剖宫产切口感染患者血清炎性因子与免疫应答、应激激素的相关性

剖宫产切口感染患者血清炎性因子与免疫应答、应激激素的相
关性
王燕妮;张娟
【期刊名称】《海南医学院学报》
【年(卷),期】2018(024)007
【摘要】目的:研究剖宫产切口感染患者血清炎性因子与免疫应答、应激激素的相关性.方法:选择在本院接受剖宫产并发生术后切口感染的产妇作为研究的感染组,另随机选取同期在临潼区妇幼保健院接受剖宫产且未发生术后切口感染的产妇作为研究的对照组.测定血清中炎性因子、应激激素的含量以及外周血中免疫细胞的含量、红细胞免疫指标的水平.结果:感染组产妇血清中T N F-α、IL-1、IL-6、IL-8、Cor、NE、INS、AT-II的含量均显著高于对照组;外周血中CD3+CD4+T 细胞、
CD16+CD25+ NK细胞的含量以及 DTER、ATER、NTER、FEER 的水平均低于
对照组,CD3+CD8+T 细胞的含量以及FEIR的水平高于对照组.感染组产妇血清中
T N F-α、IL-1、IL-6、IL-8的含量与外周血中CD3+CD4+T细胞、
CD16+CD25+NK细胞的含量以及DTER、ATER、NTER、FEER的水平呈负相关,与外周血中CD3+CD8+T 细胞的含量以及FEIR的水平以及血清中Cor、NE、INS、AT-II的含量呈正相关.结论:剖宫产切口感染患者炎症反应的异常激活、炎性因子的异常分泌与免疫应答紊乱、应激反应激活密切相关.%Objective:To study the correlation of serum inflammatory factors with immune response and stress hor-mones in patients with cesarean incision
infection.Methods:Puerperae who underwent cesarean section and got postoperative incision infection in Maternal and Child Health Care in
Lintong between January 2014 and December 2016 were selected as the infection group of the research,and puerperae who underwent cesarean section and were without postoperative incision infection in Maternal and Child Health Care in Lintong during the same period were selected as the control group of the research.The contents of inflammatory factors and stress hormones in serum as well as the contents of immune cells and the levels of eryth-rocyte immunity indexes in peripheral blood were measured.Results:TNF-α,IL-1,IL-6,IL-8,Cor,NE,INS and AT-Ⅱ con-tents in serum of infection group were significantly higher than those of control group;CD3+CD4+T cell and CD16+CD25+NK cell contents as well as DTER,ATER,NTER and FEER levels in peripheral blood were lower than those of control group whereas CD3+CD8+T cell content and FEIR level were higher than those of control group.TNF-α,IL-1,IL-6 and IL-8 con-tents in serum of infection group were negatively correlated with CD 3+CD4+T cell and CD16+CD25+NK cell contents as well as DTER,ATER,NTER and FEER levels in peripheral blood,and positively correlated with CD3+CD8+T cell content and FEIR level in peripheral blood as well as Cor,NE,INS and AT-Ⅱ contents in serum.Conclusion:The abnormal activation of inflammatory response and the abnormal secretion of inflammatory factors are closely related to the immune response disorder and stress response activation.
【总页数】4页(P759-762)
【作者】王燕妮;张娟
【作者单位】西安市临潼区妇幼保健院妇产科,陕西西安 710600;西安市临潼区妇幼保健院妇产科,陕西西安 710600
【正文语种】中文
【中图分类】R719
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