氟桂嗪对偏头痛患者氧化应激反应的作用

氟桂嗪对偏头痛患者氧化应激反应的作用
Ciancarelli I.;Tozzi Ciancarelli M.G.;Di Massimo C.;A. Carolei;黄卫东
【期刊名称】《世界核心医学期刊文摘：神经病学分册》
【年(卷),期】2005(000)002
【摘要】Prophylactic activity of flunarizine in migraine is attributed to its antioxid ant properties and to the relief of cerebral vasospasm in which nitric oxide (NO ) is involved. We investigated the antimigraine activity of flunarizine and its influence on NO and oxidative marker bioavailability in 25 subjects suffering fr om migraine without aura and in 25 healthy controls. Urinary samples collected b efore and after treatment with flunarizine (5 mg orally per day for 6 months) we re assayed for NO stable metabolites (NOx) and thiobarbituric acid reactive subs tances (TBARS). Urinary levels of NO x and TBARS were higher in migraine suffere rs before treatment than in healthy controls. No differences were observed in NO x levels in migraine sufferers, before and after flunarizine treatment; urinary TBARS levels were decreased after flunarizine treatment (P < 0.05) and remained persistently higher than in healthy controls (P < 0.05). Our results suggest th at flunarizine did not prevent NOmediated vasodilatation, while it proved effect ive in limiting the oxidative reactions occurring in migraine sufferers.
【总页数】1页(P9-9)
【作者】Ciancarelli I.;Tozzi Ciancarelli M.G.;Di Massimo C.;A. Carolei;黄卫东
【作者单位】Department of Neurology;University of L ’Aquila;67100
L’Aqu ila Coppito;Italy Dr.
【正文语种】中文
【中图分类】R747.2
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