Differential Proteomic Analysis of Endometriosis
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Differential Proteomic Analysis of Endometriosis ZHANG Li-hui;LIU Hong-yan;LI He-lian;ZHAN
【期刊名称】《高等学校化学研究：英文版》
【年(卷),期】2010(000)001
【摘要】Differential proteins expressing in ectopic and eutopic endometria were investigated by means of proteomic analysis. Five patients in secretary phase were diagnosed as endometriosis by laparoscopy. The five ectopic endometria(two at stage Ⅱ, two at stage Ⅲ and one at stage IV) and five eutopic endometria were surgically excised. One-dimensional electrophoresis coupled with liquid chromatography and mass spectrometry was used to screen and identify differential proteins. Three differential bands in one-dimensional electrophoresis were resolved by liquid chromatography and mass spectrometry and 14 up-regulated proteins were identified, including collagen α-1, α-2, α-3(VI), α-1(XIV) chain, actin, annexin A2, EMILIN-1, ferritin light polypeptide variant, fucosyltransferase 10, myosin-9, protein S100-A9, KIAA1783 protein, and two hypothetical proteins. Our data provides a list of potential biomarkers for endometriosis. The identifications may be used to develop new diagnoses for endometriosis.
【总页数】5页(P70-74)
【关键词】子宫内膜异位症;蛋白质组;差异分析;液相色谱;蛋白质表达;生物标志物;胶原蛋白;肌动蛋白
【作者】ZHANG Li-hui;LIU Hong-yan;LI He-lian;ZHAN
【作者单位】Department;of;Gynecology;
＆;Obstetrics;Department;of;Thoracic;Surgery;Department;of;Pathology,;the ;Second;Hospital;of;Jilin;University,;Changehun;130041,;P.;R.;China
【正文语种】中文
【中图分类】Q579.13
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