janumet康诺胰说明书

janumet康诺胰说明书

Manufacturer:MSD

Distributor:Hong Kong: DKSH/Macau: Four Star

Contents:Per 50/500 mg tab Sitagliptin 50 mg, metformin HCl 500 mg. Per 50/1000 mg tab Sitagliptin 50 mg, metformin HCl 1,000 mg Indications:Adjunct to diet & exercise to improve glycemic control in adult w/ type 2 DM when treatment w/ both sitagliptin & metformin is appropriate.

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Dosage:Individualised dosage not exceeding max daily dose of 100 mg sitagliptin & 2,000 mg metformin. Generally given bd. Patients inadequately controlled on metformin alone Usual starting dose: Sitagliptin 50 mg bd, plus the dose of metformin already being taken. For patients taking metformin 850 mg bd, the recommended starting dose is 50 mg sitagliptin/1,000 mg metformin HCl bd. Patients inadequately controlled on sitagliptin alone Usual starting dose: 50 mg sitagliptin/500 mg metformin HCl bd. Dose may be titrated up to 50 mg sitagliptin/1,000 mg metformin HCl bd. Switching from

co-administration of sitagliptin & metformin May be initiated at the dose of sitagliptin & metformin already being taken.

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Overdosage:View Janumet overdosage for action to be taken in the event of an overdose.

Administration:Should be taken with food

Contraindications:Renal disease or renal dysfunction (serum creatinine levels ≥1.5 mg/dL for males, ≥1.4 mg/dL for females or abnormal CrCl) which may also result from conditions eg CV collapse (shock), acute MI & septicemia. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, w/ or w/o coma. Temporarily discontinue in radiologic studies involving intravascular administration of iodinated contrast materials. Type 1 diabetes. Lactation.

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Special Precautions:Monitor renal function. Debilitated, malnourished patients & w/ adrenal or pituitary insufficiency or alcohol intoxication in which patients are susceptible to hypoglycaemia. Hypoglycaemia (in combination w/ a sulfonylurea or insulin), lactic acidosis, hypoxic states, surgery, impaired hepatic function, decreased vit B12absorption. Pregnancy. Elderly.

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Adverse Drug Reactions:Diarrhea, nausea, dyspepsia, flatulence, vomiting, abdominal discomfort, indigestion, asthenia, headache, hypoglycaemia, nasopharyngitis, fungal skin infection, peripheral edema. Hypersensitivity reaction. Pancreatitis, worsening of renal function,