Synthesis of Reo Circuits For Implementation Of Component-Connector Automata Specifications
ADC76中文资料
% of FSR/%VS % of FSR/%VS
µs µs µs Min
ppm/°C ppm of FSR/°C ppm of FSR/°C ppm of FSR/°C
°C °C
TTL Loads
TTL Loads
TTL Loads TTL Loads
kHz
©1990 Burr-Brown Corporation
PDS-1063A
Printed in U.S.A. December, 1993
元器件交易网
SPECIFICATIONS
ELECTRICAL
At +25°C, and rated power supplies, unless otherwise noted.
W VDC VDC mA mA mA
°C °C
*Specification same as ADC76J, K.
NOTES: (1) CMOS/TTL compatible, i.e., Logic “0” = 0.8V, max, Logic “1” = 2.0V, min for inputs. For digital outputs Logic “0” = 0.4V, max, Logic “1’ = 2.4V, min.
}Input Range Select
Comparator In
Clock
Clock Rate Control Clock Out Status Serial Out
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电路与电子技术课件(英文版)-第一章 电路的基本概念
Topics Covered
Week 1
Week 2
Monday Nov. 25, 2019
Tuesday Nov. 26, 2019
Friday Nov. 29, 2019
Monday Dec. 2, 2019
Tuesday Dec. 3, 2019
Friday Dec. 6, 2019
Fundamentals of Electric Circuits: Elements of electric circuits; Kirchhoff’s law; Voltage/Current divider laws; Series and parallel circuits
10
Alessandra Volta (1745 – 1827)
Kirchhoff’s Voltage Law(KVL)
▪ The voltage, or potential difference, btw two points in a circuit indicates the energy required to move charge from one point to the other.
13
Kirchhoff’s Voltage Law(KVL)
▪ The principle underlying KVL is that no energy is lost or created in an electric circuit; in circuit terms, the sum of all voltages associated with source must equal the sum of the load voltages, so that the net voltage around a closed circuit is _________?.
化学化工英语试题及答案
化学化工英语试题及答案一、选择题(每题2分,共20分)1. Which of the following is a chemical element?A. WaterB. OxygenC. HydrogenD. Carbon答案:B, C, D2. The chemical formula for table salt is:A. NaOHB. NaClC. HClD. NaHCO3答案:B3. What is the process called when a substance changes from a solid to a liquid?A. SublimationB. VaporizationC. MeltingD. Condensation答案:C4. In the periodic table, which group contains alkali metals?A. Group 1B. Group 2C. Group 17D. Group 18答案:A5. What is the name of the process where a substance decomposes into two or more substances due to heat?A. CombustionB. OxidationC. ReductionD. Decomposition答案:D6. Which of the following is a physical property of a substance?A. ColorB. TasteC. SolubilityD. Reactivity答案:A7. What is the term for a compound that releases hydrogen ions (H+) when dissolved in water?A. BaseB. AcidC. SaltD. Neutral答案:B8. The law of conservation of mass states that in a chemical reaction:A. Mass is lostB. Mass is gainedC. Mass remains constantD. Mass can be converted into energy答案:C9. Which of the following is a type of chemical bond?A. Ionic bondB. Covalent bondC. Hydrogen bondD. All of the above答案:D10. What is the name of the process where a substance absorbs energy and changes from a liquid to a gas?A. MeltingB. VaporizationC. SublimationD. Condensation答案:B二、填空题(每题2分,共20分)1. The symbol for the element iron is ________.答案:Fe2. The pH scale ranges from ________ to ________.答案:0 to 143. A compound that produces a basic solution when dissolvedin water is called a ________.答案:base4. The smallest particle of an element that retains its chemical properties is called a ________.答案:atom5. The process of separating a mixture into its individual components is known as ________.答案:separation6. The study of the composition, structure, and properties of matter is called ________.答案:chemistry7. The process of a substance changing from a gas to a liquid is called ________.答案:condensation8. A(n) ________ reaction is a type of chemical reactionwhere two or more substances combine to form a single product. 答案:synthesis9. The volume of a gas at constant temperature and pressureis directly proportional to the number of ________.答案:moles10. The process of converting a solid directly into a gas without passing through the liquid phase is known as ________. 答案:sublimation三、简答题(每题10分,共30分)1. Explain what is meant by the term "stoichiometry" in chemistry.答案:Stoichiometry is the calculation of the relative quantities of reactants and products in a chemical reaction.It is based on the law of conservation of mass and involvesthe use of balanced chemical equations and the molar massesof substances to determine the amounts of reactants needed to produce a certain amount of product or the amounts ofproducts formed from a given amount of reactant.2. Describe the difference between a physical change and a chemical change.答案:A physical change is a change in the state or form of a substance without altering its chemical composition. Examples include melting, freezing, and boiling. A chemical change, on the other hand, involves a change in the chemical composition of a substance, resulting in the formation of new substances. Examples include combustion and rusting.3. What are the three main types of chemical bonds, and givean example of each.答案:The three main types of chemical bonds are ionic bonds, covalent bonds, and metallic bonds. An ionic bond is formed when electrons are transferred from one atom to another, resulting in the formation of oppositely charged ions. An example is the bond between sodium (Na) and chloride (Cl) in table salt (NaCl). A covalent bond is formed when two atoms share electrons, as seen in water (H2O) where hydrogen atoms share electrons with oxygen. Metallic bonds occur in metals, where a "sea" of delocalized electrons is shared among positively charged metal ions, as in sodium metal。
Integrated-circuit
Integrated circuitIn electronics,an integrated circuit (also known as IC, microcircuit, microchip, silicon chip, or chip)is a miniaturized electronic circuit (consisting mainly of semiconductor devices, as well as passive components) that has been manufactured in the surface of a thin substrate of semiconductor material。
Integrated circuits are used in almost all electronic equipment in use today and have revolutionized the world of electronics.Integrated circuits were made possible by experimental discoveries which showed that semiconductor devices could perform the functions of vacuum tubes,and by mid—20th—century technology advancements in semiconductor device fabrication。
The integration of large numbers of tiny transistors into a small chip was an enormous improvement over the manual assembly of circuits using electronic components. The integrated circuit's mass production capability,reliability, and building—block approach to circuit design ensured the rapid adoption of standardized ICs in place of designs using discrete transistors。
NORMA 4000 5000 Power Analyzer 用户说明手册说明书
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BEGRENZTE GEWÄHRLEISTUNG UND HAFTUNGSBESCHRÄNKUNG
Fluke gewährleistet, daß jedes Fluke-Produkt unter normalem Gebrauch und Service frei von Material- und Fertigungsdefekten ist. Die Garantiedauer beträgt 2 Jahre ab Versanddatum. Die Garantiedauer für Teile, Produktreparaturen und Service beträgt 90 Tage. Diese Garantie wird ausschließlich dem Erster
电气工程专业英语试卷及参考答案
《电气工程专业英语》试卷一、根据英文单词,写出中文意义(20X0.5=10,共10分)alternator 交流发电机automation 自动控制,自动操作bandwidth 带宽,频带宽度built-in 内置的,固定的,嵌入的capacitance 容量,电容charge 负荷,电荷,费用,充电coil 线圈converter 转换器,变换器diode 二极管impedance 阻抗,全电阻insulator 绝缘体semiconductor 半导体sensor 传感器suppression 抑制switch 开关,电闸threshold 临界值vacuum 真空,空间vector 向量,矢量waveform 波形ammeter 电表二、根据中文意义,写出英文单词(20X0.5=10,共10分)n.近似值,接近,走近Approximationn.能力,性能,容量Capabilityv.补偿,偿还Compensaten.损耗Depletionadj.微分的Differentialn.打扰,干扰Disturbancen.以太网Ethernetn.频率, 周率Frequencyadj.不相容的, 矛盾的n.隔绝, 绝缘adj.瞬间的, 刹那间的Momentaryn.极性Polarityn.转发器,中继器Repeatern.排斥Repusionn.阻力,电阻,阻抗Resistancevt.模拟,模仿Simulaten.晶体管Transistorn.传感器,发送器,传递器n.阀n.波长三、根据英文词组,写出中文意义(30X0.5=15,共15分)between…and在……之间on the other hand 另一方面take advantage of 利用negative charge 负电荷electric field 电场free electron 自由电子current flow 电流sine wave 正弦波Root-Mean-Square 均方根(值)series circuit 串联电路voltage drop 电压降parallel circuit 并联电路compound circuit s复合电路parallel branch 并联分支decimal system 十进制系统programmable controller 可编程控制器truth table 真值表carbon brus 碳刷permanent magnet 永久磁铁armature field 电枢场magnetic lines 磁力线proportional system 比例系统 sampling period 采样周期 analog signal 模拟信号 baud rate 波特 discrete input 开关量输入 limit switch 限位开关 proximity switch 接近开关 industrial bus 工业总线 voltage difference电压差四、根据英文缩写,写出英文完整形式及中文意思(10X2=20,共20分)PLC PPI CNC EIA RF FCCCMOS VLSI CEMF五、根据下列方框中所给的词填空(5X1=5,共5分)Resistance in a material arises from the collision of electrons with the atoms and with each other as they move. The ___ 1、 collisions ___ produce heat, increasing the temperature of the material. Consider the ordinary toaster. Current flows through the ___2、wires ___ of the power cord and through the toaster's filament (the glowing wire you see inside). The same current must flow in the power cord as flows through the filament. The cord has very little ___ 3、resistance ___, while the filament has considerably more. Since the filament has a much higher resistance than the cord, it ___ 4、produces ___ much more heat. That's as it should be. Y ou want the heat for your toast, but you do not want the power cord getting ___ 5、hot ___! The standard incandescent light bulb is another example. The filament inthe light bulb glows white hot (hence, the word "incandescent") to produce light and a lot of heat as well. But, the low-resistance power cord stays cool.六、根据下列短文回答问题,回答请使用英文。
高分子论文参考文献
Published:May 12,2011COMMUNICATION /JACSInterface-Directed Assembly of One-Dimensional Ordered Architecture from Quantum Dots Guest and Polymer HostShengyang Yang,Cai-Feng Wang,and Su Chen*State Key Laboratory of Materials-Oriented Chemical Engineering,and College of Chemistry and Chemical Engineering,Nanjing University of Technology,Nanjing 210009,P.R.ChinabSupporting Information ABSTRACT:Assembly of inorganic semiconductor nano-crystals into polymer host is of great scienti fic and techno-logical interest for bottom-up fabrication of functional devices.Herein,an interface-directed synthetic pathway to polymer-encapsulated CdTe quantum dots (QDs)has been developed.The resulting nanohybrids have a highly uniform fibrous architecture with tunable diameters (ranging from several tens of nanometers to microscale)and enhanced optical performance.This interfacial assembly strategy o ffers a versatile route to incorporate QDs into a polymer host,forming uniform one-dimensional nanomaterials po-tentially useful in optoelectronic applications.Similar to the way that atoms bond to form molecules and complexes,inorganic nanoparticles (NPs)can be combined to form larger ensembles with multidimensional ordered hier-archical architecture,evoking new collective functions.To this end,the development of the controlled self-assembly method for well-de fined structures of these ensembles is signi ficant for creating new and high-performance tunable materials and hence has aroused appealing scienti fic and industrial interest.1Particu-larly,much e ffort has been devoted to the construction of one-dimensional (1D)structures of NPs,owing in part to their application as pivotal building blocks in fabricating a new generation of optoelectronic devices.2In this context,directed host Àguest assembly of NPs into polymer matrices is an e ffective “bottom-up ”route to form 1D ordered functional materials with advantageous optical,electrical,magnetic,and mechanical properties.3Some typical routes have been developed for the generation of these 1D hybrids so far,involving template-assisted,4seeding,5and electro-static approaches.6However,the challenge still remains to precisely manipulate assembly of aqueous NPs and water-insoluble polymers into uniform 1D nanocomposites with a high aspect ratio because of phase separation and aggregation.7Moreover,facile synthetic strate-gies are highly needed to fabricate homogeneous 1D composites in which each component still preserves favorable properties to produce optimal and ideal multifunctional materials.A liquid Àliquid interface o ffers an ideal platform to e fficiently organize NPs into ordered nanostructures driven by a minimiza-tion of interfacial energy.8While much of this research has been directed toward NP hybrids with diverse morphologies based on small organic ligand-directed assembly,9some success has also been achieved in polymer-based NPs nanocomposites.10Russelland co-workers developed ultrathin membranes and capsules of quantum dots (QDs)stabilized by cross-linked polymers at the toluene/water interface.10a,11Brinker ’s group reported the fab-rication of free-standing,patternable NP/polymer monolayer arrays via interfacial NP assembly in a polymeric photoresist.12Herein,a simple host Àguest assembly route is developed to facilely create homogeneous 1D CdTe/polymer hybrids without any indication of phase separation at the aqueous/organic inter-face for the first time.The CdTe nanocrystal is a semiconductor that has been used extensively for making thin film for solar cells.13Some elegant studies have been made in synthesizing pure inorganic 1D CdTe nanowires via assembly from corre-sponding individual CdTe nanocrystals.14In this work,CdTe QDs are covalently grafted with poly(N -vinylcarbazole-co -glycidylmethacrylate)(PVK-co -PGMA)to form uniform fibrous fluorescent composites at the water/chloroform interface via the reaction between epoxy groups of PVK-co -PGMA and carboxyl groups on the surface of CdTe QDs (Scheme 1).15These 1D composite fibers can be allowed to grow further in the radial direction by “side-to-side ”assembly.Additionally,this type of interfacial QD Àpolymer assembly can observably improve the fluorescence lifetime of semiconductor QDs incorporated in theScheme 1.Schematic Representation of the Synthesis of PVK-co -PGMA/CdTe QDs Composite Nano fibersReceived:February 8,2011polymeric matrix.It can be expected that this example of both linear axial organization and radial assembly methodology can be applied to fabricate spatial multiscale organic Àinorganic com-posites with desired properties of NPs and polymers.Figure 1a shows a typical scanning electron microscope (SEM)image of PVK-co -PGMA/CdTe QDs composite nano fi-bers obtained at the water/chloroform interface after dialysis.The as-prepared fibers have uniform diameters of about 250nm and typical lengths in the range of several tens to several hundreds of micrometers (Figures 1a and S4Supporting In-formation [SI]).Interestingly,PVK-co -PGMA/CdTe composite fibers can randomly assemble into nestlike ring-shaped patterns (Figures 1b and S5[SI]).Given the interaction among epoxy groups,the formation of nestlike microstructures could be attributed to incidental “head-to-tail ”assembly of composite fibers.Moreover,in order to establish the relationship between the role of epoxy groups and the formation of composite nano fibers,control experiments were performed,in which pure PGMA or PVK was used to couple CdTe QDs.The PGMA/CdTe composites could be obtained with fibrous patterns (Figure S6[SI]),but no fibrous composites were achieved at the biphase interface with the use of PVK under the same conditions.The microstructures and fluorescence properties of PVK-co -PGMA/CdTe composite fibers were further character-ized using laser confocal fluorescence microscopy (LCFM).Confocal fluorescence micrographs of composite fibers show that the di fferently sized QDs have no obvious in fluence on the morphology of composites (Figure 1c Àe).Clearly,uniform and strong fluorescence emission is seen throughout all the samples,and the size-dependent fluorescence trait of CdTe QDs in PVK-co -PGMA matrix remains well.In order to verify the existence and distribution of CdTe QDs in the fibers,transmission electron microscopy (TEM)was employed to examine the assembled structures.Figure 2a shows a TEM image of PVK-co -PGMA/CdTe QDs composite nano fi-bers,indicating each composite fiber shown in Figure 1a was assembled from tens of fine nano fibers.An individual fine nano fiber with the diameter of about 30nm is displayed in Figure 2b,from which we can see that CdTe QDs have been well anchored into the fiber with polymeric protection layer,revealing this graft-form process at the interface e ffectively avoidednon-uniform aggregation in view of well-dispersed CdTe QDs within the composite fiber,consistent with the LCFM observa-tion.Unlike previous works where the nanoparticles were ad-sorbed onto the polymer fibers,16CdTe QDs were expelled from the surface of fibers (∼2.5nm)in our system (Figure 2c),albeit the high percentage of QDs in the polymer host (23wt %)was achieved (Figure S7[SI]).This peculiarity undoubtedly confers CdTe QDs with improved stability.The clear di ffuse rings in the selected area electron di ffraction (SAED)pattern further indicate excellent monodispersion and finely preserved crystalline struc-ture of QDs in the nano fibers (Figure 2d).The SAED data correspond to the cubic zinc blende structure of CdTe QDs.A possible mechanism for the assembly of 1D nanostructure was proposed,as illustrated in Figure S8[SI].The hydrophilic epoxy groups of the PVK-co -PGMA chain in the oil phase orient toward the biphase interface and then react with carboxyl groups on the surface of CdTe QDs in the aqueous phase to a fford premier PVK-co -PGMA/CdTe QDs composites.Such nanocomposites will reverse repeatedly,resulting from iterative reaccumulation of epoxy groups at the interface and the reaction between the active pieces (i.e.,epoxy or carboxyl groups)in the composites with intact CdTe QDs or PVK-co -PGMA,forming well-de fined nano-fibers.The control experiments showing that the diameter of composite fibers increases with the increase in the concentration of PVK-co -PGMA are in agreement with the proposed mechan-ism (Figure S9[SI]).In addition,it is expected that the pure polymeric layer on the surface of the fibers (red rectangular zone in Figure 2c)will allow further assembly of fine fibers into thick fibers,and these fibers also could randomly evolve into rings,forming nestlike microstructures when the “head ”and “tail ”of fibers accidentally meet (Figure 1b).To further examine the assembly behavior of composite fibers,the sample of PVK-co -PGMA/CdTe QDs composite nano fibers were kept at the water/chloroform interface for an additional month in a close spawn bottle at room temperature (Figure S10[SI]).With longer time for assembly,thicker composite fibers with tens of micrometers in diameter were obtained (Figure 3a).These micro-fibers have a propensityto form twisted morphology (Figure 3a,b),Figure 1.(a,b)SEM images of PVK-co -PGMA/CdTe QDs composite nano fibers.(c Àe)Fluorescence confocal microscopy images of PVK-co -PGMA/CdTe QDs composite nano fibers in the presence of di fferently sized QDs:(c)2.5nm,(d)3.3nm,and (e)3.6nm.The excitation wavelengths are 488(c),514(d),and 543nm (e),respectively.Figure 2.(a,b)TEM images of PVK-co -PGMA/CdTe QDs composite nano fibers,revealing composite nano fiber assemblies.(c)HRTEM image and (d)SAED pattern of corresponding PVK-co -PGMA/CdTe QDs composite nano fibers.while their re fined nanostructures still reveal relatively parallel character and con firm the micro fibers are assembled from countless corresponding nano fibers (Figure 3c).The corresponding LCFM image of an individual micro fiber is shown in Figure 3d (λex =488nm),indicating strong and homogeneous green fluorescence.Another indication is the fluorescent performance of PVK-co -PGMA/CdTe QDs composite micro fibers (Figure 4a).The fluorescent spectrum of composite fibers takes on emission of both PVK-co -PGMA and CdTe QDs,which suggests that this interfacial assembly route is e ffective in integrating the properties of organic polymer and inorganic nanoparticles.It is worth noting that there is a blue-shift (from 550to 525nm)and broadening of the emission peak for CdTe QDs upon their incorporation into polymeric hosts,which might be ascribed to the smaller QD size and less homogeneous QD size distribution resulting from the photooxidation of QD surfaces.17Since the emission spectra of PVK-co -PGMA spectrally overlap with the CdTe QD absorption (Figure S11[SI]),energy transfer from the copolymer to the CdTe QDs should exist.18However,the photoluminescence of PVK-co -PGMA does not vanish greatly in the tested sample in comparison with that of polymer alone,revealing inferior energy transfer between the polymer host and the QDs.Although e fficient energy transfer could lead to hybrid materials that bring together the properties of all ingredients,18it is a great hurdle to combine and keep the intrinsic features of all constituents.19In addition,by changing the polymeric compo-nent and tailoring the element and size of QDs,it should be possible to expect the integration of organic and inorganic materials with optimum coupling in this route for optoelectronic applications.Finally,to assess the stability of CdTe QDs in the composite micro fibers,time-resolved photoluminescence was performed using time-correlated single-photon counting (TCSPC)parative TCSPC studies for hybrid PVK-co -PGMA/CdTe QDs fibers and isolated CdTe QDs in the solid state are presented in Figure 4b.We can see that the presence of PVK-co -PGMA remarkably prolongs the fluorescence lifetime (τ)of CdTe QDs.Decay traces for the samples were well fittedwith biexponential function Y (t )based on nonlinear least-squares,using the following expression.20Y ðt Þ¼R 1exp ðÀt =τ1ÞþR 2exp ðÀt =τ2Þð1Þwhere R 1,R 2are fractional contributions of time-resolved decaylifetimes τ1,τ2and the average lifetime τhcould be concluded from the eq 2:τ¼R 1τ21þR 2τ22R 1τ1þR 2τ2ð2ÞFor PVK-co -PGMA/CdTe QDs system,τh is 10.03ns,which is approximately 2.7times that of isolated CdTe QDs (3.73ns).Photooxidation of CdTe QDs during the assembly process can increase the surface states of QDs,causing a delayed emission upon the carrier recombination.21Also,the polymer host in this system could prevent the aggregation of QDs,avoid self-quench-ing,and delay the fluorescence decay process.22The increased fluorescence lifetime could be also ascribed to energy transfer from PVK-co -PGMA to CdTe QDs.18c The result suggests that this host Àguest assembly at the interface could find signi ficant use in the fabrication of QDs/polymer hybrid optoelectronic devices.In summary,we have described the first example of liquid/liquid interfacial assembly of 1D ordered architecture with the incorporation of the QDs guest into the polymer host.The resulting nanohybrids show a highly uniform fibrous architecture with tunable diameter ranging from nanoscale to microscale.The procedure not only realizes the coexistence of favorable properties of both components but also enables the fluorescence lifetime of QDs to be enhanced.This interesting development might find potential application for optoelectronic and sensor devices due to high uniformity of the 1D structure.Further e fforts paid on optimal regulation of QDs and polymer composition into 1D hybrid nanostructure could hold promise for the integration of desirable properties of organic and inorganic compositions for versatile dimension-dependent applications.In addition,this facile approach can be easily applied to various semiconductor QDs and even metal NPs to develop highly functional 1D nanocomposites.’ASSOCIATED CONTENTbSupporting Information.Experimental details,FT-IR,GPC,UV Àvis,PL,SEM,TGA analysis,and complete ref 9c.This material is available free ofcharge via the Internet at .Figure 3.(a,b)SEM and (c)FESEM images of PVK-co -PGMA/CdTe QDs composite micro fibers.(d)Fluorescence confocal microscopy images of PVK-co -PGMA/CdTe QDs composite micro fibers inthe presence of green-emitting QDs (2.5nm).Figure 4.(a)Fluorescence spectra of PVK-co -PGMA,CdTe QD aqueous solution,and PVK-co -PGMA/CdTe QDs composite micro-fibers.(b)Time-resolved fluorescence decay curves of CdTe QDs (2.5nm diameter)powders (black curve)and the corresponding PVK-co -PGMA/CdTe QDs composite micro fibers (green curve)mea-sured at an emission peak maxima of 550nm.The samples were excited at 410nm.Biexponential decay function was used for satisfactory fitting in two cases (χ2<1.1).’AUTHOR INFORMATIONCorresponding Authorchensu@’ACKNOWLEDGMENTThis work was supported by the National Natural Science Foundation of China(21076103and21006046),National Natural Science Foundation of China-NSAF(10976012),the Natural Science Foundations for Jiangsu Higher Education Institutions of China(07KJA53009,09KJB530005and10KJB5 30006),and the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).’REFERENCES(1)(a)Kashiwagi,T.;Du,F.;Douglas,J.F.;Winey,K.I.;Harris, R.H.;Shields,J.R.Nat.Mater.2005,4,928.(b)Shenhar,R.;Norsten, T.B.;Rotello,V.M.Adv.Mater.2005,17,657.(c)Akcora,P.;Liu,H.; Kumar,S.K.;Moll,J.;Li,Y.;Benicewicz,B.C.;Schadler,L.S.;Acehan, D.;Panagiotopoulos,A.Z.;Pryamitsyn,V.;Ganesan,V.;Ilavsky,J.; Thiyagarajan,P.;Colby,R.H.;Douglas,J.F.Nat.Mater.2009,8,354.(d)Dayal,S.;Kopidakis,N.;Olson,D.C.;Ginley,D.S.;Rumbles,G. 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英语作文-集成电路设计师需要了解的基础知识与技术要点
英语作文-集成电路设计师需要了解的基础知识与技术要点Integrated circuit (IC) design is a sophisticated field that requires a deep understanding of both foundational knowledge and technical nuances. At the heart of modern electronics, IC designers are the architects of the microscopic systems that power everything from smartphones to satellites. The journey to becoming a proficient IC designer is paved with the mastery of several critical areas.Fundamental Knowledge。
The bedrock of IC design lies in a solid grasp of electronic engineering principles. Designers must be well-versed in digital logic design, which includes understanding logic gates, flip-flops, multiplexers, and the ability to create state machines. Analog design principles are equally important, as they involve dealing with operational amplifiers, transistors, resistors, capacitors, and inductors. Knowledge of semiconductor physics is crucial, as it provides insight into how electronic components conduct and control the flow of electricity on a microscopic level.Design and Simulation Tools。
Diastereoselecti...
Diastereoselecti...Diastereoselective Synthesis of Chiral Pyrrolidine and Piperidine Ring SystemsSHAO,Zhi-Hui(邵志会);PENG,Fang-Zhi(彭芳芝);ZHU,Bao-Kun(朱保昆);TU,Yong-Qiang(涂永强);ZHANG,Hong-Bin(张洪彬) 【期刊名称】《中国化学(英文版)》【年(卷),期】2004(022)007【摘要】A diastereoselective method for the synthesis of chiral pyrrolidine and piperidine ring containing compounds was described. The protocol of bromination followed by aminocyclization furnishes an easily handled while highly efficient procedure for the intramolecular amidation of an isolated double bond. High diastereomeric excess was observed in this synthetic procedure.【总页数】5页(727-731)【关键词】diastereoselective;pyrrolidine;piperidine;aminocyclization 【作者】SHAO,Zhi-Hui(邵志会);PENG,Fang-Zhi(彭芳芝);ZHU,Bao-Kun(朱保昆);TU,Yong-Qiang(涂永强);ZHANG,Hong-Bin(张洪彬)【作者单位】State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China;School of Pharmacy, Yunnan University, Kunming, Yunnan 650091, China;School of Pharmacy, Yunnan University, Kunming, Yunnan 650091, China;School of Pharmacy, Yunnan University, Kunming, Yunnan 650091, China;State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou,。
微波辅助合成英语
微波辅助合成英语Microwave-Assisted SynthesisMicrowave-assisted synthesis, a revolutionary technique in the field of organic chemistry, has gained widespread recognition for its efficiency, versatility, and environmentally friendly nature. This powerful methodology has revolutionized the way chemists approach the synthesis of various organic compounds, offering significant advantages over traditional heating methods.At the core of microwave-assisted synthesis is the utilization of electromagnetic radiation in the microwave region of the electromagnetic spectrum. This radiation interacts directly with the reaction mixture, causing the molecules to vibrate and generate heat through molecular friction and dipole rotation. This targeted heating approach leads to a rapid and uniform rise in temperature, dramatically accelerating the reaction kinetics and often resulting in higher yields and increased selectivity compared to conventional heating methods.One of the primary benefits of microwave-assisted synthesis is the significant reduction in reaction times. Whereas traditional heatingmethods can take hours or even days to complete a reaction, microwave irradiation can often complete the same process in a matter of minutes or even seconds. This time-saving advantage is particularly valuable in the pharmaceutical and fine chemical industries, where rapid optimization and scale-up are crucial for efficient and cost-effective production.Another compelling aspect of microwave-assisted synthesis is its ability to promote the formation of novel and complex molecular structures. The intense and localized heating generated by microwaves can drive the formation of products that may be difficult to obtain through conventional heating methods. This unique property has been exploited in the synthesis of a wide range of organic compounds, including heterocyclic molecules, natural products, and pharmaceutically relevant compounds.Importantly, microwave-assisted synthesis also offers environmental benefits. By reducing reaction times and energy consumption, this technique contributes to a more sustainable and eco-friendly approach to chemical synthesis. Additionally, the precise control over reaction conditions and the ability to use smaller reaction volumes can lead to a significant reduction in waste production, further enhancing the green credentials of this method.The versatility of microwave-assisted synthesis is another keyadvantage. It can be applied to a diverse range of organic transformations, including esterifications, oxidations, reductions, cycloadditions, and cross-coupling reactions, among others. This versatility has led to its widespread adoption in both academic and industrial settings, where it has become an indispensable tool in the arsenal of modern organic chemists.Furthermore, the development of specialized microwave reactors and instrumentation has further expanded the capabilities of this technique. These advanced systems allow for the precise control of temperature, pressure, and irradiation power, enabling researchers to fine-tune reaction conditions and optimize the synthesis of target compounds.In the field of medicinal chemistry, microwave-assisted synthesis has played a crucial role in the rapid development and optimization of drug candidates. The ability to quickly screen and synthesize large numbers of compounds has accelerated the drug discovery process, leading to the identification of promising lead compounds and the efficient exploration of structure-activity relationships.Beyond organic synthesis, microwave-assisted techniques have also found applications in a variety of other scientific disciplines, such as materials science, analytical chemistry, and even biology. The versatility and efficiency of this approach have made it an invaluabletool for researchers working in diverse fields.In conclusion, microwave-assisted synthesis has emerged as a game-changing technique in the world of organic chemistry. Its ability to dramatically reduce reaction times, promote the formation of novel structures, and contribute to more sustainable and environmentally friendly practices has cemented its place as an indispensable tool in the modern chemical laboratory. As research and development in this field continue to progress, the impact of microwave-assisted synthesis is poised to grow even further, revolutionizing the way we approach the synthesis of complex organic compounds.。
各种专业课程英文名称翻译
课程的英文词汇(一)生物物理学Biophysics真空冷冻干燥技术Vacuum Freezing & Drying Technology16位微机16 Digit Microcom puterALGOL语言ALGOL LanguageBASIC 语言BASIC LanguageBASIC 语言及应用BASIC Language & ApplicationC 语言C LanguageCAD 概论Introduction to CADCAD/CAM CAD/CAMCOBOL语言COBOL LanguageCOBOL语言程序设计COBOL Language Program DesigningC与UNIX环境C Language & Unix EnvironmentC语言与生物医学信息处理C Language & Biomedical Information Processing dBASE Ⅲ课程设计C ourse Exercise in dBASE ⅢFORT RAN语言FORT RAN LanguageIBM-PC/XT Fundam entals of Microcomputer IBM-PC/XTIBM-PC微机原理Fundamentals of Microcom puter IBM-PCLSI设计基础Basic of LSI DesigningPASCAL大型作业PASCAL Wide Range WorkingPASCAL课程设计Course Exercise in PASCALX射线与电镜X-ray & Electric MicroscopeZ-80汇编语言程序设计Z-80 Pragramming in Assembly Languages板壳理论Plate Theory板壳力学Plate Mechanics半波实验Semiwave Experiment半导体变流技术Semiconductor Converting Technology半导体材料Semiconductor Materials半导体测量Measurement of Semiconductors半导体瓷敏元件Semiconductor Porcelain-Sensitive Elements半导体光电子学Semiconductor Optic Electronics半导体化学Semiconductor Chemistry半导体激光器Semiconductor Laser Unit半导体集成电路Semiconductor Integrated Circuitry半导体理论Semiconductive Theory半导体器件Semiconductor Devices半导体器件工艺原理Technological Fundamentals of Semiconductor Device 半导体物理Semiconductor Physics半导体专业Semiconduction Specialty半导体专业实验Specialty Experiment of Semiconductor薄膜光学Film Optics报告文学专题Special Subject On Reportage报刊编辑学Newspaper & Magazine Editing报纸编辑学Newspaper Editing泵与风机Pumps and Fans泵与水机Pumps & Water Turbines毕业设计Graduation Thesis编译方法Methods of Compiling编译技术Technique of Compiling编译原理Fundamentals of Compiling变电站的微机检测与控制Computer Testing & Control in Transformer Substatio n变分法与张量Calculus of Variations & Tensor变分学Calculus of Variations变质量系统热力学与新型回转压Variable Quality System Thermal Mechanics & N eo-Ro表面活性物质Surface Reactive Materials并行算法Parallel Algorithmic波谱学Wave Spectrum材料的力学性能测试Measurement of Material Mechanical Performance材料力学Mechanics of Materials财务成本管理Financial Cost Management财政学Public Finance财政与金融Finance & Banking财政与信贷Finance & Credit操作系统Disk Operating System操作系统课程设计Course Design in Disk Operating System操作系统原理Fundamentals of Disk Operating System策波测量技术Technique of Whip Wave Measurem ent测量原理与仪器设计Measurement Fundamentals & Meter Design测试技术Testing Technology测试与信号变换处理Testing & Signal Transformation Processing产业经济学Industrial Econom y产业组织学Industrial Organization Technoooligy场论Field Theory常微分方程Ordinary Differentical Equations超导磁体及应用Superconductive Magnet & Application超导及应用Superconductive & Application超精微细加工Super-Precision & Minuteness Processing城市规划原理Fundamentals of City Planning城市社会学Urban Sociology成组技术Grouping Technique齿轮啮合原理Principles of Gear Connection冲击测量及误差Punching Measurement & Error冲压工艺Sheet Metal form ing Technology抽象代数Abstract Algebra传动概论Introduction to Transmission传感器与检测技术Sensors & Testing Technology传感器原理Fundamentals of Sensors传感器原理及应用Fundamentals of Sensors & Application传热学Heat Transfer传坳概论Introduction to Pass Col船舶操纵Ship Controling船舶电力系统Ship Electrical Power System船舶电力系统课程设计Course Exercise in Ship Electrical Power System船舶电气传动自动化Ship Electrified Transmission Autom ation船舶电站Ship Power Station船舶动力装置Ship Power Equipment船舶概论Introduction to Ships船舶焊接与材料Welding & Materials on Ship船舶机械控制技术Mechanic Control Technology for Ships船舶机械拖动Ship Mechamic Towage船舶建筑美学Artistic Designing of Ships船舶结构力学Structual Mecham ics for Ships船舶结构与制图Ship Structure & Graphing船舶静力学Ship Statics船舶强度与结构设计Designing Ship Intensity & Structure船舶设计原理Principles of Ship Designing船舶推进Ship Propeling船舶摇摆Ship Swaying船舶阻力Ship Resistance船体建造工艺Ship-Building Technology船体结构Ship Structure船体结构图Ship Structure Graphing船体振动学Ship Vibration创造心理学Creativity Psychology磁测量技术Magnetic Measurement Technology磁传感器Magnetic Sensor磁存储设备设计原理Fundamental Design of Magnetic Mem ory Equipm ent 磁记录技术Magnetographic Technology磁记录物理Magnetographic Physics磁路设计与场计算Magnetic Path Designing & Magnetic Field Calculati磁盘控制器Magnetic Disk Controler磁性材料Magnetic Materials磁性测量Magnetic Measurement磁性物理Magnetophysics磁原理及应用Principles of Catalyzation & Application大电流测量Super-Current Measurement大电源测量Super-Power Measurem ent大机组协调控制Coordination & Control of Generator Networks大跨度房屋结构Large-Span House structure大型锅炉概况Introduction to Large-Volum e Boilers大型火电机组控制Control of Large Therm al Power Generator Networks大学德语College German大学俄语College Russian大学法语College French大学日语College Japanese大学英语College English大学语文College Chinese大众传播学Mass Media代用运放电路Simulated Transmittal Circuit单片机原理Fundamentals of Mono-Chip Computers单片机原理及应用Fundamentals of Mono-Chip Computers & Applications 弹性力学Theory of Elastic Mechanics当代国际关系Contem porary International Relationship当代国外社会思维评价Evaluation of Contem porary Foreign Social Thought 当代文学Contem porary Literature当代文学专题Topics on Contem porary Literature当代西方哲学Contem porary Western Philosophy当代戏剧与电影Contem porary Drama & Films党史History of the Party导波光学Wave Guiding Optics等离子体工程Plasma Engineering低频电子线路Low Frequency Electric Circuit低温传热学Cryo Conduction低温固体物理Cryo Solid Physics低温技术原理与装置Fundamentals of Cryo Technology & Equipment低温技术中的微机原理Priciples of Microcom puter in Cryo Technology低温绝热Cryo Heat Insulation低温气体制冷机Cryo Gas Refrigerator低温热管Cryo Heat Tube低温设备Cryo Equipment低温生物冻干技术Biological Cryo Freezing Drying Technology低温实验技术Cryo Experimentation Technology低温物理导论Cryo Physic Concepts低温物理概论Cryo Physic Concepts低温物理概念Cryo Physic Concepts低温仪表及测试Cryo Meters & Measurement低温原理Cryo Fundamentals低温中的微机应用Application of Microcom puter in Cryo Technology低温装置Cryo Equipment低噪声电子电路Low-Noise Electric Circuit低噪声电子设计Low-Noise Electronic Designing低噪声放大与弱检Low-Noise Increasing & Decreasing低噪声与弱信号检测Detection of Low Noise & Weak Signals地理Geography第二次世界大战史History of World War II电测量技术Electric Measurement Technology电厂计算机控制系统Computer Control System in Power Plants电磁测量实验技术Electrom agnetic Measurement Experiment & Technology电磁场计算机Electrom agnetic Field Computers电磁场理论Theory of Electrom agnetic Fields电磁场数值计算Numerical Calculation of Electrom agnetic Fields电磁场与电磁波Electrom agnetic Fields & Magnetic Waves电磁场与微波技术Electrom agnetic Fields & Micro-Wave Technology电磁场中的数值方法Numerical Methods in Electrom agnetic Fields电磁场中的数值计算Numerical Calculation in Electromagnetic Fields电磁学Electrom agnetics电动力学Electrodynamics电镀Plating电分析化学Electro-Analytical Chemistry电工测试技术基础Testing Technology of Electrical Engineering电工产品学Electrotechnical Products电工电子技术基础Electrical Technology & Electrical Engineering电工电子学Electronics in Electrical Engineering电工基础Fundamental Theory of Electrical Engineering电工基础理论Fundamental Theory of Electrical Engineering电工基础实验Basic Experiment in Electrical Engineering电工技术Electrotechnics电工技术基础Fundamentals of Electrotechnics电工实习Electrical Engineering Practi ce电工实验技术基础Experiment Technology of Elec trical Engineering电工学Electrical Engineering电工与电机控制Electrical Engineering & Motor Control电弧电接触Electrical Arc Contact电弧焊及电渣焊Electric Arc Welding & Electroslag Welding电化学测试技术Electrochemical Measurement Technology电化学工程Electrochem ical Engineering电化学工艺学Electrochemical Technology电机测试技术Motor Measuring Technology电机电磁场的分析与计算Analysis & Calculation of Electrical Motor & Electrom agnetic Fields电机电器与供电Motor Elements and Power Supply电机课程设计Course Exercise in Electric Engine电机绕组理论Theory of Motor Winding电机绕组理论及应用Theory & Application of Motor Winding电机设计Design of Electrical Motor电机瞬变过程Electrical Motor Change Processes电机学Electrical Motor电机学及控制电机Electrical Machinery Control & Technology电机与拖动Electrical Machinery & Towage电机原理Principle of Electric Engine电机原理与拖动Principles of Electrical Machinery & Towage电机专题Lectures on Electric Engine电接触与电弧Electrical Contact & Electrical Arc电介质物理Dielectric Physics电镜Electronic Speculum电力电子电路Power Electronic Circuit电力电子电器Power Electronic Equipment电力电子器件Power Electronic Devices电力电子学Power Electronics电力工程Electrical Power Engineering电力生产技术Technology of Electrical Power Generation电力生产优化管理Optimal Management of Electrical Power Generation电力拖动基础Fundamentals for Electrical Towage电力拖动控制系统Electrical Towage Control System s电力系统Power System s电力系统电源最优化规划Optimal Planning of Power Source in a Power System 电力系统短路Power System Shortcuts电力系统分析Power System Analysis电力系统规划Power System Planning电力系统过电压Hyper-Voltage of Power System s电力系统继电保护原理Power System Relay Protection电力系统经济分析Economical Analysis of Power System s电力系统经济运行Economical Operation of Power System s电力系统可靠性Power System Reliability电力系统可靠性分析Power System Reliability Analysis电力系统无功补偿及应用Non-Work Compensation in Power System s & Applicati 电力系统谐波Harmonious Waves in Power System s电力系统优化技术Optimal Technology of Power System s电力系统优化设计Optimal Designing of Power System s电力系统远动Operation of Electric System s电力系统远动技术Operation Technique of Electric System s电力系统运行Operation of Electric System s电力系统自动化Autom ation of Electric System s电力系统自动装置Power System Automation Equipment电路测试技术Circuit Measurement Technology电路测试技术基础Fundamentals of Circuit Measurem ent Technology电路测试技术及实验Circuit Measurement Technology & Experiments电路分析基础Basis of Circuit Analysis电路分析基础实验Basic Experiment on Circ uit Analysis电路分析实验Experiment on Circuit Analysis电路和电子技术Circuit and Electronic Technique电路理论Theory of Circuit电路理论基础Fundamental Theory of Circuit电路理论实验Experiments in Theory of Circuct电路设计与测试技术Circuit Designing & Measurement Technology电器学Electrical Appliances电器与控制Electrical Appliances & Control电气控制技术Electrical Control Technology电视接收技术Television Reception Technology电视节目Television Porgrams电视节目制作Television Porgram Designing电视新技术New Television Technology电视原理Principles of Television电网调度自动化Autom ation of Electric Network Management电影艺术Art of Film Making电站微机检测控制Computerized Measurement & Control of Power Statio电子材料与元件测试技术Measuring Technology of Electronic Material and Elem ent电子材料元件Electronic Material and Element电子材料元件测量Electronic Material and Element Measurement电子测量与实验技术Technology of Electronic Measurement & Experiment电子测试Electronic Testing电子测试技术Electronic Testing Technology电子测试技术与实验Electronic Testing Technology & Experiment电子机械运动控制技术Technology of Electronic Mechanic Movem ent Control电子技术Technology of Electronics电子技术腐蚀测试中的应用Application of Electronic Technology in Erosion Measurement电子技术基础Basic Electronic Technology电子技术基础与实验Basic Electronic Technology & Experiment电子技术课程设计Course Exercise in Electronic Technology电子技术实验Experiment in Electronic Technology电子理论实验Experiment in Electronic Theory电子显微分析Electronic Micro-Analysis电子显微镜Electronic Microscope电子线路Electronic Circuit电子线路设计与测试技术Electronic Circuit Design & Measurement Technology电子线路实验Experiment in Electronic Circuit电子照相技术Electronic Photographing TechnologyPurPoison2006-03-15 14:56课程的英文词汇(二)雕塑艺术欣赏Appreciation of Sculptural Art调节装置Regulation Equipment动态规划Dynamic Programming动态无损检测Dynamic Non-Destruction Measurement动态信号分析与仪器Dynamic Signal Analysis & Apparatus锻压工艺Forging Technology锻压机械液压传动Hydraulic Transmission in Forging Machinery锻压加热设备Forging Heating Equipment锻压设备专题Lectures on Forging Press Equipm ents锻压系统动力学Dynamics of Forging System锻造工艺Forging Technology断裂力学Fracture Mechanics对外贸易概论Introduction to International Trade多层网络方法Multi-Layer Network Technology多目标优化方法Multipurpose Optim al Method多项距阵Multi-Nominal Matrix多元统计分析Multi-Variate Statistical Analysis发电厂Power Plant发电厂电气部分Electric Elem ents of Power Plants法律基础Fundamentals of Law法学概论An Introduction to Science of Law法学基础Fundamentals of Science of Law翻译Translation翻译理论与技巧Theory & Skills of Translation泛函分析Functional Analysis房屋建筑学Architectural Design & Construction非电量测量Non-Electricity Measurem ent非金属材料Non-Metal Materials非线性采样系统Non-Linear Sampling System非线性光学Non-Linear Optics非线性规划Non-Linear Programming非线性振荡Non-Linear Ocsillation非线性振动Non-Linear Vibration沸腾燃烧Boiling Combustion分析化学Analytical Chemistry分析化学实验Analytical Chemistry Experiment分析力学Analytical Mechanics风机调节Fan Regulation风机调节.使用.运转Regulation,Application & Operation of Fans风机三元流动理论与设计Tri-Variate Movem ent Theory & Design of Fans风能利用Wind Power Utilization腐蚀电化学实验Experiment in Erosive Electrochem istry复变函数Complex Variables Functions复变函数与积分变换Functions of Com plex Variables & Integral Transformation复合材料力学Compound Material Mechanics傅里叶光学Fourier Optics概率论Probability Theory概率论与数理统计Probability Theory & Mathem atical Statisti cs概率论与随机过程Probability Theory & Stochastic Process钢笔画Pen Drawing钢的热处理Heat-Treatm ent of Steel钢结构Steel Structure钢筋混凝土Reinforced Concrete钢筋混凝土及砖石结构Reinforced Concrete & Brick Structure钢砼结构Reinforced Concrete Structure高层建筑基础设计Designing bases of High Rising Buildings高层建筑结构设计Designing Structures of High Rising Buildings高等材料力学Advanced Material Mechanics高等代数Advanced Algebra高等教育管理Higher Education Management高等教育史History of Higher Education高等教育学Higher Education高等数学Advanced Mathem atics高电压技术High-Voltage Technology高电压测试技术High-Voltage Test Technology高分子材料High Polymer Material高分子材料及加工High Polymer Material & Porcessing高分子化学High Polymer Chemistry高分子化学实验High Polymer Chemistry Experiment高分子物理High Polymer Physics高分子物理实验High Polymer Physics Experiment高级英语听说Advanced English Listening & Speaking高能密束焊High Energy-Dense Beam Welding高频电路High-Frenquency Circuit高频电子技术High-Frenquency Electronic Technology高频电子线路High-Frenquency Electronic Circuit高压测量技术High-Voltage Measurem ent Technology高压测试技术High-Voltage Testing Technology高压电场的数值计算Numerical Calculation in High-Voltage Electronic Field 高压电器High-Voltage Electrical Appliances高压绝缘High-Voltage Insulation高压实验High-Voltage Experim entation高压试验技术High-Voltage Experimentation Technology工程材料的力学性能测试Mechanic Testing of Engineering Materials工程材料及热处理Engineering Material and Heat Treatm ent工程材料学Engineering Materials工程测量Engineering Surveying工程测试技术Engineering Testing Technique工程测试实验Experiment on Engineering Testing工程测试信息Information of Engineering Testing工程动力学Engineering Dynamics工程概论Introduction to Engineering工程概预算Project Budget工程经济学Engineering Economics工程静力学Engineering Statics工程力学Engineering Mechanics工程热力学Engineering Thermodynamics工程项目评估Engineering Project Evaluation工程优化方法Engineering Optimizational Method工程运动学Engineering Kinematics工程造价管理Engineering Cost Management工程制图Graphing of Engineering工业分析Industrial Analysis工业锅炉Industrial Boiler工业会计学Industrial Accounting工业机器人Industrial Robot工业技术基础Basic Industrial Technology工业建筑设计原理Principles of Industrial Building Design工业经济理论Industrial Economic Theory工业经济学Industrial Economics工业企业财务管理Industrial Enterprise Financial Management工业企业财务会计Accounting in Industrial Enterprises工业企业管理Industrial Enterprise Management工业企业经营管理Industrial Enterprise Adminstrative Management 工业社会学Industrial Sociology工业心理学Industrial Psychology工业窑炉Industrial Stoves工艺过程自动化Technics Process Autom ation公差Common Difference公差技术测量Technical Measurement with Common Difference公差与配合Common Difference & Cooperation公共关系学Public Relations公文写作Document Writing古代汉语Ancient Chinese古典文学作品选读Selected Readings in Classical Literature固体激光Solid State Laser固体激光器件Solid Laser Elements固体激光与电源Solid State Laser & Power Unit固体物理Solid State Physics管理概论Introduction to Managem ent管理经济学Management Econom ics管理数学Management Mathem atics管理系统模拟Management System Simulation管理心理学Management Psychology管理信息系统Management Information System s光波导理论Light Wave Guide Theory光电技术Photoelectric Technology光电信号处理Photoelectric Signal Processing光电信号与系统分析Photoelectric Signal & System atic Analysis光辐射探测技术Ray Radiation Detection Technology光谱Spectrum光谱分析Spectral Analysis光谱学Spectroscopy光纤传感Fibre Optical Sensors光纤传感器Fibre Optical Sensors光纤传感器基础Fundamentals of Fibre Optical Sensors光纤传感器及应用Fibre Optical Sensors & Applications光纤光学课程设计Course Design of Fibre Optical光纤技术实验Experiments in Fibre Optical Technology光纤通信基础Basis of Fibre Optical Communication光学Optics光学测量Optical Measurement光学分析法Optical Analysis Method光学计量仪器设计Optical Instrument Gauge Designing光学检测Optical Detection光学设计Optical Design光学信息导论Introduction of Optical Infom ation光学仪器设计Optical Instrument Designing光学仪器与计量仪器设计Optical Instrument & Gauge Instrument Designing 光学仪器装配与校正Optical Instrument Installation & Adjust m ent广播编辑学Broadcast Editing广播新闻Broadcast Journalism广播新闻采写Broadcast Journalism Collection & Composition广告学Advertisem ent锅炉燃烧理论Theory of Boiler Combustion锅炉热交换传热强化Boiler Heat Exchange,Condction & Intensification锅炉原理Principles of Boiler国际金融International Finance国际经济法International Economic Law国际贸易International Trade国际贸易地理International Trade Geography国际贸易实务International Trade Affairs国际市场学International Marketing国际市场营销International Marketing国民经济计划National Economical Planning国外社会学理论Overseas Theories of Sociology过程(控制)调节装置Process(Control) Adjust m ent Device过程调节系统Process Adjust m ent System过程控制Process Control过程控制系统Process Control System海洋测量Ocean Surveying海洋工程概论Introduction to Ocean Engineering函数分析Functional Analysis焊接方法Welding Method焊接方法及设备Welding Method & Equipment焊接检验Welding Testing焊接结构Welding Structure焊接金相Welding Fractography焊接金相分析Welding Fractography Analysis焊接冶金Welding Metallurgy焊接原理Fundamentals of Welding焊接原理及工艺Fundamentals of Welding & Technology焊接自动化Autom ation of Welding汉语Chinese汉语与写作Chinese & Composition汉语语法研究Research on Chinese Grammar汉字信息处理技术Technology of Chinese Information Processing毫微秒脉冲技术Millimicrosecond Pusle Technique核动力技术Nuclear Power Technology合唱与指挥Chorus & Conduction合金钢Alloy Steel宏观经济学Macro-Economics宏微观经济学Macro Micro Economics红外CCD Infrared CCD红外电荷耦合器Infrared Electric Charge Coupler红外探测器Infrared Detectors红外物理Infrared Physics红外物理与技术Infrared Physics & Technology红外系统Infrared System红外系统电信号处理Processing Electric Signals from Infrared System s厚薄膜集成电路Thick & Thin Film Integrated Circuit弧焊电源Arc Welding Power弧焊原理Arc Welding Principles互换性技术测量基础Basic Technology of Exchangeability Measurement互换性技术测量Technology of Exchangeability Measurement互换性与技术测量Elementary Technology of Exchangeability Measurement互换性与技术测量实验Experiment of Exchangeability Measurement Technology 画法几何及机械制图Descriptive Geometry & Mechanical Graphing画法几何与阴影透视Descriptive Geometry,Shadow and Perspective化工基础Elementary Chemical Industry化工仪表与自动化Chemical Meters & Autom ation化工原理Principles of Chemical Industry化学Chemistry化学反应工程Chemical Reaction Engineering化学分离Chemical Decom position化学工程基础Elementary Chemical Engineering化学计量学Chemical Measurement化学文献Chemical Literature化学文献及查阅方法Chemical Literature & Consulting Method化学粘结剂Chemical Felter环境保护理论基础Basic Theory of Environmental Protection环境化学Environomental Chemistry环境行为概论Introduction to Environmental Behavior换热器Thermal Transducer回旧分析与试验设计Tem pering Analysis and Experiment Design回转式压缩机Rotary Compressor回转压缩机数学模型Mathematical Modeling of Rotary Compressors会计学Accountancy会计与财务分析Accountancy & Financial Analysis会计与设备分析Accountancy & Equipment Analysis会计原理及外贸会计Principles of Accountancy & Foreign Trade Accountancy 会计原理与工业会计Principles of Accountancy & Industrial Accountancy活力学Energy Theory活塞膨胀机Piston Expander活塞式制冷压缩机Piston Refrigerant Compreessor活塞式压缩机Piston Compressor活塞式压缩机基础设计Basic Design of Piston Compressor活塞压缩机结构强度Structural Intensity of Piston Com pressor活赛压机气流脉动Gas Pulsation of Piston Pressor货币银行学Currency Banking基本电路理论Basis Theory of Circuit基础写作Fundamental Course of Composition机床电路Machine Tool Circuit机床电器Machine Tool Electric Appliance机床电气控制Electrical Control of Machinery Tools机床动力学Machine Tool Dynamics机床设计Machine Tool design机床数字控制Digital Control of Machine Tool机床液压传动Machinery Tool Hydraulic Transmission机电传动Mechanical & Electrical Transm ission机电传动控制Mechanical & electrical Transm ission Control机电耦合系统Mechanical & Electrical Combination System机电系统计算机仿真Computer Simulation of Mechanic/Electrical System s机电一体化Mechanical & Electrical Integration机构学Structuring机器人Robot机器人控制技术Robot Control Technology机械产品学Mechanic Products机械产品造型设计Shape Design of Mechanical Products机械工程控制基础Basic Mechanic Engineering Control机械加工自动化Autom ation in Mechanical Working机械可靠性Mechanical Reliability机械零件Mechanical Elements机械零件设计Course Exercise in Machinery Elements Design机械零件设计基础Basis of Machinery Elements Design机械设计Mechanical Designing机械设计基础Basis of Mechanical Designing机械设计课程设计Course Exercise in Mechanical Design机械设计原理Principle of Mechanical Designing机械式信息传输机构Mechanical Information Transmission Device机械原理Principle of Mechanics机械原理和机械零件Mechanism & Machinery机械原理及机械设计Mechanical Designing机械原理及应用Mechanical Principle & Mechanical Applications机械原理课程设计Course Exercise of Mechanical Principle机械原理与机械零件Mechanical Principle and Mechanical Elements机械原理与机械设计Mechanical Principle and Mechanical Design机械噪声控制Control of Mechanical Noise机械制造概论Introduction to Mechanical Manufacture机械制造工艺学Technology of Mechanical Manufacture机械制造基础Fundamental of Mechanical Manufacture机械制造基础(金属工艺学) Fundamental Course of Mechanic Manufacturing (Meta机械制造系统自动化Automation of Mechanical Manufacture System机械制造中计算机控制Computer Control in Mechanical Manufacture机制工艺及夹具Mechanical Technology and Clamps积分变换Integral Transformation积分变换及数理方程Integral Transformation & Mathematical Equations积分变换控制工程Integral Transformation Control Engineering积分变换与动力工程Integral Transforms & Dynamic Engineering激光电源Laser Power Devices激光焊Laser Welding激光基础Basis of Laser激光技术Laser Technology激光加工Laser Processing激光器件Laser Devices激光器件与电源Laser Devices & Power Source激光原理Principles of Laser激光原理与技术Laser Principles & Technology极限分析Limit Analysis集合论与代数结构Set Theory & Algebraical Structure技术管理Technological Management技术经济Technological Economy技术经济学Technological Economics技术市场学Technological Marketing计量经济学Measure Economics计算方法Computational Method计算机导论Introduction to Com puters计算机导论与实践Introduction to Com puters & Practice计算机辅助设计CAD计算机辅助设计与仿真Computer Aided Design & Imitation 计算机辅助语言教学Computer-Aided Language Teaching计算机辅助制造Computer-Aided Manufacturing计算机概论Introduction to Com puters计算机绘图Computer Graphics计算机基础Basis of Computer Engineering计算机接口技术Computer Interface Technology计算机接口与通讯Computer Interface & Communication计算机局域网Regional Network of Com puters计算机控制Computer Controling计算机设计自动化Autom ation of Computer Design计算机实践Computer Practice计算机数据库Computer Database计算机算法基础Basis of Computer Algorithm计算机图形显示Computer Graphic Demonstration计算机图形学Computer Graphics计算机网络Computer Networks计算机系统结构Computer Architecture计算机语言处理Computer Language Processing计算机原理Principle of Computer Engineering计算机在化学中的应用Application of Com puter in Che mistry 计算机组成原理Principles of Computer Composition计算力学Computational Mechanics计算力学基础Basis of Computational Mechanics计算流体Fluid Computation继电保护新技术New Technology of Relay Protection继电保护原理Principles of Relay Protection继电保护运行Relay-Protected Operation检测技术Measurement Technique检测系统动力学Detection System Dynamics检测与控制Detection & Controling简明社会学Concise Sociology简明世界史Brief World History减振设计Vibration Absorption Designing渐近方法Asymptotical Method建筑材料Building Materials建筑初步Elementary Architecture建筑防火Building Fire Protection建筑概论Introduction to Architecture建筑构造Architectural Construction建筑结构Architectural Structure建筑结构抗震设计Anti-quake Architectural Structure Design建筑经济与企业管理Architectural Econom y & Enterprise Managem ent建筑力学Architectural Mechanics建筑名作欣赏Appreciation of Architectural Works建筑入门Elementary Architecture建筑摄影Architectural Photographing建筑设备Architectural Equipment建筑设计Architectural Design建筑施工Construction Technology建筑绘画Architectural Drawing建筑物理Architecural Physics建筑制图Architectural Graphing胶体化学Colloid Chemistry交流调速系统Alternating Current Governor System教育心理学Pedagogic Psychology接口与控制器Interface and Controler接口与通讯Interface and Communication结构程序设计Structural Program Designing结构动力学Structural Dynamics结构化学Structural Chemistry结构检验Structural Testing结构力学Structural Mechanics结构素描Structure Sketching结构塑性分析Structural Plasticity Analysis结构稳定Stability Analysis of Structures结构先进技术Advanced Structuring Technology结构优化理论Optim al Structure Theory结构优化设计Optim al Structure DesigningPurPoison2006-03-15 14:56课程的英文词汇(三)解析几何Analytic Geometry介质波导Medium Wave Guide介质测量Medium Measurem ent介质光学Medium Optics金属X射线学Metal X-Ray Analysis金属材料焊接Metal Material Welding金属材料学Metal Material Science金属材料与热处理Metal Material & Heat Treatm ent金属腐蚀与保护Metal Erosion & Protection金属腐蚀原理Principles of Metal Erosion金属工艺学Metal Technics金属焊接性基础Elementary Metal Weldability金属焊接原理Principles of Metal Welding金属机械性能Mechanical Property of Metal金属力学性能Metal Mechanic Property金属切削机床Metal Cutting Machine Tool金属切削原理及刀具Principles of Metal Cutting & Cutters金属熔焊原理Principles of Metal Molten Welding金属熔焊原理及工艺Principles of Metal Molten Welding & Technique 金属熔炼Metal Melting金属塑性成形原理Principles of Metal forming金属物理性能Physical Property of Metal金属学Metallography金属学与热处理Metallography & Heat Treatm ent金属学原理Principles of Metallography金相分析Metallographic Analysis金相技术Metallographic Techniques近代光学测试技术Modern Optical Testing Technology近代光学计量技术Modern Optical Measuring Technology近代经济史Modern History of Economics近代物理实验Lab of Modern Physics近世代数Modern Algebra晶体管原理Principles of Transistors晶体光学Crystallographic Optics精密测量技术Technology of Precision Measurement精密电气测量Precise Electric Measurem ent精密合金Precise Alloy精密机械CAD CAD for Precision Machinery精密机械课程设计Course Design for Precision Machinery精密机械零件Precision Machinery Elements精密机械设计基础Elementary Precision Machinery Design精密机械学Precision Machinery精细有机合成Minute Organic Synthesis经济地理Economical Geography经济法Law of Econom y经济法学Law of Econom y经济分析基础Basis of Economic Analysis经济控制论Economical Cybernetics经济社会学Economic Sociology经济新闻Economic News经济学说史History of Economics经济学原理Principles of Economics经济预测Economic Predicting经济预测与管理奖惩Economic Predicting & Manage ment经济原理Principles of 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Hydraulic Machinery。
科技翻译技巧与方法
• 名词与名词
以语法判定词义 • 词性 eg: Bricks are also produced in many different colors and with various finishes.
砖可以烧制成许多不同的颜色,具有不同的光洁度。 • 句子结构 +根据上下文 eg: Change can caused stress but, contrary to popular opinion , stress can be good for you. It releases endorphins into yo ur bloodstream, acting as a natural high.
科技文翻译
科技英语的概念、分类、特点、标准及原则 词汇特点及翻译技巧 句法特点及翻译技巧 科技语篇翻译
组员分工
科技英语的概念等内容 资料查找:李敏、罗露 PPT制作及讲解:李敏
科技英语词汇的特点及翻译技巧 资料查找:张月、赵丽丽 PPT制作及讲解:张月
科技英语句法特点及翻译技巧 资料查找:郭奕伶、戈文丽 PPT制作及讲解:郭奕伶
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专用英语 radioactive nuclear energy
dispose discover process
简单词 词语平易 通俗易懂
科普英语
atomic
atomic energy
do with
study
produce
regarding/concerning
根据这个定律,在恒定温度下,某定量 气体的压力和该气体的体积成反比。
由于卢瑟福成功地提出了a 粒子散射理论,因此, 人们将发现原子核的荣誉归功与他。
氧化还原对srvo_x外延膜晶相及物性的可逆调控
英语作文-集成电路设计的核心步骤与流程解析
英语作文-集成电路设计的核心步骤与流程解析Integrated circuit design is a complex process that involves several core steps and procedures. In this article, we will analyze the key steps and workflow involved in designing integrated circuits.The first step in integrated circuit design is defining the specifications and requirements of the circuit. This involves understanding the functionality of the circuit, the performance requirements, power consumption constraints, and other design parameters. Once the specifications are defined, the next step is to create a high-level design of the circuit, which includes the overall architecture and block diagram of the circuit.After the high-level design is complete, the next step is to create a detailed design of each block in the circuit. This involves designing the individual components such as logic gates, flip-flops, and other building blocks of the circuit. The design is typically done using hardware description languages such as Verilog or VHDL.Once the individual blocks are designed, the next step is to simulate the circuit using specialized software tools. This allows designers to verify the functionality of the circuit and identify any potential issues or bugs. The simulation also helps in optimizing the design for performance, power consumption, and other parameters.After the simulation is complete and the design is verified, the next step is to layout the circuit on a silicon wafer. This involves placing the individual components of the circuit on the wafer and connecting them using metal traces. The layout is a critical step in the design process as it directly impacts the performance and reliability of the circuit.Once the layout is complete, the next step is to fabricate the integrated circuit using semiconductor manufacturing processes. This involves etching the circuit pattern onto the silicon wafer, depositing metal layers, and other steps to create the final integrated circuit.The fabricated circuit is then tested to ensure that it meets the specifications and requirements defined in the initial design phase.In conclusion, designing integrated circuits is a complex and iterative process that involves several core steps and procedures. By following a systematic workflow and using specialized software tools, designers can create high-performance and reliable integrated circuits for a wide range of applications.。
肼合环反应
New Practical Synthesis of Indazoles via Condensation ofo -Fluorobenzaldehydes and Their O -Methyloximes with HydrazineKirill Lukin,*Margaret C.Hsu,Dilinie Fernando,and M.Robert LeannaGPRD Process Research and De V elopment,Abbott Laboratories,North Chicago,Illinois 60064kirill.lukin@ Recei V ed July 3,2006The reaction of o -fluorobenzaldehydes and their O -methyloximes with hydrazine has been developed as a new practical synthesis of indazoles.Utilization of the methyloxime derivatives of benzaldehydes (in the form of the major E -isomers)in this condensation effectively eliminated a competitive Wolf -Kishner reduction to fluorotoluenes,which was observed in the direct preparations of indazoles from aldehydes.Reaction of Z -isomers of methyloximes with hydrazine resulted in the formation of 3-aminoindazoles via a benzonitrile intermediate.IntroductionInvestigation of biologically active compounds possessing the indazole (1)heterocyclic core has resulted in the discovery of potent HIV protease inhibitors,serotonin receptor antagonists,aldol reductase inhibitors,and acetylcholinesterase inhibitors.1,2Recently,another indazole derivative,ABT-102(2),has been identified as a potent vanilloid receptor (VR1)pound 2is currently undergoing advanced clinical develop-ment for the treatment of chronic pain.3The current synthesis of 2utilizes 4-haloindazoles 3or 4as starting materials.Development of a reliable and efficient preparation of these indazoles was required to provide access to large quantities of bulk drug for the studies.Inspection ofthe literature 4revealed that the indazoles substituted on the six-membered ring (including 3and 4)were generally prepared via diazotation of the corresponding toluidines 5(eq 1)5,6or thenitrozation of their N -acetyl derivatives 7(Jacobsen modifica-tion,eq 2).7,8Unfortunately,these methods could not be considered practi-cal for multikilogram preparations.9,10Other innovative approaches for indazoles synthesis have been reported,but they either gave mixtures of isomeric products 11or were only limited to the synthesis of indazoles substituted at the 1-N or 3-C positions.4,12However,among the latter methods,(1)Rodgers,J.D.;Johnson,B.L.;Wang,H.;Greenberg,R.A.;Erickson-Viitanen,S.;Klabe,R.M.;Cordova,B.C.;Reyner,M.M.;Lam,G.N.;Chang,C.-H.Bioorg.Med.Chem.Lett .1996,6,2919-2924.(2)See,for example:Brase,S.;Gil,C.;Knepper,K.Bioorg.Med.Chem .2002,10,2415-2437.(3)Gomtsyan,A.;Bayburt,E.K.;Koenig,J.R.;Lee,C.-H.U.S.Patent Application 2004254188,Dec 16,2004.(4)For reviews see:(a)Elguero,J.In Comprehensi V e Heterocyclic Chemistry ;Katrizky,A.R.,Rees,C.W.,Eds.;Pergamon Press:New York,1984;Vol.5,p 167.(b)Behr,L.C.;Fusco,R.;Jarobe,C.H.In Pyrazoles,Pyrazolines,Pyrazolidines,Indazoles and Condensed Rings ;Wiley,R.H.,Ed.;Wiley Int.:New York,1969;p 28.(5)Ruechardt,C.;Hassmann,V.Liebigs Ann.Chem.1980,6,908-927.(6)For other examples of indazoles synthesis via diazonium salt see:Schumann,P.;Collot,V.;Hommet,Y.;Gsell,W.;Dauphin,F.;Sopkova,J.;MacKenzie,E.T.;Duval,D.;Boulouard,M.;Rault,S.Bioorg.Med.Chem .Lett .2001,11,1153-1156.(7)(a)Tono-oka,S.;Tone,Y.;Marques,V.E.;Cooney,D.;Sekikawa,I.;Azuma,I.Bull.Chem.Soc.Jpn.1985,58,309-315.(b)Shoda,M.;Kuriyama,H.U.S.Patent Application 2003070686,Aug 28,2003.(8)(a)Jacobsen,P.;Huber,L.Chem.Ber.1908,41,660.(b)Ruchardt,C.;Hassmann,V.Liebigs Ann.Chem.1980,908-927..Chem.2006,71,8166-817210.1021/jo0613784CCC:$33.50©2006American Chemical SocietyPublished on Web 09/15/2006a condensation of ortho-substituted benzaldehydes with hydra-zines (eq 3)looked particularly straightforward and attractivefor the adaptation for the synthesis of indazoles 3and 4.The condensation outlined in eq 3,utilizing nitro as a leaving group (Z )NO 2)was first reported more than a century ago.13It was demonstrated that several substituted hydrazones (R *H),which were initially formed in the reactions of o -nitroben-zaldehydes with the corresponding hydrazines,could be further converted into the indazoles in the presence of a base under very forcing ter,this method was adapted by employing the corresponding o -fluoro-and o -mesyloxy-substituted 14benzocarbonyl compounds.Several groups reported that various 3-substituted indazoles 9(R *H,eq 4)could beefficiently prepared via condensations of the corresponding esters of 2-fluorobenzoic acid (10a ,R )OMe),fluoroaceto,and fluorobenzophenones (10a ,R )Me,Ar),as well as 2-fluorobenzonitriles 10b ,with hydrazine.15-18Surprisingly though,we could not find any references of similar condensations involving o -fluorobenzaldehydes s starting materials required for the preparation of indazoles unsubstituted at the 3-position.The results of our investigation of the latter reaction,which led to the development of a new practical synthesis of indazoles,are provided below.Results and Discussion1.Synthesis of 4-Haloindazoles.Our initial investigation into the synthesis of 4-bromo and 4-chloroindazoles (3,4)via a condensation of the corresponding 6-halo-2-fluorobenzaldehydes 11and 12with hydrazine gave fairly promising results.For example,when the reaction of aldehyde 11with hydrazine hydrate (3equiv)in the presence of sodium bicarbonate was monitored by HPLC,a fast and quantitative formation of hydrazone intermediate 13was initially observed (eq 5).Furtherheating of this mixture to 90-100°C for 5h resulted in conversion of 13into an approximately 2:3mixture of the desired indazole 3and an unknown side product.The side product was subsequently identified as bromofluorotoluene 14,19apparently resulting from the Wolf -Kishner type reduction of the intermediate hydrazone 13(eq 5).Similar results were observed with 6-chloro analogue 12.As it was generally presumed that the formation of indazoles from ortho-substituted hydrazones proceeded as an intramo-lecular cyclization (eq 3),we decided to further optimize the reaction conditions for this cyclization using the isolated pure hydrazone 13.First,we found that a careful selection of a base was critical for minimizing the Wolf -Kishner pathway.Thus,in the presence of bases stronger than sodium bicarbonate (e.g.,potassium carbonate,triethylamine)fast and quantitative reduc-tion of hydrazone 13to toluene 14was observed.The formation of indazole 3was only observed in the presence of weak bases (e.g.,sodium bicarbonate,pyridine).However,the cyclization of the isolated hydrazone 13proceeded remarkably slower,compared to the described above reaction of the same hydra-zone,when it was formed in situ.Even after 72h at 100°C,some of the starting hydrazone remained in the mixture.Moreover,the yield of indazole 3obtained in this experiment was lower than 10%,due to the formation of toluene 14and other numerous side products.These data suggested that the(9)The diazotation method generally requires the isolation of a potentially explosive diazonium salt intermediate.The formation and cyclization of the diazonium salt proceed simultaneously under the reaction conditions only in the presence of additional highly electron-withdrawing groups (e.g.,nitro):(a)Bartsch,R.A.;Tang,I.-W.J.Heterocycl.Chem.1984,21,1063.(b)Porter,H.D.;Peterson,.Synth .1955,III (Collective Vol.),660.(10)Even the most advanced modification of the Jacobsen reaction remains relatively impractical,as it requires the addition of 0.1equiv of expensive and toxic crown ether catalyst,employs toxic chloroform as a preferred solvent,and adds a deprotection step to recover the indazole:(a)Beadle,J.R.;Korzeniowski,S.H.;Rosenberg,D.E.;Garcia-Slanga,B.J.;Gokel,.Chem.1984,49,1594-1603.(b)Sun,J.-H.;Teleha,C.A.;Yan,J.-S.;Rodgers,J.D.;Nugiel D.A..Chem.1997,62,5627-5629.(11)Bromoindazole 3was obtained as one of the products resulting from the condensation of bromobenzyne with (trimethylsilyl)diazomethane:Shoji,Y.;Hari,Y.;Aoyama,T.Tetrahedron Lett.2004,45,1769-1771.(12)Song,J.J.;Yee,N.K.Tetrahedron Lett.2001,42,2937-2940.(13)(a)Meyer,V.Chem.Ber .1889,22,319.(b)Reich,S.;Gaigalian,G.Chem.Ber .1913,46,2380-2387.(14)Caron,S.;Vazquez,E.Synthesis 1999,4,588-592.(15)Cui,J.J.;Araldi,G.-L.;Reiner,J.E.;Reddy,K.M.;Kemp,S.J.;Ho,J.Z.;Siev,D.V.;Mamedova,L.;Gibson,T.S.;Gaudette,J.A.;Minami,N.K.;Anderson,S.;M.;Bradbury,A.E.;Nolan,T.G.;Semple,J.E.Bioorg.Med.Chem .Lett .2002,12,2925-2930.(16)Henke,B.R.;Aquino,C.J.;Birkemo,L.S.;Croom,D.K.;Dougherty,R.W.;Ervin,G.N.;Grizzle,M.K.;Hirst,G.C.;James,M.K.;Johnson,M.F.;Queen,K.L.;Sherrill,R.G.;Sugg,E.E.;Suh,E.M.;Szewczyk,J.W.;Unwalla,R.J.;Yingling,J.;Willson,T.M.J.Med.Chem.1997,40,2706-2725.(17)(a)Shutske,G.M.;Allen,R.C.;Forsch,M.F.;Setescak,L.L.;Wilker,J.C.J.Med.Chem.1983,26,1307-1311.(b)Dehmlow,H.;Aebi,J.D.;Jolidon,S.;Ji,Y.-H.;Mark,E.M.;Himber,J.;Morand,O.H.J.Med.Chem.2003,46,3354-3370.(18)Witherington,J.;Bordas,V.;Gaiba,A.;Naylor,A.;Rawlings,A.D.;Slingsby,B.P.;Smith,D.G.;Takle,A.K.;Ward,R.W.Bioorg.Med.Chem .Lett .2003,13,3059-3062.(19)Dewar,M.J.S.;Grisdale,.Chem .1963,28,1759-1762.Synthesis of Indazoles from o-Fluorobenzaldehydes.Chem ,Vol .71,No .21,20068167formation of indazoles in reactions of o -fluorobenzaldehydes with hydrazine under the investigated set of conditions did not proceed via an intramolecular cyclization of hydrazone 13.20In search of an explanation for the above results,we found that the indazole formation from 11could be facilitated in the presence of excess hydrazine.Indeed,when the isolated hydra-zone 13was added to hydrazine hydrate,which was used as a solvent,heating the solution to 100°C for only 1h resulted in consumption of the starting material.Based on these data we rationalized that the mechanism for the conversion of the o -fluorophenylhydrazones into indazoles in the presence of excess hydrazine proceeded by substitution of the aryl fluoride with another molecule of hydrazine,followed by the cyclization of 13b as outlined in Scheme 1.According to this mechanism,the hydrazine molecule,which was initially incorporated into the hydrazone fragment of 13,would be later eliminated as a result of a subsequent cyclization step via aminal 13c (Scheme 1).To support this proposed mechanism we prepared benzyl-substituted hydrazone 16and subjected it to the cyclization conditions in hydrazine hydrate (eq 6).As we expected,nonbenzylated indazole 3was formedas a major product (the 10:1ratio of indazole 3and benzylin-dazole 17was determined by HPLC methodology).Importantly,only traces of toluene side product were observed in the reaction mixture (in comparison to the cyclization of 13which gave 30-40%of reduction product),suggesting that hydrazone 13was not a major intermediate in this reaction and that the indazole formation proceeded in an intramolecular fashion,after the fluoride substitution in 16(Scheme 1).As an outcome of the above mechanistic rationalization,we were able to prepare 4-haloindazoles 3and 4simply by refluxing the corresponding aldehydes in hydrazine hydrate.Upon the completion of the reaction,the product typically precipitated out during cooling of the crude reaction mixture and was conveniently isolated through filtration.The yields of indazoles 3and 4obtained in this reaction were satisfactory (50-60%),however,still negatively affected by the formation of toluenes 14and 15,as side products.Upon further optimization of the reaction parameters,we have found that the extent of the reduction could be attenuated by conducting the reaction in etheral solvents such as THF,DME,or dioxane and employing anhydrous hydrazine as a cosolvent.Under these optimized conditions (1:1THF -98%hydrazine,70°C,15h)the isolated yields of indazoles 3and 4were increased to 80-85%,respectively.2.Condensation of Other o -Fluorobenzaldehydes with Hydrazine.In an attempt to determine the generality of this practical approach,the condensations of several substituted o -fluorobenzaldehydes (18-24)were evaluated using the condi-tions found optimal for aldehydes 11and 12.The selection of the o -fluorobenzaldehydes was designed to evaluate both the impact of the substitution pattern and the electronic effect of substituents (eq 7).The results of this study are summarized inTable 1.We were pleased to find that the desired indazoles could be obtained in good yields in most of the cases studied.At the same time,the data in Table 1show that the cyclizations of unsubstituted fluorobenzaldehyde 18and 5-bromo-2-fluoroben-zaldehyde (20)gave reduced yields of the corresponding indazoles,whereas 5-methoxy-substituted aldehyde 23gave only the corresponding toluene reduction product.The lower ef-ficiency of the condensation reaction in the latter examples could be rationalized by considering the effect of substituents on the rates of the two competitive processes s nucleophilic substitution of the fluoride leading to indazole formation and the hydrazone intermediate reduction leading to the toluene.For example,introduction of the electron-donating methoxy substituent in para or ortho positions relative to the carbonyl group (compounds 22,24)would presumably decelerate the hydrazone reduction,while having little effect on the fluoride substitution.At the same,introduction of the methoxy substituent in the para position relative to the fluoride (compound 23)would deactivate the fluoride substitution,with little effect on the hydrazone reduction rate.Accordingly,the condensation of aldehyde 24resulted in a high yield of 4-methoxyindazole (31),whereas the analogous reaction of aldehyde 23gave the reduction product only.Although in all studied cases the toluene side products could be conveniently removed from the indazoles by a heptane wash,or simply during the product drying under vacuum,we still sought better control over the reduction pathway to achieve higher yields of indazoles regardless of the substitution.3.Condensation of 2-Fluorobenzaldehyde O -Methyloximes with Hydrazine.The condensation of benzylhydrazone 16with hydrazine (eq 6)provided important clues for further method development.As noted above,this reaction resulted in replace-ment of benzylhydrazine and gave nearly exclusively indazole unsubstituted at the 1-N position.These findings allowed us to propose that not only various substituted hydrazones (e.g.,16)but other appropriately protected aldehydes could be utilized in the condensations with hydrazine for indazoles preparation.Moreover,elimination of the hydrazone intermediate from this new process would avoid the Wolf -Kishner pathway leading to the toluene side products.We thought that easily accessible oximes could be good surrogates to investigate this approach.(20)It is possible that intramolecular cyclization of hydrazones with the formation of indazoles still could be accomplished at higher temperatures.In the related study of the intramolecular cyclizations of 2-mesyloxyac-etophenones hydrazones (ref 18,eq 4),the indazole formation was observed at temperatures above 130°C.However,a DSC scan of hydrazone 13indicated that it underwent highly exothermic decomposition at 140-150°C,prompting us to set 110°C as the upper limit for all our experiments.S CHEME1Lukin et al..Chem.,Vol .71,No .21,2006However,it has been reported that unprotected oximes of substituted 2-fluorobenzaldehydes could undergo a self-cycliza-tion into isoxazoles,as outlined in eq 8.21The isoxazole side product formation was obviated by using O -methyloximes 32instead of pounds 32could be simply prepared in quantitative yields by reacting the equivalent amounts of fluorobenzaldehydes and methyloxime hydrochloride in the presence of potassium carbonate (eq 9).We were pleased to find that the reaction of 2-fluorobenzalde-hyde O -methyloxime prepared in this manner with hydrazine cleanly gave indazole,which was isolated in 80%yield (eq 9,X )H)representing a nearly 3-fold yield improvement overthe standard conditions using the hydrazone intermediate (Table 1,entry 3).Adding to the convenience of this procedure,no isolation of the methyloxime intermediate was required before the indazole formation step.The reaction with hydrazine was conducted simply after filtering off the inorganics from the crude oxime solution (vide infra).In a similar manner,the benzaldehydes referenced in Table 1,as well as 2,6-difluorobenzaldehyde (39),were converted into the corresponding methyloximes and,subsequently,indazoles in high yields,as summarized in Table 2.The only exception to this generality was the methyloxime of highly deactivated 5-methoxy-substituted aldehyde 23,which upon extended reac-tion time gave only 5%yield of 30.Surprisingly,6-bromo-and 6-chloro-substituted benzalde-hydes 11and 12,which gave the highest yields of indazoles in the cyclizations via hydrazone intermediate (Table 1,entries 1and 2),behaved unusually in the cyclization via their requisite methyloxime.It was found that in addition to the corresponding indazoles 3and 4,other more polar products (12-14%by HPLC peak area vs 3or 4)were formed in these reactions (eq 10).These side products were identified as 3-aminoindazoles 34a and 34b ,22respectively.It was also observed that formation of 34could be related to the increased amounts of the minor Z -isomers of oximes 35or 36formed during the oximation of aldehydes 11and 12,respectively (see Table 2).23To confirm that 3-aminoindazoles were indeed formed from the correspond-ing Z -oxime isomers,we attempted the isolation of individual compounds 35a and 35b .Although the separation of these isomers via chromatography was not achievable,it was possible to isolate the major E -form 35b (<5%Z )by fractional crystallization of the mixture from pentane at 0°C.The cyclization of this enriched material under the standard condi-tions resulted in the expected decrease in the yield of 34a ,which dropped to 3%vs 3,confirming the aminoindazole origination from Z -isomer 35a .We do not have an explanation for the increased amounts of Z -isomers formation in the oximations of aldehydes 11and 12.However,a comparison of the oxime ratios listed in Table 2suggests that this phenomenon is related to the size of the substituent at the 6-position of the aldehyde.Thus,a gradual(21)Strupczewski,J.T.;Allen,R.C.;Gardner,B.A.;Schmid,B.L.;Stache,U.;Glamkowski,E.J.;Jones,M.C.;Ellis,D.B.;Huger,F.P.;Dunn,R.W.J.Med.Chem.1985,28,761-769.(22)Voss,G.;Eichner,S.J.Prakt.Chem.2000,342,201-204.(23)The Z /E ratios of 25:75and 22:78were determined for methyloximes 35and 36by HPLC methodology.Other investigated methyloximes had less than 10%of Z -isomer.Isomers assignment in methyloximes is based on 13C NMR data:Gordon,M.S.;Sojka,S.A.;Krause .Chem.1984,49,97-100.T ABLE 1.Indazole Formation from Benzaldehydes 11,12,18-24aReaction yield,as determined by HPLC assay.b Additionally,toluene 15was formed in 13%yield (HPLC assay).c Additionally,2-fluorotoluene was formed in 45%yield (HPLC assay).Synthesis of Indazoles from o-Fluorobenzaldehydes.Chem ,Vol .71,No .21,20068169increase in the amounts of Z -isomers was observed when the 6-substituent in the benzaldehyde molecule was changed from hydrogen to bromine (Br >Cl >MeO >F >H,see Table 2).The same substituents did not significantly affect the ratio of oxime isomers,if they were placed in other positions in the molecule.Accordingly,we did not observe the formation of any side products with an HLPC peak area higher than 5%in the condensations of the latter oximes (see Table 2).24A plausible mechanism for the observed formation of 3-aminoindazoles in the condensations of Z -methyloximes with hydrazine is outlined in eq 11.This mechanism is based on the reported literature prece-dents.14,17It was also demonstrated that O -methyloximes of benzaldehydes,possessing electron-withdrawing groups,could be converted into the corresponding nitriles in the presence of bases as strong as aqueous sodium hydroxide.25The selective benzonitrile formation from the Z -isomer of oxime under the reaction conditions probably represented a kinetic effect.Relatively faster elimination of methanol from the Z -isomer could be explained by the preferred orbital orientation in the elimination transitions state of this isomer,in line with the general stereochemical considerations for the reactions proceed-ing via an E2mechanism.26Further support of the mechanism outlined in eq 11was obtained during monitoring the condensation of oximes 36with hydrazine by HPLC.While no intermediates were observed in the cyclization of 36b into 4,the formation of aminoindazole 34b clearly proceeded via an intermediate (40%peak area vs 34b after 1h;10%after 2h;<1%,after 4h).Although we could not detect the presence of nitrile 37in this reaction mixture directly,the intermediate was identified as its derivative,hydrazide 38,by spiking the reference compound into the HPLC sample of the reaction mixture.Hydrazide 38was in turnisolated from the reaction of nitrile 37with hydrazine at room temperature (eq 12).27-29As expected,compound 38was further converted into indazole 34b by heating the reaction mixture to 75°C.ConclusionsWe have established a new practical synthesis of indazoles via reaction of o -fluorobenzaldehydes and/or their O -methyl-oximes with excess hydrazine.High yields of indazoles (70-85%)were obtained in the condensations of aldehydes with various substitution patterns with the exception of those possessing electron-donating groups in the 5-position,as well as unsubtituted o -fluorobenzaldehyde.The yields of indazoles prepared from the nonoptimal aldehydes were lower due to competitive Wolf -Kishner reduction.This side reaction was effectively eliminated via utilization of O -methyloxime deriva-tives of the aldehydes for the preparation of indazoles in the condensation with hydrazine.All studied aldehydes (with the exception of the poorly reactive 5-methoxy compound)were efficiently converted into the corresponding indazoles using the methyloxime method.A side reaction,resulting in the formation of 3-aminoindazoles,was observed in the experiments with oximes possessing relatively high levels of Z -isomers.The aminoindazole side products were selectively formed from Z -isomers of these oximes,via the corresponding nitrile intermediates under the reaction conditions.Finally,we would like to note that condensations of O -methyloximes with nucleophiles other than hydrazine could potentially provide a new practical methodology for the prepara-tion of various heterocyclic systems.We will report on this chemistry in a due time.Experimental Sectionmercially available o -fluorobenzaldehydes and 2-chloro-6-fluorobenzonitrile (37)were used in this study.Reaction mixtures and isolated products were analyzed by HPLC (Zorbax Rx C8column,detection at 205nm).All isolated indazole compounds had an HPLC purity better than 95%.1H NMR spectra were recorded at 400MHz;13C NMR spectra were recorded at 100MHz.General Procedure for the Preparation of Indazoles from Fluorobenzaldehydes.Method A.Hydrazine (98%,10mL)was added over 5min to a solution of an aldehyde (10mmol)in DME (10mL).The reaction mixture was refluxed for 15h and concentrated in vacuo to approximately 10mL.Water (10-20mL)was added to the mixture.The resulting product precipitate was filtered off and dried in vacuo.Indazoles 3,4,25-29,and 31were obtained using this procedure.DME solvent could be replaced with THF or dioxane.(24)We did not attempt to identify the structures of minor side products formed in these reactions in less than 5%peak area by HPLC methodology.(25)Hagarty,A.F.;Tuobey,P.J.J.Chem.Soc.,Perkin Trans.21980,1313.(26)Marchese,G.;Naso,F.;Modena,G.J.J.Chem.Soc.B 1968,958.(27)The structure of intermediate 37was supported by 13C NMR,which showed the presence of a nitrile carbon at 155.1ppm and the disappearance of 13C -19F coupling.(28)For examples of halogen displacement with hydrazine in substituted benzonitrile see:(a)Parnell J.Chem.Soc.1959,2363.(b)Voss,G.;Eichner,S.J.Prakt.Chem.2000,342,201-204.(29)Alternatively,nitrile formation could occur after fluoride substitution with hydrazine.This,however,seems less likely,as a highly electron-donating hydrazide will deactivate the methyloxime group for elimination.T ABLE 2.Conversion of o -Fluorobenzaldehydes into theIndazoles via the Methyloxime Method indazole X (eq 9)isolated yield(%)a Z /E oximes ratio b25H 805/95266-Br 706/94275-Br 946/94287-Cl 846/94296-MeO 698/92305-MeO 5b 4/96334-F 759/91314-MeO 7015/8534-Br 70(86/14)c 25/7544-Cl72(88/12)d22/78a The isolated yields of individual compounds were not optimized.bDetermined by HPLC methodology.c Compounds 3/34a ratio in the reaction mixture determined by HPLC methodology.d Compounds 4/34b ratio in the reaction mixture determined by HPLC methodology.Lukin et al..Chem.,Vol .71,No .21,2006General Procedure for the Preparation of Indazoles from Fluorobenzaldehydes via O-Methyloxime Intermediates.MethodB.An aldehyde(5mmol),methylhydroxylamine hydrochloride(0.41g,5mmol),and potassium carbonate(0.76g,5.5mmol)were mixed in DME(10mL)for4-5h at40°C.The reaction mixture was filtered,and the filtrate containing the oxime intermediate was concentrated in vacuo to approximately5mL.Hydrazine(98%,5 mL)was added to the concentrated oxime solution,and the mixture was refluxed for5-25h,until the reaction was complete per HPLC analysis.The reaction mixture was concentrated in vacuo to approximately5mL.Water(10mL)was added to the mixture. The resulting product precipitate was filtered off and dried in vacuo. Indazoles3,4,25,27-29,31,and33were obtained using this procedure.4-Bromoindazole(3)7b,11was obtained in81%yield by method A:1H NMR(DMSO-d6,δ,ppm)7.28(t,1H,J)7.6Hz),7.34 (d,1H,J)7.4Hz),7.59(d,1H,J)7.5Hz),8.05(s,1H),13.46 (s,1H,-NH).Attempted preparation of4-bromoindazole by method B gave a mixture of indazoles3and34a in86:14ratio.The mixture was separated by column chromatography on silica gel eluting with9:1 heptane-ethyl acetate.Bromoindazole3was eluted first and isolated in70%yield.3-Amino-4-bromoindazole(34a)was obtained in10%yield: 1H NMR(DMSO-d6,δ,ppm)5.18(s,2H,-NH),7.05-7.19(m, 2H),7.29(d,1H,J)7.8Hz),11.88(s,1H,-NH).13C NMR (DMSO-d6,δ,ppm)109.0(CH),111.5(C),113.1(C),120.7(CH), 127.0(CH),141.8(C),147.7(C).Anal.Calcd for C7H6BrN3:C, 39.65;H,2.85;N,19.82.Found:C,39.75;H,2.80;N,19.36. 4-Chloroindazole(4)5,7a was obtained in82%yield by method A:1H NMR(CDCl3,δ,ppm)7.15(d,1H,J)7.4Hz),7.30(t, 1H,J)7.4Hz),7.40(d,1H,J)7.5Hz),8.16(s,1H),10.61(s, 1H,-NH).Attempted preparation of4-chloroindazole by method B gave a mixture of indazoles3and34b in88:12ratio.The mixture was separated by column chromatography on silica gel eluting with9:1 heptane-ethyl acetate.Chloroindazole3was eluted first and isolated in72%yield.3-Amino-4-chloroindazole(34b)26was obtained in8%yield: 1H NMR(methanol-d4,δ,ppm)5.18(s,2H,-NH),7.05-7.19 (m,2H),7.29(d,1H,J)7.8Hz),11.88(s,1H,-NH).13C NMR (methanol-d4,δ,ppm)109.0(CH),111.5(C),113.1(C),120.7 (CH),127.0(CH),141.8(C),147.7(C).Indazole(25)was obtained in29%yield by method A and80% yield by method B:1H NMR(DMSO-d6,δ,ppm)7.09(t,1H,J) 7.5Hz),7.33(t,1H,J)7.5Hz),7.52(d,1H,J)8.4Hz),7.75(d, 1H,J)8.1Hz),8.05(s,1H),13.01(s,1H,-NH).5-Bromoindazole(27)31was obtained in45%yield by method A and94%yield by method B:1H NMR(CDCl3,δ,ppm)7.38 (d,1H,J)8.8Hz),7.47(dd,1H,J)1.7,8.7Hz),7.90(dd,1H, J)0.9,1.7Hz),8.01(d,1H,J)0.9Hz),10.08(s,1H,-NH). 6-Bromoindazole(26)32was obtained in78%yield by method A and70%yield by method B:1H NMR(DMSO-d6,δ,ppm)7.24 (d,1H,J)8.5Hz),7.74(d,1H,J)8.5Hz),7.78(s,1H),8.11 (s,1H),13.18(s,1H,-NH).13C NMR(DMSO-d6,δ,ppm)112.2 (CH),118.9(C),121.3(C),121.9(CH),122.9(CH),133.3(CH), 140.1(C).7-Chloroindazole(28)32was obtained in74%yield by method A and84%yield by method B:1H NMR(CDCl3,δ,ppm)7.12(t, 1H,J)7.9Hz),7.38(d,1H,J)7.5Hz),7.66(d,1H,J)7.9 Hz),8.12(s,1H).6-Methoxyindazole(29)6was obtained in72%yield by method A and in69%yield by method B:1H NMR(CDCl3,δ,ppm)3.86(s,3H),6.81-6.84(m,2H),7.60(d,1H,J)8.7Hz),7.97(s,1H),8.16(s,1H).4-Methoxyindazole(31)7a was obtained in47%yield by methodA and70%yield by method B:1H NMR(CDCl3,δ,ppm)3.97(s,3H),6.48(d,1H,J)7.7Hz),7.07(d,1H,J)7.6Hz),7.29(t,1H,J)7.7Hz),8.16(s,1H),10.48(s,1H).4-Fluoroindazole(33)30was obtained in75%yield by methodB:1H NMR(CDCl3,δ,ppm)6.80(m,1H),7.28-7.32(m,2H),8.16(s,1H),10.5(s,1H,-NH).Bromo-6-fluorobenzaldehyde Hydrazone(13).Bromofluo-robenzaldehyde11(2.0g,10mmol)was added to a magneticallystirred mixture of hydrazine hydrate(∼55%in water,2.0g)andtoluene(10mL)over0.5h at50°C.After additional1h at50°Cthe mixture was cooled to room temperature and diluted with water(5mL).The organic layer was separated and concentrated to drynessin vacuo.The residue was slurried in heptane(30mL).Filtrationand drying(40°C,vacuum)gave hydrazone13(1.83g,91%):1HNMR(DMSO-d6,δ,ppm)7.13-7.27(m,2H),7.31(s,2H,-NH2),7.42-7.49(m,1H),7.79(s,1H,-NH).13C NMR(DMSO-d6,δ,ppm)115.3(d,CH,J)22.2Hz),121.7(d,C,J)4.2Hz),123.3(d,C,J)13.1Hz),128.3(d,CH,J)3.4Hz),128.6(d,CH,J)9.4Hz),131.1(d,CH,J)4.3Hz),158.8(d,C,J)254Hz).Anal.Calcd for C7H6BrFN2:C,38.74;H,2.79;N,12.91.Found:C,38.82;H,2.76;N,12.70.Reduction of Bromofluorobenzaldehyde Hydrazone13.2-Bro-mo-6-fluorotoluene(14).A mixture of hydrazone13(0.22g,1mmol),potassium carbonate(0.28g,2mmol),hydrazine hydrate(∼55%,1mL),and DMA(1mL)was heated to100°C for1hunder nitrogen atmosphere.The mixture was cooled to roomtemperature and diluted with hexane(2mL)and water(3mL).The hexane layer was separated and washed with water(2×2mL).Careful evaporation of the hexane solution in vacuo gavebromofluorotoluene1419(0.15g,81%):1H NMR(CDCl3,δ,ppm)2.33(s,3H),6.91-7.08(m,2H),7.32(d,1H,J)7.8Hz).2-Bromo-6-fluorobenzaldehyde Benzylhydrazone(16).Ben-zylhydrazine dihydrochloride(0.98g,5mmol)and sodiumhydroxide(0.6g,15mmol)were mixed in THF(5mL)for10h.The mixture was filtered,and the filtrate containing benzylhydrazinewas combined with bromofluorobenzaldehyde11(0.97g,4.8mmol).After2h at room temperature the mixture was concentratedto dryness in vacuo.The residue was slurried in heptane(30mL).Filtration and drying(40°C,vacuum)gave benzylhydrazone16(1.35g,92%):1H NMR(CDCl3,δ,ppm)4.46(s,2H),6.99-7.08(m,2H),7.24-7.41(m,6H),7.64(s,1H).13C NMR(CDCl3,δ,ppm)52.8(CH2),115.3(d,CH,J)22.6Hz),123.1(C),123.5(d,C,J)23Hz),127.3(CH),127.9(2C,CH),128.38(2C,CH),128.42(CH),128.5(CH),130.5(d,CH,J)3.8Hz),137.0(C),159.8(d,C,J)255Hz).Reaction of Bromofluorobenzaldehyde Benzylhydrazone16with Hydrazine.Hydrazine(98%,1mL)was added to a solutionof benzylhydrazone16(0.31g,1mmol)in THF(1mL).Thereaction mixture was refluxed for15h and cooled to roomtemperature.A10:1ratio of bromoindazole3and1-benzylbromoindazole17was determined by HPLC methodology.1-Benzyl-4-bromoindazole(17).A solution of bromoindazole3(1.0g,5mmol),benzylbromide(0.9g,5.5mmol),and potassiumtert-butoxide(0.59g,5.3mmol)in DMF(5mL)was mixed at25°C for1h.The mixture was diluted with heptane(10mL)and water(20mL).The organic layer was separated,washed withpotassium dihydrogen phosphate solution(10%in water,10mL),and concentrated in vacuo.The resulting55:45mixture of1-and2-benzylated indazoles was separated by column chromatographyon silica gel eluting with5:1heptane-ethyl acetate;the1-N isomereluted last.Concentration of the desired fractions gave benzylbro-moindazole17(0.57g,40%):1H NMR(CDCl3,δ,ppm)5.56(s,2H),7.10-7.18(m,3H),7.23-7.32(m,5H),8.04(s,1H).13CNMR(CDCl3,δ,ppm)53.51(CH2),108.3(CH),114.5(C),123.24(CH),125.2(C),126.8(2C,CH),126.9(CH),128.5(2C,CH),(30)Suschitzky,H.J.Chem.Soc.1955,4026-4027.(31)Boulton,B.E.;Coller,B.A.W.Aust.J.Chem.1974,27,2343-2347.(32)Ruchardt,C.;Hassmann,V.Synthesis1955,375.Synthesis of Indazoles from o-Fluorobenzaldehydes.Chem,Vol.71,No.21,20068171。
烯烃复分解反应_2005年诺贝尔化学奖成果介绍_高正曦
烯烃复分解反应
—— 2005 年诺贝尔化学奖成果介绍
Olefin Metathesis——Introduction to Achievements of Nobel Prize for Chemistry 2005
高正曦 / GAO Zheng-xi,姚祝军 / YAO Zhu-Jun 中国科学院上海有机化学研究所,上海 200032
料材料的研发上“,烯烃复分解反应是寻找治疗人类主要疾病的药物的重要武器”[1~2]。 在共同获奖的 3人中,法国人伊夫·肖万(Yves Chauvin)最为年长,今年 75岁 的他在法国石油研究所担任名誉所长职务。1970年,肖万发表重要论文,阐明了烯烃 复分解反应的反应机制,这一机制解释了此前有关烯烃复分解反应的各种问题。烯烃复 分解反应的概念和最初的研究工作就是由他开始的。这位老人至今对获奖都感到惊讶,
程简直就是碰运气;换而言之,科学家们 一直在黑暗中摸索、撞大运,毫无方向可 言。这样的反应可以产生许多新的物质, 但是对于反应中催化剂扮演的角色却知之 甚少。伊夫·肖万在这个反应的机理研究 中取得了重大的突破,揭示了催化剂在反 应中的作用。随着反应机理问题的解决, 更加实际的问题摆在了化学家的面前,那 就是发展更加实用有效的催化剂来完成反 应,并拓展该反应的实际应用范围。此后, 罗伯特·格拉布和理查德·施罗克的基础 研究渐渐走上了历史的舞台,他们对于发 展实用的催化剂做出了卓越的贡献。 2.3 伊夫·肖万对反应机理的解释 此后,越来越多的化学家意识到,揭 示金属复分解反应的机理对于有机合成的 发展有着重大的意义。尽管很多研究人员 对此提出了各种各样的解释,但是,真正 的突破发生在 1970年。那一年,伊夫·肖 万和他的学生提出了烯烃复分解反应的催 化剂是一种金属卡宾化合物(注:金属卡 宾是一种金属和碳之间存在双键的化合 物)。在后来的文献中,金属卡宾变成了金 属烃基化合物,而其它的金属卡宾化合物 也在同年的早些时候被发现。肖万向当时 的科学界展示了金属卡宾化合物是怎样在 烯烃复分解反应中起到催化作用的,他为 烯烃复分解反应提出了全新的机理解释。 后来的实验结果完全支持了他提出的这个 新的机理解释;并且,实验现象不能被以 往任何的机理所解释。 在图2 中的反应式3-1,亚甲基金属 卡宾(A: [M]=CH )作为催化剂,使 2
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Synthesis of Reo Circuits For Implementation OfComponent-Connector Automata SpecificationsFarhad Arbab a,c,Christel Baier b,Frank de Boer a,c,Jan Rutten a,d,Marjan Sirjani ea CWI,Amsterdam,The Netherlands,{farhad|janr|frb}@cwi.nlb Universität Bonn,Institut für Informatik I,Germany,baier@cs.uni-bonn.dec Universiteit Leiden,The Netherlandsd Vrije Universiteit,Amsterdam,The Netherlandse Sharif University of Technology,Tehran,Iranposition of a concurrent system out of components involves coor-dination of their mutual interactions.In component-based construction,this coor-dination becomes the responsibility of the glue-code language and its underlyingrun-time middle-ware.Reo offers an expressive glue-language for constructionof coordinating component connectors out of primitive channels.In this paper weconsider the problem of synthesizing Reo coordination code from a specificationof a behavior as a relation on scheduled-data streams.The specification is givenas a constraint automaton that describes the desired input/output behavior at theports of the components.The main contribution in this paper is an algorithm thatgenerates Reo code from a given constraint automaton.1IntroductionComposing components into a concurrent system involves coordination of their mutual interactions.The internals of black-box components cannot be modified to implement such coordinated interactions.Coordination,therefore,becomes the responsibility of the“glue-code”that inter-connects the constituent components of a composite system, and of its underlying run-time middle-ware.Reo[3]offers a powerful glue language for implementation of coordinating component connectors that resemble electronic circuits and are based on a calculus of mobile channels.Reo is being used,for instance,in the context of the Cybernetic Incident Management project[13]for composition of web services,which constitute the black-box components of dynamically configured dis-tributed applications[15];to model business processes,such as electronic auctions[30]; and for modeling coordination in biological systems[6].This paper addresses the synthesis problem of component connectors with Reo as our target implementation language.The input for this problem is a specification of a co-ordination protocol and its output is a Reo connector circuit that implements this pro-tocol.Synthesis problems address the issue of the(algorithmic)generation of an im-plementation from a given specification and have a long tradition in computer science. In the context of switching circuits,the synthesis problem wasfirst raised by Church [12]and is nowadays well-understood;see,e.g.,[11,25,21,19].For temporal logical specifications,several synthesis algorithms have been suggested that rely on the close relationship between the synthesis and satisfiability problem[17,22,9,24,8]or on agame-theoretic view where a system must be designed to meet a specification,no mat-ter how an opponent(the environment)behaves[24,1,16,26,29,28,18].The output of these synthesis algorithms are some kind of automata or state-transition graphs.Our goal is a step further toward an implementation by generating Reo code from a given automaton specification.Thus,our contribution is more in the spirit of gate-level hard-ware synthesis from given automata specifications.More precisely,our starting point is a specification of a component connector as a re-lation over timed data streams[10,7],represented by a constraint automaton[5].Con-straint automata are variants of labeled transition systems that operationally describe the maximally parallel data-flow activity through the nodes in a Reo circuit.In[5],con-straint automata are used to provide an operational semantics for coordination mecha-nisms formalized by composition of Reo connector graphs.In a constraint automaton, the states of the automaton represent the possible configurations(e.g.,the contents of the FIFO-channels of the Reo-connector);transitions going out of a state represent data-flow at that state and its effect on the configuration.In this paper we are not primarily concerned with the derivation of(constraint)automata representations from higher-level behavior specifications,such as in temporal logic or relations on timed data streams.Similar derivations,for instance,in thefield of digi-tal circuit design,are well-known.The main contribution of this paper is an algorithm that takes as input a constraint automaton A and produces a Reo connector graph that implements the relation on timed data streams specified by A.This is tantamount tocompiling an automaton down to actual concurrent executable code for a distributed implementation of the coordination behavior specified by that automaton.The rough idea of our synthesis algorithm is as follows.Wefirst transform the au-tomaton A into an equivalent scheduled-data expression which is a slight variant of an ordinaryω-regular expression.We then construct circuits for the atomic expressions and composition operators on Reo circuits that capture the semantics of concatenation, union,and infinity-closures.The major difficulty is the treatment of the atomic ex-pressions that describe a complex“one-step”coordination scenario with possibly data-dependent synchronous and asynchronous behavior.Given an automaton all of whose data constraints are in disjunctive normal form,our algorithm produces a circuit whose size is linear in the length of the given expression.Superficially,compiling constraint automata specifications to Reo circuits seems sim-ple.By analogy,derivation of digital circuits from Mealy automata specifications are well understood.However,constraint automata(and Reo circuits)can exhibit far more complex behavior than digital circuits,including combinations of synchrony and asyn-chrony,and relational,as well as simple(input/output)functional,interdependencies. In the light of this fact,it is far from obvious if synthesis of Reo circuits from constraint automata is possible at all,and if so,whether it can be done efficiently.The rest of this paper is organized as follows.Section2contains a summary of the main features of Reo.Section3recalls the definition of constraint automata and their accepted TDS-languages.In Section4,we show the equivalence of scheduled-data ex-pressions and constraint automata.The construction of a Reo circuit from a given ex-pression is explained in Section5.Section6concludes the paper.The submitted version of this paper contains an appendix which provides an example2Fig.1.Basic channel-types in Reoand a correctness proof for our synthesis algorithm.To meet the length restriction,the appendix can be removed in thefinal version.2A Reo primerReo[3]is a channel-based exogenous coordination model wherein complex coordi-nators,called connectors,are compositionally built out of simpler ones.The simplest connectors in Reo are a set of channels with well-defined behavior supplied by users. Components can instantiate,compose,connect to,and perform I/O operations through connectors.Here,as in[7,5],we do not consider the dynamic creation,composition, and reconfiguration of connectors by components.We restrict our attention to connec-tors that have a static graphical representation as a Reo circuit which coordinates the data-flow through the channels connecting the input/output ports of components. Reo’s notion of channel is far more general than its common interpretation and allows for any primitive communication medium with exactly two ends.The channel ends are classified as source ends through which data enters and sink ends through which data leaves a channel.Although Reo allows for an open-ended set of channel-types with user-defined semantics,for our purposes in this paper,we restrict ourselves to the channel-types shown in Fig.1.The simplest form of an asynchronous channel is a FIFO channel with one buffer cell (called a1-bounded FIFO channel or simply a FIFO1channel).We graphically repre-sent a FIFO1channel by a small box in the middle of an arrow.In the example in Fig.1, the left channel-end is a source,and the right end is a sink.The buffer is assumed to be initially empty if no data item is shown in the box(this is the case in Fig.1).The graph-ical representation of a FIFO1-channel whose buffer initially contains a data element d shows d inside the box.FIFO channels with two or more buffer cells can be produced by composing several FIFO1channels,as for instance,explained in[7,5].A synchronous channel(depicted as a simple solid arrow)has a source and a sink end, and no buffer.It accepts a data item through its source end iff it can simultaneously dispense it through its sink.A lossy synchronous channel(depicted as a dashed arrow) is similar to a synchronous channel,except that it always accepts all data items through its source end.If it is possible for it to simultaneously dispense the data item through its sink(e.g.,there is a take operation pending on its sink)the channel transfers the data item;otherwise the data item is lost.For a synchronousfilter channel,its“pattern”P (for our purposes here,formalized as a set P⊆Data)specifies the type of data items that can be transmitted through the channel.Any value d∈P is accepted through its3source end iff its sink end can simultaneously dispense d;all data items d/∈P are always accepted through the source end but are immediately lost.The P-producer is a variant of a synchronous channel whose source end accepts any data item d∈Data,but the value dispensed through its sink end is always a data element d∈P.More exotic channels permitted in Reo are(a)synchronous drains that have two source ends.Because a drain has no sink end,no data value can ever be obtained from these channels.Thus,a synchronous drain accepts a data item through one of its ends iff a data item is also available for it to simultaneously accept through its other end as well.All data accepted by this channel are lost.An asynchronous drain accepts and loses data items through its two source ends,but never simultaneously.Synchronous and asynchronous spouts are duals of their corresponding drain channel types,as they have two sink ends.A complex connector has a graphical representation,called a Reo circuit,which can be produced by applying certain composition operators to channels.In our setting,where we do not consider dynamic aspects of the Reo language,a Reo-circuit is afinite graph where the nodes are labeled with pair-wise disjoint,non-empty sets of channel ends,and where the edges represent their connecting channels.The set of channel ends coincident on a node A is disjointly partitioned into the sets Src(A)and Snk(A),denoting the sets of source and sink channel ends that coincide on A,respectively.A node is called a source node if Src(A)=/0∧Snk(A)=/0.Analogously,A is called a sink node if Src(A)=/0∧Snk(A)=/0.Node A is called a mixed node if Src(A)=/0∧Snk(A)=/0. In this paper,it suffices to assume that all mixed nodes are hidden.In other words,we abstract away from their names and formalize the behavior of a Reo circuit by means of the data-flow at its sink and source nodes.Intuitively,source nodes of a circuit are analogous to the input ports,and sink nodes to the output ports of a component,while mixed nodes are its hidden internal ponents cannot connect to,read from, or write to mixed nodes.Instead,data-flow through mixed nodes is totally specified by the circuits they belong to.A component can write data items to a source node of a Reo circuit that it is connected to.A write operation succeeds only if all(source)channel ends coincident on the node accept the data item,in which case the data item is transparently written to every source end coincident on the node.A source node,thus,acts as a replicator.A component can obtain data items from a sink node of a Reo circuit that it is connected to through input operations.1A take operation succeeds only if at least one of the(sink)channel ends coincident on the node offers a suitable data item;if more than one coincident channel end offers suitable data items,one is selected nondeterministically.A sink node,thus, acts as a nondeterministic merger.A mixed node is a self-contained“pumping station”that combines the behavior of a sink node(merger)and a source node(replicator)in an atomic iteration of an endless loop:in every iteration a mixed node nondeterministically selects and takes a suitable data item offered by one of its coincident sink channel ends and replicates it into all of its coincident source channel ends.A data item is suitable for selection in an iteration only if it can be accepted by all source channel ends that coincide on the mixed node.baA BFig.2.Exclusive router and shift-lossy FIFO1channelExample 1(Exclusive router and shift-lossy FIFO1channel).Fig.2a.shows an im-plementation of an exclusive router built by composing five synchronous channels,two lossy synchronous channels and a synchronous drain.The intuitive behavior of this cir-cuit is that through its source node A ,it obtains a data item d from its environment and delivers d to one of its sink nodes B or C .If both B and C are willing to accept d then (the merger in the mixed node in the middle of)the exclusive router nondeter-ministically decides to deliver d to either B or C .No data that passes through A can be lost because of the synchronous drain and the two synchronous channels in the middle of the circuit.The synchronous drain ensures that data flow at A is synchronized with data flow through the node at its opposite end.The merger inherent in this mixed node guarantees that at most one of its two coincident synchronous channels transfer data,synchronized with the data flow at either B or C .The circuit in Fig.2.b shows an implementation of a shift-lossy FIFO1channel with source node A and sink node B .This implementation uses four synchronous channels,a synchronous drain,a FIFO1channel whose buffer initially contains a token data item,o ,an empty FIFO2channel,and an instance of the exclusive router of Fig.2.a shown as the box labeled EXR.A shift-lossy FIFO1channel behaves the same as a FIFO1channel,except that writing to its source end is never blocked.If at the time of a write operation its buffer is full,the stored data item in the buffer is lost and the new data item replaces it in the buffer.The observable behavior of each of these Reo circuits is represented by a constraint automaton in Fig.3.Derivation of these constraint automata as compositions of the constraint automata representing the behavior of the individual primitives used in their respective Reo circuits appears in [5]. In spite of its simplicity,the semantics of Reo is indeed very rich,yielding a surpris-ingly expressive language [3].For instance,the relational (as opposed to functional)dependencies that result in “propagation of synchrony”as well as the way in which the local behavior of,e.g.,lossy synchronous channels imposes non-local constraints on a circuit,are already evident in the exclusive router of Fig.2.a.(We use this exclusive router later in this paper in our synthesis of Reo circuits.)Examples of Reo circuits with5more interesting behavior can be found elsewhere [2],and the reader is encouraged to see [27]and [7]for the simple,rich,and expressive formal semantics of Reo.In the remainder of the paper,we discuss the synthesis problem of Reo circuits where the input specification of the desired coordination is given as a constraint automaton ,as defined in the next section.3Constraint automataConstraint automata can serve as an operational model for Reo circuits [5].The states of an automaton represent the configurations of its corresponding circuit (e.g.,the contents of the FIFO channels),while the transitions encode its maximally-parallel stepwise behavior.The transitions are labeled with the maximal sets of nodes on which data-flow occurs simultaneously,and a data constraint (i.e.,boolean condition for the observed data values).We start with a simple example for a constraint automaton that models a component with input port A and two output ports B and C which is modeled by a Reo circuit as shown in the left of the picture below.d C =d B =0B CABC The picture on the right shows the corresponding constraint automaton where we as-sume that only bits 0and 1can be transmitted through the channels.The initial state stands for the configuration where the buffer is empty,while the two other states repre-sent the configurations where the buffer is filled with one of the data items.The outgoing transitions from the initial state are labeled with the singleton set {A }which reflects the fact that in the initial configuration only data-flow at A is possible.If the buffer is filled then data-flow at A is impossible and only B and C can take the value from the buffer.In the sequel,we specify constraint automata using a nonempty and finite set Data con-sisting of data items that can be sent (and received)via channels and a nonempty and finite set N ={A 1,...,A n }of names.Intuitively,we may think of the A i ’s to be the source or sink nodes of a Reo circuit.We refer to the subsets of N as node-sets.Data assignments,data constraints.A data assignment for /0=N ⊆N is a function δ:N →Data .DA (N )denotes the set of all data assignments for N ,and DA the set of all data assignments (on any N ).Data constraints ,which can be viewed as a symbolic representation of sets of data assignments,are formally defined as propositional formu-las built from the atoms “d A ∈P ”and “d A =d B ”,where A ,B ∈N ,d A ,d B ∈Data ,and P ⊆Data .DC (N )denotes the set of data constraints using only names from N ,and DC is a shorthand for DC (N ).We simply write “d A =d ”rather than “d A ∈{d }”.The symbol |=stands for the obvious satisfaction relation which results from interpreting data constraints over data assignments.Satisfiability and logical equivalence ≡of data constraints are defined as usual.6Fig.3.Constraint automata for some basic channels in ReoDefinition2(Constraint automata,[5]).A constraint automaton(over Data)is a tu-ple A=(Q,N,−→,Q0)where Q is afinite set of states,N afinite set of nodes,−→is afinite subset of Q×(2N×DC)×Q,called the transition relation,and Q0⊆Q a−→p instead of(q,N,g,p)∈−→and require nonempty set of initial states.We write q N,gthat(1)N=/0and(2)g∈DC(N)is satisfiable.We call N the node-set and g the guard of the transition.States without any outgoing transition are called terminal. The intuitive meaning of a constraint automaton as an operational model for Reo con-nectors is similar to the interpretation of labeled transition systems as formal models for reactive systems.The sink and source nodes of a Reo connector circuit play the role of the nodes in its corresponding constraint automaton.The states represent the config-−→p is that in configuration urations of the connector.The meaning of a transition q N,gq all the nodes A i∈N perform(synchronously)I/O-operations that meet the guard g, resulting in a new configuration p,while at the same moment there is no data-flow at the other nodes A i∈N\N.Example3(Constraint automata).Constraint automata for the various basic channels types,the exclusive router and shift-lossy FIFO1channel are shown in Figure3(where valid guards have been omitted).The automaton for a FIFO1channel with source A and sink B is the same as the one for the example in the beginning of the section, except that C has to be removed.These automata do not have terminal states as in any configuration dataflow at some nodes is possible.The left part of Fig.4shows the Reo circuit for an initializer,i.e.,a component without input ports(source nodes) and a single output port A init where data-flow at A init happens exactly once.2Thus, if we connect A init with an input port A of another component C via a synchronous channel with source A init and sink A then data-flow at A init activates the data-flow at C but prevents any“restart”of C.The situation is similar for the component“Stop”BComponent“Init”init Component “Stop”init },d A init =0stop }Fig.4.Reo circuits and automata for an initializer and a terminatoron the right of the picture where the source node B stop can put a value into the buffer exactly once,because afterward the buffer is filled forever as no data-flow is possible for an asynchronous drain with both source ends coincident on the same node.Thus,if an output port B of a component C is connected via a synchronous channel with B stop then output at B is possible exactly once.In this sense,component “Stop”can serve to terminate data-flow in other components. In [5],we formalized the semantics of a constraint automaton as a relation on timed data streams.For the purposes of this paper,an equivalent,but simpler concept suffices which abstracts away from time and describes the “traces”of a constraint automaton by scheduled-data streams :finite or infinite sequences of pairs N ,δ ,consisting of a set N of all the nodes that are scheduled to be synchronously (i.e.,atomically)active in the next step,together with a data assignment δ∈DA (N )describing the data values that are input and output.Definition 4(Scheduled-data streams,generated language).A scheduled-data stream Θ=Θ(0);Θ(1);...is a finite or infinite sequence of pairs Θ(i )∈2N ×DC ,denoted by Θ(i )= Θ.N (i ) node-set ,Θ.δ(i ) data assignment,such that Θ.N (i )is a non-empty node-set and Θ.δ(i )a data assignment for Θ.N (i ).We write |Θ|to denote the length of Θ(which can be ω).The empty scheduled-data stream is denoted by ε.SDS N or briefly SDS denotes the set of all scheduled-data streams.Let A =(Q ,N ,−→,Q 0)be a constraint automaton,Θ∈SDS and q a state in A .A q -run for Θin A is a path in Aq =q 0N 0,g 0−−→q 1N 1,g 1−−→q 2N 2,g2−−→...such that (1)q 0=q and (2)either q and Θare infinite or q consists of |Θ|transitions and ends in a terminal state and (3)N i =Θ.N (i ),Θ.δ(i )|=g i for all 0≤i <|Θ|.The generated language L (A )of A is the set of all scheduled-data streams Θ∈SDS which have a q 0-run in A for some initial state q 0∈Q 0. For instance,the SDS-language generated by the automaton for a synchronous channel consists of all infinite scheduled-data streams Θwith Θ.N (i )={A ,B }and where data assignment Θ.δ(i )assigns the same data item to A and B .Although the formal definition of scheduled-data streams does not impose a relation8between the data assignmentsΘ.δ(i),for a given constraint automaton,there can be a link between the data constraintsΘ.δ(i)andΘ.δ(i+1).For instance,the automaton for a FIFO1channel with source node A and sink node B generates the SDS-languageconsisting of all infinite scheduled-data streamsΘwithΘ.N(2i)={A},Θ.N(2i+1)= {B},and withΘ.δ(2i)=[A→d]andΘ.δ(2i+1)=[B→d],for some d∈Data.In[5],we explain how an automaton for a Reo circuit can be constructed in a com-positional way.(For the purpose of this paper,the details of that construction do notmatter.The only thing that we use later,in Section5,is that by applying the above def-inition to the automaton for a Reo circuit R,we obtain an SDS-language L(R)for R.) In what follows we show,conversely,how to construct a Reo circuit from a constraintautomaton.4Scheduled-data expressionsThefirst step of our construction of a Reo circuit from a given automaton is to trans-form the automaton into an equivalentω-regular expression,a so-called scheduled-data expression.These are built byεrepresenting the singleton SDS-language{ε}and the atoms N,g where/0=N⊆N and g is a satisfiable data constraint for N.The SDS-language L( N,g )consists of all scheduled-data streamsΘof length1such that Θ.N(0)=N andΘ.δ(0)|=g.Moreover,we use the standard composition operators; (concatenation),∪(union)and the closure operatorsαω(infinitely many repetitions) andα∞(finite or infinite repetitions).The formal definition of L(α)for composite ex-pressions is defined as for ordinaryω-regular expressions and is omitted here.Similar to the construction of afinite automaton from ordinary regular expressions(see e.g.[20]),we can assign a constraint automaton to any scheduled-data expression that generates the same SDS-language and which is linear in the size of the expression. Since this construction does not play a role in the present paper,its description is omit-ted.Instead,we use the reverse construction,i.e.,of a scheduled-data expression for a constraint automaton.Although to do so,we may apply the standard algorithms for generating(ω-)regular expressions from automata(see e.g.[20]),we suggest here an alternative algorithm.Rather than describing the construction in general,we treat a typ-ical example.Consider the constraint automaton as shown on the left of the following picture where a,b,c are pairs of node-sets with corresponding data constraints.α0=a;α1α1=(b;α0)∪(c;α2)α2=εLetαi denote the scheduled-data expression corresponding to(the SDS-language gen-erated by)state q i,for i=0,1,2.The three transitions of this automaton give rise to three equations for the expressions as shown above.Together,they imply the following equation:α0=(a;b;α0)∪(a;c).This equation can be solved,using the following gen-eral laws for scheduled-data expressions:“ifα=(β;α)∪γandε∈βthenα=β∞;γ”and“ifα=β;αandε∈βthenα=βω”.Applying thefirst law to the equation aboveyields the expressionα0=(a;b)∞;a;c for the state q0.9Fig.5.Structure of the Reo-circuit Rα5From scheduled-data expressions to ReoWe now address the issue of constructing a Reo circuit for a scheduled-data expression α0.Because the source and the sink nodes of a Reo circuit play different roles with respect to its environment,and this distinction is abstracted away in scheduled-data expressions(and constraint automata),wefirst need to identify the“input”and“output”of a circuit by partitioning its node set N.That is,our starting point is a description of a component connector by its input ports C1,...,C n and its output ports D1,...,D m andby(the scheduled-data expressionα0of)a given constraint automaton that specifies the observable dataflow at the C i’s and D j’s.In the sequel,let N={C1,...,C n}∪{D1,...,D m}contain all nodes occurring in the node-sets N of the atoms N,g inα0,where we assume that the C i’s are source nodes and the D j’s are sink nodes.Our goal is the construction of a Reo circuit R with source nodes C1,...,C n and sink nodes D1,...,D m such that L(α0)=L(R).For the construction of R,we use a compositional approach that builds a Reo circuit Rαfor each subexpressionαofα0.Fig.5shows the general structure of Rα:if the source node Aαis fed from outside with some data element,then it is put into the buffer between Aαand˜Aα.As soon as˜Aαtakes the data element from the buffer,the sub-circuit in the middle is“activated”.Similarly,data-flow inside this sub-circuit stops as soon as a data element arrives at˜Bα,which puts it into the buffer between˜Bαand Bα. Thus,data-flow at the sink node˜Bαcan be viewed as a signal that Rαhas“terminated”. The nodes C,D in Fig.5are there to indicate that there will be some channels connect-ing the sub-circuit in the middle of Rαwith(some of)the source nodes C and(some of)the sink nodes D in N.The construction of a circuit R for an expressionα0will be completed by a last step,in which“Init”and“Stop”components,defined in Example3,are added to begin and end the data-flow of in the circuit Rα0,as shown in Fig.6.The construction of the circuit will be such that at any moment,exactly one of the left-most and rightmost buffers or buffers inside Rα0will befilled.Thus,we may considerdata-flow through R as a token game,where the token is passed on from left to right.The reason why we put Rα0in the context of an initializer and a terminator is that thecircuit Rα0allows a“restart”of dataflow at node Aαwhenever˜Aαhas consumed thedata item in the buffer between Aα0and˜Aα.In fact,the initializer ensures that dataflow at Aα0occurs exactly once.The reason for using the stop-component is similar.Concatenation,union and closure.Wefirst explain how to construct a circuit Rα,as-suming we have already constructed the circuits forα’s subexpressions.(If a subex-pressionαoccurs more than once inα0,e.g.ifα0=α;α,then we need a copy of the10。