冠心病患者纤维蛋白原、血栓前体蛋白、高浓度脂蛋白(a)及Copeptin水

[文献标识码] A
[文章编号] 1674-4721渊2019冤9渊a冤-0045-04
Study on the changes and clinical significance of fibrinogen, thrombus precursor protein, high concentration lipoprotein (a) and Copeptin levels in patients with coronary heart disease
FA N Pei-ying Department of Cardiology, Jiangbei People忆s Hospital in Nanjing City, Jiangsu Province, Nanjing 210000, China [Abstract] Objective To investigate the changes and clinical significance of plasma fibrinogen (Fg), thrombus precur鄄 sor protein (TpP), high concentration lipoprotein (a) (LP[a]) and Copeptin in patients with coronary heart disease (CHD). Methods A total of 173 patients with CHD admitted to our hospital from January 2015 to December 2016 were en鄄 rolled as the observation group. Eighty healthy participants in the same period were selected as the control group. In the observation group, patients were divided into single-branch lesion group (n=41), double-branch lesion group (n=87) and multi-branch lesion group (n=45) according to the number of different coronary lesion branches. The clinical data (blood lipid, blood sugar, blood pressure levels) of the two groups were compared. Plasma Fg, TpP, LP (a) and Copeptin levels of the two groups were compared. The levels of plasma Fg, TpP, LP (a) and Copeptin in patients with different coronary lesions were compared. The correlations between plasma Fg, TpP, LP(a), Copeptin levels and Gensini score in the observation group were investigated. Results The levels of triacylylycerol (TG) and total cholesterol (TC) in the serum of the observation group were higher than those of the control group, and the differences were statistically signifi鄄 cant (P<0.05). The level of serum high density lipoprotoin cholesterol (HDL-C) in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). The levels of plasma Fg, TpP, LP(a) and Copeptin in the observation group were higher than those in the control group, the differences were statistically sig鄄 nificant (P<0.05). The levels of plasma Fg, TpP, LP(a) and Copeptin in patients with different coronary lesion branches were compared, single-branch lesion group < double-branch lesion group < multi-branch lesion group, the differences were statistically significant (P<0.05), the plasma levels of Fg, TpP, LP(a), and Copeptin in CHD patient were all posi鄄 tively correlated with Gensini score (r=0.613, 0.557, 0.702, 0.614, P<0.001). Conclusion The levels of Fg, TpP, LP(a) and Copeptin in plasma of CHD patients are higher than those of normal people, and their levels are related to the de鄄 gree of coronary artery disease in patients. [Key words] Coronary heart disease; Fibrinogen; Thrombus precursor protein; High concentration lipoprotein (a); Copeptin
血浆 Fg尧TpP尧LP渊a冤及 Copeptin 水平曰比较不同冠脉病变组患者的血浆 Fg尧TpP尧LP渊a冤尧Copeptin 水平曰考察观察组
患者血浆 Fg尧TpP尧LP渊a冤尧Copeptin 水平与 Gensini 评分的相关性遥 结果 观察组的血清中三酰甘油渊TG冤尧总胆固醇
渊TC冤水平高于对照组袁差异有统计学意义渊P<0.05冤曰观察组的血清高密度脂蛋白胆固醇渊HDL-C冤水平低于对照
中国当代医药 2019 年 9 月第 26 卷第 25 期
窑 心血管疾病 窑
冠心病患者纤维蛋白原、血栓前体蛋白、高浓度脂蛋白（a） 及 Copeptin 水平的变化及临床意义研究
范沛英 南京市江北人民医院心内科袁江苏南京 210000
Байду номын сангаас
[摘要]目的 探讨冠心病渊CHD冤患者血浆中纤维蛋白原渊Fg冤尧血栓前体蛋白渊TpP冤尧高浓度脂蛋白渊a冤[LP渊a冤]及
Copeptin 的变化及临床意义遥 方法 选取 2015 年 1 月~2016 年 12 月我院收治的 173 例 CHD 患者作为观察组袁选
取同期的 80 例健康人群作为对照组遥 观察组中袁根据患者不同冠脉病变支数袁将其分为单支病变组渊n=41冤尧双支
病变组渊n=87冤尧多支病变组渊n=45冤遥 比较两组研究对象的临床资料渊血脂尧血糖尧血压水平冤曰比较两组研究对象的
组袁差异有统计学意义渊P<0.05冤遥 观察组的血浆 Fg尧TpP尧LP渊a冤尧Copeptin 水平高于对照组袁差异有统计学意义渊P<
0.05冤遥 不同冠脉病变支数患者中的血浆 Fg尧TpP尧LP渊a冤尧Copeptin 水平比较袁单支病变组<双支病变组<三支病变
组袁差异有统计学意义渊P<0.05冤遥 CHD 血浆 Fg尧TpP尧LP渊a冤尧Copeptin 水平与患者 Gensini 评分均成正相关关系袁差
异有统计学意义渊r=0.6128尧0.557尧0.702尧0.614袁P<0.001冤遥 结论 CHD 患者血浆中 Fg尧TpP尧LP渊a冤及 Copeptin 的水平
明显高于正常人袁其水平高低与患者冠脉病变程度有关遥
[关键词]冠心病曰纤维蛋白原曰血栓前体蛋白曰高浓度脂蛋白渊a冤曰Copeptin
[中图分类号] R541.4