帕米膦酸二钠联合骨架型芬太尼透皮贴剂治疗肿瘤骨转移疼痛的临床观察

帕米膦酸二钠联合骨架型芬太尼透皮贴剂治疗肿瘤骨转移疼痛
的临床观察
胡晓华;王美玲;姜斌
【期刊名称】《临床肿瘤学杂志》
【年(卷),期】2011(16)3
【摘要】目的研究帕米膦酸二钠联合骨架型芬太尼透皮贴剂治疗恶性肿瘤骨转移疼痛的临床疗效及毒副反应.方法收集30例多发性骨转移伴重度疼痛恶性肿瘤患者,均经骨架型芬太尼透皮贴剂治疗＞15天未达到中度以上缓解,给予帕米膦酸二钠45mg连续2天联合骨架型芬太尼透皮贴剂治疗,观察两药联合治疗的临床止痛效果及不良反应.结果联合治疗前疼痛数字评分法评分为8.10±1.13,治疗后降至3.10±1.27 (P＜0.01),总有效率为70.0%,生活质量改善明显.治疗过程中2例患者出现发热,经对症处理后体温降至正常.结论帕米膦酸二钠联合骨架型芬太尼透皮贴剂治疗肿瘤多发性骨转移疼痛疗效及耐受性好,患者易接受,生活质量明显提高.%Objective To investigate the therapeutic efficacy and adverse effects of novel fentanyl transdermal system combined with pamidronate disodium for patients with multiple osseous metastasis pain.Methods Thirty patients with painful osseous metastasis were enrolled.They all had severe pain and didn't get midrange relief after 15 days' treatment by novel fentanyl transdermal system.All the patients received 45mg pamidronate disodium on day 1 and day 2 combined with novel fentanyl transdermal system, and then the therapeutic efficacy and adverse effects were observed.Results The score measuring decreased from 8.10± 1.13
down to 3.10 ± I.27 ( P ＜ O.O1 ) after therapeutic alliance.Total effective rate was 70.0％.Quality of life was improved.Fever happened in 2 patients and recovered soon.Conclusion Novel fentanyl transdermal system combined with pamidronate disodium is effective and safe in relieving pain of osseous metastasis, and the quality of life could be improved.
【总页数】3页(P265-267)
【作者】胡晓华;王美玲;姜斌
【作者单位】201900,上海,上海交通大学医学院附属第三人民医院肿瘤科;201900,上海,上海交通大学医学院附属第三人民医院肿瘤科;201900,上海,上海交通大学医学院附属第三人民医院肿瘤科
【正文语种】中文
【中图分类】R730.5
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