14. TRANSPORT INFFORMATIONDOTProper shipping name: Not regulatedTGD(Canada)WHMIS hazard class: Non - controlledIMDG/IMOIMDG – Hazard Classifications Not ApplicableIMO – labels:15. REGULATORY INFOTMATION International Inventories16. OTHER INFORMATIONPrepared by: Health & SafetyDisclaimer: The information and recommendations contained herein are based upon tests believed to be reliable.However, XABC does not guarantee the accuracy or completeness NOR SHALL ANY OF THIS INFORMATION CONSTITUTE A WARRANTY, WHETHER EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE GOOD, THE MERCHANTABILITY OF THE GOODS, OR THE FITNESS OF THE FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE. Adjustment to conform to actual conditions of usage maybe required. XABC assumes no responsibility for results obtained or for incidental or consequential damages, including lost profits arising from the use of these data. No warranty against infringement of any patent, copyright or trademark is made or implied.End of safety data sheet。
环泊酚与丙泊酚的药效动力学特性比较
环泊酚与丙泊酚的药效动力学特性比较*朱锋① 邓义江① 周再银① 钟粤① 【摘要】 目的：比较环泊酚与丙泊酚在临床药效动力学特性上的差异。
方法：将2021年7—10月于攀枝花学院附属医院拟行上肢远端骨折内固定术的80例患者随机分为环泊酚组和丙泊酚组，各40例。
两组患者完成超声引导下臂丛神经阻滞后，分别静脉泵注2 mg/kg丙泊酚及0.4 mg/kg环泊酚，1 min泵完。
记录并比较两组给药前（T0）及开始泵注药物后1 min （T1）、2 min（T2）、3 min（T3）、4 min（T4）、5 min（T5）平均动脉压（MAP）、心率（HR）、血氧饱和度（SpO2）、脑电双频指数（BIS）；观察两组诱导时间、意识恢复时间、定向力恢复时间；此外，比较两组注射痛评分及不良反应发生情况。
结果：两组组内不同时间MAP、HR、SpO2及BIS比较，差异有统计学意义（P<0.05）；丙泊酚组T1、T2、T3、T4、T5时MAP及SpO2均低于T0时，差异有统计学意义（P<0.05）；环泊酚组T1、T2时MAP低于T0时，T1、T2、T3、T4时SpO2低于T0时，差异有统计学意义（P<0.05）；环泊酚组T1、T2、T3、T4、T5时MAP及SpO2均高于丙泊酚组，差异有统计学意义（P<0.05）；两组T1、T2时HR均显著高于T0，差异有统计学意义（P<0.05）；环泊酚组T1、T2时HR低于丙泊酚组，差异有统计学意义（P<0.05）；两组T1、T2、T3、T4、T5时BIS值均低于T0时，差异有统计学意义（P<0.05）。
环泊酚组诱导时间、意识恢复时间、定向力恢复时间相比于丙泊酚组显著缩短，差异有统计学意义（P<0.05）。
环泊酚组的视觉模拟评分法（VAS）评分及低血压、低氧血症的发生率低于丙泊酚组，差异有统计学意义（P<0.05）。
结论：0.4 mg/kg环泊酚具有相当于2 mg/kg 丙泊酚的麻醉效能，并且环泊酚具有更快的起效及消退时间、更少的注射痛及不良反应。
α-蒎烯安全技术说明书MSDS
第一部分化学品及企业标识化学品中文名：α-蒎烯化学品英文名：α-pinene化学品别名：α-松油萜CASNo.：80-56-8ECNo.：201-291-9分子式：C10H16第二部分危险性概述紧急情况概述液体。
易燃,其蒸气与空气混合，能形成爆炸性混合物。
如果被吞食，可能会造成严重肺部损伤。
对皮肤有刺激性。
跟皮肤接触可能会引起敏化作用。
对水生物有剧毒,使用适当的容器,以预防污染环境。
对水生环境可能会引起长期有害作用。
使用适当的容器,以预防污染环境。
GHS危险性类别根据GB30000-2013化学品分类和标签规范系列标准（参阅第十六部分），该产品分类如下：易燃液体，类别3；吸入危险，类别1；皮肤腐蚀/刺激，类别2；皮肤敏化作用，类别1；危害水生环境-急性毒性，类别1；危害水生环境-慢性毒性，类别1。
标签要素象形图警示词：危险危险信息：易燃液体和蒸气，吞咽并进入呼吸道可能致命，造成皮肤刺激，可能导致皮肤过敏反应，对水生生物毒性极大，对水生生物毒性极大并具有长期持续影响。
预防措施：远离热源、热表面、火花、明火以及其它点火源。
禁止吸烟。
保持容器密闭。
容器和接收设备接地和等势联接。
使用不产生火花的工具。
采取措施，防止静电放电。
避免吸入粉尘/烟/气体/烟雾/蒸气/喷雾。
作业后彻底清洗。
受沾染的工作服不得带出工作场地。
避免释放到环境中。
戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
事故响应：不得诱导呕吐。
清洗后方可重新使用。
收集溢出物。
如误吞咽：立即呼叫中毒急救中心/医生。
如发生皮肤刺激或皮疹：求医/就诊。
脱去被污染的衣服，清洗后方可重新使用。
如皮肤(或头发)沾染：立即去除/脱掉所有沾染的衣服。
用水清洗皮肤或淋浴。
安全储存：存放处须加锁。
存放在通风良好的地方。
保持低温。
废弃处置：按照地方/区域/国家/国际规章处置内装物/容器。
物理化学危险：易燃液体，其蒸气与空气混合，能形成爆炸性混合物。
健康危害：在正常生产处理过程中，吞咽本品并进入呼吸道可能致命。
多环芳烃(PAHs)标样
美国Accustandard 多环芳烃（PAHs）标样AccuStandard 是唯一经过NIST/NVLAP、EPA 认证的标准物质的专业供应商，可以为包括美国官方机构EPA、ASTM、NIST 在内的全球专业检测机构提供各类标样近35000种！可提供特种标样的专门配制，所有标样均可提供质检报告、材料安全数据卡。
标样品种分为：农残和兽残标样、环境标样、食品标样、石化标样、无机标样等各类标准品及标准物质。
Accustandard 多环芳烃（PAHs）产品列表：西域库存号 中文名称 英文名称 CAS No. 包装 L22783830 苊 Acenaphthene 83-32-9 100mg L22783836 蒽 Anthracene 120-12-7 100mg L22783888 芴 Fluorene 86-73-7 100mg L22783892 茚 Indene 95-13-6 100mg L22783900 萘 Naphthalene 91-20-3 100mg L22783903 芘 Perylene 198-55-0 10mg L22783905 菲 Phenanthrene 85-01-8. 100mg L22783907 苉 Picene 213-46-7 5mg L22783909 芘 Pyrene 129-00-0 100mg L22783857 联苯 Biphenyl 92-52-4 500mg L22783859 咔唑 Carbazole 86-74-8 100mg L22783863 晕苯 Coronene 191-07-1 5mg L22783886 荧蒽 Fluoranthene 206-44-0 100mg L22783890 茚满 Indan 496-11-7 100mg L22783896 吲哚 Indole 120-72-9 100mg L22783911 吡咯 Pyrrole109-97-7 100mg L22783919 二苯肼 1,2-Diphenylhydrazine 122-66-7 100mg L22784045联苯胺Benzidine92-87-5100mg工业品· 仪器· 医疗The future is now!TEL: 400-880-8822FAX: 400-880-8812Add: 18/F, Qiangsheng Building,145 Pujian Rd, Pudong New Area,Shanghai 200127, P .R.C* A WESTINGAREA COMPANYL22784047 硝基苯 Nitrobenzene 98-95-3 100mg L22783765 并四苯 2,3-Benzanthracene 92-24-0 10mg L22783834 蒽嵌蒽 Anthanthrene 191-26-4 10mg L22783898 异喹啉 Isoquinoline 119-65-3 100mg L22783940 1-萘胺 1-Aminonaphthalene 134-32-7 50mg L22783978 2-萘胺 2-Aminonaphthalene 91-59-8 10mg L22783724 四氢荧蒽 1,2:3,4-Tetrahydrofluoranthene 42429-92-5 10mg L22783767 四甲基茚 2,3-Benzofluorene 243-17-4 10mg L22783769 苯并呋喃 2,3-Benzofuran 271-89-6 10mg L22783838 奥苷菊环 Azulene 275-51-4 10mg L22783913 苯并噻吩 Thianaphthene 95-15-8 100mg L22783936 1-氨基蒽 1-Aminoanthracene 610-49-1 50mg L22783942 1-羟基芘 1-Hydroxypyrene 5315-79-7 10mg L22783944 1-硝基萘 1-Nitronaphthalene 86-57-7 100mg L22783946 1-硝基芘 1-Nitropyrene 5522-43-0 5mgL22783970 2-氨基蒽 2-Aminoanthracene 613-13-8 50mg L22783976 7-氨基屈 2-Aminofluorene 153-78-6 10mg L22783982 2-硝基萘 2-Nitroanthracene 3586-69-4 5mgL22783988 2-硝基芴 2-Nitrofluorene 607-57-8 100mg L22783990 2-硝基萘 2-Nitronaphthalene 581-89-5 100mg L22784010 3-硝基菲 3-Nitrophenanthrene 17024-19-0 5mgL22784030 6-氨基屈 6-Aminochrysene 2642-98-0 10mg L22784032 6-羟基屈 6-Hydroxychrysene 37515-51-8 10mg L22784041 9-硝基蒽 9-Nitroanthracene 602-60-8 5mgL22784043 9-硝基菲 9-Nitrophenanthrene 954-46-1 5mgL22783749 1-甲基蒽 1-Methylanthracene 610-48-0 10mg L22783753 1-甲基萘 1-Methylnaphthalene 90-12-0 100mg L22783755 1-甲基菲 1-Methylphenanthrene 832-69-9 10mg L22783757 1-甲基芘 1-Methylpyrene 238-71-7 10mg L22783759 1-苯基萘 1-Phenylnaphthalene 605-02-7 100mg L22783775 2-甲基蒽 2-Methylanthracene 613-12-7 10mg L22783781 2-甲基萘 2-Methylnaphthalene 91-57-6 100mg L22783784 2-苯基萘 2-Phenylnaphthalene 612-94-2 5mgL22783824 9-甲基蒽 9-Methylanthracene 779-02-2 10mg L22783828 9-苯基蒽 9-Phenylanthracene 602-55-1 100mgL22783876 二苯并呋喃 Dibenzofuran 132-64-9 50mg L22783882 二苯并噻吩 Diphenylenesulfide 132-65-0 100mg L22783938 1-氨基蒽醌 1-Aminoanthraquinone 82-45-1 50mg L22783972 2-氨基蒽醌 2-Aminoanthraquinone 117-79-3 5mgL22783974 2-氨基联苯 2-Aminobiphenyl 90-41-5 10mg L22783980 2-硝基苯胺 2-Nitroaniline 88-74-4 100mg L22783984 2-硝基联苯 2-Nitrobiphenyl 86-00-0 100mg L22783992 2-硝基苯酚 2-Nitrophenol 88-75-5 100mg L22783994 2-硝基甲苯 2-Nitrotoluene 88-72-2 100mg L22784002 3-硝基苯胺 3-Nitroaniline 1999-9-2 100mg L22784004 3-硝基联苯 3-Nitrobiphenyl 2113-58-8 100mg L22784008 3-硝基荧蒽 3-Nitrofluoranthene 892-21-7 5mgL22784018 4-氨基联苯 4-Aminobiphenyl 92-67-1 10mg L22784022 4-硝基苯胺 4-Nitroaniline 100-01-6 100mg L22784024 4-硝基联苯 4-Nitrobiphenyl 92-93-3 100mg L22784026 4-硝基苯酚 4-Nitrophenol 100-02-7 100mg L22784035 6-硝基联苯 6-Nitrochrysene 7496-2-8 5mgL22783779 2-甲基荧蒽 2-Methylfluoranthene 33543-31-6 10mg L22783791 3-甲基胆蒽 3-Methylcholanthrene 56-49-5 10mg L22783843 苯并[b]屈 Benzo[b]chrysene 214-17-5 5mg L22783847 苯并[c]菲 Benzo[c]phenanthrene 195-19-7 10mg L22783849 苯并[e]菲 Benzo[e]pyrene 192-97-2 10mg L22783861 苯并菲(屈) Chrysene 218-01-9 100mg L22783964 2,7-硝基芴 2,7-Dinitrofluorene 5405-53-8 100mg L22783968 2-乙酰氨基氟 2-Acetamidofluorene 53-96-3 10mg L22783845 苯并[b]荧蒽 Benzo[b]fluoranthene 205-99-2 10mg L22783853 苯并[j]荧蒽 Benzo[j]fluoranthene 205-82-3 10mg L22783855 苯并[k]荧蒽 Benzo[k]fluoranthene 207-08-9 10mg L22783923 1,3-二硝基芘 1,3-Dinitropyrene 75321-20-9 5mgL22783925 1,5-二硝基萘 1,5-Dinitronaphthalene 605-71-0 100mg L22783927 1,6-二硝基芘 1,6-Dinitropyrene 42397-64-8 5mgL22783929 1,8-二氨基萘 1,8-Diaminonaphthalene 479-27-6 100mg L22783931 1,8-二硝基萘 1,8-Dinitronaphthalene 602-38-0 100mg L22783960 2,7-二氨基芴 2,7-Diaminofluorene 525-64-4 10mg L22784020 对二甲胺基偶氮苯 4-Dimethylaminoazobenzene 60-11-7. 10mgL22784057 1,3,5-三嗪 s-Triazine 290-87-9 10mg L22783735 1,2-二甲基萘 1,2-Dimethylnaphthalene 573-98-8 10mg L22783737 1,3-二甲基萘 1,3-Dimethylnaphthalene 575-41-7 10mg L22783739 1,4-二甲基萘 1,4-Dimethylnaphthalene 571-53-4 10mg L22783741 1,5-二甲基萘 1,5-Dimethylnaphthalene 571-61-9 10mg L22783743 1,6-二甲基萘 1,6-Dimethylnaphthalene 575-43-9 10mg L22783745 1,8-二甲基萘 1,8-Dimethylnaphthalene 569-41-5 10mg L22783761 2,2'-联萘酚 2,2'-Binaphthyl 612-78-2 50mg L22783771 2,3-二甲基蒽 2,3-Dimethylanthracene 613-06-9 10mg L22783773 2,6-二甲基萘 2,6-Dimethylnaphthalene 581-42-0 10mg L22783786 3,6-二甲基萘 3,6-Dimethylphenanthrene 1576-67-6 10mg L22783799 5,6-苯并喹啉 5,6-Benzoquinoline 85-02-9. 10mg L22783810 7,8-苯并喹啉 7,8-Benzoquinoline 230-27-3 100mg L22783818 9,10-二氢蒽 9,10-Dihydroanthracene 613-31-0 100mg L22783915 三亚苯(苯并菲) Triphenylene 217-59-4 10mg L22783921 1,3-二硝基萘 1,3-Dinitronaphthalene 606-37-1 100mg L22783952 2,4-二氨基甲苯 2,4-Diaminotoluene 95-80-7 100mg L22783954 2,4-二硝基苯酚 2,4-Dinitrophenol 51-28-5 100mg L22783956 2,4-二硝基甲苯 2,4-Dinitrotoluene 121-14-2 100mg L22783958 2,6-二硝基甲苯 2,6-Dinitrotoluene 606-20-2 100mg L22783986 2-硝基二苯并噻吩 2-Nitrodibenzothiophene 6639-36-7 5mgL22784006 3-硝基二苯并呋喃 3-Nitrodibenzofuran 5410-97-9 5mgL22784039 9,10-二硝基蒽 9,10-Dinitroanthracene 33685-60-8 5mgL22784051 N-苯基-1-萘胺 N-phenyl-1-naphthylamine 90-30-2 50mg L22784053 N-苯基-2-萘胺 N-Phenyl-2-naphthylamine 135-88-6 10mg L22783726 二苯并[a,e]芘 1,2:4,5-Dibenzopyrene 192-65-4 10mg L22783820 9,10-二甲基蒽 9,10-Dimethylanthracene 781-43-1 10mg L22783832 1,8-亚乙基萘 Acenaphthylene 208-96-8 100mg L22783870 二苯并[a,h]芘 Dibenzo[a,h]pyrene 189-64-0 10mg L22783872 二苯并[a,i]芘 Dibenzo[a,i]pyrene 189-55-9 5mgL22783874 二苯并[a,l]芘 Dibenzo[a,l]pyrene 191-30-0 5mgL22783878 二苯并-对-二恶英 Dibenzo-p-dioxin 262-12-4 10mg L22783934 1-氨基-4-硝基萘 1-Amino-4-nitronaphthalene 776-34-1 100mg L22783948 2,2'-二硝基联苯 2,2'-Dinitrobiphenyl 2436-96-6 100mg L22784037 7-硝基苯并[a]蒽 7-Nitrobenz[a]anthracene 20268-51-3 5mgL22784055 3,3-二甲基联苯胺 o-Tolidine (3,3'-Dimethylbenzidine) 119-93-7 100mg L22783732 1,2-苯并[A]蒽 1,2-Benzanthracene 56-55-3 10mg L22783814 7-甲基苯并[a]菲 7-Methylbenzo[a]pyrene -------- 10mg L22783822 9-甲基-9-苯基芴 9-Methyl-9-phenylfluorene 56849-83-3 10mg L22783851 苯并[g,h,i]苝 Benzo[g,h,i]perylene 191-24-2 10mg L22783865 二苯并[a,h]氮蒽 Dibenz[a,h]acridine 226-36-8 10mg L22783868 二苯并[a,e]荧蒽 Dibenzo[a,e]fluoranthene 5385-75-1 1mg L22783962 2,7-二硝基-9-芴 2,7-Dinitro-9-fluorenone 31551-45-8 100mg L22783996 3,3'-二氨基联苯胺 3,3'-Diaminobenzidine 91-95-2 50mg L22783998 3,3'-双氯苯甲酸酯 3,3'-Dichlorobenzidine 91-94-1 50mgL22784012 4,4’-亚甲基双苯胺 4,4'-Diaminodiphenylmethane(4,4'-Methylenedianiline)101-77-9 100mgL22784016 4,6-二硝基邻甲苯酚 4,6-Dinitro-o-cresol(2-Methyl-4,6-dinitrophenol)534-52-1 100mgL22783840 苯并蒽-7,12-二酮 Benz[a]anthracene-7,12-dione 2498-66-0 10mg L22783966 2,8-二硝基二苯并噻吩 2,8-Dinitrodibenzothiophene 109041-38-5 5mg L22784000 3,3'-二甲氧基联苯胺 3,3'-Dimethoxybenzidine 119-90-4 50mg L22783722 1,2:3,4-二苯并蒽 1,2:3,4-Dibenzanthracene 215-58-7 10mg L22783728 1,2:5,6-二苯并蒽 1,2:5,6-Dibenzanthracene 53-70-3 10mg L22784028 1,2-二氢-5-硝基苊 5-Nitroacenaphthene 602-87-9 5mg L22783730 1,2:8,9-二苯并五苯 1,2:8,9-Dibenzpentacene 227-09-8 10mg L22783894 茚并[1,2,3-cd]芘 Indeno[1,2,3-cd]pyrene 193-39-5 10mg L22783950 2,4,7-三硝基-9-芴酮 2,4,7-Trinitro-9-fluorenone 129-79-3 25mgL22784049 1-甲基3-硝基1-亚硝基胍N-Methyl-N'-nitro-N-nitrosoguanidine 70-25-7 50mgL22783808 7,12-二甲基苯并[a]蒽 7,12-Dimethylbenz[a]anthracene 57-97-6 10mg L22783917 三(2,3-二溴丙基)磷酸酯 Truxene 548-35-6 100mgL22784014 4,4'-亚甲基双(2-氯苯胺)4,4'-Methylene bis(2-chloroaniline) 101-14-4 50mgL22783794 4,6,8-Trimethylazulene 4,6,8-Trimethylazulene 941-81-1 10mg L22783884 -------- Dodecahydrotriphenylene 1610-39-5 100mgL22783880 二茚并(1,2,3-CD:1',2',3'-LM)苝Diindeno[1,2,3-cd-1',2',3'-1m]perylene188-94-3 5mgL22783763 -------- 2,3,6,7-Tetraethylbiphenylene -------- 10mg。
Pimecrolimus_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :PimecrolimusCatalog No. :HY-13723CAS No. :137071-32-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4),H302Acute aquatic toxicity (Category 1),H400Chronic aquatic toxicity (Category 1),H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effects.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents/ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:SDZ⁻ASM 981Formula:C43H68ClNO11Molecular Weight:810.45CAS No. :137071-32-04. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077Class: 9Packing group: IIIEMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutant.IATAUN number: 3077Class: 9Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
1,2,4,5,6,7,8,8-八氯-2,3,3a,4,7,7a-六氢-4,7-亚甲基茚
相对密度（水=1）：1.59-1.63
相对密度（空气=1）：无资料
饱和蒸气压／kPa：0.27（175℃）
燃烧热（kJ/mol）：-3810.95
临界温度／℃：无资料
临界压力／MPa：无资料
闪点／℃：56
自燃温度／℃：无意义
爆炸下限（%）：2.8
爆炸上限（%）：30.5
分子式：C10H6Cl8
相对分子质量：409.779
危险化学品序号：43
CAS号：57-74-9
UN编号：2996
危险性类别：急性毒性-经皮,类别3；致癌性,类别2；危害水生环境-急性危害,类别1；危害水生环境-长期危害,类别1
理化特性
外观与性状：无色或淡黄色液态，工业品为有杉木气味的琥珀色液体
熔点／℃：无资料
1,2,4,5,6,7,8,8-八氯-2,3,3a,4,7,7a-六氢-4,7-亚甲基茚
标识
中文名：1,2,4,5,6,7,8,8-八氯-2,3,3a,4,7,7a-六氢-4,7-亚甲基茚；氯丹；八氯化茚
英文名：chlordane;1,2,4,5,6,7,8,8-octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindan;M-410
分解温度／℃：沸点分解
溶解性：不溶于水，溶于多数有机溶剂
危险性概述
物理和化学危险：不燃，无特殊爆燃特性。
健康危害：急性中毒：中毒症状发生较快，几小时即可死亡。主要症状为中枢神经系统兴奋症状，如激动、震颤、全身抽搐；摄入中毒症状出现更快，有恶心、呕吐、全身抽搐。严重中毒紫抽搐剧烈和反复发作后陷于木僵、昏迷和呼吸衰竭。慢性中毒：主要症状为神经系统功能紊乱，肝、肾退行性改变。有头痛、眼球痛、全身乏力、失眠、噩梦、头晕、心前区不适、四肢麻木和酸痛。
高效液相色谱法测定注射用美罗培南的有关物质
第35卷第3期 长治医学院学报2021 年 6 月JOURNAL OF CHANGZHI MEDICAI COLLEGE167Vol. 35 No. 3Jun. 2021高效液相色谱法测定注射用美罗培南的有关物质李金格禹玉洪**作者单位山西医科大学药学院药剂教研室(030001)* 通信作者(E-mail ：3024546064@ qq. com)摘要目的：探讨优化注射用美罗培南杂质A 、B 的测定方法。
方法：运用高效液相色谱法(HPLC) 进行检测，色谱柱以十八烷基硅烷键合硅胶为填充剂；流动相A ：20. 0 mmol-L'1磷酸二氢钠-甲醇(89 ：11, V/V)，流动相B ：甲醇，流速1.0 mL-min 1,检测波长220 nm,柱温30 P 。
结果：主成分峰与杂质峰可实现基线分离，杂质A 检测限和定量限分别为1. 62,5.15 ng,杂质B 检测限和定量限分别为0. 85,2. 51 ng ；1.2~24.0 ixg-mL -1的杂质A 具有良好的线性关系(r=0. 999 9) ,0.7-14.0 ixg-mL 1的杂质B 具有良好的线性 关系(r=0. 999 9)；杂质A 平均加样回收率为101.2%(RSD= 1.38%,“ = 9),杂质B 平均加样回收率为100.2%(RSD=1.29%,n = 9)o 经破坏性试验，美罗培南可能的降解杂质A 、B 均不干扰美罗培南主峰的测定。
结论:检测限及定量限、精密度、稳定性、耐用性试验结果均符合HPLC 有关物质测定的方法学验证要求。
本HPLC 法专属性良好，可用于美罗培南的主要杂质A 、B 的定量控制。
关键词美罗培南；有关物质；高效液相色谱法中图分类号R97&1文献标识码 A 文章编号1006(2021)03-167-05Determination of Related Substances of Meropenem for Injection by High Performance Liquid ChromatographyLI Jinge , YU YuhongDepartment of Pharmacy , School of Pharmacy , Shanxi Medical UniversityAbstract Objective : To explore and optimize the determination method of impulity A andB of meropenem for injection. Meth ods :Using the high performance liquid chromatography ( HPLC ) to detection , Octadecylsilane-bonded silica gel was used as the fi ler ； The mobile phase A : 20. 0 mmol * L -1 sodium dihydrogen phosphate-methanol ( 89 ： 11, V/V) . The mobile phase B : methanol ,the flow rate was 1. 0 mL *m in _1 and the detection wavelength was set at 220 nm. The column temperature was set at 30 % . Re sults :The principal component peak and impurity peak could achieve baseline separation. The detection limit and quantitative limit of impurity A were 1. 62 ng and 5. 15 ng respectively , and the detection limit and quantitative lim 让 of impurity B were 0. 85 ng and 2. 51 ng respectively. There was A good linear relationship between impurity A (r = 0. 999 9) and impurity B ( r= 0. 999 9 ) in therange of 1. 2-24. 0 |xg *m L _1 and 0. 7 ~ 14. 0 jig * mL -1. The average recovery of impurity A was 101. 2% ( RSD = 1. 38% , n = 9),and that of impurity B was 100. 2% ( RSD = 1. 29% , n= 9). After stressing test, both of impurities A and B of meropenem didn * tinterfere w 让h the determination of meropenem main peak. Conclusion : The test results of detection lim 让 and quant N ative lim 让，pre cision ,stabil 让y and durability all meet the methodological verification requirements of HPLC related substance determination. The HPLC method has good specificity and can be used for the quant N ative control of major impurities A and B.Key words meropenem ； related substances ； HPLC注射用美罗培南(Meropenem, C ”H25弘0申) 是由日本住友制药公司与英国ICI 制药公司共同 开发的第二代碳青霉烯抗生素，通过干扰细菌细胞壁的合成发挥杀菌作用，具有广谱耐酶的特 点[1_4]o 在美罗培南原料中常检测出杂质A 及杂质B,杂质A(C 17H 27N 3O 6S)为美罗培南四元内酰 胺环结构发生水解反应而形成，系美罗培南的降 解产物；杂质B(C 34H 50N 6O 10S 2)为美罗培南与杂质A 发生聚合反应而形成，系美罗培南的二聚体X 。
超高效液相色谱-串联质谱法测定化妆品中15种N-亚硝胺化合物
第42 卷第 11 期2023 年11 月Vol.42 No.111469~1478分析测试学报FENXI CESHI XUEBAO（Journal of Instrumental Analysis）超高效液相色谱-串联质谱法测定化妆品中15种N-亚硝胺化合物汪毅1，梁文耀1，何国山1，陈张好2，周智明2，吴谦1，席绍峰1，谭建华1*（1．广州质量监督检测研究院，国家化妆品质量检验检测中心（广州），广东广州511447；2．广东省药品检验所，广东广州510663）摘要：采用超高效液相色谱-串联质谱（UPLC-MS/MS）建立了化妆品中15种痕量N-亚硝胺化合物的分析方法。
水剂样品以水或乙腈分组超声提取，膏霜乳液样品采用亚铁氰化钾-乙酸锌溶液沉淀大分子或者饱和氯化钠-乙腈盐析分组处理后，以Agilent Poroshell 120 SB-Aq（100 mm×3.0 mm，2.7 μm）色谱柱分离，经大气压化学电离源（APCI）电离，多反应监测模式检测，以同位素内标法定量。
结果表明，15种N-亚硝胺化合物在相应质量浓度范围内线性关系良好（r2＞0.995），检出限和定量下限分别为5~15 ng/g和15~45 ng/g。
水、乳、膏霜3种化妆品基质在25、50、100 ng/g加标水平下的平均回收率为88.0%~111%，相对标准偏差（RSD，n=6）为1.4%~9.8%。
该方法用于市售化妆品检测，发现13批次样品检出N-亚硝基二乙醇胺（NDELA），其中1批次超限量值。
方法的专属性强，灵敏度高，精密度好，解决了N-亚硝胺化合物稳定性差、易被干扰等问题，适用于化妆品中15种N-亚硝胺化合物的痕量测定。
关键词：N-亚硝胺化合物；化妆品；超高效液相色谱-串联质谱法（UPLC-MS/MS）；大气压化学电离源中图分类号：O657.63；O623.732文献标识码：A 文章编号：1004-4957（2023）11-1469-10 Determination of Fifteen N-nitrosamine Compounds in Cosmetics by Ultra Performance Liquid Chromatography-TandemMass SpectrometryWANG Yi1，LIANG Wen-yao1，HE Guo-shan1，CHEN Zhang-hao2，ZHOU Zhi-ming2，WU Qian1，XI Shao-feng1，TAN Jian-hua1*（1．Guangzhou Quality Supervision and Testing Institute，National Quality Supervision and Testing Center for Cosmetics（Guangzhou），Guangzhou 511447，China；2．Guangdong Institute for Drug Control，Guangzhou 510663）Abstract：An ultra performance liquid chromatography-tandem mass spectrometric（UPLC-MS/MS）method was established for detecting 15 trace N-nitrosamine compounds in cosmetics. The final estab⁃lished method involved ultrasonic extraction of cosmetics using water or acetonitrile for different com⁃pounds. The samples were treated with potassium ferrocyanide-zinc acetate solution for precipitating macromolecules or saturated sodium chloride-acetonitrile for salting out.An Agilent Poroshell 120 SB-Aq（100 mm × 3.0 mm，2.7 μm） chromatography column was used for separation，followed by atmospheric pressure chemical ionization（APCI） source and multiple reaction monitoring mode detec⁃tion in the isotope internal standard method for quantification. The result showed good linearity（r2> 0.995） for the 15 N-nitrosamine compounds in their respective concentration ranges，with detection and quantitation limits of 5-15 ng/g and 15-45 ng/g，respectively.The average recoveries for the three cosmetic matrices（aqueous，emulsion，cream） at spiked levels of 25，50，100 ng/g were be⁃tween 88.0% and 111%，with relative standard deviations（RSD，n=6） of 1.4%-9.8%. The method was applied to the detection of commercial cosmetics and N-nitrosodiethanolamine（NDELA） was de⁃tected in 13 batches，with one batch exceeding the limit. The strong specificity，high sensitivity，and good precision made the method could solve the problems of poor stability and easy interference ofdoi：10.19969/j.fxcsxb.23051602收稿日期：2023－05－16；修回日期：2023－06－10基金项目：广东省药品监督管理局化妆品风险评估重点实验室专项（2021ZDZ03）；广东省市场监督管理局科技项目（2022CZ06）∗通讯作者：谭建华，博士，正高级工程师，研究方向：色谱－质谱检测技术研究，E-mail：tanjianhua0734@第 42 卷分析测试学报N-nitrosamine compounds，and was suitable for the trace determination of 15 N-nitrosamine com⁃pounds in cosmetics.Key words：N-nitrosamine compounds；cosmetics；ultra performance liquid chromatography-tan⁃dem mass spectrometry（UPLC-MS/MS）；atmospheric pressure chemical ionization（APCI） sourceN-亚硝胺化合物是一类具有N-亚硝基结构的化合物，因取代基的不同，形成了种类繁多的同系物，目前已发现超过300种［1］。
2480-26-4 N-甲基-L-丝氨酸_MedBio
≥98%
2、同类产品列表：
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED11100
Fmoc-L-天冬氨酸beta-叔丁酯
Fmoc-Asp(OtBu)-OH
71989-14-5
25g
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED11061
Fmoc-N-甲基-L-天冬氨酸4-叔丁酯
Fmoc-N-Me-Asp(OtBu)-OH
【脉铂医药】
1、产品物理参数：
常用名
N-甲基-L-丝氨酸
英文名
H-N-Me-Ser-OH.HCl
CAS号
2480-26-4
分子量
119.119
密度
1.2±0.1 g/cm3
沸点
326.2±32.0 °C at 760 mmHg
分子式
C4H9NO3
熔点
190℃ (dec.)
闪点
151.1±25.1 °C
100g
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
Moc-L-八氢吲哚-2-甲酸
Fmoc-Oic-OH
130309-37-4
250mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED11130
Fmoc-L-苏氨酸
Fmoc-Thr-OH
73731-37-0
100g
≥98%
品牌
高效液相色谱法测定甲基泼尼松龙琥珀酸钠含量
高效液相色谱法测定甲基泼尼松龙琥珀酸钠含量乔晓芳【摘要】目的建立测定甲基泼尼松龙琥珀酸钠含量的高效液相色谱(HPLC)法.方法色谱柱采用Thermo C18柱(250 mm×4.0 mm,5μm),流动相为乙腈-3%冰醋酸(29:71),检测波长为254 nm,柱温为25℃,流速为1.0 mL/min,进样量为20μL.结果甲基泼尼松龙琥珀酸钠质量浓度在0.08~0.12 g/L范围内与峰面积线性关系良好(r=0.9995);平均回收率为99.16%,RSD为0.09%(n=5).结论该方法准确性高,重复性好,可用于甲基泼尼松龙琥珀酸钠原料药的质量控制.%Objective To establish an HPLC method for the content determination of methylprednisolone sodium succinate. Methods The mobile phase consisted of acetonitrile-3% glacial acetic acid(29 :71). The detection wavelength was 254 nm, the column temperature was 25 ℃ and the flow rate was 1. 0 mL/min. The sample volume was 20 μL. Results The linear relation of the concentration and peak area was good in the range of 0. 08-0. 12 mg/mL( r=0. 9995). The average percentage of recovery was 99. 16%, the RSD was 0. 09%( n=5). Conclusion The method is accurate and reproducible, which can be used for the quality control of methylprednisolone sodium succinate.【期刊名称】《中国药业》【年(卷),期】2017(026)005【总页数】3页(P29-31)【关键词】甲基泼尼松龙琥珀酸钠;高效液相色谱法;含量测定【作者】乔晓芳【作者单位】河南省食品药品审评查验中心,河南郑州 450000【正文语种】中文【中图分类】R927.2甲基泼尼松龙琥珀酸钠是甲基泼尼松龙琥珀酸钠针的原料药，临床上主要用于抗炎[1－2]、免疫抑制、休克[3－5]和内分泌失调的治疗。
317种化学物质IDLH(立即威胁生命和健康浓度)
317种化学物质IDLH(立即威胁生命和健康浓度)附录B：IDLH浓度本附录提供的IDLH浓度采纳自美国国家职业安全卫生研究所（NIOSH）正式出版物DHHS No。
90-117版本的IDLH浓度。
具体浓度请参见表B.1.表B.1 IDLH浓度序号。
污染物中文名称。
污染物英文名称。
浓度（PPM）系数（2（）C）。
IDLH浓度（mg/m3）（20C）1.乙醛。
acetaldehyde。
acetic aldehyde。
10,000.18,0002.乙酸，醋酸。
acetic acid。
1,000.2,5003.乙酸酊，醋酸酊。
acetic anhydride。
1,000.4,2004.丙酮，阿西通。
acetone。
20,000.18,0005.乙腊，甲基割。
acetonitrile。
methyl cyanide。
4,000.6,8006.四溴乙烷。
acetylene tetrabromide。
tetrabromoethane。
6.17.乙烯醛。
acrolein。
allyl aldehyde。
500.2,5008.丙烯睛，乙烯基睛。
acrylonitrile。
vinyl cyanide。
150.4,2009.艾氏剂。
aldrin。
300.18,00010.烯丙醇。
allyl alcohol。
270.6,80011.烯丙卤代烷。
allyl chloride。
500.1,00012.烯丙环氧乙烷。
allyl glycidyl ether。
4,000.4,20013.2-氨基吡啶。
2-aminopyridine。
9,000.5,41014.氨。
ammonia。
100.5,41015.硫酸铵。
ammonium sulfamate。
14.37.3.87016.戊酸乙酯。
n-amyl acetate。
40.1,00017.异戊酸乙酯。
sec-amyl acetate。
95.2,50018.氨基苯。
aminobenzene。
6066-82-6_MedBio_N-Hydroxysuccinimide分子量
95-98 °C(lit.)
闪点
112.5±22.6 °C
2、同类产品列表：
品牌
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MED11052
芴甲氧羰基-L-天冬氨酸-1-叔丁酯
Fmoc-Asp-OtBu
129460-09-9
25g
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
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MED11112
Fmoc-Ser(HPO3Bzl)-OH
158171-14-3
10g
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED11128
Fmoc-丝氨酸磷酸苄酯
Fmoc-Ser(HPO3Bzl)-OH
158171-14-3
50g
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED11097
MED11058
D-2,4-二氨基丁酸二盐酸盐
H-D-Dab-OH.2HCl
127531-11-7
1g
≥98%
6066-82-6_MedBio_N-Hydroxysuccinimide
1、产品物理参数：
常用名
N-羟基琥珀酰亚胺
英文名
N-Hydroxysuccinimide
CAS号
6066-82-6
分子量
115.087
密度
1.6±0.1 g/cm3
沸点
262.4±23.0 °C at 760 mmHg
高效液相色谱法测定注射用盐酸瑞芬太尼有关物质
高效液相色谱法测定注射用盐酸瑞芬太尼有关物质杨争;戎晓娟;曹俊涵;马玉洁;李诗草;杨红【摘要】建立高效液相色谱法测定注射用盐酸瑞芬太尼的有关物质,色谱柱采用Kromasil氰基柱,流动相为0.03 mol/L磷酸二氢钾缓冲液(pH 3.0)-甲醇-乙腈(80∶16∶4),检测波长225 nm.盐酸瑞芬太尼在0.504 6～1 009.2 μg/mL范围内与杂质峰面积显示有良好的线性关系(r=0.999 9),最低检出限为0.001 μg.该法简便、准确,专属性强,可用于注射用盐酸瑞分太尼有关物质测定.【期刊名称】《中国测试》【年(卷),期】2014(040)004【总页数】4页(P56-59)【关键词】盐酸瑞芬太尼;高效液相色谱;测定【作者】杨争;戎晓娟;曹俊涵;马玉洁;李诗草;杨红【作者单位】中国医药集团总公司四川抗菌素工业研究所,四川成都610052;中国医药集团总公司四川抗菌素工业研究所,四川成都610052;成都市食品药品检测中心,四川成都610045;中国医药集团总公司四川抗菌素工业研究所,四川成都610052;中国医药集团总公司四川抗菌素工业研究所,四川成都610052;中国医药集团总公司四川抗菌素工业研究所,四川成都610052【正文语种】中文【中图分类】R971+.2;TQ460.7+2;O657.7+2;TQ463+.3盐酸瑞芬太尼（remifentanil hydrochloride）是一种由酯酶代谢的强效阿片受体激动剂，其作用起效迅速且极快消失，给药剂量小，半衰期短，已逐渐成为镇痛性麻醉药市场上销售份额最大的品种。
目前，盐酸瑞芬太尼及注射用盐酸瑞芬太尼尚未被国内外药典收载，国内国家药品标准有收载[1]，但有关物质的分析方法文献未见报道。
国外文献报道大多是有关药代动力学方面研究测定生物样品中盐酸瑞芬太尼的HPLC方法[2-5]，由于原国家药品标准中注射用盐酸瑞芬太尼有关物质检查方法主峰保留较小，各峰之间分离度差，本文经研究改进建立的HPLC法测定注射用盐酸瑞芬太尼的有关物质，分离度高，准确性好，能很好地用于控制本品质量。
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MSDS
1 Composition
7 Accident Release Measure
Product Name:A-867744
Chemical Name:
PROCEDURE(S) OF PERSONAL PRECAUTION(S)-Wear respirator, chemical safety goggles, rubber boots, and heavy
rubber gloves.METHODS FOR CLEANING UP-Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and
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Benzenesulfonamide, 4-[5-(4-chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]-
CAS No.:1000279-69-5
8 Accident Release Measure
Appearance:White to off-white(solid)Formula:C20H19ClN2O3S 9 Toxicological Information
Solubility:
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
No data available.
p p p p DMSO
2 Handling and Storage
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CLASSIFICATION- Substance not yet fully tested.SAFETY PHASES- 26-36 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.) 36/37/38 (Irritating to eyes,respiratory system and skin.)
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Special indication of hazards to humans and the environment.Irritating to eyes, respiratory system and skin.
MATERIALS TO AVOID- Strong oxidizing agents.REACTIVITY- May emit toxic gasses like Carbon monoxide,Carbon dioxide, Nitrogen oxides upon thermal decomposition.
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