Miller-Fisher综合征的临床特点(附3例报告)

Miller-Fisher综合征的临床特点(附3例报告)
靳哲;庄建华;杨月嫦;徐瑾;谢雪微;赵忠新
【期刊名称】《临床神经病学杂志》
【年(卷),期】2013(26)4
【摘要】Objective To explore the clinical features of Miller-Fisher syndrome.Methods The clinical data of 3 patients with Miller-Fisher syndrome were analyzed retrospectively.Results There were one male and two female patients in this group,and the range of age was 43 to 56 years old.All the patients were acute onset,and they had antecedent respiratory symptoms.The common manifestations were double vision and unsteadiness; ptosis was in 2 cases,and distal numbness in 1 case.Bilateral ophthalmoplegia,decreased or absent tendon reflex and ataxia were in all the patients ; hypesthesia was in 2 cases,and autonomic dysfunction in 1 case.Examination of cerebrospinal fluid showed albuminocytologic dissociation in 2 cases.Electrophysiological studies showed abnormal H reflex in all the cases.Three cases had a good prognosis after being treated with high dosage of immunoglobulin.Conclusions The main manifestations of Miller-Fisher syndrome are ophthalmoplegia,decrease of tendon reflex and ataxia.And they may have sensory and autonomic
symptoms.Treatment with high dosage of immunoglobulin may be effective.%目的探讨Miller-Fisher综合征的临床特点.方法回顾性分析3例Miller-Fisher综合征患者的临床资料.结果本组男1例,女2例,年龄43～56岁；
均急性起病,且存在前期呼吸道症状.临床表现均有复视及行走不稳,眼睑下垂2例,手足麻木1例.本组均有双侧眼肌麻痹、腱反射减弱(或消失)及共济失调征,有感觉减退2例、自主神经功能障碍1例.脑脊液检查示蛋白-细胞分离2例.神经电生理检查均有H反射异常.经大剂量丙种球蛋白静脉滴注治疗,3例患者均预后良好.结论MFS患者以眼肌麻痹、腱反射减低及共济失调为主要表现,还可伴有感觉和自主神经的症状；大剂量免疫球蛋白治疗的效果较好.
【总页数】2页(P286-287)
【作者】靳哲;庄建华;杨月嫦;徐瑾;谢雪微;赵忠新
【作者单位】200003 第二军医大学附属上海长征医院神经内科;200003 第二军医大学附属上海长征医院神经内科;200003 第二军医大学附属上海长征医院神经内科;200003 第二军医大学附属上海长征医院神经内科;200003 第二军医大学附属上海长征医院神经内科;200003 第二军医大学附属上海长征医院神经内科
【正文语种】中文
【中图分类】R745.43
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