TNF-Α AND TWEAK DUAL ANTAGONIST FOR THE PROPHYLAX

专利名称：TNF-Α AND TWEAK DUAL ANTAGONIST FOR THE PROPHYLAXIS AND TREATMENT
OF AUTOIMMUNE DISEASES
发明人：LEE, Eun Kyung,이은경,이은경,이은경,OH, Jin Mi,오진미,오진미,오진미,CHO, Kyu Won,조규원,
조규원,조규원,CHO, Mi La,조미라,조미라,조미
라,KIM, Ho Youn,김호연,김호연,김호연,PARK,
Mi Kyung,박미경,박미경,박미경,OH, Hye Jwa,오
혜좌,오혜좌,오혜좌,PARK, Jin Sil,박진실,박진실,박
진실,WOO, Yun Ju,우윤주,우윤주,우윤주,BYUN,
Jae Kyeong,변재경,변재경,변재경,RYU, Jun
Geol,유준걸,유준걸,유준걸,PARK, Young Woo,
박영우,박영우,박영우,JO, Ki Won,조기원,조기원,
조기원,YOO, Srok Ho,유석호,유석호,유석호,YU,
Jung,유정,유정,유정,KIM, Dong Jin,김동진,김동
진,김동진,YOON, Sun-Ha,윤선하,윤선하,윤선
하,SONG, Eun Jung,송은정,송은정,송은정
申请号：KR2011/001900
申请日：20110318
公开号：WO2011/115456A3
公开日：
20120126
专利内容由知识产权出版社提供专利附图：
摘要：The present invention relates to a TNFR2-TWEAKR fusion protein, and more specifically the TNFR2-TWEAKR fusion protein of the present invention can be used advantageously as an active ingredient in compositions that are efficacious in the prophylaxis and treatment of autoimmune diseases since TNFR2-TWEAKR fusion protein plays the role of a dual antagonist with respect to TNF-α and TWEAK which are known to be major causes of one type of autoimmune disease namely autoimmune arthritis, and, when Th17 cells are treated with a composition comprising TNFR2-TWEAKR fusion protein as an active ingredient, secretion of inflammatory cytokine IL-17 is reduced while secretion of anti-inflammatory cytokine IL-10 produced from Treg cells is increased, and this effect means that not only is the effect of TNFR2-TWEAKR fusion protein far better than TNFR2-Fc and TWEAK-Fc single proteins, but also not only is a therapeutic effect exhibited against arthritis in CIA arthritic mice but also a therapeutic effect is exhibited against autoimmune arthritis due to increased expression of Treg cells which are immunosuppressive cells.
申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY,한국생명공학연구원,LEE, Eun Kyung,이은경,OH, Jin Mi,오진미,CHO, Kyu Won,조규원,CHO, Mi La,조미라,KIM, Ho Youn,김호연,PARK, Mi Kyung,박미경,OH, Hye Jwa,오혜좌,PARK, Jin Sil,박진
실,WOO, Yun Ju,우윤주,BYUN, Jae Kyeong,변재경,INDUSTRY-ACADEMIC COOPERATION FOUNDATION, THE CATHOLIC UNIVERSITY OF KOREA,가톨릭대학교산학협력단,RYU, Jun Geol,유준걸,PARK, Young Woo,박영우,JO, Ki Won,조기원,YOO, Srok Ho,유석호,YU, Jung,유정,KIM, Dong Jin,김동진,YOON, Sun-Ha,윤선하,SONG, Eun Jung,송은정
地址：111 Gwahangno Yuseong-gu Daejeon 305-806 KR,대전시유성구과학로 111, 305-806 Daejeon KR,#101-1202 Unnam 1Danji Apt. 778-1 Busan-dong Osan-si Gyeonggi-do 447-717 KR,경기도오산시부산동 778-1 운암1단지 101-1202, 447-717 Gyeonggi-do KR,#918 Trebo 26-25 Uman-dong Paldal-gu Suwon-si Gyeonggi-do 442-190 KR,경기도수원시팔달구우만동 26-25 트레보 918호, 442-190 Gyeonggi-do KR,1429-23 Sillim-dong Gwanak-gu Seoul 151-891 KR,서울시관악구신림동 1429-23, 151-891 Seoul KR,#102-3507 Parktower Apt. Ichon-dong Yongsan-gu Seoul 140-030 KR,서울시용산구이촌동파크타워아파트 102-3507, 140-030 Seoul KR,#5-205 Daelim Apt. 2 Okum-dong Songpa-gu Seoul 138-737 KR,서울시송파구오금동 2번지대림아파트 5-205, 138-737 Seoul KR,#104-202 Green Villa 385-26 Songnae-2dong Sosa-gu Bucheon-si Gyeonggi-do 422-819 KR,경기도부천시소사구송내2동385-26 그린빌라 104-202, 422-819 Gyeonggi-do KR,#5017 The Catholic University of Korea Medicine and Science Institute 505 Banpo-dong Seocho-gu Seoul 137-701 KR,서울시서초구반포동 505번지가톨릭의과학연구소 5017호, 137-701 Seoul KR,#201 29-113 Nokbeon-dong Eunpyeong-gu Seoul 122-826 KR,서울시은평구녹번동 29-113 201호, 122-826 Seoul KR,#202 Daeheung Villa 346-2 Bulgwang-2dong Eunpyeong-gu Seoul 122-862 KR,서울시은평구불광2동 346-2 대흥빌라 202호, 122-862 Seoul KR,27-9 Jungangno-2ga Jecheon-si Chungcheongbuk-do 390-012 KR,충청북도제천시중앙로2가 27-9, 390-012
Chungcheongbuk-do KR,505 Banpo-dong Seocho-gu Seoul 137-040 KR,서울시서초구반포
동 505 가톨릭대학교산학협력단, 137-040 Seoul KR,#1301 SunMung5cha Apt. Hwangji-dong
Taebaek-si Gangwon-do 235-010 KR,강원도태백시황지동선명5차아파트 1301호, 235-010
Gangwon-do KR,#506-104 Expo Apt. Jeonmin-dong Yuseong-gu Daejeon 305-762 KR,대전
시유성구전민동엑스포아파트 506-104, 305-762 Daejeon KR,#105-603 Taeyoung Desian
Apt. Mabuk-dong Giheung-gu Yongin-si Gyeonggi-do 446-559 KR,경기도용인시기흥구마북
동태영데시앙아파트 105-603, 446-559 Gyeonggi-do KR,#104-510 Eunhasu Apt. Dunsan-
2dong Seo-gu Daejeon 302-733 KR,대전시서구둔산2동은하수아파트 104-510, 302-733
Daejeon KR,#27-703 Samsung Apt. Oryu-dong Jung-gu Daejeon 301-788 KR,대전시중구오
류동삼성아파트 27-703, 301-788 Daejeon KR,#201-1304 Humansia Apt. Bongsan-dong
Yuseong-gu Daejeon 305-763 KR,대전시유성구봉산동휴먼시아아파트 201-1304, 305-763
Daejeon KR,#106-1206 Jindalrae Apt. Wolpyeong-3dong Seo-gu Daejeon 302-280 KR,대전
시서구월평3동진달래아파트 106-1206, 302-280 Daejeon KR,202-4 Biryong-dong Dong-gu
Daejeon 300-310 KR,대전시동구비룡동 202-4, 300-310 Daejeon KR
国
籍：KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR,KR 代理人：LEE, Won-Hee,이원희
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