INHIBITION OF CYTOKINE PRODUCTION
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专利名称：INHIBITION OF CYTOKINE PRODUCTION 发明人：EAGLES, Peter, Anthony, Minter,ZHENG, Richard, Qihao
申请号：EP99902654.5
申请日：19990120
公开号：EP1049773B1
公开日：
20070725
专利内容由知识产权出版社提供
摘要：The invention provides a ds-DNA oligomer which has from 25 to 150 base pairs, preferably 25 to 50 base pairs, and comprises the palindrome-containing sequence (one strand only shown) of formula (1): 5'B1... xN...B 2 3', wherein B1 is ¿ttgg? or ccaa and B?2¿is correspondingly ¿ccaa? or ttgg and xN represents from 1 to 30 native nucleotides of substantially the native promoter sequence, together with the complementary strand, the oligomer being modified to make it resistant to degradation and denaturing in vivo. This oligomer or a vector carrying the palindrome-containing sequence (but not necessarily with the modification and not limited by any upper limit on the length of the oligomer sequence) can be used to inhibit transcription of the cytokine gene in vivo and is therefore useful in the therapy of diseases associated with undesired or excess production of cytokine.
申请人：BTG INT LTD
地址：GB
国籍：GB
代理机构：Sutcliffe, Nicholas Robert
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