BONE MARROW-, RETICULOENDOTHELIAL SYSTEM-, ANDOR
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专利名称：BONE MARROW-, RETICULOENDOTHELIAL SYSTEM-, AND/OR LYMPH NODE-TARGETED
RADIOLABELED LIPOSOMES AND METHODS
OF THEIR DIAGNOSTIC AND THERAPEUTIC
USE
发明人：PILLARSETTY, Naga Vara Kishore,LARSON, Steven M.,LEE, Sang-gyu
申请号：US2017/021092
申请日：20170307
公开号：WO2017/155948A1
公开日：
20170914
专利内容由知识产权出版社提供
摘要：Described herein are liposome-based nanocarriers that selectively target bone marrow, minimize tumor delivery, and maintain high drug concentrations in bone marrow when compared to conventional systemic delivery. The composition of the liposome-based nanocarriers may also be tuned to selectively target lymph nodes and other reticuloendothelial system organs (e.g., spleen, e.g., liver). Also described herein are methods of imaging and mapping the bone marrow and/or other reticuloendothelial system organs using the described liposome-based nanocarriers. These methods provide high resolution non-invasive and quantitative imaging via PET, which offers advantages over conventional imaging/tracking methods. Furthermore, in certain embodiments, the liposome-based carriers are used to stabilize and deliver radioprotectant/free radical scavenger drugs to the bone marrow, thereby protecting the bone marrow from subsequent radiation exposure, thereby limiting the adverse impact of radiation exposure
on the individual.
申请人：MEMORIAL SLOAN KETTERING CANCER CENTER 地址：10065 US
国籍：US
代理人：MONROE, Margo R. et al.
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