1,3-β-D葡聚糖在侵袭性真菌感染临床诊断中的价值研究

1,3-β-D葡聚糖在侵袭性真菌感染临床诊断中的价值研究梁剑;曾玲
【期刊名称】《国际医药卫生导报》
【年(卷),期】2015(21)18
【摘要】目的探讨血浆1,3-β-D葡聚糖检测在侵袭性真菌感染临床诊断中特异性和敏感性及其价值.方法 2013年10月至2014年10月我院收治的70例侵袭性真菌感染患者作为观察组,选取我院同期收治的70例非侵袭性真菌感染患者作为对照组,比较观察组与对照组血浆1,3-β-D葡聚糖检测结果,并分析血浆1,3-β-D葡聚糖检测的敏感性、特异性和准确度.结果观察组以白色假丝酵母菌(28.57％)、卡氏肺孢子菌为主(24.28％),两组菌种分类比较差异有统计学意义(P＜0.05).观察组组患者血清1,3-β-D葡聚糖浓度显著高于对照组,两组比较差异有统计学意义(P＜
0.05).1,3-β-D葡聚糖在侵袭性真菌感染临床诊断的敏感性为89.83％,特异性为81.81％,准确性为88.57％.结论 1,3-β-D葡聚糖检测在侵袭性真菌感染早期诊断中敏感性和特异性均较好,尤其适用于白色假丝酵母菌和菌烟曲霉菌等引起的侵袭性真菌感染,临床应用价值较高.%Objective To study the diagnostic
value,specificity and sensitivity of 1,3-β-D-glucan in invasive fungal infection.Methods 70 cases of invasive fungal infection in our hospital from October 2013 to October 2014 were selected as observation group,70 cases of noninvasive fungal infection were selected as control
pared the level of 1,3-β-D-glucan of two groups.Analyzed sensitivity,specificity and accuracy of 1,3-β-D-glucan detection.Results The major fungus species were Candida albicans (28.57％),Pneumocystis carinii
(24.28％),there was statistically significant difference in fungus species classification between two groups (P＜0.05).The level of 1,3-βD-glucan in observation group was significantly higher than that in control group,with statistically significant difference (P＜0.05).The sensitivity of 1,3-β-D-glucan in the clinical diagnosis of invasive fungal infection was 89.83％,the specificity was 81.81％ and the accuracy was 88.57％.Conclusion 1,3-β-D-glucan in the early diagnosis of invasive fungal infection has better sensitivity and specificity,especially suitable for invasive fungal infection caused by Candida albicans and aspergillus,with a high clinical value.
【总页数】3页(P2759-2761)
【作者】梁剑;曾玲
【作者单位】410002 长沙,湖南省人民医院检验科;410002 长沙,湖南省人民医院检验科
【正文语种】中文
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