宫颈癌放疗后复发用FDG-PET检测——肿瘤的容积和FDG摄取值

宫颈癌放疗后复发用FDG-PET检测——肿瘤的容积和FDG
摄取值
Sakurai H.;Suzuki Y.;Nonaka T.;翁梨驹
【期刊名称】《世界核心医学期刊文摘：妇产科学分册》
【年(卷),期】2006(2)6
【摘要】Purpose. We evaluated the use of positron emission tomography (PET) with fluorine- 18- labeled fluoro- 2- deoxy- d- glucose (FDG) in follow- up study after radiation therapy in patients with uterine cervical carcinoma. Materials and methods. Thirty- two studies in 25 patients were reviewed. Twenty patients were treated with external beam irradiation and intracavitary brachytherapy, and five with irradiation following initial surgery. Time frominitial treatment to FDG- PET was 23.3 (5.2- 88.0) months. Rationale for FDG- PET was the presence of symptoms in 6 patients, abnormal serum tumor marker values in 13, abnormal lesions on other diagnostic imaging modalities in 19, and patient request in 2. On visualization of a lesion, the maximum standardized uptake value (maxSUV) of the lesion was calculated, and values over 2.0 were classified as FDG- positive. Maximum tumor diameter and tumor volume in the corresponding disease were estimated by computed tomography (CT) or magnetic resonance imaging (MRI). Results. Sensitivity and specificity of FDG- PET in the detection of recurrent disease were 91.5% (43/47) and 57.1% (4/7), respectively. Four false negative findings were seen for small
lung metastases having a volume less than 1 cm3. Three false- positive cases were a localized pneumonitis, a benign pubic bone fracture,and a fibrosis after interstitial brachytherapy. Sensitivity for extrapelvic lymph node metastases was extremely high (100% ); in contrast, sensitivity and specificity for lung and bone lesions were 75.0% (12/16) and 33.3% (1/3), respectively. Regarding tumor volume measurement, good correlation between maxSUV on FDG- PET and tumor volume was obtained (lung metastases, P = 0.03; extrapelvic nodes, P < 0.0001). Within this study, all corresponding lesions over 1 cm3 showed a maxSUV value greater than 2.0. Conclusion. FDG- PET is a useful tool for the detection of extrapelvic lesions during the follow- up period after radiation therapy for cervical cancer. This study suggests that FDG uptake is associated with tumor volume, and FDG- PET has limitations in the detection of lesions less than 1 cm3 or microscopic disease. Careful diagnostic agreement between PET and CT/MRI for positive but benign lesions, such as inflammation and bone fracture, remains important.
【总页数】2页(P50-51)
【作者】Sakurai H.;Suzuki Y.;Nonaka T.;翁梨驹
【作者单位】Department of Radiation Oncology, Gunma University, Graduate School of Medicine, 3- 39- 22, Showa- machi, Maebashi, Gunma 371- 8511, Japan
【正文语种】中文
【中图分类】R734.2;R734.204
【相关文献】
1.18F-FDG 显像与肿瘤标记物检测用于宫颈癌治疗后的临床监测 [J], 王茜;李原;高平;岳明纲;李河北
2.FDG-PET判断鼻咽癌放疗后复发的临床价值 [J], 林映如;陈应瑞;李伟雄
3.联合检测SCC-Ag和CA125对预测中晚期宫颈癌放疗后复发转移的价值 [J], 杨悦;张翔;高永良;张平
4.125I粒子植入治疗放疗后盆腔局部复发宫颈癌的临床疗效分析及对肿瘤标志物血清SCC-Ag、CEA水平的影响 [J], 纪立秋;郝珊瑚;王治国;张文文;葛香妍;李根;王有超;张国旭
5.MRI和FDG PET/CT对鼻咽癌化疗和放疗后肿瘤残留和(或)复发的检出及“再分期”价值的比较 [J],
oretto;L.Balestreri;E.Borsatti;M.Cimitan;G.Franchin;M.Lise;向贤宏
因版权原因，仅展示原文概要，查看原文内容请购买。