复方丹参注射液对早发型重度子痫前期患者内皮功能及炎症水平的影响

复方丹参注射液对早发型重度子痫前期患者内皮功能及炎症水
平的影响
郭永平;杨冯;王晓静
【期刊名称】《国际妇产科学杂志》
【年(卷),期】2016(043)002
【摘要】Objective:To investigate the effect of compound salvia miltiorrhiza injection on early onset severe pre-eclampsia patients and their neonatals. Methods:Total 130 patients diagnosed with early onset severe pre-eclampsia between March 2013 and March 2015 in Baoji Maternal and Child Care Service Centre were randomly divided into compound salvia miltiorrhiza injection group (67 cases) and control group (63 cases). Control group patients gave spasmolysis, calm, step-down diuresis, appropriate and dexamethasone to promote fetal lung maturity, high-protein low-fat diet routine therapy, salvia miltiorrhiza group patients gave compound salvia miltiorrhiza injection on the basis of control group treatment, both groups of patients were treated with two weeks. Nitric oxide, endothelin-1 (ET-1), TNF-αand IL-6 levels were detected and compared before and after treatment in two groups. And also, the blood pressure before and after the treatment, childbirth neonatal gestational age, postpartum neonatal deaths, quality of the placenta, survival neonatal weight and 1 min Apgar score were compared between two groups. Results:The indicators of the two groups of patients had no statistical
differences before treatment (P>0.05). ET-1, ET-1/NO, TNF-α, IL-6 levels, systolic pressure, diastolic pressure and mean arterial pressure were reduced by two treatment methods in early onset severe pre-eclampsia patients, nitric oxide was elevated significantly (P<0.05). The degree of changes in ET-1, ET-1/NO, TNF-α, IL-6 and nitric oxide in compound salvia miltiorrhiza injection group before and after treatment were greater than control group (P<0.001). Salvia miltiorrhiza treatment group neonatal mortality is lower than the control group, to those who gave live births, childbirth neonatal gestational age was longer in the salvia miltiorrhiza group (P<0.001). Quality of the placenta, neonatal weight, quality of the placenta and 1 min Apgar score in survival subjects were improved in compound salvia miltiorrhiza injection group than control group (P<0.001). Conclusions:Compound salvia miltiorrhiza injection improved prognosis of early onset severe pre-eclampsia patients by mechanism of anti-inflammation and regulation of endothelial function.%目的：探讨复方丹参注射液对早发型重度子痫前期患者及新生儿的疗效。

方法：选取2013年3月—2015年3月于宝鸡市妇幼保健院产科住院患者中符合早发型重度子痫前期诊断标准的患者130例，按照随机数字表法分为丹参组（67例）和对照组（63例）。

对照组患者给予解痉、镇静、降压和适当利尿、地塞米松促进胎肺成熟、高蛋白低脂饮食等常规治疗，丹参组患者在对照组治疗的基础上接受复方丹参注射液治疗，2组患者均治疗2周。

治疗结束后比较2组患者血清一氧化氮（NO）、内皮素1（ET-1）、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）变化的差异；比较2组患者治疗前、后血压以及娩出新生儿孕周、产后新生儿死亡数、胎盘质量、存活新生儿体质量、1 min Apgar评分等指标的差异。

结果：2组患者治疗前各项
指标比较差异均无统计学意义（P＞0.05）；2组患者治疗后血清ET-1、ET-
1/NO、TNF-α和IL-6水平以及收缩压、舒张压和平均动脉压均较治疗前降低，NO水平显著升高（P＜0.05）。

丹参组治疗前后ET-1、ET-1/NO、TNF-α、IL-6的下降程度和NO的升高程度高于对照组（P＜0.001）。

丹参治疗组新生儿病死率低于对照组，在分娩活胎的研究对象中，丹参组患者治疗后分娩孕周长于对照组（P＜0.001），胎盘质量、存活新生儿体质量、胎盘质量和存活新生儿1 min Apgar评分均高于对照组（P＜0.001）。

结论：复方丹参注射液可通过调节内皮细胞功能、发挥抗炎作用而降低早发型重度子痫前期患者血压，且能显著改善娩出新生儿的预后。

【总页数】4页(P234-237)
【作者】郭永平;杨冯;王晓静
【作者单位】721000 陕西省宝鸡市妇幼保健院产科;721000 陕西省宝鸡市妇幼保健院产科;721000 陕西省宝鸡市妇幼保健院产科
【正文语种】中文
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