帕罗西汀对抑郁症及其IL-1、IL-6、hs-CRP水平的影响

帕罗西汀对抑郁症及其IL-1、IL-6、hs-CRP水平的影响
何晓燕;连俊红
【期刊名称】《河南科技大学学报（医学版）》
【年(卷),期】2017(035)002
【摘要】Objective To explore paroxetine treatment the first-episode depression and its effect of serum IL-1, IL-6 and c-reactive protein (hs-CRP) levels.Methods 50 cases of first-episode depression patients were selected in our hospital as observation group.The IL-1,IL-6 and hs-CRP were detected before and after paroxetine treatment 1 week, 4 weeks, 6 weeks, and the Hamilton depression rating scale (HAMD) scores also was assessment.At the corresponding time period, the IL-1,IL-6 and hs-CRP of 50 cases of health examination were detected as the control group.Results The IL-1,IL-6 and hs-CRP in observation group were higher than that of control group (all P<0.05).After paroxetine treatment the IL-1,IL-6 and hs-CRP were significantly decreased in observation group (all P<0.05), and HAMD scores also was obviously decreased (P<0.05).Conclusion The efficacy of paroxetine in the treatment of first-episode depression might be associated with change of IL-1, IL-6 and hs-CRP.%目的探讨帕罗西汀治疗首发抑郁症及其对白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)水平的影响.方法选择50例我院住院治疗的新发抑郁症患者为观察组,分别在治疗前、治疗后1周、4周、6周后抽血检测 IL-1、IL-6和hs-CRP,并进行汉密尔顿抑郁分级量表(HAMD)评分.选择50例同期健康体检职工的血清作为对照组
测定IL-1、IL-6和hs-CRP.结果观察组IL-1、IL-6和hs-CRP均高于对照组(均P<0.05);观察组的IL-1、IL-6和hs-CRP在帕罗西汀治疗1、4、6周后均明显降低,HAMD评分也降低 (均P<0.05).结论帕罗西汀治疗首发抑郁症的疗效可能与IL-1、IL-6和hs-CRP变化有关.
【总页数】3页(P137-139)
【作者】何晓燕;连俊红
【作者单位】洛阳市精神卫生中心河南洛阳 471013;洛阳市精神卫生中心河南洛阳 471013
【正文语种】中文
【中图分类】R749.05
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