左西孟旦在体外循环心脏手术中的心肌保护作用

左西孟旦在体外循环心脏手术中的心肌保护作用
李政;葛圣林;张成鑫
【期刊名称】《安徽医科大学学报》
【年(卷),期】2013(48)6
【摘要】将60例需体外循环下行二尖瓣替换术的风湿性心脏病患者随机分为对照组和治疗组.治疗组应用左西孟旦(LEV)注射液,对照组用等量生理盐水代替LEV注
射液.分别于麻醉诱导前、升主动脉开放后1 h、升主动脉开放后8 h、术后24 h、术后48 h、术后72 h检测血浆中心肌肌钙蛋白I(cTnI)、乳酸脱氢酶(LDH)、磷酸肌酸激酶同工酶(CK-MB)指标,并记录术毕心脏自动复跳率.结果显示在体外循环心
脏手术中应用LEV注射液对心肌缺血再灌注损伤有一定的保护作用.%A total of
60 patients who suffered from rheumatic heart diseases and received valves replacement surgeries were divided randomly into control group and treatment group, 30 patients for each. Patients in treatment group received levosimendan injection, while those of control group received the same volume of physiological saline. The concentration of cardiac troponin I ( cTnI ), lactate dehydrogenase ( LDH ), creatine kinase-MB ( CK-MB ) in plasma level of samples was taken among the following points: before induction of anesthesia, 1 hour after declamping of aorta, 8 hours after declamping of aorta, 24 hours after CPB, 48 hours after CPB, 72 hours after CPB. The recovery rate of heart founction after surgeries was also recorded at the same time. The results suggested that levosimendan injection might
be an effective agent against myocardium injury during valves replacement surgeries with CPB.
【总页数】3页(P698-700)
【作者】李政;葛圣林;张成鑫
【作者单位】安徽医科大学第一附属医院心脏外科,合肥,230022;安徽医科大学第一附属医院心脏外科,合肥,230022;安徽医科大学第一附属医院心脏外科,合
肥,230022
【正文语种】中文
【中图分类】R654.1
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