稳定性心绞痛患者血糖水平与循环微小RNA-92a表达关系的研究

稳定性心绞痛患者血糖水平与循环微小RNA-92a表达关系
的研究
王虹;刘伶;龚国平;李友琼;陆红梅;林英忠
【期刊名称】《中华老年心脑血管病杂志》
【年(卷),期】2012(14)12
【摘要】目的探讨稳定性心绞痛(SAP)患者循环微小RNA-92a(microRNA-
92a,miR-92a)表达与血糖的关系.方法将93例SAP患者分为A组:降糖治疗+空腹血糖(FPG)＜7.0 mmol/L 18例,B组:降糖治疗+FPG≥7.0 mmol/L8例,C组:非降糖治疗+FPG＜7.0 mmol/L 61例,D组:非降糖治疗+FPG≥7.0 mmol/L 6例.比较4组患者血糖水平与循环miR-92a表达的关系.结果 SAP患者合并2型糖尿病发病率为34.4％,降糖治疗后,仍有30.8％FPG≥7.0 mmol/L.A组与B组miR-92a 是否＞-0.1或＞0.5水平的OR值分别为2.67或0.17,C组与D组OR值分别为0.36、0.48.A组miR-92a＞-0.1的患者为88.9％,显著高于C组的41.0％(P＜0.01).B组miR-92a＞0.5的患者为75.0％,高于A组的33.3％(P＞0.05).结论单纯测定FPG诊断2型糖尿病漏诊率高.循环miR-92a有助于FPG＜7.0 mmol/L 的SAP合并2型糖尿病的诊断及疗效评价.%Objective To study the relation between blood glucose level and circulating microRNA-92a expression in patients with stable angina pectoris (SAP). Methods Ninety-three SAP patients were divided into hypoglycemic treatment (HT) + fasting plasma glucose (FPG)< 7. 0 mmol/L group(group A,n = 18),HT+FPG≥7. 0 mmol/L group(group B, n= 8) , non-HT + FPG<7. 0 mmol/L group(group
C,n=61),and non-HT+FPG≥7. 0 mmol/L group(group D,n = 6). Relation
between blood glucose level and circulating microRNA-92a expression was compared in 4 groups. Results The incidence of type 2 diabetes
mellitus(DM) was 34. 4% in SAP patients. The FPG level was ≥7. 0 mmol/L in 30. 8% of the patients after HT. The OR value was 2. 67 and 0. 17 respectively in groups A and B,and 0. 36 and 0. 48 respectively in groups C and D. The proportion of patients in group A with their microRNA-92a expression level up-regulated was significantly higher than that of those in group C(88. 9% vs 41. 0%,P<0. 01). The proportion of patients in group B with their microRNA-92a expression level up-regulated(>0. 5) was significantly higher than that of those in group A(75. 0% vs 33. 3% ,P>0. 05). Conclusion The missed diagnosis rate of type 2 DM is high according to the simple FPG level. MicroRNA-92a expression level contributes to the diagnosis of SAP accompanying type 2 DM and to the assessment of its therapeutic effect when the FPG level is <7. 0 mmol/L.
【总页数】4页(P1252-1255)
【作者】王虹;刘伶;龚国平;李友琼;陆红梅;林英忠
【作者单位】530021南宁,广西壮族自治区人民医院心内科;530021南宁,广西壮族自治区人民医院心内科;530021南宁,广西壮族自治区人民医院心内科;530021南宁,广西壮族自治区人民医院中心实验室;530021南宁,广西壮族自治区人民医院心内科;530021南宁,广西壮族自治区人民医院心内科
【正文语种】中文
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