Amplification and Disorder Effects on the Coherent Backscattering in a Kronig-Penney Chain
6.增词法amplification
In the evening, after the banquets, the concerts and the table tennis exhibitions, he would work on the drafting of the final communiqué. 晚上在参加宴会、出席音乐会、观看乒乓球表演之后, 他还得起草最后公报。
backwardness
现代化
必要性
落后状态/落后局面
normalization modification advantage
正常状态
修改方案 有利条件/有利地位/有利之处
remedies
confusion saturation
补救措施/补救方法 混乱局面 饱和状态
measurement
ห้องสมุดไป่ตู้
1. 1 Amplifying Verbs
Tom Canty, born in rags and dirt and misery, what sight is this!?
译文一:啊,汤姆·康第,生在破烂、肮脏和苦难中, 现在这番景象却是多么显赫啊!
译文二:汤姆·康第原来(who was born)生在可怜巴巴 的人家(in misery),穿得破破烂烂(in rags),一身邋 里邋遢(in dirt),现在(what sight is this)换了这身装 束,啊,是何等气派!
This new type of computer is indeed cheap and fine. 这部打字机真是价廉物美。
以貌取人的英语作文
In the contemporary world,the phenomenon of judging people based on their appearance is prevalent and deeply ingrained in society.This practice,often referred to as appearanceism,can lead to a myriad of negative consequences and is a topic that warrants discussion in English composition.Title:The Perils of Judging by AppearanceIntroduction:The essay begins by highlighting the commonality of appearancebased judgments in our daily lives.It sets the stage for a discussion on the importance of looking beyond the surface to understand the true essence of a person.Body Paragraph1:Historical ContextThis section delves into the historical roots of appearanceism,discussing how societal norms and standards of beauty have evolved over time.It also touches upon how these standards have been perpetuated through various forms of media,influencing peoples perceptions and judgments.Body Paragraph2:Psychological ImpactThe essay then examines the psychological effects of being judged by appearance.It discusses issues such as low selfesteem,body image disorders,and the pressure to conform to societal standards.This paragraph also explores the impact on mental health and the potential for discrimination and exclusion.Body Paragraph3:Societal ImplicationsThis part of the essay focuses on the broader societal implications of appearanceism.It discusses how this practice can lead to stereotypes and prejudices,affecting areas such as employment,education,and social interactions.The paragraph also addresses the role of appearance in reinforcing social hierarchies and inequalities.Body Paragraph4:The Power of PerceptionHere,the essay discusses the power of perception and how it shapes our understanding of others.It emphasizes the importance of recognizing the individuality of people and the unique qualities they possess,rather than reducing them to their physical attributes. Body Paragraph5:Personal ExperiencesThe essay could include personal anecdotes or stories that illustrate the impact of appearancebased judgments.These experiences can help to humanize the issue and provide a relatable perspective on the topic.Conclusion:The conclusion summarizes the main points discussed in the essay and reinforces the message that judging people by their appearance is detrimental.It calls for a shift in societal attitudes towards a more inclusive and understanding approach,where individuals are valued for their character and abilities rather than their looks. Recommendations:The essay could end with recommendations for individuals and society as a whole. Suggestions might include promoting selfacceptance,challenging media portrayals,and encouraging open dialogue about the issue of appearanceism.Final Thoughts:The essay concludes with a reflection on the potential for positive change when we choose to see beyond the superficial and embrace the diversity of human experiences and qualities.It leaves the reader with a call to action to contribute to a more empathetic and equitable world.。
芝麻酚通过AMPK信号通路调控巨噬细胞极化减轻脂肪组织炎症
网络出版时间:2023-11-0711:01:21 网络出版地址:https://link.cnki.net/urlid/34.1086.R.20231106.1723.010芝麻酚通过AMPK信号通路调控巨噬细胞极化减轻脂肪组织炎症刘 瞩,程明慧,张劝劝,秦 虹(中南大学湘雅公共卫生学院营养与食品卫生学教研室,湖南长沙 410078)收稿日期:2023-03-27,修回日期:2023-06-29基金项目:国家自然科学基金面上项目(No82073556)作者简介:刘 瞩(1996-),女,硕士生,研究方向:植物化学物与慢性病防治,E mail:liuzhucsu@163.com;秦 虹(1982-),女,博士,教授,博士生导师,研究方向:植物化学物与慢性病防治,通信作者,E mail:qinhong@csu.edu.cndoi:10.12360/CPB202302063文献标志码:A文章编号:1001-1978(2023)11-2082-07中国图书分类号:R 332;R329 24;R364 5;R345 57;R916 4摘要:目的 探讨芝麻酚(sesamol,SEM)对高脂饮食诱导的肥胖小鼠脂肪组织炎症的影响及对脂多糖(lipopolysaccha ride,LPS)诱导的RAW264 7巨噬细胞极化的调控分子机制。
方法 将C57BL/6J小鼠随机分成正常对照组、肥胖模型对照组和SEM干预组。
干预结束后取小鼠血清和脂肪组织,ELISA法测定小鼠血清和脂肪组织中炎症因子、抗炎因子及趋化因子的分泌水平,Westernblot法测定脂肪组织巨噬细胞M1型极化标志物的蛋白表达水平。
以LPS刺激RAW264 7巨噬细胞诱导炎症模型并用SEM进行干预,使用AMPK抑制剂compoundC进行机制探讨和验证,Westernblot法检测巨噬细胞极化标志物及AMPK信号通路相关蛋白表达水平,ELISA法检测巨噬细胞炎症相关因子。
病理生理学名词解释 pothophysiology definition
Pathogenesis 发病学: the development of morbid conditions or of disease; more specifically the cellular events and reactions and other pathologic mechanisms occurring in the development of disease.Fever 发热: elevation of body temperature above the normal (37°C),which is caused by the set-point invrease due to pyrogens.Myocardial stunning 心肌顿抑: its refer to After a short period of myocardial ischemia Necrosis does not occur, But induced the structure, Metabolic and functional changes in the delayed recovery after reperfusion phenomenon, characterized by systolic dysfunction.Hepatic insufficiency 肝功能不全: a failure or partial failure of normal liver function, Various factors caused by liver damage severe damage to liver cells to metabolism, secretion, synthesis, detoxification and immune function in a serious obstacle, the body often jaundice, bleeding, secondary infection, renal dysfunction, encephalopathy.multiple organ dysfunction syndrome MODS 多器官功能障碍综合征: failure of two or more organ systems in a critically ill patient because of a complex and interrelated series of events. Following a significant insult.paradoxical alkaluria 反常性碱性尿: renal tubular acidosis –decrease HCO3 reabsorption or decrease H excretion, hyperkalemia lead to decrease renal H excretion so H in urine decreases, and the urine is alkaline instead of acidic.. paradoxical aciduria 反常性酸性尿: in alkalosis when hypokalemia occurs, renal tubular epithelium cells increase HCO3 reabsorption or increase H excretion so H in urine increases and the urine is acidic instead of alkaline. Autoinfusion 自身输液: Forcing the blood from the extremities, as by the application of a bandage or pressure device, to raise the blood pressure and fill vessels in the vital organs.Acute renal failure ARF急性肾功能衰竭:acute decline of renal function results in disturbances of homeostasis, characterized by azotemia, water electrolytes, acid-base imbalance, usually oliguria.Anion gap(AG) 阴离子间隙: The difference between the sum of cations and anions found in plasma or serum. Calcium overload 钙超载: the abnormal increase of intracellular calcium which causes cell injury.Calcium paradox 钙反常: the restoration of normal calcium concentration followed by transient no calcium perfusion my induce lethal cell injury.Conscious disorder 意识障碍: parenchymal mental disorder in which there is impairment of the ability to maintain a warness of self and environmental to respond tp environmental stimuli.Cyanosis 发绀: a bluish coloration of the skin or mucous membranes, caused by concentration of HB in capillaries>50 g/L.Dead space like ventilation死腔样通气: partial alveolar hypofusion without corresponding decrease of ventilation in pulmonary embolism, DIC, pulmonary arteritis.Disseminated intravascular coagulation DIC弥散性血管内凝血:a pathologic syndrome characterized by the disturbance of the balance of coagulation, anticoagulation and fibrinolytic processes, extensive activation of intravascular coagulation and fibrinolysis causes diffusing formation of microthrombus and bleeding.Eccentric hypertrophy离心性肥大:Hypertrophic growth of the walls of a hollow organ, especially the heart, in which the overall size and volume are enlarged.Edema 水肿: an abnormal accumulation of fluid in cells, tissues, or cavities of the body, resulting in swelling. endogenous pyrogen 内生致热源:the pyrogenic cytokines which can increase the set-point of body temperature released by EP- releasing cells.false neurotransmitter 假性神经递质: a biological amine that can be stored in presynaptic vesicles but that has little or no effect on postsynaptic receptors when released into the synaptic cleft.functional shunt 功能性分流: COPD—ventilation decreases with normal blood flow ---- V/Q<0.84 . the process of venous blood flowing through these units have not been totally arterialized and mixes into arterial blood.heart failure心力衰竭:is the inability of the heart to supply adequate blood flow and generate a cardiac putput sufficient to meet the metabolic demands of the body.hemic hypoxia 血液性缺氧:tissue hypoxia which is caused by HB decrease, degeneration or intoxication, blood becomes depleted of oxygen-carrying chemicals.hypotonic hypoxia低张性缺氧: hypoxia which is caused by decreased PaO2 so HB cant be saturated by O2, CaO2 decrease, O2 supply decrease atmospheric and respiratory hypoxia.Circulatory hypoxia循环性缺氧: hypoxia which caused by decreased blood flow, O2 supply decrease ischemic andcongestive hypoxia.Histogenous hypoxia 组织性缺氧: hypoxia which caused by O2 utilization trouble, ATP↓.hepatic encephalopathy肝性脑病: neuropsychiatric syndrome secondary to severe hepatic disease, Hepatic coma is the final stage of hepatic encephalopathy.hyperthermia 过热: greatly increased body temperature without set-point upwards, thermoregulation is out of control or in barrier.hypertonic dehydration高渗性脱水:the condition with water loss>sodium loss which causes Serum sodium concentration>150mmol/L and the osmotic pressure higher than 310mmol/L.hypotonic dehydration 低渗性脱水:the condition with sodium loss>water loss which causes Serum sodium concentration<135mmol/L and the osmotic pressure lower than 280mmol/L.hypoxia缺氧:the pathological process of the metabolic, functional and structural abnormal changes of tissue cells because they cant obtain enough oxygen or cant fully utilize oxygen.ischemia reperfusion injury 缺血再灌注损伤:reperfusion injury refers to damage to tissue caused when blood supply returns to the tissue after period of ischemia.respiratory acidosis 呼吸性酸中毒:Acidosis that is caused by retention of CO2, due to inadequate pulmonary ventilation or hypoventilation, and that results in a decrease in blood pH unless compensated for by renal retention of bicarbonate.restrictive hypoventilation限制性通气不足: alveolar hypoventilation caused by restrictive expansion of the lung (impaired activity of respiratory muscle, decreased compliance of thorax, decreased compliance of lungs, thorax fluidify or pneumothorax).hyperpolarized blocking 超极化阻滞:when neuromuscular irritability is decreased, the muscle will response less readily to neural stimulation.depolarization block去极化阻滞: Paralysis of skeletal muscle associated with loss of polarity of the motor end plate, as occurs following administration of succinylcholine.no-reflow phenomenon 无复流现象:is the failure of blood to reperfuse an ischemic area after the physical obstruction has been removed or bypassed.compensatory antiinflammatory response syndrome CARS代偿性抗炎反应综合征:heper-inflammatory (SIRS) of the immune system with overshooting release of pro-inflammatory mediators may be followed by an anti-inflammatory response characterized by paralysis of immune competence.pathological process病理过程:a process in which some common regular alterations of function, metabolism and structure take place in many difference diseases, e.g. fever, shock etc.microangiopathic hemolytic anemia 微血管病性溶血性贫血:The fragmentation of red blood cells because of narrowing or obstruction of small blood vessels. Induced by some chronic or sbacute DIC because of mechanical injury of red blood cells blocked in the capillaries.health健康: indicates not only without any evidence of disease but also a state of complete well-beingphysically psychologicallyand socially.Disease致病: is refereed as aberrant manifestation of deregulated homeostasis caused by harmful agents. Cardiogenic shock 心源性休克: shock resulting from inadequate cardiac function, as from myocardial infarction or mechanical obstruction; characteristics include hypovolemia, hypotension, cold skin, weak pulse, and confusion. cardiac insufficiency 心功能不全: inability of the heart to perform its function properly; heart failure.休克shock: a condition of acute circulatory failure due to derangement of circulatory control or loss of circulating fluid, lead tissue perfusion reduced greatly, severe dysfunction of vital organs, cell damage and eventurally death. trade-off hypothesis矫枉失衡学说:argued that pathogens would tend to evolve toward ever decreasing virulence because the death of the host (or even serious disability) is ultimately harmful to the pathogen living inside.stress 应激: nonspecific response to variety of stimuli, mainly with the activation of sympathetic adrenal medulla and hypothalamus pituitary adrenocortical axis.General adaption syndrome 全身适应综合征: an expression for prolonged stress which finally leads to homeostasis disorder and disease.systemic inflammatory response syndrome全身炎症反应综合症:uncontrolled systemic inflammatory responsefollowing severe trauma, infection, shock ,burns etc, self continuous amplification and destruction.Equal pressure point 等压点:the point along airway where the intra-airway pressure equals tp the extra-airway pressure.。
2010考研英语二作文
In the2010Graduate Entrance Examination for English II,the essay topic was likely to focus on a social issue or a personal development topic that would require the examinee to express their views,opinions,and suggestions in a structured and coherent manner.Possible Essay Prompt:Title:The Impact of Social Media on Modern SocietyIntroduction:The essay might begin with an introduction that outlines the prevalence of social media in contemporary society and its growing influence on various aspects of life.Body Paragraph1:The Positive ImpactsEnhanced Communication:Discuss how social media platforms have revolutionized the way people communicate,enabling instant messaging and sharing of information across the globe.Community Building:Elaborate on the formation of online communities that bring together individuals with common interests,fostering a sense of belonging and support.Body Paragraph2:The Negative ImpactsPrivacy Concerns:Highlight the issues of privacy invasion and data misuse that are prevalent with the rise of social media.Impact on Mental Health:Address the potential negative effects on mental health,such as increased anxiety and depression due to social comparison and cyberbullying.Body Paragraph3:Balancing the Use of Social MediaDigital Literacy:Emphasize the importance of digital literacy to help users navigate social media responsibly.Regulation and Guidelines:Suggest the need for stronger regulations and community guidelines to protect users and ensure a safe online environment.Conclusion:Conclude the essay by summarizing the key points and reiterating the significance of finding a balance between the benefits and drawbacks of social media usage.Sample Essay:Social media has become an integral part of modern society,connecting individuals in ways previously unimaginable.While it offers numerous advantages,such as enhancedcommunication and community building,it also presents challenges that need to be addressed.The ability to communicate instantly with people around the world has made social media a powerful tool for sharing ideas and experiences.Furthermore,it has facilitated the creation of online communities where individuals can find support and a sense of belonging,regardless of their geographical location.However,the rise of social media has not been without its drawbacks.Privacy concerns are rampant,with personal data often being collected and used without consent. Additionally,the constant exposure to others curated lives can lead to feelings of inadequacy and contribute to mental health issues such as anxiety and depression.To mitigate these negative impacts,it is crucial to promote digital literacy among users. Understanding how to use social media responsibly and保护自己的隐私is essential. Moreover,platforms must implement stricter regulations and guidelines to ensure a safe and respectful online environment.In conclusion,while social media has undoubtedly transformed the way we interact and connect with one another,it is imperative that we remain vigilant about its potential pitfalls.By fostering digital literacy and advocating for responsible use,we can harness the power of social media while minimizing its adverse effects on society.。
五行音乐干预慢病患者抑郁焦虑及睡眠障碍疗效Meta分析
【临床论著】光明中医2021年5月第36卷第9期CJGMCM May 2021. Vol 36.9• 1369•五行音乐干预慢病患者抑郁焦虑及睡眠障碍疗效Meta分析$刘彦培1吉华星2摘要:目的基于Meta分析评价中医五行音乐对慢病患者焦虑抑郁及睡眠障碍的临床疗效与文献质量,为中医五行音乐参与 慢病管理提供理论依据。
方法查阅中国知网、PubMed等中外文数据库,获取中医五行音乐疗法干预焦虑抑郁及失眠患者的相关 文献,筛选整理后进行Meta分析,对五行音乐治疗焦虑抑郁和失眠的临床效果进行评估。
结果中医五行音乐对焦虑抑郁的干预 效果:干预后观察组的SDS评分改善情况明显优于对照组(Z=7. 6,P<0.00001);观察组SAS评分变化与对照组比较有统计学差 异(2=4. 47,P<0.00001 )。
中医五行音乐对失眠的干预效果:干预后观察组与对照组在PSQI评分上差异有统计学意义(2 = 3.61,P=0.0003)。
所纳入的各项研究之间均存在异质性,且均未提及设盲及ITT分析。
结论中医五行音乐在干预患者焦虑抑 郁症状及睡眠障碍等方面的临床疗效缺乏证据,文献质量有待进一步提高。
可借助大样本随机对照试验,并适当完善评价机制,以提高目前中医五行音乐对照研究的循证证据。
关键词:五行音乐;焦虑抑郁;睡眠障碍;Meta分析doi: 10. 3969/j. issn. 1003-8914. 2021.09. 001 文章编号:1003-8914(2021) -09-1369-05Meta Analysis on the Curative Effect of Five Elements Music Intervention on Depression,Anxiety and Sleeping Disorder in Patients with Chronic DiseaseLIU Yanpei1JI Huaxing2(1. Geriatrics Department, Pinggu Hospital, Beijing Hospital of Traditional Chinese Medicine, Beijing 101200,China;2. General Medicine Department, Dongfang Hospital,Beijing University of Chinese Medicine, Beijing 102600, China) Abstract:Objective To evaluate the clinical effect and literature quality of five elements music of traditional Chinese medicine on anxiety, depression and sleep disorder based on Meta analysis, and to provide theoretical basis for the participation of five elements of traditional Chinese medicine music in the management of chronic disease. Methods Consulting the Chinese and foreign language databases such as China knowledge Network,pubmed and other Chinese and foreign languages,the relevant literatures of traditional Chinese medicine five elements music therapy intervention anxiety, depression and insomnia were obtained, the meta analysis was screened and sorted out, and the clinical effect of the five elements music in the treatment of anxiety, depression and insomnia was evaluated. Results Intervention effect of traditional Chinese medicine five-element music on anxiety and depression :the improvement of SDS score in the observation group after intervention was significantly better than that in the control group ( Z = 7. 6, P < 0. 00001 ). There was a significant difference in SAS score between the observation group and the control group (Z = 4. 47, P <0. 00001). Intervention effect of five elements of traditional Chinese medicine music on insomnia, and there was statistical significance in PSQI score between observation group and control group after intervention (Z =3. 61 , P= 0.0003). Heterogeneity existed among the included studies, and blindness and ITT analysis were not mentioned. Conclusion The clinical efficacy of TCM five elements music in the intervention of anxiety and depression symptoms and sleep disorders in patients is lack of evidence, and the quality of literature needs to be further improved. The large sample randomized controlled trial and appropriate evaluation mechanism can be used to improve the evidence-based evidence of the five elements of traditional Chinese medicine music control study.Key words:five elements music;anxiety and depression;sleep disorder;Meta analysis慢性非传染性疾病[1]主要是以疾病持续时间长、*基金项目:中央高校基本科研业务费专项资金资助项目(N o. 2020- JYB-XJSJJ-048)作者单位:1.北京中医医院平谷医院老年病科(北京101200) ;2.北 京中医药大学东方医院综合内科(北京102600)通讯方式:E-mail:******************机制不确定、健康损害和加重社会负担为特点的一组疾病。
Amplification
Amplification of small electric fields by neurons; implications for spike timing Thomas Radman, Lucas Parra (Member, IEEE), Marom BiksonAbstract— Small (down to 1 mV/mm) electric fields will polarize neurons by only a small amount; for this reason small electric fields have previously been considered to have no physiologically relevant effects. However, here we propose a novel mechanism by which the non-linear properties of single neurons 'amplify' very small electric fields. Specifically, an amplified change in timing of action potential firing (∆T) is inversely proportional to the slope of depolarizing ramp stimulation and proportional to the amount of polarization (∆V) caused by the electric fields: ∆T=∆V/(ramp slope). Thus, when responding to slow depolarizing synaptic input, small electric fields can have significant effects on spike timing. Hippocampal CA1 pyramidal neurons were depolarized with injections of depolarizing current ramps approximating synaptic input. Simultaneously, neurons were polarized by either DC holding currents or extracellular uniform DC electrical fields and the resulting changes in spike timing quantified. Consistent with our hypothesis, the polarization induced by each method was found to affect firing time linearly with the amount of polarization, scaled (amplified) with the inverse of the injected ramp slope consistent with our hypothesis.I.I NTRODUCTIONhough it is well established that electric fields can modulate brain function, many aspects of the interaction of electric fields with nervous tissue remain unclear [1]. In particular the mechanisms by which small (down to 1 mV/mm) electric fields modulate nervous system function needs to be quantified [2]. The study of how small electric fields affect brain function is important for several reasons. First, these studies directly address concerns about the potential risks of human exposure to environmental electro-magnetic fields such as those generated by power-lines and mobile phones. Second, these studies provide insight into the mechanisms by which electric fields generated by the brain itself (as are manifest in the EEG) could 'feed-back' unto the brain and modulate brain function. Lastly, they have practical application in the design of low-intensity brain stimulation devices for the treatment of neurological diseases.Temporal coding is emerging as an important concept of information processing in the central nervous system. While neurons often encode information in their firing rate, the timing of individual action potentials (spikes) has also been shown to carry significant information [3]. Cortical neurons have been identified that fire with an accuracy of a few milliseconds in response to sensory stimuli [4]-[8], in synchrony with overt behavior [9], and in phase with ongoing extracellular field potential oscillations [10], [11].Manuscript received April 24, 2006. This work was supported in part by the Wallace H. Coulter FoundationT. Radman, L. Parra, and M. Bikson are with the Biomedical Engineering Department, City College of the City University of New York, NY 10031 USA (contact: 212-650-6791; fax: 212-650-6727; e-mail: bikson@ ).Here we consider for the first time, how small electric fields, which are in themselves not sufficient to trigger or suppress action potential activation in response to synaptic input, may nonetheless have a profound effect on neuronal information processing through induced changes in spike timing. Specifically, we investigated in CA1 pyramidal neurons, if the neuronal firing time in response to a depolarizing ramp, varies linearly with field induced potential, with a gain factor equal to the inverse of the ramp slope.II.M ETHODSTransverse hippocampal slices (350 µm) were prepared from male Sprague-Dawley rats (125–150 g); anaesthetized with intraperitoneal ketamine (7.4 mg kg-1) and xylazine (0.7 mg kg-1) and killed by cervical dislocation. The slices were stored in a holding chamber submerged in artificial cerebrospinal fluid (ACSF) consisting of (mM): 125 NaCl, 26 NaHCO3, 3 KCl, 1.6 CaCl2, 1.5 MgS04, 1.25 NaH2PO4, and 10 glucose, bubbled with a mixture of 95% O2–5% CO2. After >60 min, slices were transferred to an interface recording chamber at 33°C.Uniform DC electric fields were generated across individual slices by passing current between two parallel electrodes placed on the surface of the ACSF in the interface chamber (Figure 1); the wires were parallel to the direction of perfusate flow. Fields were applied using chlorided Ag wires, 12 mm long and placed 10 mm apart. Field waveforms were generated by a Power 1401 signal acquisition system (Cambridge Electronic Design, Cambridge, UK) and converted to a constant current by a stimulus isolation unit (2200, A-M Systems, Carlsborg, WA, USA). The electric field (mV mm-1) in the chamber was measured by two recording electrodes separated by 1 mm and calibrated to the current passed through the Ag–AgCl electrodes [12]-[14]; the polarity convention used refers to the anode on the Alveus side of the hippocampus.T-+Ag/AgCl uniform field stimulation electrode+-18141062Electric fields were generated across tissue and the resulting potential of a single neuron was monitored. Application of a constant uniform field induced a membrane polarization. As explained, this polarization linearly affected the time to action potential in response to a depolarizing current ramp. The inverse of the ramp slope determined the efficacy of the field to induce this timing change. The polarization of the neuron was dependent on the direction of the field. Consistent with previous reports [14], the magnitude of the polarization was a linear function of field strength (Figure 4A). The steady-state sensitivity (coupling strength) of neurons ranged from 0.06 to 0.22 mV per 1 mV/mm applied uniform field (n =24).Fig. 1. A) Schematic of method for generating uniform extracellular fields across the CA1 region of the hippocampus and method for measuring artifact free transmembrane potential. B) Measured field strength distribution in mV/mm in relation to field generating electrodes.Conventional recording technniques were used to measure activity from the CA1 pyramidal cell region. Intracellular electrodes (70–120 M Ω, pulled on a P-97; Sutter Instruments, Novato, CA, USA) were filled with 3M potassium chloride. The voltage recorded by a field electrode (placed within 50 µm of the impaled neuron) was subtracted from the intracellular potential to obtain the transmembrane voltage and remove the exogenous potential artefact. Depolarizing intracellular current ramps were generated and triggered to halt upon action potential detection. The field waveforms were applied 400 ms before activation of depolarizing intracellular current ramps. The current ramps used (.1-.6nA/S) were selected to ensure a quasi-linear voltage response prior to sodium channel activation. Signals were subtracted, amplified, and low-pass filtered (1–10 kHz) with an Axoclamp-2B (Axon Instruments, Union City, CA, USA) and FLA-01 amplifiers (Cygnus Technology, Delaware Water Gap, PA, USA); digitized and processed using a Power 1401 and Signal software (CED).III. R ESULTSThe novel single neuron amplification mechanism was validated in hippocampal slices. CA1 Pyramidal neurons were slightly polarized by varied levels of DC intracellular holding current and their firing time in response to depolarizing ramps were measured. For each ramp, we determined the change in firing time resulting from a change in DC holding current. In separate experiments, the linear effects of DC electrical field polarization of a single neuron were then quantified and verified to be linear. Finally, current ramps were incorporated into electric field experiments to verify DC holding current timing amplification mechanisms held true for analogous extracellular DC electric field polarizations. A. Validation of Novel Amplification Mechanism Hyper-polarization of the neuron with an increasingly negative DC holding current, incrementally delayed action potential firing time in response to an intracellular ramp (n=10). The change in timing increased with the holding current, and inversely with ramp slope (Figure 2,3). These results show that the membrane dynamics of real CA1pyramidal neurons support the novel single neuron amplification mechanism proposed.B. Effects of Uniform DC Electric FieldsApplied fields could significantly modulate the firing latency of single neurons to intracellular ramp current injection. Fields inducing membrane hyperpolarization delayed action potential initiation while fields inducing membrane depolarization had the opposite effect (Figure 4B). The relationship between AP timing and depolarizing ramp slope, demonstrated for changes in intracellular holding current (Figure 3), was shown to be valid for polarization by extracellular fields (Figure 4).Using a ramp slope of .4 nA/s and 80 repetitions per field magnitude, we observed a significant (p<.05) change in timing under +/- 1 mV/mm field strengths (n=3). It is expected further experimental optimization can be incorporated in future studies of single neurons to resolve the effects of smaller fields on timing.IV. D ISCUSSIONHere we show the effects of electric fields, when coupled with a depolarizing input, affect the timing to firingthreshold. This process results from the non-linear properties of brain cells, and depends on the following: the threshold voltage is not a function of the baseline membrane potential100ms5mVAP Threshold∆T∆T = ∆V / Ramp Slope∆V∆TA) B)Fig. 2. Intracellular recordings of CA1 pyramidal cell response to depolarizing current ramps. A) Response to a .6nA/S intracellular current ramp. B) Response to a .4nA/S intracellular current ramp. In both cases hyperpolarization (∆V) delayed the AP firing time. The change (∆T), is inversely proportional to depolarizing ramp slope, ∆T A < ∆T B ). Action potentials clipped.or the depolarizing ramp slope. This holds if an injected current ramp to a neuron relates linearly to an induced voltage ramp [15], and that a uniform DC electric field has a linear relationship to neuronal polarization. Our previous studies have shown that hippocampal neuron polarization is a quasi-linear function of field magnitude, indicating that even very small extracellular fields will polarize neurons [14].We found that a 1 mV/mm uniform field induced a transmembrane potential change up to ~0.2 mV. Compared to the scale of depolarization necessary to bring a neuron from rest to threshold (~15 mV), these fields were previously considered insignificant with respect to actionpotential initiation. Previous action potential threshold studies identified changes due to electric fields less than 5 mV/mm [16]. Rather than spike generation, here we examined changes in timing, with respect to our novel amplification mechanism. Our results provide a mechanism for the effects on network spike timing previously demonstrated with exogenous uniform fields as low as 0.1 mV/mm [17], [18].In summary, these results demonstrate our hypothesis for magnification of the effect of small electric fields through changes in the timing of action potentials. These results are particularly relevant for situations in which small electric fields are manifest in the brain.A CKNOWLEDGMENTMadeline Lindvall; Chris Leonard of New York Medical College; Denis Paré of Rutgers University; Jack Belgum, Adair Osterle, and Rick Ayer of Sutter Instruments; Tim Bergel and Simon Gray of Cambridge Electronic Design (CED).-10-8-6-4-200.00.20.40.60.8 1.0Slope of Depolarizing Ramp (nA/s)E f f e c t o f P o l a r i z a t i o n o n T i m i n g (s /n A )Fig. 3. The inverse relationship between the ramp slope and the sensitivity to membrane polarization due to negative DC holding current can be summarized in a single plot. Experimental results (“x”) fit directly to the theoretical prediction of a 1/ramp slope timing change per transmembrane polarization. Error bars represent standard error of the slope of a regression line fitting holding current (nA) versus AP timing (s) data.Electric Field Strength (mV/mm)-20A)B)Polarization (mV)42-2-4-5-4-3-2-101234540200-20-40P o l a r i z a t i o n (m V )0.00.20.40.60.81.01.21.41.61.82.0403020100-10-30-40Electric Field Strength (mV/mm)T i m e t o A c t i o n P o t e n t i a l (s e c )Fig. 4. A) Application of a uniform field caused the polarization of a CA1 pyramidal neuron; the magnitude of the polarization was linearly related to the amplitude of the electric field (reported: mean +/- SD). B) Relationship between change in firing time and initial membrane polarization (induced by applied field) for three different ramp slopes. Note that for each ramp slope, the relationship between firing time (∆T) and polarization (∆V) is linear; moreover, the slope of this relationship is inversely related to the ramp slope. The injected current ramp (.4, .5, .6 nA/S) reported as voltage (6.8, 8.5, 10.2 mV/S respectively, scaled by this particular cell resistance of 17.5M Ω). The change in timing for any given membrane polarization increases (is ‘amplified’) as the slope of the ramp is decreased .R EFERENCES[1] Faber DS, Korn H. Field effects trigger post-anodal rebound excitationin vertebrate CNS. Nature . 1983 Oct 27-Nov 2;305(5937):802-4 [2] Parra LC, Bikson M. Model of the effect of extracellular fields onspike time coherence, 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1 - 4 September 2004[3] de Ruyter van Steveninck RR, Lewen GD, Strong SP, Koberle R,Bialek W. Reproducibility and variability in neural spike trains. Science . 1997 Mar 21; 275 (5307): 1805-8.[4] Mainen ZF, Sejnowski TJ. Influence of dendritic structure on firingpattern in model neocortical neurons . Nature . 1996 Jul 25;382(6589):363-6.[5] Trussell LO. S ynaptic mechanisms for coding timing in auditoryneurons. Annu Rev Physiol . 1999;61:477-96.[6]Reinagel P, Reid RC. Temporal coding of visual information in thethalamus. J Neurosci. 2000 Jul 15;20(14):5392-400.[7]Kara P, Reinagel P, Reid RC. Low response variability insimultaneously recorded retinal, thalamic, and cortical neurons.Neuron. 2000 Sep;27(3):635-46.[8]DeWeese MR, Wehr M, Zador AM.Binary spiking in auditory cortex.J Neurosci. 2003 Aug 27;23(21):7940-9.[9]Riehle A, Grammont F, Diesmann M, Grun S. Dynamical changesand temporal precision of synchronized spiking activity in monkeymotor cortex during movement preparation. J Physiol Paris. 2000Sep-Dec;94(5-6):569-82.[10]Harris KD, Csicsvari J, Hirase H, Dragoi G, Buzsaki G. Organizationof cell assemblies in the hippocampus. Nature. 2003 Jul31;424(6948):552-6.[11]Kashiwadani H, Sasaki YF, Uchida N, Mori K. Synchronizedoscillatory discharges of mitral/tufted cells with different molecularreceptive ranges in the rabbit olfactory bulb. J Neurophysiol. 1999Oct;82(4):1786-92.[12]Ghai RS, Bikson M & Durand DM (2000). Effects of applied electricfields on low-calcium epileptiform activity in the CA1 region of rathippocampal slices. J Neurophysiol 84, 274–280.[13]Durand DM & Bikson M (2001).Suppression and control ofepileptiform activity by electrical stimulation: a review. Proc IEEE 89, 1065–1082[14]Bikson M, Inoue M, Akiyama H, Deans JK, Fox JE, Miyakawa H,Jefferys JG. Effects of uniform extracellular DC electric fields onexcitability in rat hippocampal slices in vitro. J Physiol. 2004 May15;557(Pt 1):175-90. Epub 2004 Feb 20.[15]Fricker D, Verheugen J, Miles R (1999).Cell-attached measurementsof the firing threshold of rat hippocampal neurones. J Physiol 517.3,791-804[16]Jefferys JG. Influence of electric fields on the excitability of granulecells in guinea-pig hippocampal slices. J Physiol. 1981;319:143-52. [17]Deans JK, Bikson M, Fox JE & Jefferys JGR (2003). Effects of ACfields at powerline frequencies on gamma oscillations in vitro.Program No. 258.1 2003 Abstract Viewer/Itinerary Planner.Washington DC: Society for Neuroscience On-line[18]Francis JT, Gluckman BJ, Schiff SJ Journal of Neuroscience, 23(19)pp. 7255-7261, 2003。
英语作文关于环境问题
Environmental issues have become a global concern that affects every individual on our planet.The degradation of the environment is a complex problem that requires a multifaceted approach to address.In this essay,we will delve into the various aspects of environmental problems,their causes,and potential solutions.Introduction to Environmental IssuesThe Earths environment is under immense pressure due to human activities.From deforestation and habitat destruction to pollution and climate change,the consequences are farreaching and often irreversible.The loss of biodiversity,the depletion of natural resources,and the disruption of ecosystems are just a few examples of the challenges we face.Causes of Environmental Problems1.Industrialization and Urbanization:The rapid growth of industries and urban areas has led to significant pollution.Factories emit harmful gases and chemicals into the air and water,contributing to air and water pollution.2.Deforestation:The clearing of forests for agriculture,logging,and urban expansion has resulted in the loss of habitats for countless species and the release of carbon dioxide into the atmosphere.3.Overconsumption:The modern lifestyle,characterized by high consumption rates, generates a massive amount of waste,leading to landfill overflow and pollution.4.Agricultural Practices:The use of chemical fertilizers and pesticides in agriculture not only affects the quality of soil and water but also harms the health of humans and wildlife.5.Climate Change:The increase in greenhouse gas emissions,primarily from the burning of fossil fuels,is causing global temperatures to rise,leading to a myriad of environmental problems such as melting ice caps,rising sea levels,and extreme weather events.Effects of Environmental Problems1.Health Impacts:Pollution and climate change can lead to respiratory diseases, heatrelated illnesses,and the spread of vectorborne diseases.2.Economic Consequences:The degradation of the environment can lead to reducedagricultural productivity,loss of tourism revenue due to environmental degradation,and increased costs associated with disaster recovery.3.Social Implications:Environmental issues can lead to conflicts over resources, displacement of communities,and increased social inequality.Solutions to Environmental Problems1.Sustainable Practices:Adopting sustainable practices in agriculture,industry,and urban planning can help reduce the environmental impact of human activities.2.Renewable Energy:Transitioning to renewable energy sources such as solar,wind,and hydroelectric power can significantly reduce greenhouse gas emissions.3.Conservation Efforts:Protecting and restoring natural habitats,as well as implementing conservation programs for endangered species,can help preserve biodiversity.4.Waste Management:Implementing effective waste management strategies,including recycling and reducing waste production,can help mitigate the problem of pollution.5.Public Awareness and Education:Raising public awareness about the importance of environmental conservation and educating individuals on sustainable practices can lead to behavioral changes that benefit the environment.ConclusionAddressing environmental issues is a collective responsibility that requires the cooperation of governments,businesses,and individuals.By understanding the causes and effects of environmental problems and implementing sustainable solutions,we can work towards a healthier and more sustainable future for our planet.It is crucial that we act now,as the consequences of inaction will be felt by future generations and the planet itself.。
amplification
amplificationAmplification: Exploring the Power of EnhancementIntroductionAmplification, in its essence, refers to the process of magnifying or enhancing something in order to make it more prominent or impactful. It is a concept that can be observed in various domains, from technology to communication to artistic expression. Amplification plays a vital role in shaping the world we live in today, as it allows for the expansion and enrichment of ideas, experiences, and phenomena.Technological AmplificationOne of the most evident and pervasive forms of amplification can be found in technology. Advancements in technology over the years have allowed us to amplify our abilities and accomplish feats that were once unimaginable. From the invention of the printing press, which enabled the amplification of knowledge and the spread of information, to modern devices like computers and smartphones that amplifycommunication, technology has drastically transformed the way we live and interact with the world.The amplification of human capabilities can be seen in various fields, such as medicine, where advancements in medical technology have amplified our ability to diagnose, treat, and prevent diseases. Surgeries that were previously considered risky or impossible have now become routine procedures due to the development of surgical tools and techniques that amplify the precision and effectiveness of medical procedures.In addition, the amplification of computing power has revolutionized industries such as data analysis, artificial intelligence, and virtual reality. The ability to process massive amounts of data in real-time has amplified our capacity to understand complex systems and make better-informed decisions. Furthermore, the amplification of virtual reality has opened up new possibilities for enhanced immersive experiences in fields like entertainment, architecture, and education.Communication AmplificationAnother prominent realm where amplification is evident is communication. Throughout history, humans have continually sought ways to amplify their voices and ideas in order to reach a larger audience. The invention of writing amplified human communication by allowing ideas to be recorded and shared across time and space. With the advent of the printing press, this amplification was taken to new heights as books could be mass-produced and distributed, allowing knowledge and information to reach a wider audience.With the rise of the internet and social media, communication amplification has reached unprecedented levels. Individuals have the power to amplify their thoughts and opinions to a global audience with just a few clicks. This has both positive and negative implications, as the amplification of communication has facilitated the spread of both valuable information and misinformation. Therefore, it becomes crucial to cultivate critical thinking skills to navigate the amplified communication landscape and discern between reliable and unreliable sources of information.Artistic AmplificationArtistic expression is another domain where amplification is frequently employed. Artists often amplify certain elementsor aspects of their work to evoke specific emotions or create a more impactful experience for the audience. This amplification can take various forms, such as exaggerating certain features in a painting or sculpture, using dramatic lighting or sound in a performance, or employing poetic devices to intensify the emotional impact of a written work.Amplification in art not only enhances the aesthetic experience but also serves as a tool for social commentary and activism. Artists often amplify marginalized voices, shed light on important social issues, and challenge prevailing narratives through their work. By amplifying stories and perspectives that are often overlooked or silenced, art has the power to raise awareness, provoke thought, and inspire change.ConclusionAmplification is a powerful force that has shaped various aspects of our lives. From technological advancements to communication platforms to artistic expression, amplification has allowed us to enhance our abilities, expand our reach, and create more impactful experiences. However, it is important to recognize that with great amplification comes great responsibility. We must use this power wisely andethically, ensuring that the amplified messages we share contribute positively to the world.。
英语专四作文题目
1.The Impact of Social Media on Modern CommunicationDiscuss the ways in which social media has transformed the way we communicate and the potential consequences of this shift.2.The Role of Technology in EducationExplore how technological advancements have influenced the educational landscape and the benefits and challenges that come with it.3.The Importance of Environmental ProtectionArgue the significance of environmental conservation and the steps that individuals and governments can take to protect our planet.4.The Influence of Cultural Diversity on SocietyExamine how cultural diversity enriches society and the importance of embracing and celebrating different cultures.5.The Challenges of Balancing Work and LifeReflect on the difficulties faced by individuals trying to maintain a healthy worklife balance and suggest possible solutions.6.The Significance of Volunteering in Community DevelopmentDiscuss the role of volunteers in enhancing community welfare and the personal benefits of engaging in volunteer work.7.The Impact of Globalization on Local CulturesAnalyze how globalization affects local cultures,both positively and negatively,and the measures that can be taken to preserve cultural heritage.8.The Ethics of Genetic EngineeringDebate the moral implications of genetic engineering,considering both its potential benefits and the ethical concerns it raises.9.The Role of Public Transportation in Urban PlanningEvaluate the importance of public transportation systems in the planning and development of modern cities.10.The Impact of COVID19on Global Mental HealthDiscuss the psychological effects of the COVID19pandemic on individuals worldwide and the importance of mental health support.11.The Importance of Digital Literacy in the21st CenturyArgue the necessity of digital literacy in todays digital age and how it can be promoted among different age groups.12.The Benefits and Drawbacks of Online LearningCompare the advantages and disadvantages of online education and its potential to transform traditional learning methods.13.The Role of Art in SocietyExplore the various ways in which art contributes to society,from cultural expression to social commentary.14.The Challenges of Climate Change and Sustainable DevelopmentDiscuss the challenges posed by climate change and the importance of sustainable development practices.15.The Impact of Artificial Intelligence on EmploymentConsider the ways in which artificial intelligence is changing the job market and the potential implications for the future of work.16.The Importance of Bilingualism in a Globalized WorldReflect on the benefits of being bilingual in an increasingly interconnected world and the challenges of language learning.17.The Ethics of Animal Testing in Scientific ResearchDebate the ethical considerations surrounding the use of animals in scientific experiments and the alternatives to animal testing.18.The Role of Sports in Promoting Health and WellbeingDiscuss how sports can contribute to physical and mental health and the importance of encouraging sports participation.19.The Impact of Technology on PrivacyAnalyze the ways in which technological advancements have affected personal privacy and the measures that can be taken to protect it.20.The Importance of Critical Thinking in Problem SolvingArgue the significance of developing critical thinking skills for effective problem solving in various aspects of life.。
唐氏综合症英文资料
Down syndrome, or Down's syndrome (primarily in the United Kingdom),[1][2]trisomy 21, or trisomy G, is a chromosomal disorder caused by the presence of all or part of an extra 21st chromosome. It is named after John Langdon Down, the British physician who described the syndrome in 1866. The disorder was identified as a chromosome 21 trisomy by Jérôme Lejeune in 1959. The condition is characterized by a combination of major and minor differences in structure. Often Down syndrome is associated with some impairment of cognitive ability and physical growth, and a particular set of facial characteristics. Down syndrome in a fetus can be identified with amniocentesis during pregnancy, or in a baby at birth.Individuals with Down syndrome tend to have a lower than average cognitive ability, often ranging from mild to moderate developmental disabilities. A small number have severe to profound mental disability. The incidence of Down syndrome is estimated at 1 per 800 to 1,000 births, although it is statistically much more common with older mothers. Other factors may also play a role.Many of the common physical features of Down syndrome may also appear in people with a standard set of chromosomes, including microgenia (an abnormally small chin)[3], an unusually round face, macroglossia[4](protruding or oversized tongue), an almond shape to the eyes caused by an epicanthic fold of the eyelid, upslanting palpebral fissures (the separation between the upper and lower eyelids), shorter limbs, a single transverse palmar crease (a single instead of a double crease across one or both palms, also called the Simian crease), poor muscle tone, and a larger than normal space between the big and second toes. Health concerns for individuals with Down syndrome include a higher risk for congenital heart defects, gastroesophageal reflux disease, recurrent ear infections, obstructive sleep apnea, and thyroid dysfunctions.Early childhood intervention, screening for common problems, medical treatment where indicated, a conducive family environment, and vocational training can improve the overall development of children with Down syndrome. Although some of the physical genetic limitations of Down syndrome cannot be overcome, education and proper care will improve quality of life.[5]CharacteristicsIndividuals with Down syndrome may have some or all of the following physical characteristics: microgenia (abnormally small chin)[3], oblique eye fissures with epicanthic skin folds on the inner corner of the eyes (formerly known as a mongoloid fold[4]), muscle hypotonia (poor muscle tone), a flat nasal bridge, a single palmar fold, a protruding tongue (due to small oral cavity, and an enlarged tongue near the tonsils) or macroglossia[4], a short neck, white spots on the iris known as Brushfield spots,[6] excessive joint laxity including atlanto-axial instability, congenital heart defects, excessive space between large toe and second toe, a single flexion furrow of the fifth finger, and a higher number of ulnar loop dermatoglyphs.Most individuals with Down syndrome have mental retardation in the mild (IQ50–70) to moderate (IQ 35–50) range,[7] with individuals having Mosaic Down syndrome typically 10–30 points higher.[8] In addition, individuals with Down syndrome can have serious abnormalities affecting any body system. They also may have a broad head and a very round face.The medical consequences of the extra genetic material in Down syndrome are highly variable and may affect the function of any organ system or bodily process. The health aspects of Down syndrome encompass anticipating and preventing effects of the condition, recognizing complications of the disorder, managing individual symptoms, and assisting the individual and his/her family in coping and thriving with any related disability or illnesses.[7]Down syndrome can result from several different genetic mechanisms. This results in a wide variability in individual symptoms due to complex gene and environment interactions. Prior to birth, it is not possible to predict the symptoms that an individual with Down syndrome will develop. Some problems are present at birth, such as certain heart malformations. Others become apparent over time, such as epilepsy.The most common manifestations of Down syndrome are the characteristic facial features, cognitive impairment, congenital heart disease(typically a ventricular septal defect), hearing deficits (maybe due to sensory-neural factors, or chronic serous otitis media, also known as Glue-ear), short stature, thyroid disorders, and Alzheimer's disease. Other less common serious illnesses include leukemia, immune deficiencies, and epilepsy.However, health benefits of Down syndrome include greatly reduced incidence of many common malignancies except leukemia and testicular cancer[9]— although it is, as yet, unclear whether the reduced incidence of various fatal cancers among people with Down syndrome is as a direct result of tumor-suppressor genes on chromosome 21,[10]because of reduced exposure to environmental factors that contribute to cancer risk, or some other as-yet unspecified factor. In addition to a reduced risk of most kinds of cancer, people with Down syndrome also have a much lower risk of hardening of the arteries and diabetic retinopathy.[11]Cognitive developmentCognitive development in children with Down syndrome is quite variable. It is not currently possible at birth to predict the capabilities of any individual reliably, nor are the number or appearance of physical features predictive of future ability. The identification of the best methods of teaching each particular child ideally begins soon after birth through early intervention programs.[12]Since children with Down syndrome have a wide range of abilities, success at school can vary greatly, which underlines the importance of evaluating children individually. The cognitiveproblems that are found among children with Down syndrome can also be found among typical children. Therefore, parents can use general programs that are offered through the schools or other means.Language skills show a difference between understanding speech and expressing speech, and commonly individuals with Down syndrome have a speech delay, requiring speech therapy to improve expressive language.[13]Fine motor skills are delayed[14]and often lag behind gross motor skills and can interfere with cognitive development. Effects of the disorder on the development of gross motor skills are quite variable. Some children will begin walking at around 2 years of age, while others will not walk until age 4. Physical therapy, and/or participation in a program of adapted physical education (APE), may promote enhanced development of gross motor skills in Down syndrome children.[15]Individuals with Down syndrome differ considerably in their language and communication skills. It is routine to screen for middle ear problems and hearing loss; low gain hearing aids or other amplification devices can be useful for language learning. Early communication intervention fosters linguistic skills. Language assessments can help profile strengths and weaknesses; for example, it is common for receptive language skills to exceed expressive skills. Individualized speech therapy can target specific speech errors, increase speech intelligibility, and in some cases encourage advanced language and literacy. Augmentative and alternative communication(AAC) methods, such as pointing, body language, objects, or graphics are often used to aid communication. Relatively little research has focused on the effectiveness of communications intervention strategies.[16]In education, mainstreaming of children with Down syndrome is becoming less controversial in many countries. For example, there is a presumption of mainstream in many parts of the UK. Mainstreaming is the process whereby students of differing abilities are placed in classes with their chronological peers. Children with Down syndrome may not age emotionally/socially and intellectually at the same rates as children without Down syndrome, so over time the intellectual and emotional gap between children with and without Down syndrome may widen. Complex thinking as required in sciences but also in history, the arts, and other subjects can often be beyond the abilities of some, or achieved much later than in other children. Therefore, children with Down syndrome may benefit from mainstreaming provided that some adjustments are made to the curriculum.[17]Some European countries such as Germany and Denmark advise a two-teacher system, whereby the second teacher takes over a group of children with disabilities within the class. A popular alternative is cooperation between special schools and mainstream schools. In cooperation, the core subjects are taught in separate classes, which neither slows down the typical students nor neglects the students with disabilities. Social activities, outings, and many sports and arts activities are performed together, as are all breaks and meals.[18]FertilityFertility amongst both males and females is reduced; males are usually unable to father children, while females demonstrate significantly lower rates of conception relative to unaffected individuals.[citation needed] Approximately half of the offspring of someone with Down syndrome also have the syndrome themselves.[19]There have been only three recorded instances of males with Down syndrome fathering children.[20][21]Ethical issuesA 2002 literature review of elective abortion rates found that 91–93% of pregnancies in the United Kingdom and Europe with a diagnosis of Down syndrome were terminated.[34] Data from the National Down Syndrome Cytogenetic Register in the United Kingdom indicates that from 1989 to 2006 the proportion of women choosing to terminate a pregnancy following prenatal diagnosis of Down Syndrome has remained constant at around 92%.[35][36] Some physicians and ethicists are concerned about the ethical ramifications of this.[37] Conservative commentator George Will called it "eugenics by abortion".[38]British peer Lord Rix stated that "alas, the birth of a child with Down's syndrome is still considered by many to be an utter tragedy" and that the "ghost of the biologist Sir Francis Galton, who founded the eugenics movement in 1885, still stalks the corridors of many a teaching hospital".[39] Doctor David Mortimer has argued in Ethics & Medicine that "Down's syndrome infants have long been disparaged by some doctors and government bean counters."[40] Some members of the disability rights movement "believe that public support for prenatal diagnosis and abortion based on disability contravenes the movement's basic philosophy and goals."[41]Medical ethicist Ronald Green argues that parents have an obligation to avoid 'genetic harm' to their offspring,[42]and Claire Rayner, then a patron of the Down's Syndrome Association, defended testing and abortion saying "The hard facts are that it is costly in terms of human effort, compassion, energy, and finite resources such as money, to care for individuals with handicaps... People who are not yet parents should ask themselves if they have the right to inflict such burdens on others, however willing they are themselves to take their share of the burden in the beginning."[43]Peter Singer argued that "neither haemophilia nor Down's syndrome is so crippling as to make life not worth living, from the inner perspective of the person with the condition. To abort a fetus with one of these disabilities, intending to have another child who will not be disabled, is to treat fetuses as interchangeable or replaceable. If the mother has previously decided to have a certain number of children, say two, then what she is doing, in effect, is rejecting one potential child in favour of another. She could, in defence of her actions, say: the loss of life of the aborted fetus is outweighed by the gain of a better life for the normal child who will be conceived only if the disabled one dies."[44]ManagementTreatment of individuals with Down Syndrome depends on the particular manifestations of the disorder. For instance, individuals with congenital heart disease may need to undergo major corrective surgery soon after birth. Other individuals may have relatively minor health problems requiring no therapy.Plastic surgeryPlastic surgery has sometimes been advocated and performed on children with Down syndrome, based on the assumption that surgery can reduce the facial features associated with Down syndrome, therefore decreasing social stigma, and leading to a better quality of life.[45] Plastic surgery on children with Down syndrome is uncommon,[46] and continues to be controversial. Researchers have found that for facial reconstruction, "...although most patients reported improvements in their child's speech and appearance, independent raters could not readily discern improvement...."[47]For partial glossectomy (tongue reduction), one researcher found that 1 out of 3 patients "achieved oral competence," with 2 out of 3 showing speech improvement.[48]Len Leshin, physician and author of the ds-health website, has stated, "Despite being in use for over twenty years, there is still not a lot of solid evidence in favor of the use of plastic surgery in children with Down syndrome."[49]The National Down Syndrome Society has issued a "Position Statement on Cosmetic Surgery for Children with Down Syndrome"[50] which states that "The goal of inclusion and acceptance is mutual respect based on who we are as individuals, not how we look."Alternative treatmentSee also: Alternative therapies for developmental and learning disabilitiesThe Institutes for the Achievement of Human Potential is a non-profit organization which treats children who have, as the IAHP terms it, "some form of brain injury," including children with Down syndrome. The approach of "Psychomotor Patterning" is not proven,[51] and is considered alternative medicine.Role of the professional social workerProfessional social workers have a strong tradition of working for social justice and refusing to recreate unequal social structures. This means going beyond state sponsored practices which merely cater to individual needs. Social work maintains this radical kernel with the objective of transforming society as a whole. Today many social workers internationally have strong connections with social and political movements for the emancipation of the oppressed.The main tasks of professional social workers are case management (linking clients with agencies and programs that will meet their psychosocial needs), medical social work, counseling (psychotherapy), human services management, social welfare policy analysis, community organizing, advocacy, teaching (in schools of social work), and social science research.Professional social workers work in a variety of settings, including: non-profit or public social service agencies, grassroots advocacy organizations, hospitals,agencies, schools, faith-based organizations, and even the military. Other social workers work as psychotherapists, counselors, or mental health practitioners, normally working in coordination with psychiatrists, psychologists, or other medical professionals. Additionally, some social workers have chosen to direct the focus their efforts on social policy or academic research towards the practice or ethics of social work. While the emphasis has varied among these task areas in different eras and countries, some areas have been the subject of controversy as to whether they are properly part of social work's mission.United StatesIn the United States of America, leaders and scholars in the field of social work have debated the purpose and nature of the profession since its beginning in the late 1800s. Workers, beginning with the settlement house movement, have argued for a focus on social reform, political activism, and systemic causes of poverty. Social workers of the Settlement House Movement were primarily young women frommiddle-income families and chose to live in lower-income neighbourhoods to engage in community organizing. These workers sometimes received stipends from charitable organizations and sometimes worked for free. In contrast to the settlement house movement, the friendly visitors were women from middle-income families who visited (but did not reside among) families in lower-income neighbourhoods. Friendly visitors emphasized conventional morality (such as thrift and abstinence from alcohol) rather than social activism.Others have advocated an emphasis on direct practice, aid to individual clients and families with targeted material assistance or interventions using the diagnostic and statistical manual of mental diseases DSM-IV. While social work has been defined as direct, individual practice in the last quarter of the twentieth century, there is a growing resurgence of community practice in social work. Of broad and growing significance are the relationship counseling and Relationship Education movements which seek to assist in interpersonal social skill building which can be of great societal value in promoting marriage and family stability. Relationship education and counseling primarily aid the majority of individuals who are free of pathology or who have found that DSM-IV based services are ineffectual. This majority can benefit from education and exposure to relationship skills that have not otherwisebeen discussed and distributed by social services in this time of weakened family, church, and societal conventions. Another new development in social work is the focus on informatics (Parker-Oliver & Demiris, 2006). For many social workers, the use of any online technology is problematic due to persistent concerns about privacy. However, other social workers recognize that clients are going on line for many purposes. Some schools of social work, such as University of Southern California are offering courses to build informatics skills at the graduate level.Community practice is the new term of art for what used to be known as "macro practice" social work. Community practice includes working for change at the systems level, including human services management (administration, planning, marketing, and program development); community organizing (community development, grassroots organizing, policy advocacy); social policy and politics; and international social development.The National Association of Social Workers(NASW) is the largest and most recognized membership organization of professional social workers in the world. Representing 150,000 members from 56 chapters in the United States and abroad, the association promotes, develops and protects the practice of social work and social workers. NASW also seeks to enhance the well-being of individuals, families, and communities through its work and advocacy.Although membership is generally not required for licensure, NASW survey data give a rough idea of how social workers are employed in the US. According to NASW:Nearly 40% of NASW members say that mental health is their primary practice area. The health sector employs 8% of NASW’s members, and 8% practice in child welfare or family organizations. Six percent of NASW members say school social work is their primary practice area, and another 3% work primarily with adolescents. (NASW, 2005) These figures are significantly confounded by the fact that NASW members are primarily licensed practitioners working in the clinical arena, and the fact that many social workers in the field do not actually hold a degree in social work. NASW is usually concerned with issues like licensing, reimbursement, etc., that are not relevant to child welfare practice, for instance.Within the mental health field, social workers may work in private practice, much like clinical psychologists or members of other counselling professions often do. Social workers are often in the position of recommending the use of psychopharmaceutical agents, though not prescribing them. The increasingly widespread usage of these agents in the U.S. has received little scrutiny by the NASW, despite that fact that these drugs are prescribed far more heavily in the U.S. than anywhere else in the world. Social workers in private practice may take direct payments from clients and may also receive third-party reimbursement from insurance companies or government programs such as Medicaid. Insurance reimbursement for mental health services involves the designation of the recipient of services asmentally ill, or more specifically a label is assigned from the DSM-IV, the diagnostic and statistical manual of mental illness. This assignment, when recorded to an individual's medical history can prove to be a significant impediment to future pursuits. It can raise the cost to the individual for health or nursing home insurance; it can be the basis of denial for life insurance; and it can limit an individual's professional choices, such as in health care, motor vehicle operation, or airplane piloting.Private practice was not part of the social work profession when it began in the late 1800s. It has been controversial among social workers, some of whom feel that the more lucrative opportunities of private practice have led many social workers to abandon the field's historic mission of assisting disadvantaged populations. The private practice model can be at odds with the community development and political activism strains of social work.Social workers in mental health may also work for an agency, whether publicly funded, supported by private charity, or some combination of the two. These agencies provide a range of mental health services to disadvantaged populations in the US.Some social workers are child welfare workers, a role that looms large in the public's perception of social work. This role contributes to a negative view of social work in the U.S., since child welfare authorities can remove abused or neglected children from the custody of their parents, a practice that is fraught with controversy and sometimes with scandalous incompetence. Many child welfare workers in the US do not in fact have social work degrees (though all caseworkers in most states have at least a Bachelor's degree in a related field).Some states restrict the use of the title social worker to licensed practitioners, who must hold a degree in the field. Such restrictions are a high legislative priority of NASW.United KingdomIn the United Kingdom and elsewhere, a social worker is a trained professional with a recognised social work qualification, employed most commonly in the public sector by local authorities.Spending on social services departments is a major component of British local government expenditure.In Social care UK, the title "social worker" is protected by law (since 1 April 2005) and can be used only by people who have a recognised qualification and are registered with the General Social Care Council (in England), the Scottish Social Services Council, the Care Council for Wales (Welsh: Cyngor Gofal Cymru), or the Northern Ireland Social Care Council.The strategic direction of statutory social work in Britain is broadly divided into children's and adults' services. Social work activity within England and Wales for children and young people is under the remit of the Department for Children, Schools and Families while the same for adults remains the responsibility for the Department of Health. Within local authorities, this division is usually reflected in the organisation of social services departments. The structure of service delivery in Scotland is different.Within children services some social workers are child protection workers, a role that looms large in the public's perception of social work. This role contributes to a negative view of social work in the UK since child protection workers for local authorities can remove suspected abused or neglected children from the custody of their parents, a practice that is fraught with controversy and media criticism.In mental health care, social workers can train to become an Approved Mental Health Professional, involved in the application of the Mental Health Act 1983(as amended by the Mental Health Act 2007) in England and Wales. Though now open to other professions, this involves a contributing a social care perspective to Mental Health Act assessments and is predominantly a social worker role.In 2007, the General Social Care Council launched a wide-ranging consultation, in concert with a number of other social care organisations, to agree a clear professional understanding of social work in the UK [1]The topic is “ role of the professional socoal work”.Professional social workers have a strong tradition of working for social justice and refusing to recreate unequal social structures.A professional social worker not only cater to individual needs,but also maintain the transforming society.Today many social workers internationally have strong connections with social and political movementsProfessional social workers work in a variety of settings, including: non-profit or public social service agencies,grassroots advocacy organizations,hospitals,hospices ,community health agencies,schools, faith-based organizations,and military,.The role of social workers is psychotherapists, counselors and mental health practitioners.Meanwhile,some social workers have chosen to direct the focus their efforts on social policy or academic research towards the practice or ethics of social work.The main tasks of professional social workers is case management ,medical social work , counseling ,human services management, social welfare policy analysis ,community organizing ,advocacy ,teaching ,social science research.(以上是原文中的)(以下是我自己写的,你可用可不用)The role of socoal workers require noble spirit of professional ethics ,recognized non-profit professional ,coordinating the relationship betwween the individual and the environment ,utilizing the resources freely ,group collaboration ,helping themselves and helping others ,upholding democracy ,and respecting for individuality. (到时候看答题的篇幅决定这段要不要写)专业英语主楼328 社会政策主楼224 社会福利西二508 社会保障西二410专业英语,4题,全部用英文回答。
脉冲射频治疗带状疱疹后神经痛疗效及影响因素的回顾性分析
•论著•脉冲射频治疗带状疱瘆后神经痛疗效及影响因素的回顾性分析张蓝予溫爽孙涛山东大学附属省立医院疼痛科,济南市 250021通信作者:孙涛,E m a i l:s u n t a o s d p h@163.c o m【摘要】目的回顾性分析脉冲射频治疗带状疱疹后神经痛(P H N)的疗效及影响因素。
方法收集2014年1月至2017年6月期间于山东大学附属省立医院疼痛科行脉冲射频(P R F)治疗的P H N患者79例,年龄>50岁,性别不限,数字等级评分(N R S)S4分,收集患者一般资料、治疗及疗效评价相关资料:比较患者治疗前与治疗后1d,6个月时的N R S,统计6个月时疼痛缓解率,并采用多因素logistic回归分析探讨其影响因素..结果共有P H N患者62例完成研究,年龄为50~87岁,其中男30例,女32例:与治疗前相比,治疗后1d及6个月时患者N R S评分明显降低(P均<0.05);多因素logistic回归分析显示超过6个月的长病程为独立危险因素,持续服药为其有利因素。
结论P R F治疗P H N疗效明确,其中长病程预后差,而持续服用镇痛药物有助于巩固疗效.【关键词】神经痛.带状疱疹后;导管消融术;危险因素DOI: 10.3760/c m a.j.c n l01379-20191101-00072Efficacy and influence factors of pulsed radiofrequency in the treatm ent of patients with postherpeticneuralgia: a retrospective studyZhang Lanyu, Wen Shuang, Sun TaoDepartment of Pain Management, Shandong Provincial Hospital, Jinan City, Shandong Province 250021, ChinaCorresponding author: Sun Tao, Email: suntaosdph@ 【A b stra c t】Objective To retrospectively analyze the efficacy and influence factors of pulsedradiofrequency for postherpetic neuralgia. Methods Seventy-nine patients with postherpetic neuralgia (PHN),aged彡50years o ld,both sex es, N R S彡4 underwent pulsed radiofrequency (PRF) treatment in ihe Department ofPain M anagem ent, Shandong Provincial H ospital from Januar)r2014to June 2017, were analysed. General data,treatment and efficacy evaluation were co llected. VAS was recorded before the treatment, 1clay and 6 monthsafter the treatment. The rem ission rate was calculated, and risk factors were analysed by logistic regressionanalysis. Results Only sixty-two patients with PHN were included according to follow-up criteria, aged 50-87years old, 30 m ales and 32 fem ales. Compared with pre-treatment, NRS was significantly lower at 1day and 6months after the treatment (all P<0.05). Multivariate logistic regression analysis showed that the d iseaseduration of more than 6 months was a risk factor for effectiven ess, and continuous m edication was a favorablefactor. Conclusion PHF is effective for patients with F>H N. and long course of d isea se is a risk factor, andcontinuous m edication is a favorable* factor.【K e y w o rd s】Neuralgia, postherpetic; Catheter ablation; Risk factorsDOI: 10.3760/cm 101379-20191101 -00072带状痕疼后神经痛(p o s t h e r p e t i c n e u r a l g i a, P H N)是带状疮疼(h e r p e s z o s t e r,H Z)最常见的并发症,据P H N诊疗共识编写专家组报道,约9%〜34%的H Z患者会发生P H N、此为神经病理性疼痛中的一种,可表现为持续性的疼痛,也可缓解后再加重。
甲基苯丙胺成瘾者冲动性_心理健康与攻击行为的关联
第 44 卷第 11 期 2023 年 11 月安徽医学Anhui Medical Journal甲基苯丙胺成瘾者冲动性 心理健康与攻击行为的关联宋佩佩 王立金 李勇辉 焦东亮 凌 强[摘 要] 目的 调查甲基苯丙胺成瘾者攻击行为特征,探讨其与冲动性、心理健康的关系,为甲基苯丙胺成瘾者攻击行为的科学管理与预防提供理论依据。
方法 抽取蚌埠强制隔离戒毒所2020年7~12月的男性甲基苯丙胺成瘾者154名和社区的健康对照组65名,采用一般情况调查表和毒品使用情况调查表、Buss-Perry 攻击问卷、Barratt 冲动量表、症状自评量表测量其攻击行为、冲动性及心理健康情况;以攻击行为总分的中位数分为高攻击性组与低攻击性组,比较高攻击性组和低攻击性组的冲动性和心理健康水平;采用Pearson 相关、多元线性回归、中介效应检验等方法分析甲基苯丙胺成瘾者攻击行为与冲动性、心理健康的关系。
结果 甲基苯丙胺成瘾组攻击行为、冲动性、心理健康水平的得分高于健康对照组得分,差异有统计学意义(P <0.05);甲基苯丙胺成瘾者高攻击性组在冲动性、心理健康水平因子得分高于低攻击性组,差异有统计学意义(P <0.05)。
Pearson 相关分析结果显示甲基苯丙胺成瘾者的攻击行为与吸毒时间、冲动性、心理健康得分呈正相关(r =0.187、0.570、0.524,P <0.05),多元线性回归分析显示吸毒时间、冲动性、心理健康水平对攻击行为有显著预测作用(B =0.054、0.484、0.118,P <0.05),运动冲动因子在吸毒时间和攻击性之间起完全中介作用,效应量0.025(t =1.224,P >0.05)。
结论 吸毒时间长、冲动性水平高、心理健康水平低的甲基苯丙胺成瘾者,发生攻击行为的可能性更大。
[关键词]甲基苯丙胺;攻击行为;冲动性;心理健康doi:10.3969/j.issn.1000-0399.2023.11.019Study on the relationship between impulsivity, mental health and aggressive behavior of methamphetamine users disorder SONG Peipei 1,2,3, WANG Lijin 3, LI Yonghui 1,2, JIAO Dongliang 3, LING Qiang 41.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China2.Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China3.School of Mental Health, Bengbu Medical College, Bengbu 233030, China4.Bengbu Compulsory Isolation Treatment Center, Bengbu 233030, ChinaFunding project:Anhui Provincial Health Commission Key Project (No.AHWJ2022a029), Anhui Provincial Department of Education Natural Science Key Project (No.KJ2018A1017), Bengbu Medical College Natural Science Fund Key Project (No.2020byzd022)Correspondingauthor:LIYonghui,******************.cn[Abstract ] Objective To investigate the characteristics of aggressive behavior in methamphetamine addicts and explore its relation⁃ship with impulsivity and mental health, so as to provide theoretical basis for management and prevention of aggressive behavior in metham⁃phetamine addicts. Methods A total of 154 male methamphetamine addicts from a drug rehabilitation center in Anhui from July to December 2020 and 65 healthy control groups in the community were selected. Their aggressive behavior, impulsivity, and mental health were measured using a general situation questionnaire, a drug use questionnaire, a Buss Perry aggression questionnaire, a Barratt impulse scale, and a symp⁃tom checklist; Divide the median score of aggressive behavior into high aggression group and low aggression group, and compare the impulsive and mental health levels of the high aggression group and low aggression group; Pearson correlation, multiple linear regression and Mesomeric effect test were used to analyze the relationship between the aggressive behavior of methamphetamine addicts and their impulsivity and mentalhealth.. Results The scores of aggression (t=5.365, P <0.01), impulsivity (t =4.036,P <0.01) and mental health level (t =3.011,P <0.01) in the· 卫生服务研究 ·基金项目:安徽省卫生健康委员会重点项目(编号:AHWJ2022a029),安徽省教育厅自然科学重点项目(编号:KJ2018A1017),蚌埠医学院自然科学基金重点项目(编号:2020byzd022)作者单位:100101 北京朝阳 中国科学院心理健康重点实验室(中国科学院心理研究所)(宋佩佩,李勇辉) 100049 北京玉泉 中国科学院大学心理学系(宋佩佩,李勇辉) 233030 安徽蚌埠 蚌埠医学院精神卫生学院(宋佩佩,王立金,焦东亮)233030 安徽蚌埠 蚌埠强制隔离戒毒所(凌强)通信作者:李勇辉,******************.cn本文引用格式:宋佩佩,王立金,李勇辉,等.甲基苯丙胺成瘾者冲动性 心理健康与攻击行为的关联[J ].安徽医学,2023,44(11):1368-1373.DOI :10.3969/j.issn.1000-0399.2023.11.0191368第 44 卷第 11 期2023 年11 月安徽医学Anhui Medical Journalmethamphetamine addiction group were higher than those in the control group. The scores of impulsivity (t=7.254, P<0.01) and mental health level (t=6.597, P<0.01) in the high aggression group were higher than those in the low aggression group (P<0.05). The aggressive behavior of methamphetamine addicts was positively correlated with drug duration (r=0.187, P<0.05), impulsivity (r=0.570, P<0.01), and mental health(r= 0.524, P<0.01) scores (P<0.05). Duration of drug use, impulsivity and mental health level were significant predicative factors of aggressive be⁃havior (F=29.944, P<0.001). The motor impulsivity factor plays a complete mediating role between drug use duration and aggression, with an ef⁃fect magnitude of 0.025 (t=1.224, P>0.05). Conclusion Methamphetamine addicts who have been taking drugs for a long time, high levels of impulsivity, and low levels of mental health are more likely to engage in aggressive behavior.[Key words] Methamphetamine;Aggression;Impulsivity;Mental health根据《2022年世界毒品报告》,甲基苯丙胺是苯丙胺类兴奋剂中的常用物质[1]。
急性脑卒中救治规范与流程(英文
the vessel.
Figs show the position of TCD probes and a sample tracing of normal MCA waveform.
TCD Criteria of vasospasm
Vasospasm Mild Severe
Mean blood flow velocity >120 cm/s >180 cm/s
The DWI map demonstrates a small area of diffusion restriction in the right MCA territory consistent with acute infarction. The MTT map demonstrates the infarct penumbra which is larger than the infarct, indicating the presence of salvageable tissue.
- Wada et al. Stroke. 2007;38:1257
- Golstein et al. Neurology. 2007;20;68(12):889-94.
Contrast extravasation predicts mortality in ICH
看脸的时代 英语作文
In the era where appearances seem to hold significant sway over opportunities and social interactions,the phrase the age of looking at faces has become a common critique of societal values.This essay will delve into the implications of this phenomenon,the reasons behind it,and the potential consequences it may have on individuals and society as a whole.The Prevalence of AppearanceFocused CultureIn todays world,the media plays a pivotal role in shaping societal norms and values.The constant exposure to images of celebrities,models,and influencers with seemingly perfect looks has led to a culture where physical attractiveness is often equated with success and happiness.This is evident in various aspects of life,from job recruitment processes,where candidates with more attractive appearances are sometimes favored,to social media platforms,where individuals with aesthetically pleasing profiles gain more followers and opportunities.The Psychological ImpactThe emphasis on physical appearance can have profound psychological effects on individuals.It can lead to low selfesteem and selfworth,especially among those who do not fit the societal standards of beauty.This can result in a range of mental health issues, including anxiety,depression,and body dysmorphic disorder.Moreover,the pressure to conform to these standards can lead to unhealthy behaviors,such as excessive dieting, cosmetic surgery,and the use of beauty products that may have harmful effects on physical health.The Economic ImplicationsThe beauty industry is a multibilliondollar sector that thrives on the insecurities of individuals.From skincare products to fitness programs,the market is flooded with products that promise to enhance ones appearance.This economic drive not only perpetuates the importance of looks but also contributes to the commodification of beauty, where individuals are encouraged to invest in their appearance as a form of selfimprovement and social currency.The Societal ConsequencesThe focus on physical appearance can also have broader societal implications.It can lead to discrimination based on looks,where individuals are judged and treated differently based on their physical appearance.This can manifest in various forms,such asworkplace discrimination,where attractive individuals may be given preferential treatment,or in social settings,where people are more likely to befriend or engage with those who are considered attractive.The Need for ChangeWhile it is natural for humans to be drawn to beauty,the current obsession with appearance is detrimental to both individuals and society.It is crucial to promote a more balanced perspective that values a persons character,skills,and contributions over their physical appearance.This can be achieved through education,media representation,and societal norms that celebrate diversity and individuality.ConclusionIn conclusion,the age of looking at faces is a complex issue that touches on various aspects of society.It is important to recognize the impact this focus on appearance has on individuals and to work towards a society that values people for who they are,rather than how they look.By doing so,we can create a more inclusive and equitable world where everyone is given the opportunity to thrive based on their merits,not their looks.。
他是双相情感障碍英语
他是双相情感障碍英语Bipolar disorder, also known as manic-depressive illness, is a mental health condition characterized by extreme mood swings that include emotional highs (mania or hypomania) and lows (depression). These episodes can significantly impact an individual's ability to function in daily life. Here's a breakdown of the term and its components in English:1. Bipolar: This term refers to the two poles or states thata person with bipolar disorder experiences. The "bi-" prefix indicates two, and "polar" refers to the contrasting nature of these states.2. Manic: This term describes the elevated, expansive, or irritable mood state that is part of bipolar disorder. During a manic episode, individuals may exhibit increased energy, reduced need for sleep, rapid speech, and impulsive or risky behavior.3. Depressive: This term refers to the low mood state, or depression, which is the other pole of the bipolar spectrum. Symptoms can include feelings of sadness, hopelessness, loss of interest in activities, and changes in appetite or sleep patterns.4. Illness: In the context of bipolar disorder, "illness" is used to describe the medical condition, emphasizing its impact on health and daily functioning.5. Mood Swings: This phrase describes the rapid and significant changes in mood that are typical of bipolar disorder. These swings can vary in intensity and duration.6. Emotional Highs: This term refers to the periods of mania or hypomania, where a person feels extremely energetic and may engage in activities that are out of character or risky.7. Lows: This term is often used to describe the depressive episodes, where a person experiences a downturn in mood and energy.Understanding the language surrounding bipolar disorder is important for those who live with the condition, their loved ones, and healthcare professionals. It's also crucial for reducing stigma and promoting accurate information about mental health.。
The Effects of Stress on Mental Health
The Effects of Stress on Mental Health Stress is a common part of life that affects everyone at some point. It can come from various sources such as work, relationships, financial problems, or health issues. While a certain level of stress can be motivating and help individuals perform better, chronic and excessive stress can have detrimental effects on mental health. In this response, we will explore the effects of stress on mental health from different perspectives, including psychological, emotional, and social impacts. From a psychological perspective, chronic stress can lead to the development or exacerbation of mental health disorders such as anxiety and depression. When individuals are constantly under stress, their bodies release stress hormones such as cortisol and adrenaline, which can have a negative impact on the brain. Prolonged exposure to these hormones can disrupt neurotransmitter function and lead to imbalances in the brain, increasing the risk of developing mental health conditions. Additionally, chronic stress can impair cognitive function, leading to difficulties in concentration, memory, and decision-making, further impacting mental well-being. Emotionally, stress can take a toll on an individual's mental health by causing feelings of overwhelm, irritability, and mood swings. The constant pressure and worry can lead to a sense of helplessness and hopelessness, contributing to the development of depressive symptoms. Moreover, individuals under chronic stress may resort to unhealthy coping mechanisms such as substance abuse or unhealthy eating habits, further exacerbating their emotional well-being. The emotional impact of stress can also strain relationships withfamily and friends, leading to social isolation and a lack of support, which are crucial for maintaining good mental health. From a social perspective, theeffects of stress on mental health can be far-reaching. Individuals under chronic stress may experience difficulties in maintaining healthy relationships and may withdraw from social activities, leading to feelings of loneliness and isolation. This social withdrawal can further exacerbate their stress and negatively impact their mental health. Additionally, the impact of stress on mental health canextend to the workplace, leading to decreased productivity, increased absenteeism, and strained work relationships. This can create a vicious cycle of stress and mental health issues, affecting not only the individual but also the broadercommunity and society as a whole. It is important to recognize the signs of stress and its impact on mental health in order to take proactive steps tomitigate its effects. Seeking professional help from mental health professionals such as therapists or counselors can provide individuals with the necessary support and coping strategies to manage their stress and improve their mentalwell-being. Additionally, incorporating stress-reducing activities such as exercise, mindfulness practices, and hobbies into daily routines can help individuals better cope with stress and protect their mental health. In conclusion, the effects of stress on mental health are multi-faceted, impacting individuals psychologically, emotionally, and socially. Chronic stress can lead to the development or exacerbation of mental health disorders, disrupt emotionalwell-being, and strain social relationships. Recognizing the signs of stress and seeking appropriate support and coping strategies are crucial in mitigating its detrimental effects on mental health. By addressing stress and its impact on mental health, individuals can work towards maintaining a healthy and balanced life.。
IBD与结核
Image Studies
Chest X-ray MRI CT Negative can not exclude ITB
Not helpful in discriminating CD from ITB— Cannot detect small calcification within node or masses
Amplification of insertion element IS6110 that is specific for the M. tuberculosis (J Clin Microbiol, 2006)
In situ PCR
(Am J Clin Pathol, 2008)
LOGO
PCR检测肠黏膜结核杆菌DNA的鉴别诊断价值
(Gut, 2007)
Mostly done in children patients, need more for verification
(Gut,2009)
Multi-marker panels
Commercial available panel: ―IBD first-step‖ pANCA and ASCA; Pilot study: anti-OmpW, anti-I2, and ASCA
Change in epidemiology of ITB and CD make it more difficult in discriminating the two diseases
Epidemiology of ITB
Epidemiology of CD
(Am J Gastroenterol,2009)
LOGO
Proteomic approaches for biomarkers
考试压力英语作文
Exam stress is a common phenomenon that affects students of all ages and levels of education.It can manifest in various ways,such as anxiety,sleep disturbances,and a decrease in academic performance.Here are some key points to consider when discussing exam stress in an English composition:1.Causes of Exam Stress:The primary cause of exam stress is the pressure to perform well,often stemming from expectations set by parents,teachers,and society. Additionally,the fear of failure,the need for scholarships,or the desire to secure a place in a prestigious institution can contribute to this stress.2.Effects on Physical Health:Prolonged stress can lead to physical symptoms such as headaches,stomachaches,and fatigue.It can also weaken the immune system,making students more susceptible to illnesses.3.Effects on Mental Health:Exam stress can lead to psychological issues like anxiety disorders,depression,and even panic attacks.It can affect a students selfesteem and confidence,impacting their overall wellbeing.4.Impact on Academic Performance:While some stress can be motivating,excessive stress can negatively affect a students ability to concentrate,recall information,and think critically.This can lead to poor exam performance.5.Coping Strategies:Effective time management,setting realistic goals,and seeking support from friends,family,or counselors can help alleviate exam stress.Regular physical exercise,a balanced diet,and adequate sleep are also essential for maintaining mental health.6.The Role of Educators:Teachers play a crucial role in managing exam stress.They can provide a supportive learning environment,offer study tips,and encourage a balanced approach to preparation.7.The Importance of a Balanced Life:Encouraging students to engage in hobbies,social activities,and relaxation techniques can help them maintain a balanced life.This balance is crucial for managing stress and preventing burnout.8.Techniques for Reducing Stress:Techniques such as deep breathing exercises, meditation,and mindfulness can help students manage their stress levels.Its also beneficial to practice relaxation before and during exams.9.The Perspective on Success:Its important to redefine success beyond exam scores.Encouraging a growth mindset and focusing on learning and personal development can help reduce the pressure associated with exams.10.Conclusion:While some level of stress is inevitable,its essential to recognize the signs of excessive stress and take proactive steps to manage it.By doing so,students can perform to the best of their abilities and maintain their mental and physical health. When writing an essay on exam stress,its important to provide a comprehensive view of the issue,including its causes,effects,and potential solutions.This will help readers understand the complexity of the problem and the importance of addressing it.。
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a r X i v :c o n d -m a t /9710173v 1 [c o n d -m a t .d i s -n n ] 17 O c t 1997Amplification and Disorder Effects on the Coherent Backscattering in a Kronig-Penney Chain of Active Potentials N.Zekri 1,2,H.Bahlouli 1,3and Asok K.Sen 1,41International Center for Theoretical Physics,34100Trieste,Italy.2U.S.T.O.,Departement de Physique,L.E.P.M.,B.P.1505El M’Naouar,Oran,Algerie.3Physics Department,King Fahd University of Petroleum and Minerals,Dhahran 31261,Saudi Arabia.4LTP Division,Saha Institute of Nuclear Physics,1/AF Bidhannagar,Calcutta 700064,India.February 7,2008AbstractWe report in this paper the analytical and numerical results on the effect of ampli-fication on the transmission and reflection coefficient of a periodic one-dimensional Kronig-Penney lattice.A qualitative agreement is found with the tight-binding model where the transmission and reflection increase for small lengths before strongly oscillating with a max-imum at a certain length.For larger lengths the transmission decays exponentially with the same rate as in the growing region while the reflection saturates at a high value.However,the maximum transmission(and reflection)moves to larger lengths and diverges in the limit of vanishing amplification instead of going to unity.In very large samples,it is anticipated that the presence of disorder and the associated length scale will limit this uninhibited growth in amplification.Also,there are other interesting competitive effects between disorder and localization giving rise to some nonmonotonic behavior in the peak of transmission.Keywords:absorption,amplification,transmission,reflection,disorder.PACS Nos.05.40.+j,42.25.Bs,71.55.Jv,72.15.RnIntroductionRecently,there has been a lot of interest in non-hermitian hamiltonians and quantum phase transitions(typically localized to extended wavefunctions)in systems characterized by them. There are in general two classes of problems in this context:one in which the non-hermiticity is in the nonlocal part[1,2]and the other in which it is in the local part[3-8].In thefirst category,one considers an imaginary vector potential added to the momentum operator in the Schrodinger hamiltonian and this is shown to represent the physics of vortex lines pinned by columnar defects where the depinning is achieved[1]by a sufficiently high transverse magnetic field.In the case of a tight-binding hamiltonian,the non-hermiticity is introduced by a directed hopping in one of the directions(or more),and again in this case,it is intuitively clear that delocalization may be obtained in the preferred direction in the presence of randomness in the local potential even in1D.In the second category(non-hermiticity in the local term),an imaginary term is introduced in the one-body potential.It is well-known from textbooks on quantum mechanics that depending on the sign of the imaginary term,this means the presence of a sink(absorber) or a source(amplifier)in the system.It may be noted that this second category does also have a counterpart in classical systems characterized by a Helmholtz(scalar)wave equation as well,where the practical application is in the studies of the effects of classical wave(light)localization due to backscattering in the presence of an amplifying(lasing)medium that has a complex dielectric constant with spatial disorder in its real part[3,6].There is a common thread binding both the problems though,namely that the spectrum for both becomes complex(the hamiltonian being non-hermitean or real non-symmetric),but can admit of real eigenvalues as well.The common property is that the real eigenvalues represent localized states and the eigenvalues offthe real lines extended states.That it is so in thefirst category has been shown in the recent works starting with Hatano and Nelson and followed by others[1,2].For the second category with sources at each scatterer and in the absence of impurities,it seems counter-intuitive that there are localized solutions;but it has been shown in a simple way[8]that the real eigenvalues are always localized. At present,there is no unified analysis of non-hermiticity of both types present.In the rest of thepaper we would be concerned with non-hermitean hamiltonians of the second category only.The interest in amplification effects of classical and quantum waves in disordered media has been strongly motivated by the recent experimental results on the amplification of light [9].The amplification was shown to strongly enhance the coherent backscattering and consequently increases the reflection [1-3].These results on the reflection naturally lead us also to predict an enhancement of the transmission in such amplifying systems (which has not been examined in previous works).However,recently Sen [8]found for periodic systems that the transmission coef-ficient starts increasing exponentially up to a certain length scale where it reaches its maximum,then it oscillates strongly before decaying at larger length scales.The reflection seems to saturate to a constant value and becomes large asymptotically.In this paper,we study in details both analytically and numerically this scaling behavior of the reflection and transmission within the framework of the Kronig-Penney model which differs from the tight-binding one by the fact that it is a continuous multiband model where the bandwidth depends on the potential strength while the tight-binding (TB)framework is a discrete single band model where the bandwidth does not depend on the energy site.We compare the results with those obtained by Sen [8]in the tight-binding model and study the evolution of this behavior with amplification.The competition effect between amplification and disorder is also examined.The ModelWe consider a non interacting electron moving in a periodic system of δ-peak potentials of a complex strength λ=λ0+iηwhere both λ0and ηare constant numbers.By using the Poincare map [10],the Schr¨o dinger equation of this system can be transformed to the following discrete second order equation [11]ψn +1+ψn −1=Ωψn ,(1)where ψn stands for the electron wavefunction at the site n andΩ=2cos(√E )E =2cos(k ),(2)where k is the wave-number.In the passive lattice (λis real)the corresponding wave-number isimaginary in the allowed band(|Ω|≤2)and the wavefunction becomes Bloch like while in the band gap it becomes real and the wavefunction is evanescent.In the case of the active lattice(λis complex)the wave-number becomes complex(k=k s+iγ)and Eq.(2)yields2cos(√E)E=(eγ+e−γ)cos(k s),(3)ηsin(√√E) e ik s e−γ−e ik s eγ 2|ce ik s L e−γL−de−ik s L eγL|2,(6)wherea= e i(k s−√E)e−γ−1 ,(7)b= e−i(k s+√E)eγ−1 ,(8)c=2− e i(k s−√E)eγ ,(9)d=2− e i(k s+√E)eγ .(10) Since we are interested to scan the growing and decaying regions of the transmission coefficient(and also the reflection coefficient)it turns out to be more efficient to write the coefficients c andd as followsc=e−ik sθc eγL0,d=e ik sθd e−γL1,(11) whereL0=ln2 cosh(γ)−cos(k s−√γ,L1=−ln2 cosh(γ)−cos(k s+√γ,(12)andθc,d are real phase parameters,which are expected to contribute to the oscillations of T,and behave linearly inγfor vanishing amplification.The transmission then readsT=4sin2(√|e i(k s L−θc)e−γ(L−L0)−e−i(k s L−θd)eγ(L−L1)|2.(13)Results and DiscussionFrom Eqs.(3and4)the amplification rateγdepends explicitely on the potential strength and the energy.However,since we are interested on the effect ofγon the transmission and reflection,we can,without loss of generality,fix the energy and the real part of the potential. The amplification will then depend on the imaginary part of the potential.In the rest of the text we take E=1andλ0=0except for the disordered case whereλ0is taken to be uniformly distributed in the domain[−W/2,W/2]where W is considered as the disorder strength.The decay of T for an absorbing chain is found from the above equations to be qualitatively similar to that for a disordered chain(withη=0).Thus,nothing particularly interesting takes place for absorbers.But,as we discuss below,in the amplifying chain there is an interesting competition between amplification and disorder in the small length scale regime.So our study below focusses on the amplification whereηmust be positive.For the numerical calculations,it is easier to use ηinstead ofγ.In the limit of smallγwe haveη=−2γ.Infigure1,we show the transmission as a function of the sample length for two different amplifications.It is shown that the transmission grows exponentially up to an oscillatory region where it assumes a maximum value.For much larger lengths the transmission decays exponentially as in the case of an absorbing chain.A similar behavior is shown infigure2for the reflectioncoefficient where in contrast to the transmission,for large lengths the backscattering saturates (instead of decaying)at a high value of the reflection coefficient.This behavior is in a close agreement with that of the TB model[8]with a slight difference in the oscillatory region due to the different dependence ofγonη.This means that this effect is globally model independent. It is also shown from thesefigures that the maximum transmission and reflection increase by decreasingηand shift to higher sample lengths.Indeed,from Eq.(13)we see that when L<L1 the coefficient d becomes dominant and then T behaves as exp(2|γ|L)while at asymptotically large lengths,the coefficient c becomes dominant and the transmission decays as exp(−2|γ|L).In the oscillatory region the two coefficients c and d are of the same order and the length of maximum transmission isL max=1E)E).(14)It is clear from this equation that L max diverges for vanishingγ.However,since the maximum transmission must be naturally unity for a passive medium,T max should not diverge forγexactly equal to zero.Thus there is an infinite discontinuity atη=0which should turn towards afinite discontinuity at afinite disorder W>0.In order to examine the limiting behavior asη→0,let us use a perturbative treatment forη≪1.In this limit k s tends to√E+γ2γ,L1=−ln(4sin2k s)γ2,(17)and the length where this highest peak is obtained is given byL max=ln(γ2/sin2k s)with the proviso that a negative value of L max indicates that the peak is only at L max=0.Obvi-ously this divergence with a discontinuity is a somewhat unexpected behavior of the transmission. This is due to the fact that whenη→0+,L max diverges faster than the amplification length-scale l a=1/γ.ThereforeγL max will also diverge and wheneverγis different from zero(positive),the current grows slowly up to a very large length scale and reaches very high values.One may note that the asymptotic reflection coefficient R(L=∞)also diverges asη→0+and has an infinite discontinuity atη=0.Hence there is an extremely high amplification in the backscattered wave for a very smallη.For example,for a chain withη=10−4,E=1.0,the transmission peak occurs at L max=2.07∗105,and T max=2.87∗1010,and the asymptotic R(L=∞)=1.13∗109which occurs at L>L max.It is also seen from Figs.1and2that the period of the oscillations increases whenγdecreases due to the increase of k s.Before passing on we would like to mention that all the effects discussed above appears qualitatively similarly in the TB model as well.For simplicity, if we take the Fermi energy at the band-center(E=0),then wefind that the maximum peak for transmission occurs at an L max≃1/ηln(8π/η)which clearly diverges with|η|→0and so does T max.However,the high amplitude of the largest peak in the transmission or the asymptotic value of the reflection coefficient even for very small amplification may not be observed experi-mentally since it occurs at very large sizes(see Eq.(18))and the experimental realization of such perfect(disorder-free)systems is very difficult.Disorder,however small,would be present(in such a very large size system)and this may cut down strongly the divergences mentioned above. Now,as soon as one introduces disorder or,rather takes care of the disorder,however small,the question regarding whether we should average or not comes up.On the one hand it is clear that experimentalists work on a typical sample,and not on a hypothetical‘average’sample.On the other hand,it may not be easy to keep a sample in the same state for a long time due to different types of relaxation processes.Thus,the sample may change its characteristic with time if the characteristic under consideration is highly configuration dependent.Below we discuss both the non-averaged and averaged transmission properties.First,we discuss the properties for a particular configuration.For this part,we keep the disorder strength constant at W=1.In Fig.3we show the effect of disorder on the transmission for different imaginary potentials.We see clearly that the disorder destroys the amplification at larger scales and shifts the maximum transmission to smaller lengths.The transmissionfluctuations appearing in Fig.3increase with the amplification(η).As is well known,disorder introduces an exponential decay of the transmission with a rateγdis=W2/96E[12]where E is the energy of the incoming electron andγdis is the Lyapunov exponent due to the disorder.Stated differently, disorder introduces the localization lengthξdis=1/γdis into the problem.For a smallη,the length L max up to which the exponential growth occurs in pure systems may be much larger thanξdis. So,in general,the transmission starts decaying due to disorder effects before it gets the maximal amplification due to a non-zeroη.Therefore,the divergence in T max observed in periodic systems disappears with the included disorder as shown in the Fig.4.For very smallη,T max tends to the trivial constant value of unity with L max=0.But we have to remember that forξdis<L<L max (for pure systems),there is afine competition between the amplification-dependent growth and disorder-dependent decay which affects the transmission sensitively in this regime.As given by the above formula,for W=1,ξdis≃100.Yet,indeed,there is a non-monotonic behavior at much larger lengths corresponding to some compensation between disorder and amplification.For η≃10−3,the transmission in general decays for L>ξdis but only to pick up again at a still larger L,and one observes a peak of T max(for the particular disorder configuration in Figs.3 and4))at L≃260.This transmission peak seems to correspond to one of the Azbel resonances that becomes sensitively amplified by a tuned value ofη≃10−3.We have actually checked that this resonance peak T max occurs at the same L max but becomes weaker both by increasing or by decreasingηaround0.001as shown in Fig.4and thus T max has a peak close to this special value of 0.001for this particular configuration.In particular,if we decreaseη→10−6,the peak remains at L max≃260while T max→1continuously.Forη<10−6,the(local)peak transmission at L≃260 becomes less than unity and hence the global T max=1(trivial constant)and L max jumps back to the trivial value of zero discontinuously(see the insert of Fig.4).Further,as expected,we foundthat in other configurations,the peak in T max at the special value ofη≃10−3as shown in Fig.4 does not exist.Next we discuss the characteristics of averaged samples.The question of what quantity to average becomes crucial now.In Fig.5,we choose E=1,W=0.01andη=0.1and show the transmission as a function of L(in semi-log plot)by averaging in(a)the quantity T itself, and in(b)the quantity ln T.For comparison we have also shown the case without disorder by dashed lines.The full line is the result of averaging with100configurations and the dotted line is the same for10000configurations in both the cases.Whereas in Fig.5(a)the average with10000 configurations lies higher than that with100configurations(both of them larger than the pure case as well!),the logarithmic average shown in Fig.5(b)is much more well-behaved in every respect. The results shown here are consistent with the fact that all the moments of the transmission and reflection diverge in the amplifying case[4,5].So,we restrict ourselves to logarithmic averaging. In the Fig.6,we show such averaged T max for two differentη’s(0.01with open squares,and0.1 with crosses).To show both the cases with very different T max’s we have normalized both of them by their values for the pure case.Now,one expects that the nonmonotonic behavior as seen above should disappear since the Azbel resonances disappear on averaging.But,interestingly enough thefine tuning between disorder and amplification is still at work,and some nonmonotonic effects still survive.We have shown in the inset of Fig.6the magnified view of the y-axis around1.Now wefind that for the case ofη=0.1,there are some values of disorder W around0.01where the T max is somewhat larger than its value for the pure case.Further,we could notfind such an interesting non-monotonic behavior for the case ofη=0.01after a lot of search,which means that even if it is there it is probably very weak or lies in an extremely narrow region for this case. In any case,Fig.6shows amply that thefine tuning between disorder and amplification may lead to quite interesting and unexpected results.ConclusionWe have studied in this paper,within the framework of the Kronig-Penney model,the effect of amplification on the transmission and reflection of a periodic system.The behaviorshown is in a close agreement with that shown in the tight-binding model[8].Therefore,this effect seems to be model independent.However,this result means that diverging transmission will be obtained at very large sample sizes for vanishing amplification while in a passive system the transmission and reflection do not exceed one.This limiting effect is due to the divergence of the maximum transmission length faster than1/γ.This effect is probably experimentally irrealizable since large periodic samples cannot be growth without disorder which can destroy this divergence.Indeed,we found that the maximum transmission decreases when amplification decreases and tends to sature at one for vanishingγ.A peak atη=0.001appears and seems to correspond to the compensation between disorder and amplification.However,the decay of the transmission is slower for smaller amplification leading to the delocalization of the electronic states. However,the compensation effect leading to some of the non-monotonic behavior in Fig.4persist by averaging in Fig.6and remain not well understood.Therefore they should be extensively examined.Also the generalization of this study to different electron energies and non-zero real parts of the potential(λ0)is necessary since the bandwidth depends on the scattering potential in this model.On the other hand,for a further understanding of the surprising amplification effect on the periodic system,it is interesting to study the amplification effect on the resonant tunnelling in a simple system of a double barrier which can give us a basis for the periodic system. //AcknowledgmentsWe would like to acknowledge the hospitality of the I.C.T.P.during the progress of this work.H.B.also acknowledges the support of the physics department at K.F.U.P.M..References[1]N.Hatano and D.R.Nelson,Phys.Rev.Lett.77,570(1996);see preprint cond-mat/9705290for further details.[2]Y.V.Fyodorov,B.A.Khoruzhenko and H.-J.Sommers,Phys.Rev.Lett.79,557(1997);R.A.Janik,M.A.Nowak,G.Papp and I.Zahed,preprints cond-mat/9612240,9705098;J.Feinberg and A.Zee,preprint cond-mat/9703087,Nucl.Phys.B(to appear);E.Brezin andA.Zee,preprint cond-mat/9708029and references therein.[3]P.Pradhan and N.Kumar,Phys.Rev.B50,9644(1994).[4]V.Freilikher,M.Pustilnik,and I.Yurkevich,Phys.Rev.Lett.73,810(1994);V.Freilikher,M.Pustilnik,and I.Yurkevich,preprint cond-mat/9605090.[5]C.W.Beenakker,J.C.J.Paasschens and P.W.Brouwer,Phys.Rev.Lett.76,1368(1996).[6]Z.Q.Zhang,Phys.Rev.B52,7960(1995).[7]A.K.Gupta and A.M.Jayannavar,Phys.Rev.B52,4156(1995).[8]A.K.Sen,Mod.Phys.Lett.B10,125(1996).[9]A.Z.Genack and D.M.Drack,Nature368,400(1994);wandy,R.M.Balachandran,A.S.L.Gomes,and E.Sauvin,Nature368,436(1994);D.S.Wiersma,M.P.van Albadaand gendijk,Phys.Rev.Lett.75,1739(1995).[10]J.Bellisard,A.Formoso,R.Lima and D.Testardi,Phys.Rev.B26,3204(1982).[11]Z.Okbani,R.Ouasti and N.Zekri,Physica A234,38(1996).[12]C.M.Soukoulis,J.V.Jose,E.N.Economou and P.Sheng,Phys.Rev.Lett.50,764(1983).Figure CaptionsFig.1Transmission coefficient versus the sample size L forη=0.05(solid curve)and0.1 (dashed curve).Fig.2Reflection coefficient versus the sample size L for the same parameters as in Fig.1.Fig.3T versus L for a disordered lattice ofλ0uniformly distributed between-1/2and1/2 (W=1)andη=0.1(solid curve)0.01(dashed curve)and10−7(dotted curve).Fig.4T max versus(η)for the same configuration of the random real potential as in Fig.3. The insert shows the corresponding length at the maximum transmission(L max)as a function of (η).The dashed curve is only a guide for the eyes.fig.5Transmission versus length for E=1,W=0.01andη=0.1for an averaging over100 samples(solid curve),over10000samples(dotted curve)and without disorder(dahsed curve).(a) averaging the quantity T itself,(b)averaging ln(T).fig.6The normalized-averaged maximum Transmission T max versus disorder forη=0.1(cross ’+’)andη=0.01(open squares).The inset shows a blown up y-axis region between0.99and 1.01.FIGURE 1T r a n s m i s s i o n Sample sizeFIGURE 2R e f l e c t i o nSample sizeFIGURE 3T r a n s m i s s i o n c o e f f i c i e n tSample size101010101010101010101101001000FIGURE 4T m a xη02000.0010.010.1110100100010000aLengthFIGURE 5T r a n s m i s s i o n 0501001502000.0010.010.11101001000b101010101010100.00.20.40.60.81.0FIGURE 6N o r m a l i z e d T m a x Disorder (W)。