重组人干扰素α-2b口腔喷雾治疗儿童手足口病的观察与护理

重组人干扰素α-2b口腔喷雾治疗儿童手足口病的观察与护理冯丽芳;卢敏君;宁辉;占琼英;林立;郭晓军;贾健;钟永;肖昕
【期刊名称】《国际医药卫生导报》
【年(卷),期】2015(21)17
【摘要】Objective To explore the clinical effect and care characteristics of children with hand foot and mouth disease (HFMD) treated by oral spray of recombinant human interferon α-2b(RHIα-2b).Methods 100 children with HFMD were randomly divided into a control group and a treatment group,50 for each group.Both groups received conventional symptomatic treatment;in addition,the treatment group were treated with oral spray of RHIα-2b,two sprays one time,for five days and the control group with oral spray of saline.The cured rate,time for fever to disappear,and time for hand,foot,and oral herpes to disappear were compared between these two groups.Results The cured rate was significantly higher in the treatment group than in the control group (Wilcoxon W=929.50,P＜0.05).The time for fever to disappear and time for hand,foot,and oral herpes to disappear were shorter in the treatment group than in the control group,with statistical differences (P＜0.01).No adverse reaction occurred in both groups.Conclusion Oral spray of RHIα-2b for children with HFMD is quite effective.Effectively implementing care measures can guarantee effective treatment.%目的探讨应用重组人干扰素α-2b口腔喷雾剂治疗儿童手足口病的临床效果和护理特点.方法将100例符合手足口病诊断的儿童随机分为观察组50例
和对照组50例.两组在常规对症治疗基础上,观察组应用重组人干扰素α-2b喷雾剂口腔喷雾,每次2喷,连续5天,对照组用生理盐水口腔喷雾,每次2喷,连续5天.比较两组儿童的疗效、退热时间和手足、口腔疱疹治愈时间.结果治疗组治愈好转率明显高于对照组(Wilcoxon W=929.50,P＜0.05).观察组退热时间和手足、口腔疱疹消失时间均较对照组缩短,两组比较差异有统计学意义(P＜0.01),未发现不良反应.结论重组人干扰素α-2b口腔喷雾剂治疗儿童手足口病临床疗效显著,有效落实各项护理措施是取得疗效的强有力保障.
【总页数】4页(P2526-2528,2531)
【作者】冯丽芳;卢敏君;宁辉;占琼英;林立;郭晓军;贾健;钟永;肖昕
【作者单位】523721 东莞市塘厦医院儿科;523721 东莞市塘厦医院儿科;523721 东莞市塘厦医院儿科;523721 东莞市塘厦医院儿科;523721 东莞市塘厦医院儿科;523721 东莞市塘厦医院儿科;523721 东莞市塘厦医院儿科;523721 东莞市塘厦医院儿科;510655 广州,中山大学附属第六医院儿科
【正文语种】中文
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