A comparative measurement study of the workload of wireless access points in campus network
英汉对照 journal of food engering
3D CFD simulation of bottle emptying processes容器排空过程的三维CFD模拟A 3-D computational fluid dynamics model for forced air cooling of eggs placed in trays强迫空气冷却纸盘中鸡蛋的流体力学3-D计算模型A kinetic study of the release of vanillin encapsulated in Carnauba wax microcapsules香兰素封装在巴西棕榈蜡微胶囊中释放的动力学研究A machine vision system for identification of micro-crack in egg shell鉴别蛋壳细微裂缝的机器影像系统On the usage of acoustic properties combined with an artificial neural network – A new approach of determining presence of dairy fouling利用声学特性结合人工神经网络-鉴定乳产品存在污染的一种新方法A potentiometric electronic tongue for the discrimination of honey according to the botanical origin. Comparison with traditional methodologies: Physicochemical parameters and volatile profile根据原植物用电子舌的电位差区别蜂蜜.与传统方法:理化性参数和挥发性进行对比A rapid method to discriminate season of production and feeding regimen of butters based on infrared spectroscopy and artificial neural networks 一个基于红外光谱和人工神经网络来区分季节性生产和黄油供给方案的快速方法A review: Crispness in dry foods and quality measurements based on acoustic–mechanical destructive techniques评审:基于声音仪器的破坏性试验对干燥食品酥脆度和质量的测量Aeration of model gels: Rheological characteristics of gellan and agar gels凝胶通气模式:结冷胶和琼脂凝胶的流变学特性Agglomeration of durum wheat semolina: Thermodynamic approaches for hydration properties measurements硬质小麦粗面粉的凝聚:热力学方法对于水合性能的测量Alleviating bottlenecks in a microbiology laboratory减少在微生物实验室中的瓶颈Effect of the amount of steam during baking on bread crust features and water diffusion面包在烘烤期间蒸汽对面包表皮特征和水扩散的影响An enzyme sensor for the determination of total amines in dry-fermented sausages一种酶传感器在腊肠风干发酵中对总有机胺的决定性An improved model of the seeded batch crystallization of glucose monohydrate from aqueous solutions从含水的溶解液中分批处理去籽的结晶化葡萄糖一水合物的一种改良模式An RFID application in the food supply chain: A case study of convenience stores in Taiwan无线射频识别在食品供应链中的应用:台湾便利储藏的案例研究Analytical model for variable moisture diffusivity estimation and drying simulation of shrinkable food products分析模型对可变湿度扩散性的估计和可收缩食品的干燥模拟Anthocyanin degradation kinetics during thermal and high pressure treatments of raspberries红草莓在高压和热处理下花青素退化的动力学Application of hybrid image features for fast and non-invasive classification of raisin图像特征混合对葡萄干快速和非侵入分类的应用Application of NIR hyperspectral imaging for discrimination of lamb muscles近红外高光谱对识别羔羊肌肉的应用Aqueous extraction of anthocyanins from Hibiscus sabdariffa: Experimental kinetics and modeling从洛神花中萃取花青素的实验历程和建模Aseptically packaged UHPH-treated apple juice: Safety and quality parameters during storage无菌包装超高压均质处理苹果汁:储藏中的安全与质量参数Automatic freshness assessment of cod (Gadus morhua) fillets by Vis/Nir spectroscopy利用可见近红外光谱对鳕鱼(大西洋鳕)鱼片新鲜度的自动评估Beer quality screening by FT-IR spectrometry: Impact of measurement strategies, data pre-processings and variable selection algorithms傅里叶变换红外光谱学光谱测定法对啤酒品质的筛选:测量方法,数据预处理和多变的算法选择对测量的影响Calcium effect on mechanical properties of model cell walls and apple tissue钙对典型细胞壁和苹果组织机械性能的作用CFD model development and validation of a thermonebulisation fungicide fogging system for postharvest storage of fruit热雾化杀菌剂系统对采收后食品储藏计算流体动力学模型的发展和确立Changes in orange juice characteristics due to homogenization and centrifugation橘子饮料特性因均化作用和离心分离所出现的变化Characterization and antimicrobial activity studies of polypropylene films with carvacrol and thymol for active packaging聚丙烯薄膜附加香芹酚和百里香酚对活性包装的表征和抗菌活性研究Characterization of bread dough: Rheological properties and microstructure面包面团的特性表述:流变性能和微观结构Coffee beans microstructural changes induced by cultivation processing: An X-ray microtomographic investigation种植加工引诱咖啡豆微观结构的变化:X射线微观层析成象的调查Combination of digital images and laser light to predict moisture content and color of bell pepper simultaneously during drying在干燥情况下,利用数字图像和激光灯的结合对灯笼椒的水分含量和颜色同时进行预测Comparative study of film forming behaviour of low and high amylose starches using glycerol and xylitol as plasticizers利用丙三醇和木糖醇作为增塑剂在高低直链淀粉质食品薄膜形成状况的对比性研究Comparison of total milk-clotting activity measurement precision using the Berridge clotting time method and a proposed optical method对比利用贝里奇凝固时间的方法和拟议光学方法对牛奶凝固活度的测量精度Compressive textural attributes, opacity and syneresis of gels prepared from gellan, agar and their mixtures压缩性组织的特性,从结冷胶,琼脂以及它们的混合物中凝胶准备的不透明度和脱水收缩作用Computer simulation model development and validation for radio frequency (RF) heating of dry food materials无线电频率对干燥食物材料加热的计算机模拟模型的发展和验证Crispiness of a microwave-expanded imitation cheese: Mechanical, acoustic and sensory evaluation微波扩大人造干酪的松脆物:力学,声学和感官评价Classification of black tea liquor using cyclic voltammetry利用循环伏安法对红茶白酒的分类Determination and removal of malondialdehyde and other2-thiobarbituric acid reactive substances in waste cooking oil检测和去除废弃食用油中丙二醛和其他2-硫代巴比土酸的反应物Determination of anthocyanin concentration in whole grape skins using hyperspectral imaging and adaptive boosting neural networks利用高光谱影像和适应促进神经网络测定全部葡萄皮中花青素浓度Determination of translucent content in mangosteen by meansof near infrared transmittance利用近红外透光率的方法对山竹果透明率的检测Development of a novel method to measure the film thickness of cured can coatings一个对腌罐头镀膜薄膜厚度测定新方法的发展Dielectric properties of sea cucumbers (Stichopus japonicus ) and model foods at 915 MHz典型食品和海参(刺参)在915MHz下的介电性能DMA peaks in potato cork tissue of different mealiness动态力学分析法在不同粉性的土豆软木组织的应用Influence of drying and hydrothermal treatment of corn on the denaturation of salt-soluble proteins and color parameters干燥和热处理玉米在可溶性盐蛋白和颜色参数变性上的影响Drying characteristics of mango slices using the Refractance Window™ technique芒果切片的干燥特性在折射窗薄层干燥技术上的应用Drying kinetics using superheated steam and quality attributes of dried pork slices for different thickness, seasoning and fibers distribution干燥动力学利用干燥猪肉切片的过热蒸汽和品质特性对不同厚度,风干和纤维分布的应用Dynamic oscillatory rheological measurement and thermal propertiesof pea protein extracted by salt method: Effect of pH and NaCl利用盐法对豌豆蛋白萃取的动态震荡流变测量和热性能:PH和盐的作用Dynamic oscillatory shear properties of O/W model system meat emulsions: Linear viscoelastic analysis for effect of temperature and oil concentration on protein network formation油水比率的动态振动剪切性能模型系统肉乳剂:线性粘弹性分析对温度和含油浓度在蛋白质网状形成的影响Effect of dimensions and geometry of co-field and co-linear pulsed electric field treatment chambers on electric field strength and energy utilization在电场强度和能量利用上共线性和共面性电场脉冲处理chambers的尺寸规模和几何体的影响Effect of high or low molecular weight of components of feed on transmembrane flux during forward osmosis促进渗透期间以跨膜通量为能源成分的分子量的高或低的影响Effect of morphology on water sorption in cellular solid foods. Part II: Sorption in cereal crackers水吸附在多细胞固体食品形态学的影响第二部分:吸附谷类饼干的吸附Effect of morphology on water sorption in cellular solid foods.Part I: Pore scale network model水吸附在多细胞固体食品形态学的影响第一部分:气孔比例网状模型Effect of salt and sucrose content on dielectric properties and microwave freeze drying behavior of re-structured potato slices盐和蔗糖含量对土豆切片复合组织介电性能和微博冷冻干燥的影响Effect of some operating variables on the microstructure and physical properties of a novel Kefir formulation一些运行变量对新克菲尔构想的微观结构和物理性能的影响Effects of electroplasmolysis treatment on chlorophyll and carotenoid extraction yield from spinach and tomato电质壁分离对菠菜和番茄中叶绿素和类胡萝卜素提取率的影响Effects of vacuum frying on structural changes of bananas真空油炸对香蕉结构变化的影响A finite element model for mechanical deformation of single tomato suspension cells一种对于单一番茄悬浮细胞的机械变形的有限元模式Enhanced survival of spray-dried microencapsulated Lactobacillus rhamnosus GG in the presence of glucose提高在葡萄糖前将装入乳酸菌鼠李糖GG的微胶囊进行喷雾干燥的残余物Enzymatic browning in sliced and puréed avocado: A fractal kinetic study 鳄梨和切片中的酶促褐变:一种分形动力学研究Enzyme inactivation kinetics and colour changes in Garlic (Allium sativum L.)blanched under different conditions在不同条件下大蒜变白中酶失活动力学和颜色的变化Evaluating banana ripening status from measuring dielectric properties利用介电性能测量香蕉成熟状况的评估Evaluating non-stick properties of different surface materials for contact frying不同表面材料的非粘性对接触油炸的评估Evaluation of Photoshop software potential for food colorimetry Photoshop软件对食品比色法可能性的评估Fast determination of boiling time of yardlong bean using visible and near infrared spectroscopy and chemometrics利用可见和近红外光谱学以及化学计量学快速测定长豇豆的沸腾时间Feasibility of NIR spectroscopy for non-destructive characterizationof table olive traits近红外光谱对表橄榄特性无损检测的可行性Food supply chain leanness using a developed QFD model食品供给链缺乏使用一种成熟的质量功能展开模式Fractal analysis of the retrogradation of rice starch by digital image processing利用数字图像处理米粉糊液凝沉的分形分析Frequency- and temperature-dependent dielectric properties of fruit juices associated with pasteurization by dielectric heating利用电介质加热杀菌法与果汁中与温度和频率有关的介电性能的相关性Development of a rapid, non-destructive method for egg contentdetermination in dry pasta using FT-NIR technique利用傅里叶变红外光谱技术测量鸡蛋内部的一种快速无损检测方法的发展Gelation properties of chicken myofibrillar protein induced by transglutaminase crosslinking利用转谷氨酰胺酶交联诱导鸡肉肌原纤维蛋白的胶凝特性Generalized microstructural change and structure-quality indicators of a food product undergoing different drying methods and conditions一种食品经过不同条件下和不同干燥方法的一般性微观结构变化和结构性能质量指标Glass transition phenomenon on shrinkage of papaya during convective drying木瓜在对流干燥期间玻璃转化现象的收缩Effect of saccharides on glass transition temperatures of frozen and freeze dried bovine plasma protein糖类在冷冻和冻结干燥牛血浆蛋白的玻璃转化温度的影响Heat transfer modelling in a refrigerated display cabinet: The influence of operating conditions冷藏展示柜的热传递模型:操作条件的影响Specific volume and compressibility measurements of tomato pasteat moderately high pressure as a function of temperature番茄酱在适当高压下作为温度函数比容和可压缩性测量Hybrid mixture theory based moisture transport and stress development in corn kernels during drying: Coupled fluid transport and stress equations基于在干燥期间玉米粒水分运输和压力发展的杂交混合理论:耦合流体运输和压力方程式Hydrodynamic, thermo-analytical and molecular structural investigations of enzyme interesterified oil and its thermo-oxidative stabilityby thermogravimetric analysis利用热重量分析对酯化油和其热氧化稳定的流体力学,热解析和分子结构的分析Classification of fresh Atlantic salmon (Salmo salar L.) fillets stored under different atmospheres by hyperspectral imaging利用高光谱影像对新鲜大西洋鲑鱼切片在不同气压下储藏的分类Imaged based estimation of food volume using circular referentsin dietary assessment饮食评估中食品体积的估计使用循环参照物的影像基础Quality classification of cooked, sliced turkey hams using NIR hyperspectral imaging system利用近红外高光谱影像系统对熟火鸡火腿切片的品质分级Implication of water activity and glass transition on the mechanicaland optical properties of freeze-dried apple and banana slices水活性和玻璃转化在冷冻干燥苹果和香蕉切片的力学光学性能的含义Inactivation of Saccharomyces cerevisiae in pineapple, grape and cranberry juices under pulsed and continuous thermo-sonication treatments酿酒酵母在菠萝,葡萄和蔓越橘汁脉冲和连续热声波降解法处理下的失活Investigating the performance of thermo nebulisation fungicide fogging system for loaded fruit storage room using CFD model利用流体力学模型计算热雾化杀菌剂雾化系统对已装水果储藏室性能的研究An Exploration of Why People Participate in Second Life Social Support Groups关于人们参加第二人生社会扶持组织原因的探索Kinetics of quality changes of pumpkin (Curcurbita maxima L.) stored under isothermal and non-isothermal frozen conditions南瓜储藏在等温和非等温冷冻条件下动力学性能的变化Kinetics studies during NaCl and KCl pork meat brining猪肉盐浸处理中氯化钠和氯化钾的动力学研究Linear and non-linear viscoelastic behaviors of crosslinked tapioca starch/polysaccharide systems交联木薯淀粉/多糖系统的线性和非线性粘弹性行为Monitoring changes in feta cheese during brining by magnetic resonanceimaging and NMR relaxometry在浸盐作用期间利用磁共振影像和核磁共振弛豫时间监测羊奶酪的变化Mathematical model of pork slice drying using superheated steam利用过热蒸汽干燥猪肉切片的数学模型Mathematical modeling of intermittent and convective drying of rice and coffee using the reaction engineering approach (REA)利用反作用工程方法间歇性和对流干燥大米,咖啡的数学建模Mathematical modeling of swelling in high moisture whey protein gels膨胀高水分乳清蛋白凝胶的数学建模Mathematical modeling of the heat and mass transfer in a stationary potato sphere impinged by a single round liquid jet in a hydro fluidization system利用单轮液体喷射在水电流态化系统在高温和质量传递在静止土豆表面撞击的数学建模An approach for the enhancement of the mechanical properties and film coating efficiency of shellac by the formation of composite films based on shellac and gelatin利用基于虫胶和明胶复合薄膜形成对虫胶的镀膜效率和机械性能提高的方法Mechanical relaxation times as indicators of stickiness in skimmilk–maltodextrin solids systems机械力松弛时间作为在粘性表层物牛奶麦芽糖糊精固体系统的指标Effect of composition on the mechanical response of agglomeratesof infant formulae初期公式的附聚物的机械回应成分的影响Combination of optical and non-destructive mechanical techniquesfor the measurement of maturity in peach光学和无损机械技术组合对桃子成熟的测量Expansion mechanism of extruded foams supplemented with wheat bran 增补挤压泡沫体伴随麦麸的膨胀原理Mechanistic model of in vitro salt release from model dairy gels based on standardized breakdown test simulating mastication乳品凝胶基于模拟粉碎稳定性试验标准在使观众盐释放的机械模型Mechanistic model to couple oxygen transfer with ascorbic acid oxidation kinetics in model solid food在固体食品模型中机械模型对结合氧运输随着抗坏血酸氧化的动力学Effect of sugar, citric acid and egg white type on the microstructuraland mechanical properties of meringues调和蛋白的糖,柠檬酸和蛋白类型在微观结构和机械性能的影响Microstructure and mechanical properties of soy protein/agar blend films: Effect of composition and processing methods大豆蛋白和琼脂膜混合的微观结构和机械性能:成分和处理方法的影响Coffea arabica beans microstructural changes induced by roasting: AnX-ray microtomographic investigation利用烘烤引诱咖啡豆微观结构的变化:一种X射线微层析调查The impact of microwave heating of infant formula model on neo-formed contaminant formation, nutrient degradation and spore destruction初级理论模型在新成立的污染物形成的微波加热的影响:营养退化和孢子退化Modeling and experimental validation of mass transfer from carbonated beverages in polyethylene terephthalate bottles从碳酸饮料在聚对苯二甲酸乙二醇酯瓶子中质量传递的实验验证和建模Modeling microbial kinetics as a function of temperature: Evaluationof dynamic experiments to identify the growth/inactivation interface根据温度对微生物动力学建模:动态实验的评估来鉴定增长/失活的分界面Modeling rehydration of porous food materials: I. Determinationof characteristic curve from water sorption isotherms多孔渗水食品材料的再水化建模:1,水等温吸附线中特性曲线的测定Modeling rehydration of porous food materials: II. The dual porosity approach多孔渗水食品材料的再水化建模:2,双重多孔性方法Modeling the effects of initial nitrogen content and temperatureon fermentation kinetics of hard cider初始含氮量和温度在苹果酒的发酵动力学的建模作用Modelling flow behaviour of dairy foams through a nozzle乳品泡沫通过喷嘴的建模流动状况Modelling of coupled heat and mass transfer during a contact baking process在联系烘烤进程期间耦合高温和质量传递的建模Monitoring and grading of tea by computer vision – A review利用计算机视觉对茶叶监测和分级-一个评审Monitoring of ATP and viable cells on meat surface by UV–Vis reflectance spectrum analysis利用紫外-可见反射比光谱分析对肉表面ATP和活细胞的监测Monitoring the dynamic density of dough during fermentation using digital imaging method利用数字影像方法在发酵期间对生面团的动态密度监测Microwave puffing: Determination of optimal conditions using a coupled multiphase porous media – Large deformation model微波膨化:利用一种耦合多相多孔介质对最适条件的测定-大型变形模型Red to far-red multispectral fluorescence image fusion for detection offecal contamination on apples利用红色对远红外多谱线的荧光影像融合对苹果排泄污染物的检测Artificial neural network model for prediction of cold spot temperature in retort sterilization of starch-based foods人工神经网络模型对淀粉性食物的蒸煮杀菌的冷点温度的预测Non-destructive analysis of anthocyanins in cherries by means of Lambert–Beer and multivariate regression based on spectroscopy and scatter correction using time-resolved analysis利用Lambert–Beer和多元回归基于光谱学和散射修正使用时间分辨分析对樱桃花青素的无损检测分析Non-destructive internal quality assessment of ‘‘Hayward’’ kiwifruitby waveguide spectroscopy利用波导光谱学对“Hayward”猕猴桃的内部品质无损检测Non-destructive maturity classification of mango based on physical, mechanical and optical properties基于物理,机械和光学特性对芒果成熟等级的无损检测Non-destructive prediction of hardening pericarp disorder in intact mangosteen by near infrared transmittance spectroscopy利用近红外线透射比光谱学对完整的山竹果无序表皮樱花的无损检测Efficacy of non-thermal technologies and sanitizer solutions on microbial load reduction and quality retention of strawberries非热能技术和食品防腐剂解决方案对草莓的微生物负荷减低和质量保持的功效Numerical modeling of heat and mass transfer during coffee roasting process咖啡豆烘烤进程的高温和质量传递数值模拟Accelerated inactivation of Geobacillus stearothermophilus spores by ohmic heating利用欧姆加热对芽孢杆菌的加速钝化Optimisation of total phenolic acids extraction from mandarin peels using microwave energy: The importance of the Maillard reaction利用微波能量从柑橘果皮对酚酸萃取的优化:美拉德反应的重要性Effect of guar gum content on some physical and nutritional properties of extruded products瓜尔豆胶在挤压产品的一些物理和营养特性的作用Physical properties of acerola and blueberry pulps金虎尾和蓝莓果肉的物理特性Physico-chemical characterization of chitosan-based edible films incorporating bioactive compounds of different molecular weight不同分子量的壳聚糖基可食用薄膜合并生物活性的化合物的理化特性Predicting cleaning time of ventilation duct systems in the food industry 通风管系统在食品工业的清洗时间预测Prediction of beef quality attributes using VIS/NIR hyperspectral scattering imaging technique利用可见/近红外高光谱散射影像技术队牛肉质量特性的预测Prediction of colloidal stability in white wines using infrared spectroscopy利用红外线光谱学对白葡萄酒胶体稳定性的预测Prediction of dry mass glass transition temperature and the spray drying behaviour of a concentrate using a desorption method利用解析方法对浓缩的干质量玻璃化温度和喷雾干燥状况的预测Production, recovery and applications of xanthan gum by Xanthomonas campestris利用白菜黄单胞菌对黄原胶的生产,恢复和应用Pulsed electric field assisted aqueous extraction of colorants from red beet电场脉冲协助红甜菜中色素的萃取Investigation of Raman chemical imaging for detection of lycopene changes in tomatoes during postharvest ripening利用拉曼化学成像在采收后成熟期间对番茄红素变化的检测的调查研究Real-time modeling of milk coagulation using in-line near infrared spectroscopy利用管线式近红外光谱学对牛奶凝结的即时性建模Removal of residual pesticide, fenitrothion, in vegetables by using ozone microbubbles generated by different methods用不同方法利用臭氧微气泡的产生对蔬菜杀虫剂(杀螟松)残渣的去除Effect of temperature on dynamic and steady-state shear rheological properties of siriguela (Spondias purpurea L.) pulp温度对松果菊果肉的动态和稳态切变流变学的影响Rheological behavior and stability of D-limonene emulsions made by a novel hydrocolloid (Angum gum) compared with Arabic gum由一种相比阿拉伯树胶的新水状胶体(Angum胶)制成的D-柠檬烯乳胶的流变特性和稳定性Modeling and estimation of rheological properties of food productsfor manufacturing simulations食品的流变特性对于制造模型的建模和评估Rheological, textural and spectral characteristics of sorbitol substituted mango jam山梨醇替代芒果果酱的流变的,组织的和光谱特性Rheology and microstructure of myofibrillar protein–plant lipid composite gels: Effect of emulsion droplet size and membrane type肌原纤维蛋白-植物油脂附和凝胶剂的流变学特性和微观结构:乳滴尺寸和薄膜类型的影响Rheometric non-isothermal gelatinization kinetics of mung bean starchslurry: Effect of salt and sugar – Part 1绿豆淀粉泥浆的流变测定非等温凝胶化动力学:盐和糖的作用-第一部分Scale-up unit of a unique moderately high pressure unit to enhance microbial inactivation唯一适度高压单元的增大单元来提高微生物失活Particle surface moisture content estimation using population balance modeling in fluidised bed agglomeration利用平衡建模的数量对使底座结块液化微粒表面水分含量的估测Shelf life prediction of aluminum foil laminated polyethylene packed vacuum dried coconut milk powder铝箔聚乙烯分层包装真空干燥椰子汁粉保质期的预测Effect of modified atmosphere and active packaging on the shelf-lifeof fresh bluefin tuna fillets改良环境和有效包装在新鲜金枪鱼切片保质期的影响Shortwave infrared hyperspectral imaging for detecting sour skin (Burkholderia cepacia)-infected onions短波红外线高光谱影像对被感染洋葱皮发酵的测定Wavelength selection in vis/NIR spectra for detection of bruises on apples by ROC analysis利用ROC分析用可见/近红外光谱对苹果损伤测定波长的选择Maltodextrin/pectin microparticles by spray drying as carrier fornutraceutical extracts喷雾干燥利用麦芽糖糊精/果胶微粒作为载体对保健品提取Structural properties of freeze-dried rice经过冷冻干燥大米的结构特性Study of contact angle, wettability and water vapor permeability in carboxymethylcellulose (CMC) based film with murta leaves(Ugni molinae Turcz) extract基于murta叶片薄膜萃取羧甲基纤维素接触角,湿润度和水蒸气渗透性的研究Granularity and its importance for traceability in a farmed salmon supply chain间隔尺寸以及其重要性对于养殖鲑鱼供给链的可追溯性Texture prediction during deep frying: A mechanistic approach油炸期间的质地预测:一种机械型工作设计方法The influence of vacuum impregnation on the fortification of apple parenchyma with quercetin derivatives in combination with pore structures X-ray analysis苹果软细胞组织附和橡黄素衍生物与X-射线孔隙结构分析结合的真空浸渍在营养强化上的影响The potential of electrospraying for hydrophobic film coating on foods 电喷镀对于在食品疏水性薄膜敷层的可能性The use of biodosimetry to measure the UV-C dose delivered to a sphere,and implications for the commercial treatment of fruit利用生物计量测定法测定紫外-C线剂量传递到球面,对于水果商业化处理的影响Corrigendum to ‘‘Theoretical and experimental analyses of drop deformation and break-up in a scale model of a high-pressure homogenizer’’ [Journal of Food Engineering 103/1 (2010) 21–28]勘误表:“高压均质器的液滴变形和终止缩尺模型的理论和实验分析”[食品工程杂志103/1(2010)21-28]Development of a two-band spectral imaging system for real-time citrus canker detection双频段光谱影像对于即时性检测柑橘溃疡的发展Shape determination of horticultural produce using two-dimensional computer vision – A review利用二维计算机影像对园艺产品形状的检测-一份评审Comparative study of high intensity ultrasound effects on foodproteins functionality高强度超声波作用在食物蛋白功能的对比性研究Uncertainty and sensitivity analysis: Mathematical model of coupled heat and mass transfer for a contact baking process不确定性和灵敏度分析:耦合高温和质量传递对于联系烘烤进程的数学模型Variable selection in visible and near-infrared spectra: Application toon-line determination of sugar content in pears可见和近红外光谱的可变性选择:应用于梨含糖量的即时检测Application of visible and near infrared spectroscopy for rapidand non-invasive quantification of common adulterants in Spirulina powder可见和近红外光谱对于螺旋藻粉共同掺杂物的快速以及非侵入性定量的应用Classification of longan fruit bruising using visible spectroscopy利用可见光谱学对桂圆损伤的分类Water diffusion and enzyme activities during malting of barley grains: A relationship assessment在大麦谷粒的麦粒发芽期间水扩散和酶活性:一个相关性评估Water transport properties of artificial cell walls人造细胞壁的水运输性能Weight loss of frozen bread dough under isothermal and fluctuating temperature storage conditions冷冻面包面团在等温和变动温度储藏条件下的质量损失Automated fish bone detection using X-ray imaging利用X-射线影像对鱼骨的自动化检测X-ray microtomography to study the microstructure of mayonnaiseX-射线显微断层显像对蛋黄酱微观结构的研究Influence of yeast and frozen storage on rheological, structural andmicrobial quality of frozen sweet dough酵母和冷冻储藏对冷冻甜面团的流变性,结构和微生物质量的影响Yield improvement in progressive freeze-concentration by partial melting of ice通过冷冻食品局部融化利用逐步冷冻浓缩提高产量。
亚像素位移插值计算方法的比较分析
GUO Ro ng2xin1 , YAN G Ba ng2c he ng1 , CAI Gua ng2c he n2 , LI J un2c ha ng2
0 引言
现代光测力学是实验力学中一个非常重要的分支[1 ]. 不论是光测力学应力法还是光测力学位移法 ,都 具有非接触 、非破坏和全场性测量的特点 ,直观性强. 它不仅可以方便有效地用于研究结构的强度和设计 方案的改进与优化 ,而且还正被越来越多地用于研究材料的特性和失效机理 ,并逐步应用于工程领域. 此 外 ,由于光测实验能测定一些用数值计算方法难于确定的力学量 ,如应力集中系数 、边界值 (应变) ,因此 , 它不仅可以弥补数值计算方法的不足 ,而且可以修正 、完善相关的理论 (如材料的本构关系) 和数值计算程 序 ,光测力学法也就与数值分析法越来越强的互补性和关联性. 目前 ,图像处理技术和利用计算机的自动 、 实时数据采集技术已广泛应用于光测图像的处理 ,并为细观力学的研究工作提供了有效的实验手段. 在这 类非接触测量中 ,通过拍摄测量对象在不同状态下的两张数字图像 ,然后利用图像处理获取测量对象形变 或位移的数字散斑技术具有重要的应用前景. 然而 ,由于 CCD 记录图像的像素数量及像素尺寸有限 ,测量 精度被限制在像素对应的尺度上 ,在许多情况下很难满足实际需要[2 ]. 为提高测量精度 ,人们不断地对亚 像素位移测量方法进行研究. 利用不同的计算方法可以实现精度低于像素尺寸的亚像素位移的测量 ,并 且也容易开发成计算机辅助测量软件 ,但是 ,当软件开发成功后 ,较准确地知道测量误差是一个十分重要 的问题.
熵值法在国外的研究报告
熵值法在国外的研究报告在国外,熵值法被广泛应用于不同领域的研究报告中。
以下是一些关于熵值法在国外的研究报告的例子:1. "Application of entropy measurement methods in the assessment of environmental quality"(《熵值法在环境质量评估中的应用》):该研究报告探讨了熵值法在评估环境质量方面的应用。
研究人员使用熵值法来测量不同环境指标(如空气质量、水质、土壤质量等)的综合影响,并评估环境的整体质量。
2. "A comparative study of sustainable development among different countries using entropy method"(《利用熵值法比较不同国家的可持续发展》):该研究报告利用熵值法比较了不同国家的可持续发展水平。
研究人员通过计算各个国家在可持续发展指标(如经济增长、环境保护、社会公正等)上的熵值,评估不同国家在可持续发展方面的表现,并提出了改进措施。
3. "A study on the efficiency of energy consumption in manufacturing industry based on entropy method"(《基于熵值法的制造业能源消耗效率研究》):该研究报告利用熵值法研究了制造业中能源消耗的效率。
研究人员通过计算不同企业的能源消耗熵值,分析了企业能源消耗的效率水平,并提出了提高能源利用效率的建议,以减少能源浪费。
4. "Entropy-based risk assessment of natural hazards"(《基于熵值法的自然灾害风险评估》):该研究报告利用熵值法对自然灾害的风险进行评估。
研究人员通过计算不同自然灾害指标(如地震震级、洪水流量等)的熵值,评估灾害的风险程度,并提出了相应的风险管理策略。
两种计算正常成年人短时心率变异性方法的比较研究
两种计算正常成年人短时心率变异性方法的比较研究李静;王步青;王卫东【摘要】目的利用光电容积脉搏波法分析心率变异性,为通过心率变异性(heart rate variability,HRV)参数表征自主神经系统的变化提供新的研究方法 .方法对46个健康成年受试者分别同步采集自主呼吸状态下的心电信号和光电容积脉搏波信号,利用二阶差分极大值提取心电图的RR间期,搜索脉搏波极大值提取脉搏波主波波峰间期PP,然后计算通用HRV参数SDNN、RMSSD和LF/HF,并利用回归的统计学方法结合Bland-Altman随机分析法对这两种方法获取的HRV结果进行比较.结果两种方法计算得到的心率变异性参数结果的Pearson相关系数分别为0.998、0.995和0.992,均显著相关(P<0.01),Bland-Altman分布图也均在一致性区间内,说明这两种方法在计算心率变异性上具有一致性.结论利用光电容积脉搏波法分析心率变异具有可行性.%Objective To study the measurement of heart rate variability by using electrocardiogram ( ECG) and photoplethysmography( PPG) . Methods We analyzed heart rate variability ( HRV) taken by ECG and photoplethysmography. After acquiring the synchronized ECG as well as the photoplethysmography on 46 healthy adults in their natural breathing state and extracting the RR intervals of ECG and PP intervals of PPG respectively,the time domain and frequency domain parameters of HRV were calculated. Results The correlation coefficients of the three short-time parameters in the two calculation methods were greater than 0. 99 significantly,and the Bland-Altman scattered plot of the parameters were in the consistent band. The two methods had coherence in the calculation of heart rate variability.Conclusions It is feasible to analyze the heart rate variation with the pulse wave method.【期刊名称】《北京生物医学工程》【年(卷),期】2017(036)005【总页数】5页(P502-506)【关键词】心电图;光电容积脉搏波;心率变异性;一致性【作者】李静;王步青;王卫东【作者单位】中国人民解放军总医院医学工程与维修中心北京100853;中国人民解放军总医院医学工程与维修中心北京100853;中国人民解放军总医院医学工程与维修中心北京100853【正文语种】中文【中图分类】R318.04心电图(electrocardiogram,ECG)所描记的是心脏收缩和舒张过程中体表感应出来的电势差,从心电图心脏节律中可以探测到正常的窦性节律,还可以探测异位节律。
A COMPARATIVE STUDY OF THE EFFECTS OF THE
This study is concerned with the effectiveness of computer-based multimedia for developing listening comprehension in English as a Foreign Language (EFL). The listening skill plays a significant role in communication and in language learning (Rubin, 1994; Dunkel, 1991; Rost, 1990; Anderson and Lynch, 1988) and is perhaps "the most fundamental language skill" (Oxford, 1993: p. 205). Although there is no agreed definition of the listening skill (Wolvin and Coakley, 1988) nor a complete understanding of all the processes involved in listening (Rubin, 1994; Buck, 1992), the development of the listening skill has always been of prime concern to language teachers. Listening assumes increased importance as not only is it a key language and communication skill in its own right, but it also provides a channel through which new language can be received and may become "intake". Many language learners experience and report difficulty with this skill (Underwood, 1990: p. 16). Traditionally, classroom or language laboratory-based listening work has used audio cassettes or video cassettes accompanied by varieties of tasks as 39
香港理工大学高分辨率的指纹(HRF)数据库_图像处理_科研数据集
⾹港理⼯⼤学⾼分辨率的指纹(HRF)数据库_图像处理_科研数据集⾹港理⼯⼤学⾼分辨率的指纹(HRF) 数据库(The Hong Kong Polytechnic University(PolyU)High-Resolution-Fingerprint (HRF)Database)数据介绍:Fingerprint is the most widely used biometric characteristic for personal identification because of its uniqueness and stability over time. Most of the existing automatic fingerprint recognition systems (AFRS) use the minutia features on fingerprints, i.e. the terminations and bifurcations of fingerprint ridges, for recognition. Although they can achieve good recognition accuracy and have been used in many civil applications, their performance still needs much improvement when a large population is involved or a high security level is required. One solution to enhancing the accuracy of AFRS is to employ more features on fingerprints other than only minutiae. Fingerprint additional features, such as pores, dots and incipient ridges (see Fig. 1 for examples), are routinely used by experts in manual latent fingerprint matching. Some of these additional features, e.g. pores, require high resolution fingerprint images to reliably capture them. Thanks to the distinctiveness of these fingerpr关键词:⾼分辨率的指纹,⾹港理⼯⼤学,UGC/CRC,High-Resolution-Fingerprint,PolyU,UGC/CRC,数据格式:IMAGE数据详细介绍:The Hong Kong Polytechnic University (PolyU)High-Resolution-Fingerprint (HRF) DatabaseOverview:Fingerprint is the most widely used biometric characteristic for personal identification because of its uniqueness and stability over time. Most of the existing automatic fingerprint recognition systems (AFRS) use the minutia features on fingerprints, i.e. the terminations and bifurcations of fingerprint ridges, for recognition. Although they can achieve good recognition accuracy and have been used in many civil applications, their performance still needs much improvement when a large population is involved or a high security level is required. One solution to enhancing the accuracy of AFRS is to employ more features on fingerprints other than only minutiae. Fingerprint additional features, such as pores, dots and incipient ridges (see Fig. 1 for examples), are routinely used by experts in manual latent fingerprint matching. Some of these additional features, e.g. pores, require high resolution fingerprint images to reliably capture them. Thanks to the distinctiveness of these fingerprint additional features and to the advent of high quality fingerprint imaging sensors, they have recently attracted increasing attention from researchers and practitioners working on AFRS.Our team in the Biometrics Research Centre (UGC/CRC) of the HongKong Polytechnic University has developed a high resolution fingerprintimaging device and has used it to constructed large-scale high resolutionfingerprint databases (HRF). We intend to publish our database to facilitate researchers designing effective and efficient algorithms for extracting andmatching fingerprint additional features.Fig. 1: Example additional features on fingerprints, pores, dots, and incipientridges.Description of the PolyU HRF Database:An optical fingerprint imaging device (see Fig. 2) has been built by our team.Its resolution is around 1,200dpi, and it can capture fingerprint images ofvarious sizes, e.g. 320*240 pixels and 640*480 pixels.(a) (b)Fig. 2: (a) The high resolution fingerprint imaging device we developed and (b) its inner structure.Two high resolution fingerprint image databases (denoted as DBI and DBII)have been set up by using the developed fingerprint imaging device. DBIconsists of a small training dataset and a large test dataset. The images of thesame finger in both databases were collected in two sessions which wereseparated by about two weeks. Each image is namedas “ID_S_X”.“ID” represents the identity of the person. “S” represents the session of the captured image. “X”represents the image number of each session. The following table gives the detailed information of the databases.We labeled the ground truth of sweat pores in 30 images selected from DBI. The central coordinates (row, col) of each pore were wrote into a text file (.txt). The ground truth of dots and incipients of 48 selected images were also offered. The central coordinates (row, col) of dots and two ends of each incipient were wrote into a text file (.txt). Here, the 48 selected images consists of 2 set of images ("SetIGroundTruthSampleimage" and "SetIIGroundTruthSampleimage") captured in two sessions. All of the original sample images and text files are contained in "Ground Truth.zip".Related Publication:1. Qijun Zhao, David Zhang, Lei Zhang, and Nan Luo, "AdaptiveFingerprint Pore Modeling and Extraction," Pattern Recognition, vol.43(8), pp. 2833-2844, 20102. Qijun Zhao, David Zhang, Lei Zhang, and Nan Luo, "High ResolutionFragmentary Fingerprint Alignment Using Pore-Valley Descriptors,"Pattern Recognition, vol. 43, pp. 1050-1061, 20103. Qijun Zhao, Lei Zhang, David Zhang, Nan Luo, and Jing Bao,“Adaptive Pore Model for Fingerprint Pore Extraction,” IAPR 19thInternational Conference on Pattern Recognition (ICPR2008), 20084. Qijun Zhao, Lei Zhang, David Zhang, and Nan Luo, “Direct PoreMatching for Fingerprint Recognition,” IAPR/IEEE 3rd InternationalConference on Biometrics (ICB2009), pp. 597-606, 20095. David Zhang, Feng Liu, Qijun Zhao, Guangming Lu, and Nan Luo,"Selecting a Reference High Resolution for Fingerprint RecognitionUsing Minutiae and Pores," IEEE Transactions on Instrumentation and Measurement, to appear6. Qijun Zhao, Feng Liu, Lei Zhang, and David Zhang, "A ComparativeStudy on Quality Assessment of High Resolution Fingerprint Images,"Proceedings of the IEEE International Conference on Image Processing (ICIP2010), Hong Kong, September 20107. Qijun Zhao, Feng Liu, Lei Zhang, and David Zhang, "Parallel versusHierarchical Fusion of Extended Fingerprint Features," Proceedings ofthe IAPR 20th International Conference on Pattern Recognition(ICPR'10), Istanbul, Turkey, August 20108. Feng Liu, Qijun Zhao, Lei Zhang, and David Zhang, "Fingerprint PoreMatching based on Sparse Representation," Proceedings of the IAPR20th International Conference on Pattern Recognition(ICPR'10), Istanbul, Turkey, August 20109. Q. Zhao, Lei Zhang, David Zhang, Wenyi Huang, and Jian Bai,“Curvature and Singularity Driven Diffusion for Oriented PatternEnhancement with Singular Points,” CVPR09. Proceedings of IEEEConference on Computer Vision and Pattern Recognition, pp. 1-7,Miami, Florida, USA, June 22-24 2009.The Announcement of the CopyrightAll rights of the PolyU HRF Database are reserved. The database is only available for research and noncommercial purposes. Commercial distribution or any act related to commercial use of this database is strictly prohibited. A clear acknowledgement should be made for any public work based on the PolyU HRF Database. A citation to "PolyU HRF Database, /doc/399f7c6fa45177232f60a2bf.html .hk/~biometrics/HRF/HRF.htm” and our related works must be added in the references. A soft copy of any released or public documents that use the PolyU HRF Database must be forwardedto: cslzhang@/doc/399f7c6fa45177232f60a2bf.html .hkDownloading Steps:Download “HRF DBI.zip”, “HRF DBII.zip”, or "Ground Truth.zip"to your local disk. Then, fill in the application forms. Send the application formto cslzhang@/doc/399f7c6fa45177232f60a2bf.html .hk. The successful applicants will receive the passwords for unzipping the files downloaded.HRF Databases:HRF DBI.zipHRF DBII.zipGround Truth.zipContact Information:Lei ZHANG, Associate ProfessorBiometric Research Centre (UGC/CRC)The Hong Kong Polytechnic UniversityHung Hom, Kowloon, Hong KongE-mail: cslzhang@/doc/399f7c6fa45177232f60a2bf.html .hk数据预览:点此下载完整数据集。
Comparative Studies of the Languages
Substitute vs. Repetitive(替换与重复)
Generally speaking, English doesn’t use so many repetitions as Chinese does. 英语多用替换词语;汉语多用重复形式。 You should help her since you have promised to do so. Men and nations working apart created these problems; men and nations working together must solve them.
During the wartime, years like these would have meant certain death for many people. Many would have become beggars and others would have been compelled to sell their children. 战争期间碰到这样的年景,很多人肯定会 死去,很多人会逃荒要饭,很多人会被迫 卖儿卖女。 Thus encouraged , they made a small bolder plan for the next year. 由于受到这样的鼓励,他们为第二年制定 了一个更大胆的计划。
Synthetic vs. Analytic (综合性与分析性)
English is a Synthetic language marked with inflexnguage without any inflexion, which is usually implied in the context or explicitly shown in such words as “ 着 ” “了”“过”etc. 英语属综合性语言,其标志为词的曲折 变化形式; 汉语为分析性语言,靠 “着”, “了”“过”之类的助动词表 达不同的时间关系。
一种外场雷达RCS测量方法
0 引言
暴露在电磁场中的物体将入射能量向各个方向散开, 这种能量的空间分布称为散射,物体本身称为散射体,返回 波源方向的能量形成物体的雷达回波。回波的强度用物体的 雷达反射截面(Radar Cross Section, RCS)来描述。目标的 RCS 包含目标的形状、尺寸等重要信息,是雷达能够获得的关 于目标电磁散射特性的主要物理量 , 随着测量技术的发展, 人们越来越重视目标 RCS 的测量,以便获取目标形状、尺寸 等测量信息,使测量信息更加精确、更加丰富。目前测量雷达 最基本的任务是探测目标,并对目标距离、方位、俯仰等位置 信息进行测量,没有对目标 RCS 测量的能力。但随着职能使 命的拓展,测量雷达测量不仅希望取得被测目标的外弹道信 息,还希望取得更多的有关目标特征信息,从而推导出目标 的形状、尺寸等信息,已达到目标识别的目的。通过分析雷达 方程,本文介绍一种比较测量方法,在不改变现有雷达结构 的基础上,通过测量已知 RCS 的标准目标,进行比较,对雷达 测量数据进行处理,能够有效地测量被测目标的 RCS,实例结 果验证了此方法的有效性。
雷达方程将雷达的作用距离和雷达发射机峰值功率、发 射信号脉冲宽度、接收机系统噪声温度、天线阵增益、目标有 效反射面积和环境等因素联系起来。因此它不仅可以用来决 定雷达检测某类目标的最大作用距离,同时通过已知雷达作 用距离和目标有效反射面积,可以推测雷达接收机性能等。 雷达跟踪方程为 :
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2019.09
A RCS Measurement method for external Field Radar
Jia Jipeng, Duan Qisheng (PLA Force 91245, Huludao Liaoning,125000)
Abstract:With the further expansion of the function and mission of the measuring radar, it is not only necessary to measure the position information of the target, but also more and more important to measure the characteristics of the radar target. With the development of the radar measurement technology, more and more RCS measurement methods are widely used. Based on the study of RCS measurement technology and combined with the fact that most measurement radars do not have the function of RCS measurement, a comparative measurement method is proposed in this paper, and an example is given to verify the effectiveness of this method. Key words: measuring radar; RCS; target characteristics
3给水排水 外文翻译 外文文献 英文文献
3给水排水外文翻译外文文献英文文献Relations between triazine flux, catchment topography and distancebetween maize fields and the drainage network F. Colina,*, C. Puecha, G. de Marsilyb,1aUMR “Syste`mes et Structures Spattiaux”, Cemagref-ENGREF 500, rue J.F. Breton 34093, Montpellier Cedex 05, FrancebUMR “Structure et Fonctionement des Syste`mes Hydriques Continentaux”, Universite´ P. et M. Curie 4, Pl. Jussieu 75252, Paris Cedex 05, FranceReceived 5 October 1999; revised 27 April 2000; accepted 19 June 2000AbstractThis paper puts forward a methodology permitting the identification of farming plots contributing to the pollution of surface water in order to define the zones most at risk from pesticide pollution. We worked at the scale of the small agricultural catchment (0.2–7.5 km2) as it represents the appropriate level oforganisation for agricultural land. The hypothesis tested was: the farther a field undergoing a pesticide treatment is from a channel network, the lower its impact on pollution at the catchment outlet.The study area, the Sousson catchment (120 km2, Gers, France), has a “herring bone” structure: 50 independent tributaries supply the main drain. Pesticide sales show that atrazine is the most frequently used compound although it is only used for treating maize plots and that its application rate is constant. In two winter inter-storm measurement exercises, triazine flux values were collected at about 30 independent sub-basin outlets.The contributory areas are defined, with the aid of a GIS, as different strips around the channel network. The correlation between plots under maize in contributory zones and triazine flux at related sub-basin outlets is studied by using non-parametric and linear correlation coefficients. Finally, the most pertinentcontributory zone is associated with the best correlation level.A catchment typology, based on a slope criterion, allows us to conclude that in steep slope catchments, the contributory area is best defined as a 50 m wide strip around the channel network. In flat zones, the agricultural drainage network is particularly well developed: artificial drains extend the channel network extracted from the 1/25.000 scale topographic map, and the total surface area of the catchment must be taken to account. q 2000 Elsevier Science B.V. All rights reserved.Keywords: Pesticide catchment; GIS artificial network1. IntroductionThe use of pesticides in western agriculture dates back to the middle of the 19th century (Fournier,1988). Since then, because of their intensive use,yields have increased and the demand for agricultural products has been satisfied. However, the pollution created by theiruse threatens both drinking water resources and the integrity of ecosystems. Therefore, there is a great demand for the reduction of pollution.The remedies lie in changes in the way that agricultural land is managed. The problem of agricultural Journal non-point source pollution by pesticides must be taken from the field, the level of action, to the catchment,the level of control of the water resource.Between these two spatial scales, different levels of organisation can be found. Fields, groups of fields,basins and main catchment, can be viewed together as nested systems (Burel et al., 1992). For each scale level, the main processes governing water movement and soluble pollutant transport are different, as are the variables characterising the system (Lebel, 1990):flow in macropores at local scale, preferential flowpaths at the hillslope scale, flows in connection withthe repartition of different soils at the catchment scale,geology influence at the regional scale(Blo¨sch and Sivapalan, 1995).At the field level, an experimental approach can be used and the relative weight of each variable can be experimentally tested (Scheunert, 1996; Bengtson et al., 1990). The major factors that concern agricultural practices have been identified and many agricultural management indicators have been developed (Bockstaller et al., 1997). Nevertheless, this approach cannot be applied at the catchment scale for several reasons: the need to measure the pollution and the environmental factors simultaneously, multiple measurement difficulties, the complexity of analysis. The variability of observations has temporal and spatial components. Rain induces pesticide leaching and therefore causes temporary high pesticide concentrations in the water; the closer the pesticide spreading date in thefield is to the measurement, the greater the concentration levels (Seux et al., 1984; Reme,1992; Laroche and Gallichand, 1995). The extensive use of Geographical Information System (GIS) has made it possible to analyse the impact on the pollution of the spatial characteristics of agricultural zones (Battaglin and Goolsby, 1996). But so far, the results of these experimentshave only led to an approximate estimate of the risks (Tim and Jolly, 1994).In order to progress in the search for ways to reduce pesticide pollution, it would be worthwhile to improve our assessment of how spatial structure and organisation affects the levels of pollutants measured.This paper presents the results of a study that concerns a particular aspect of the influence of spatial organisation on pesticide transfer: the effects of the distance between the cropland and the channel network. The longer the distance between a cultivated field and a river, the greater the retention and degradation processes (Leonard, 1990; Belamie et al.,1997). One mighttherefore imagine that the greater the distance, the lower the pollution level. However,few studies have given a numerical value to the critical distance at which a field does not influence river pollution significantly. Usually, when dealing with risk zone definition, experts establish an arbitrary distance (Bouchardy, 1992). Our main goal is to determine through spatial analysis the critical distance from a hydrographic network. The zones most at risk from pesticides, including the plots, which contribute most of the pollution, can then be determined.The study area, the Sousson catchment (Gers,France) has certain physical characteristics, which allows sampling of most of the independent subbasins, defined here as agricultural production zones. Its particular morphology made the comparative study of the production zones possible. The method involves a statistical comparison between pollution measurements and spatial characteristics of thecatchments. In order to establish the boundaries ofthe contributing areas, the pollution flux measured at the production zone outlet is compared to the landcover, estimated within strips of variable width around the channel network. Results are shown and discussed from a mainly practical viewpoint.2. The study area and collected data2.1. Study area descriptionThe study area is the Sousson catchment, in southwestern France (Gers). The Sousson River is a tributary of the river Gers. The catchment area is 120 km2. The 32 km long hydrographic network has a ‘herringbone’pattern: 53 sub-basins with fairly homogeneous surfaces areas ranging from 0.2 to 7.5 km2 serve the central drain (Fig. 1).The wide, gently sloping and heavily cultivated left bank, differs from the right bank, which is narrow, steep and mainly made up offorest and pastureland.The Sousson catchment area is exclusively agricultural.There is no industry or settlement of more than 200 inhabitants. The two main crops cultivated aremaize and winter wheat (17 and 15% of the catchment surface area, respectively). The maize fields are usually situated, on the left bank, in the upstream middle of the catchment area, and along the main river.There are two types of soil: a calcareous soil, which is quite permeable, and a non-calcareous soil called locally ‘boulbenes’ with an top limoneous layer and a lower silty layer. In order to avoid the stagnation of water in the upper layer caused by the silty impermeable layer, the fields on boulbene soil are artificially drained. Maize is cultivated for preference on thistype of soil.No significant aquifer has been found in the catchment, as the substratum is rather impervious (clays).2.2. Collected data2.2.1. Spatial dataA GIS was developed for the area, which contains the following information layers:²the hydrographic network and the catchment boundaries digitized from 1/25.000 scale topographic map;² a gridded Digital Elevation Model (DEM) of the zone providing landsurface slopes generated from DEM with a resolution of 75 m;²the boundaries of cultivated fields digitized from aerial photos at scale of 1/15.000;²landcover for both 1995 and 1996 was defined in detail in the study area. For 1997, landcover was identified by remote sensing. Knowledge of agricultural antecedents enhanced the classification of a SPOT (Satellite Pour l0Observation de la Terre) image. As a result, the maize areas for the entire Sousson catchment were determined for 1995, 1996 and 1997 (Fig. 2).GIS functions are capable of determining the landcover of each catchment by intersecting the two information layers “landcover” and “catchment boundaries”, or defining a zone of constant width around the hydrographic network, which is called the buffer zone.In order to evaluate the pesticide application rate, figures for local pesticide sales were collected. Atrazine, alachlor and glyphosate are the most commonly used compounds, atrazine far outstrips the others triazines as the most frequently used product (ten times less simazine is sold). In this region, atrazine is only used in maize cultivation. The application rate (mass of atrazine sold/maize surface area) does not vary from one municipality to another.To simplify the investigations, we chose to study the atrazine spread on maize plots in May. We assume that all the maize plots are treated with atrazine and that the application rate is uniform.2.2.2. Water pollution dataTwo series of measurements were made during the winter period: 23 sub-basins were sampled on December 3rd and 4th 1997, and 26 sub-basins were sampled March 17th to 19th 1998. Hence, the atrazine treatments were carried out 7 or 10 months before and the maize harvest was 1 and 4 months before the measurements were taken.To obtain stable hydrological conditions, the chosen measurement dates coincided with decreasing flow as shown in Fig. 3. The same operator collected the quality samples and gauged the river flow in order to limit measurement errors.The triazine concentration was measured with an ELISA water test (Transia Plate PE 0737). This measurement technique is less accurate than the classical chromatography technique, but it permits a faster analysis of a large number of samples (Rauzy and Danjou, 1992; Lentza-Rios, 1996). As atrazine is the mostwidely commercialised triazine product in this region, we will consider that observed triazine concentrations are representative of atrazine concentrations.December 1997 values, and March 1998 values were grouped together in order to assemble a large enough sample for statistical analysis (Fig. 4). The instantaneous triazine flux was obtained by multiplying the triazine concentration with the dischargevalue. As shown in Table 1, water flow in December 1997 was double that in March 1998, but the corresponding triazine flux are comparable.2.2.3. Quality assuranceTo control the quality of ELISA water-test measurements, each concentration was analysed 142 F. Colin et al. / Journal of Hydrology 236 (2000) 139–152 Fig. 2. Hydrographic network (topographic 1/25.000 map) and subcatchments, parcel limits and land-cover (example of maizeplots). twice. A maximum difference of 20% is tolerated between two duplicate samples, the median error is 10%, and mean values are used. It is possible that ELISA measurement induces a consistent error by comparing with gas chromatography measurements (Tasli et al., 1996), but this bias is compensated by comparative reasoning on all the samples.A few points were measured two or three times during the exercise in order to evaluate the daily variations during the sampling period. Table 2 shows that the flux variation between different days of a sampling period ranges from 2 to 49%. It is therefore possible to compare the different samples from the period in question. All the measurements from each period are then grouped together.The uncertainty on the triazine flux is the sum of the uncertainty of discharge and concentration measurements. The uncertainty on the discharge measurements ranges from 15 to 20%. Therefore, the triazine flux value isgiven with a maximum uncertainty of 40%.3. MethodTo define the zones most at risk we tested how the distance to the river of the areas where pesticides are applied influence pollution levels. Thus, we have to determine the relative position of the hydrographic network and the contaminating plots.In our case, the data on pollution is provided by triazine flux measurements taken at basin outlets and the potentially contaminating fields are maize plots.3.1. Efficiency curve and spatial partitionThe basic hypothesis is that the impact of the field as a contributor to pollution decreases the further it is from the channel network. Thus, there is a critical distance at which the field makes little contribution to outlet pollution. In other words, we assume that plot contribution to pollution level can be modelled through adecreasing efficiency curve. This hypothesis will be tested with a very simple curve: a step function. This curve is defined using only one parameter, the threshold limit distance, d, beyond, which a plot stops contributing to river pollution.In practice, this hypothesis implies a three-step approach:²determination of the location of the maize fields;²definition of a buffer of width d, equal to the threshold distance and, which surrounds the channel network;²determination of the contaminating fields inside these limits.The fields define the contributing maize areas depending on the buffer width (Fig. 5). At this stage, GIS functionality is required, particularly for the buffer function.3.2. Correlation between contributing area and pollution at the catchment outletWe studied the correlation level between triazine flux measured at the catchment outlet and the different contamination contributing areas defined by strips of variable width. Three parameters are used to determine the correlation level (further information is provided on this point in Appendix A):²The Kendall rank correlation coefficient (Siegel, 1956) t gives a measure of the degree of association or correlation between two sets of ranks. It expresses the difference between the probability that the two data sets are ranked according to the same order and the probability that they are ranked according to a different order. If t . 1.21.; a positive (negative) relation exists between the two data series, if t . 0; there is no relation between the two data series.²The Spearman rank correlation coefficient R (Siegel, 1956) requires that individuals under study be ranked in two ordered series. As the Kendall coefficient t , R expresses the existence of any one relation between two data series if itsvalue is close to 1.²The linear correlation coefficient r (Wonnacott and Wonnacott, 1991) expresses the intensity of a linear relation between two data series; r2 is the part of the variance explained by the linear model.The two first parameters evaluate if a relation exists between observed triazine flux and the different tested maize areas without hypothesis on the form of the relation. The linear correlation coefficient allows a special relation type to be tested. The squared value of the Spearman coefficient R, as the correlation coefficient r, expresses a part of total variance on the ranks. The Kendall coefficient represents the probability of two series being ranked in the same way against the probability of them being ranked in a different way. The use of non-parametric coefficients confers robustness to the method in relation to distributional skewing (Barringer et al., 1990).The most significant correlation levelcorresponds to the most accurate threshold distance d. This distance d defines the zone for which the relation between fields undergoing atrazine treatment and triazine flux is the highest. The buffer of width d will be defined as, “the zone most at risk”, even if plots outside this buffer zone may contribute in a small way to the pollution.3.3. Catchment typologyThe study of the slopes in the whole catchment shows a significant disparity between the upstream and downstream zones. The slopes in the upstream zone are gentle while those in the downstream zone are steep. In order to describe these morphological differences, the index Islope threshold was calculated for each basin: Islope . Sslope.5%=Stotal .1. where Sslope.5% is the basin surface area where the slope is steeper than 5% and Stotal the total surface area of the basin.The 5% threshold slope was chosen because itrepresents the upper limit at which mechanised agriculture can still be practised.The higher the Islope, the greater the proportion of steep slope zones in the basin. In order to sequence basins, a limit of Islope . 0:5 was chosen. This value corresponds to an equal part of flat and steep slope zones in a catchment. Furthermore, this typology separates the sampled basins into two groups of a comparable number of elements. This catchment typology shows a classification according to the position upstream and downstream in the Sousson catchment (Fig. 6).4. ResultsDuring the winter, in December 1997 and March 1998, water quality and discharge measurements were made to determine triazine flux. The network was digitized from the 1/25.000 scale topographic map. The buffers tested are 50 m, 100 m, and 200 m wide. The entire catchment corresponds to the maximumwidth, which is close to 500 m for the downstream group basins and 250 m for the upstream group, which has a more pointed shape. As it is noted by Barringer et al. (1990), the minimum used buffer width must be superior to that of the mapping unit. Here, maize field were determined using information provided by SPOT satellite imagery, (resolution 20 m), with field boundary definition based on 1/10.000 aerial photos (1 mm on the map is equal to 10 m on field).The area was divided into strips around the channel network. Then, the maize fields were putback into this division of space to obtain, for each basin, maize surface area within 50, 100 and 200 m of the hydrographic network, and within the whole catchment.4.1. Study of the whole set of basinsResults of regressions for 23 catchment areas in December 1997 and 26 in March 1998, whichinclude a Kendall rank correlation, a Spearman rank correlation and linear correlation coefficients are given with their significance level in Table 3. Calculated correlation coefficients do not seem to vary consistently as a function of the selected threshold distances: the number of coefficients increase in all cases when the buffer area is enlarged with the exception of December where they decreased in number for the whole catchment area. Considering these results, one might think that the distance of the field from the river has no effect on the pollution. However, if upstream and downstream basins are separated, according to the slope criterion Islope, the results are very different.4.2. Study of the downstream basins Regressions were carried out on nine basins in December 1997 and on 13 in March 1998, mean triazine concentrations are 42.0 and 123.0 ng/l, respectively. Results are shown in Table 4. Calculated correlation coefficients decreasewhen the strip width around the channel network increases. The best correlation levels are obtained for a distance d of 50 m (100 m for the linear correlation in December 1997). The Kendall and the Spearman correlation coefficients show the existence of a relation between maize area inside a 50 m wide buffer zone around the channel network and the triazine flux at the catchment outlet. The linear relation is quite adequate to model this variable association given that 69% of the total variance is explained in December 1997 and 56% in March 1998 considering that d equals 50 m. Resultsobtained for the two measurement dates are mutually coherent although differences exist. In December, whatever the value of d, the significance level is above the acceptance limit (p . 5%). The relation between maize area and triazine flux is optimal for d equal to 50 or 100 m but still exists for d equal to 200 m or considering the whole catchment surface area.The correlation between pollutant flux and maize areas far from the river can be explained by two ways. On the one hand, there is a correlation between the different maize areas (cf. Table 6). Indeed, if maize surface areas within different buffer zones were perfectly proportional, i.e. if linear correlation coefficients between the different maize surfaces areas were equal to one, no variation wouldbe detected in the correlation coefficients between maize surface areas and triazine flux. The sets of basins studied were not exactly the same during the two measurement exercises. For December 1997, the level of correlation between the different maize surface areas is higher than for March 1998 (as it is shown in Table 6). This difference between the two series is partly responsible for the slow decrease in the number of correlation coefficients concerning distance d for December 1997. On the other hand, as it is shown in Fig. 3, December 1997 measurements were made during the falling limb of thehydrograph and thus we can assume that, in these hydrological conditions, the area contributing to pollution is larger and includes zones distant from the hydrographic network for the whole catchment area. However, in March 1998, in lower water level conditions, only correlations where d is equal to 50 m are significant at the 5% threshold.We can conclude that the limit of 50 m is the most appropriate to define the zones most at risk for the two monitoring periods — seven and ten months after the triazine applications —even if hydrological conditions are also important when defining the contribution of the other maize plots located on the whole catchment area.4.3. Study of the upstream basinRegressions were made on 14 catchments for December 1997 and 13 basins for March 1998, mean triazine concentrations are 177.9 and 314.6 ng/ l, respectively. Results are shown inTable 5. The correlation coefficients become more numerous with strip width, while the opposite is true for the downstream basins. In most cases, the best results are obtained by considering the whole catchment area. The linear model is less accurate for the December data set .r2 . 38%. than the Spearman rank correlation .R2 . 70%.: It suggests an association between variables more complex than the linear relation does.Field investigations provide the explanation of the difference between the two catchment groups. For upstream catchments, the hydrographic network taken as the reference is irrelevant. In this flat zone, the artificial drain network around each plot extends the channel network; thus, the real active network is denser than that of the topographic 1/25.000 map. Fig.7 shows, for a particular catchment, the differences between the topographic 1/25.000 map network and the active one observed in the field. Moreover, this ditch network is connectedwith buried drains located under most of the fields in this upstream zone. The consequence is that each field is artificially connected with the catchment outlet.This difference in optimal width between the upstream and downstream catchments is the consequenceof man’s activities on the flat upstream area. In this case, the total catchment surface area must beconsidered as a contributing area.5. DiscussionWe chose to take the measurements in winter because it is easier to compare triazine flux at the catchment outlets. In spring, which is the atrazine spreading period, the differences in flux could be due to differences in the application dates. We used instantaneous inter-storm triazine flux measurements to maximise the stability of the transfer processes (Woods and Sivapalan, 1995). Thus, our resultsdo not necessarily apply to transfer during peak runoff. As the measurements were made between stormy periods our attention was focussed on the slow components of water movement such as subsurface runoff, drainage flow and water circulation in soil, where leaching favours the transport of soluble compounds such as atrazine. These conditions are not maximal from the point of view of instantaneous pollutant quantity export, but do represent a nonnegligible quantity and this over long periods of the year. However, this was a way to acquire comparable data sets at several basin outlets. Moreover, with these data sets it is possible to integrate the spatial diversity and give the results in a form that can be generalised.A simple model of contribution through buffers of stationary width around the hydrographic network was used, where each buffer defines a zone contributing to pollution. The degree of correlation between thecontributing areas and the pollution at the basin outlet was determined.The results show that a critical contribution distance cannot be defined for all basins studied. However, basin typology based on morphology criteria permitted the identification of two groups of basins.These basins have to be considered separately as their water movement characteristics are very different.For the downstream basins, which have a marked relief, the channel is well defined by the network that figures on the 1/25.000 scale topographic map. The model identifies a critical contribution distance, which ranges from 50 to 100 m. Atrazine is little adsorbed by soil, very soluble and easily leached. In inter-storm periods, it is not surface runoff, which causes the water transfers but sub-surface runoff and the draining of local aquifers surrounding the hydrographic network. The area of strongest influence ranges from 50 to 100 m and gives a good representation of the zone where atrazinetransport processes are active. This optimal distance should be determined for different climatic conditions and different periods of the agricultural year. Then we would know if the contributing area possesses temporal dynamics or if it remains stable.The upstream basins have higher triazine concentrations. These areas are characterised by the high proportion of flat zones (slopes of less than 5%), and an artificial drainage network connecting each plot to the main drain in order to avoid flooding. Thus, each plot contributes to the pollution measured at the basin outlet. The topographic 1/25.000 map network does not include this effect of the human intervention on the water circulation, and it is not pertinent in a drained region to evaluate the distance between cropland and the river.How the hydrographic network is defined is critical to the success of this analysis. The initial choice was based on the network digitized from the 1/25.000 scale topographic map. The mainbenefit to be derived from using such a network is its availability, which allows us to easily transpose the methodology. It represents the perennial flow network, stable in time. But, from the point of view of water movement, it lacks locations of manmade drains that can accelerate he transport of solute pollution. From a practical point of view, it is preferable to study the farmlandand identify zones with intensive artificial drainage before defining the boundaries of contributing areas around the channel network.6. ConclusionsIn order to reduce surface water pollution, the application of pesticides has to be controlled and agricultural practices must be such that they respect the environment. But the proper management of cropland must not be neglected either. The spatial organisation of fields has an impact on river pollution.The effect of the distance between fields contributing to the。
烯丙基半胱氨酸综述
大蒜蒜氨酸:S-烯丙基-L-半胱氨酸亚砜alliinSACS蒜氨酸酶:蒜苷酶alliinase大蒜素:蒜素allicin二烯丙基硫醚:daillylsulfide,DAS二烯丙基二硫醚:diallyldisulfide,DADS二烯丙基三硫醚:diallyltrisulfide,DATS阿霍烯:ajoeneS-烯丙基-L-半胱氨酸:脱氧蒜氨酸、S-烯丙基半胱氨酸、S-烯丙基别半胱氨酸、L-脱氧蒜氨酸、烯丙基-L-半胱氨酸;S-allylcysteine,SAC,S-烯丙基硫基半胱氨酸:S-allylmercaptocysteine,SMACγ-谷酰胺半胱氨酸化合物:γ-glutamy-l-S-allylcystein)一、《大蒜中含硫氨基酸研究进展》药理活性1、清除自由基与抗氧化活性:SAC保护肺动脉内皮细胞由H2O2引起的细胞损伤,抑制内皮细胞释放乳酸脱氢酶(LDH),抑制脂质过氧化物的产生(Kourounakis,1991)。
在1,1-二苯基-2-二苦基偕腙肼(DPPH)检测中,SAC显示出对自由基的消除作用。
(InaiJ,1994)。
2、抗肿瘤活性:SAC除能保护肝细胞外,对DMH诱发的结肠癌有预防作用,对人体成神经细胞瘤有抗增生的作用(NagaeS,1994)。
每周灌胃3次,连续两周,SAC可有效地抑制大鼠乳房组织中7,12-二甲基苯并蒽诱导的DNA加合物的形成,提示有抗乳腺癌发生作用(SongK,1999)。
3、保肝活性:Hikino等用原代培养的大鼠肝细胞进行试验,证明大蒜挥发油和SAMC对CCl4所致肝细胞毒有拮抗作用,主要有效成分也包括SACS及微量的SAC 和SMC。
4、神经营养活性:Moriguchi报道从大蒜中提取的几个有机硫化物能促进小鼠海马神经元功能,SAC能提升有学习效应的轴索分支神经的功能,该研究结果也证明了S-烯丙基基团对产生神经营养作用是必须的。
二、《大蒜提取单体化合物生物学功能的研究进展》施枝军,唐圣松,20081、大蒜所含的主要单体化合物γ-谷酰胺半胱氨酸化合物(γ-glutamy-l-S-allylcystein)是天然生大蒜中存在的最主要含硫物质,除此之外,其他绝大多数含硫化合物都并非天然存在于大蒜的球茎内,而是以γ-谷酰胺半胱氨酸化合物为前体转化而来。
计量的比较法的英文
计量的比较法的英文Comparative Methods in MeasurementMeasurement is a fundamental aspect of scientific inquiry and technological advancement. It allows us to quantify the physical world around us, enabling us to understand and manipulate the various phenomena we encounter. However, the process of measurement itself can be complex and subject to various sources of error. One approach to addressing these challenges is the use of comparative methods in measurement.Comparative methods in measurement involve the comparison of a quantity or property of interest to a known reference or standard. This approach provides a systematic way to assess the accuracy and precision of measurements, as well as to identify and mitigate potential sources of error. By comparing the measurement of interest to a reliable reference, researchers and engineers can gain a deeper understanding of the characteristics of the system or phenomenon under investigation.One of the primary advantages of comparative methods in measurement is the ability to improve the reliability and consistencyof measurements. When a measurement is compared to a known reference, any discrepancies or deviations can be identified and addressed. This allows for the identification and correction of systematic errors, such as those caused by instrument calibration, environmental conditions, or operator bias. By addressing these sources of error, the overall accuracy and precision of the measurement can be enhanced.Another key benefit of comparative methods in measurement is the ability to establish traceability. Traceability refers to the ability to link a measurement result to a recognized reference or standard, typically through an unbroken chain of comparisons. This is crucial in many scientific and industrial applications, where the reliability and reproducibility of measurements are of utmost importance. By establishing traceability, researchers and practitioners can ensure that their measurements are consistent with accepted standards and can be compared to measurements made by others in the same or different contexts.Comparative methods in measurement can take various forms, depending on the specific application and the nature of the quantity or property being measured. Some common examples include:1. Calibration: This involves the comparison of a measurement instrument or device to a known reference standard to ensure itsaccuracy and precision. Calibration is essential for maintaining the reliability of measurement equipment and is a fundamental aspect of quality assurance in many industries.2. Interlaboratory comparisons: In this approach, multiple laboratories or research groups measure the same quantity or property and compare their results. This allows for the identification of systematic biases or inconsistencies between different measurement methods or protocols, and can help to establish consensus on the true value of the measured quantity.3. Proficiency testing: Proficiency testing involves the distribution ofa known reference material or sample to multiple laboratories or individuals, who then measure the relevant properties and compare their results. This approach is commonly used in fields such as analytical chemistry, environmental monitoring, and clinical diagnostics to assess the competence and reliability of measurement practices.4. Reference materials: The use of well-characterized reference materials, such as certified reference materials (CRMs) or standard reference materials (SRMs), provides a reliable basis for comparison in measurement. By comparing the measurement of a sample to the known value of a reference material, researchers and practitioners can evaluate the accuracy and precision of their own measurementmethods.The application of comparative methods in measurement extends across a wide range of scientific and technological domains, from physics and chemistry to engineering and medicine. In each of these fields, the ability to make accurate and reliable measurements is crucial for advancing our understanding of the world and developing innovative solutions to complex problems.For example, in the field of materials science, comparative methods are used to characterize the physical, chemical, and mechanical properties of various materials. By comparing the measurements of a material sample to known reference standards, researchers can assess the quality, performance, and suitability of the material for specific applications. This information is essential for the development of new materials and the optimization of manufacturing processes.In the healthcare sector, comparative methods in measurement are critical for ensuring the accuracy and reliability of diagnostic tests and medical devices. Clinical laboratories, for instance, routinely participate in proficiency testing programs to verify the accuracy of their analytical methods and instruments. Similarly, medical imaging technologies, such as X-ray and MRI, rely on comparative methods to calibrate and validate the performance of their imaging systems,ensuring that the resulting images provide a reliable representation of the patient's anatomy and physiology.In the field of environmental monitoring, comparative methods are used to assess the quality and purity of various environmental media, such as air, water, and soil. By comparing the measurements of environmental samples to known reference standards, regulatory agencies and research organizations can evaluate the extent of environmental pollution, the effectiveness of remediation efforts, and the overall health of the ecosystem.Overall, the use of comparative methods in measurement is a crucial aspect of scientific and technological advancement. By providing a systematic approach to ensuring the accuracy and reliability of measurements, these methods contribute to the advancement of knowledge, the development of innovative solutions, and the protection of human health and the environment. As our understanding of the world continues to evolve, the importance of comparative methods in measurement will only grow, driving further progress and discovery across a wide range of disciplines.。
管理会计论文题目参考10篇
管理会计论文题目参考10篇1. “Impact of Activity-Based Costing (ABC) on Business Performance: An Empirical Study”This paper examines how the implementation of Activity-Based Costing (ABC) affects a company's business performance. The study uses quantitative methods to analyze data from various companies that have adopted ABC. Results suggest that ABC leads to more accurate cost information, better decision-making, and improved financial performance.2. “The Role of Management Accounting in Corporate Social Responsibility (CSR) Reporting”This paper explores the connection between management accounting and Corporate Social Responsibility (CSR) reporting. It discusses the role of management accountingin providing the necessary data and information for CSR reporting, and identifies challenges faced by companies when implementing CSR reporting. The study concludes with recommendations for companies to improve their CSRreporting processes.3. “Impact of Budgeting on Organizational Performance: Evidence from the Manufacturing Sector”This paper aims to determine the correlation between budgeting and organizational performance in the manufacturing sector. Using data from a sample of manufacturing firms, the study uses regression analysis to test hypotheses. Results suggest that budgeting has a positive impact on organizational performance and that awell-designed budgeting process can lead to betterfinancial results and increased organizational efficiency.4. “Performance Measurement Systems in the Public Sector: A Comparative Study of Two Countries”This paper compares performance measurement systems in the public sector of two countries: the United States andthe United Kingdom. It analyzes the different approaches to measuring performance within each country and identifieskey similarities and differences. The study concludes with recommendations for improving performance measurement systems in the public sector.5. “The Role of Cost-Volume-Profit (CVP) Analysis in Decision-Making for Small and Medium-Sized Enterprises (SMEs)”This paper examines the role of Cost-Volume-Profit (CVP) analysis in decision-making for Small and Medium-sizedEnterprises (SMEs). The study uses a case study approach to demonstrate how SMEs can use CVP analysis to make better decisions about pricing, production, and cost control. Results suggest that CVP analysis can be a valuable toolfor SMEs to improve their profitability and manage their costs.6. “The Impact of Lean Accounting on Organizational Performance: A Case Study of a Manufacturing Company”This paper investigates the impact of Lean Accounting on the organizational performance of a manufacturing company. The study uses a case study approach to demonstrate how Lean Accounting principles can lead to improved financial performance and organizational efficiency. Results suggest that the implementation of Lean Accounting can result in improved cost control and increased profitability.7. “The Use of Activity-Based Management (ABM) in Healthcare Organizations”This paper explores the use of Activity-Based Management (ABM) in healthcare organizations. It discusses the challenges of implementing ABM in the healthcare sector and identifies the benefits of using ABM for cost controland quality improvement. The study concludes with recommendations for healthcare organizations to improvetheir use of ABM.8. “Budgeting and Forecasting in the Hospitality Industry: A Case Study of a Hotel Chain”This paper examines budgeting and forecasting practices in the hospitality industry, using a case study of a hotel chain. The study discusses the challenges faced by hotels when budgeting and forecasting, and identifies ways inwhich they can improve their process to achieve better financial results. Results suggest that the implementationof a flexible budgeting process can lead to improved profitability.9. “The Role of Management Accounting in the Implementation of Environmental Management Accounting (EMA)”This paper explores how management accounting can support the implementation of Environmental Management Accounting (EMA). It discusses the key concepts of EMA and identifies the benefits of implementing EMA in organizations. The study concludes with recommendations for companies to improve their use of EMA to achievesustainable development goals.10. “Performance Measurement in Nonprofit Organizations: A Comparative Study of Two Organizations”This paper compares performance measurement practices in two nonprofit organizations. The study discusses the challenges of measuring performance in the nonprofit sector and identifies key differences in measurement practices between the two organizations. The study concludes with recommendations for nonprofits to improve their performance measurement practices.。
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Journal of Pharmaceutical and Biomedical Analysis 52 (2010) 645–651Contents lists available at ScienceDirectJournal of Pharmaceutical and BiomedicalAnalysisj o u r n a l h o m e p a g e :w w w.e l s e v i e r.c o m /l o c a t e /j p baSurvey and qualification of internal standards for quantification by 1H NMR spectroscopyTorgny Rundlöf a ,∗,Marie Mathiasson a ,Somer Bekiroglu b ,1,Birgit Hakkarainen a ,b ,Tim Bowden c ,Torbjörn Arvidsson a ,baMedical Products Agency,P.O.Box 26,SE-75103Uppsala,SwedenbDivision of Analytical Pharmaceutical Chemistry,Department of Medicinal Chemistry,Uppsala University,Biomedical Centre,Box 574,SE-75123,Uppsala,Sweden cDivision of Polymer Chemistry,Department of Materials Chemistry,Uppsala University,Ångström Laboratory,Box 538,SE-75121Uppsala,Swedena r t i c l e i n f o Article history:Received 23November 2009Received in revised form 29January 2010Accepted 4February 2010Available online 11 February 2010Keywords:Nuclear magnetic resonance spectroscopy QuantificationInternal reference standard Absolute puritya b s t r a c tIn quantitative NMR (qNMR)selection of an appropriate internal standard proves to be crucial.In this study,25candidate compounds considered to be potent internal standards were investigated with respect to the ability of providing unique signal chemical shifts,purity,solubility,and ease of use.The 1H chemical shift (ı)values,assignments,multiplicities and number of protons (for each signal),appropri-ateness (as to be used as internal standards)in four different deuterated solvents (D 2O,DMSO-d 6,CD 3OD,CDCl 3)were studied.Taking into account the properties of these 25internal standards,the most versatile eight compounds (2,4,6-triiodophenol,1,3,5-trichloro-2-nitrobenzene,3,4,5-trichloropyridine,dimethyl terephthalate,1,4-dinitrobenzene,2,3,5-triiodobenzoic acid,maleic acid and fumaric acid)were quali-fied using both differential scanning calorimetry (DSC)and NMR spectroscopy employing highly pure acetanilide as the reference standard.The data from these two methods were compared as well as utilized in the quality assessment of the compounds as internal standards.Finally,the selected internal standards were tested and evaluated in a real case of quantitative NMR analysis of a paracetamol pharmaceutical product.© 2010 Elsevier B.V. All rights reserved.1.IntroductionQuantitative NMR (qNMR)was introduced already more than 50years ago and the first study on pharmaceuticals was published in 1963[1,2].The state of the art of qNMR in the field of pharmaceu-ticals and related areas was reviewed [3–6]and during the recent years scientific publications emerged at an escalating rate.An advantage of qNMR compared to other instrumental analyt-ical methods is that it is a primary ratio method of measurement,since the peak areas are proportional to the number of corre-sponding nuclei giving rise to the signals [7–9].The uncertainty in quantification measurement by NMR spectroscopy is low [10,11]and the performance of qNMR is similar to that of the alternative analytical techniques [12].Compared to the traditional chromato-graphic methods that are still favored in routine quantitative analyses,NMR spectroscopy have certain advantages [10]such as∗Corresponding author at:Medical Products Agency,P.O.Box 26,SE-75103Upp-sala,Sweden.Tel.:+4618174842;fax:+4618548566.E-mail address:torgny.rundlof@mpa.se (T.Rundlöf).1Present address:TUBITAK Marmara Research Center,Food Institute,P.O.Box 21,41470Gebze/Kocaeli,Turkey.(i)simple and easy sample preparation,(ii)possibility to simulta-neously determine molecular structures,(iii)no need for individual experimental setup,e.g .,reference of the same compound and cal-ibrations,(iv)relatively short measuring times,(v)non-invasive and non-destructive character of the method,(vi)no need for prior isolation of the analyte present in a mixture,(vii)possibility of simultaneous quantitative analysis of multiple target analytes in a mixture.The applicability of qNMR has increased due to availability of high sensitivity/homogeneity NMR systems together with modern software packages which allow accurate and precise data process-ing.In qNMR a reference standard of the analyte is not needed,i.e .,the quantification may be performed using an internal stan-dard [1,5].Various internal standards have been used in qNMR [6],usually co-dissolved with the analyte,but also introduced in a separate coaxial insert tube [13].In recent time also quantifica-tion towards an electronically generated signal (peak)in the NMR spectrum,so-called Eretic,was evolved [14].However,a descrip-tive and comparative study on internal standards is non-existent in the literature.The scope of the present work was to study compounds that can be used as internal standards using 1H NMR experiments,since 1H nuclei are at the core of qNMR applications due to high sensitivity0731-7085/$–see front matter © 2010 Elsevier B.V. All rights reserved.doi:10.1016/j.jpba.2010.02.007646T.Rundlöf et al./Journal of Pharmaceutical and Biomedical Analysis52 (2010) 645–651Chart 1.and widespread presence in organic molecules,even though other NMR active nuclei like 13C,19F,and 31P can be employed [1].In qNMR the signal from the internal standard and the signal from the analyte must not overlap,and in the selection of compounds in this study attention was attempted so as to avoid normally crowded spectral regions.In the present work 25candidate qNMR internal standards were thoroughly investigated.Chemical shift (ı)values,assignments,multiplicities and number of protons (for each signal),appropri-ateness (as to be used as internal standards)of 25compounds in four different deuterated solvents (D 2O,DMSO-d 6,CD 3OD,CDCl 3)were examined.Some of these compounds were previously used in NMR quantification,while some others are novel.A method for qualification of the standards was also developed,in order to ensure accurate and precise qNMR measurements.Quantification of a pharmaceutical product was also performed using selected internal standards.2.Experimental2.1.Materials and chemicalsInternal standard substances,whose abbreviations and cer-tified purities from the manufacturer are given in respective parentheses,were as follows:dimethyl terephthalate (4,100.0%),maleic acid (5,100.0%),fumaric acid (8,100.0%),acetanilide (9,N -phenylacetamide,99.99%),dimethyl sulfone (10,99.9%),3,4,5-trimethoxybenzaldehyde (11,99.4%),hexamethylcyclotrisiloxane (12,99.9%),dimethylmalonic acid (13,99.8%),5-fluorouracil (99.9%),anthracene (99.0%),acetamide (99.9%)and l -leucine (100.0%)were purchased from Sigma Aldrich,Stockholm,Sweden,3,4,5-trichloropyridine (1,99.9%),1,3,5-trichloro-2-nitrobenzene (3,98.65%),2,4,6-triiodophenol (6,97.8%),2,3,5-triiodobenzoic acid (7,99.3%),2,4,5-trichloropyrimidine (14,99.4%),2,4,6-trifluorobenzoic acid (99.8%),2,3,4-trifluorobenzamide (99.9%)and 2,4,6-trichlorobenzoyl chloride (99.0%)were purchased from Fisher Scientific,Göteborg,Sweden,1,4-dinitrobenzene (2,99.9%)and 2,3,5-tribromothiophene (98.2%)were purchased from Alfa Aesar,Frölunda,Sweden,and sodium acetate (15,>99%),hexamine (99.5%),uracil (99.8%),3-sulfolene and 1,3,5-trimethoxybenzene were purchased from Merck,Stockholm,Sweden.The chemical structures of substances 1–15are depicted in Chart 1.Disposable 5mm NMR tubes,HIP-7,as well as deuteriumoxide (D 2O,99.8%),dimethylsulfoxide-d 6(DMSO-d 6,99.9%),methanol-d 4(CD 3OD,99.8%)and chloroform-d (CDCl 3,99.8%)with the chemical formulae and degrees of deuteration in parentheses,manufactured by Armar Chemicals,Döttingen,Switzerland,were purchased from Glaser Lab-Kemikalier,Göteborg,Sweden.The paracetamol 500mg medicinal product was obtained from Apoteket AB,Sweden.2.2.NMR sample preparationThe NMR samples used for determination of spectral properties and T 1relaxation times were prepared by dissolving a few mil-ligrams of the respective internal standard in ca.0.8ml deuterated solvent,followed by agitation on a vibrating test tube shaker until the solutions were clear.For the compounds dissolving poorly,ca .10-min sonication treatment in ultrasonic bath was used.Finally the clear solutions were transferred into NMR tubes.Samples for purity determination were prepared by precise weighing of 5–10mg of the selected substance and ca.5mg of acetanilide on separate aluminum pans using a Mettler-Toledo UMT2(Mettler-Toledo GmbH,Greifensee,Switzerland)microbal-ance with a resolution of 0.0001mg.Both pans were transferred to a 10ml glass sample tube,and 0.8ml deuterated solvent was added.The mixture was shaken,sonicated,and finally the solution was transferred into a disposable NMR tube.Six weighings were performed for each substance.For the commercially available 500mg paracetamol product sample,one tablet was weighed and,afterwards,pounded on a mortar.Every sample was made of ca .12mg powder and 5mg of the respective internal standard.Each mixture was then dissolved in ca.1.0ml of DMSO-d 6,shaken,sonicated and the solution trans-ferred into an NMR tube.Three weighings were performed for each internal standard.2.3.NMR instrumentationAll 1H NMR spectra were acquired at 25◦C using a Bruker Avance 300spectrometer operating at 300.13MHz.The spectrometer was equipped with a 5mm Z-gradient BB probe using a 1H 90◦pulse width of 7.2s.Processing and spectra handling was performed using Topspin 1.3program suite (Bruker Biospin GmbH,Rheinstet-ten,Germany).The experimental settings were as follows:excitation frequency 6.175ppm,spectral width 20ppm,64K complex data points,mea-surement temperature 25◦C,preacquisition delay (de)6s.A 30◦pulse was used.Data processing was performed using 64K dataT.Rundlöf et al./Journal of Pharmaceutical and Biomedical Analysis52 (2010) 645–651647Table1Spectral properties of the internal standards in different solvents.pound Mol.Weight(g/mol)SolventıH(ppm),multiplicity a,number of H bD2O DMSO-d6CD3OD CDCl313,4,5-Trichloropyridine182.448.44(s)[2]c8.77(s)[2]8.61(s)[2]8.53(s)[2] 21,4-Dinitrobenzene168.118.36(s)[4]c8.46(s)[4]8.47(s)[4]8.44(s)[4] 31,3,5-Trichloro-2-nitrobenzene226.45d8.12(s)[2]7.80(s)[2]7.47(s)[2] 4Dimethyl terephthalate194.19 3.85(s)[6]c 3.89(s)[6] 3.94(s)[6] 3.96(s)[6]8.02(s)[4]c8.09(s)[4]8.11(s)[4]8.11(s)[4]5Maleic acid116.07 6.21(s)[2] 6.03(s)[2] 6.26(s)[2]d 62,4,6-Triiodophenol471.80d7.97(s)[2]7.97(s)[2]7.94(s)[2]9.72(s)[1] 5.77(s)[1]72,3,5-Triiodobenzoic acid499.817.41(d)[1]c7.72(d)[1]7.75(d)[1]7.94(d)[1]c8.19(d)[1]c8.31(d)[1]8.35(d)[1]8.37(d)[1]c8Fumaric acid116.07 6.73(s)[2] 6.63(s)[2] 6.76(s)[2]d13.12(s)[2]9Acetanilide135.16 2.05(s)[3] 2.03(s)[3] 2.12(s)[3] 2.19(s)[3]7.15(m)[1]7.01(t)[1]7.10(t)[1]7.12(t)[1]∼7.3(m)[4]7.28(t)[2]7.30(t)[2]7.25(s)[1]7.56(d)[2]7.53(d)[2]7.33(t)[2]9.91(s)[1]7.51(d)[2]10Dimethyl sulfone94.13 3.03(s)[6] 2.99(s)[6] 3.01(s)[6] 2.99(s)[6] 113,4,5-Trimethoxybenzaldehyde196.20 3.76(s)[3] 3.76(s)[3] 3.86(s)[3] 3.95(m)[9]3.82(s)[6] 3.86(s)[6] 3.92(s)[6]7.14(s)[2]7.19(s)[2]7.26(s)[2]7.25(s)[2]9.88(s)[1]9.67(s)[1]9.88(s)[1]9.85(s)[1]12Hexamethylcyclotrisiloxane222.460.06(s)[18]c0.13(s)[18]∼0.1e0.18(s)[18] 132,2-Dimethylmalonic acid132.11 1.32(s)[6] 1.27(s)[6] 1.39(s)[6]d12.61(s)[2]142,4,5-Trichloropyrimidine183.428.67(s)[1]9.04(s)[1]8.79(s)[1]8.61(s)[1]15Sodium acetate82.03 1.80(s)[3] 1.58(s)[3] 1.89(s)[3]da Splitting pattern of the signal;(s)singlet,(d)doublet,(t)triplet,(m)multiplet or overlap.b Number of equivalent protons in the signal.c Very limited solubility.d Insoluble.e Multiple peaks observed.points and an exponential line broadening factor of0.3Hz.The chemical shifts were reported in parts per million(ppm)and all the spectra were referenced to the residual proton signals of the respective solvent:ıH4.67for D2O,ıH2.50for DMSO-d6,ıH3.31 for CD3OD,ıH7.27for CDCl3.Relaxation time measurements,using the inversion recovery technique,were performed under automation using16different tau delays ranging from0.001to5s,a repetition delay of50s,8 FID repetitions,16K complex acquisition data points,8K process-ing data points,1.0Hz line broadening factor,and non-linearfit of peak intensities.2.4.Quantification by NMRIn order to ensure reliable results for the purity determinations a repetition delay of90s was used,and64FID repetitions(num-ber of scans)resulted in a suitable signal-to-noise ratio.The other experimental settings were as stated above for1H NMR spectra. The measurement time was∼100min per sample.Phasing and integration of the spectrum was performed manu-ally,and the start and end points of each integral region were forced to zero amplitude using afifth order polynomial baseline correction algorithm.Integration regions around the signals of interest were selected to cover the entire frequency interval between the two carbon satellite signals,and did,in all cases,suffice a substantially wider range than the required32×the signal half width on both sides[15].Each integral edge was checked to be almost horizontal and,if needed,manual bias and/or slope correction was applied to the integral.The area of the signals appearing on a1D1H spectrum is directly proportional to the number of protons present in the active vol-ume of the sample.Hence,using Eq.(1),all the determinations in this study were performed on1D1H NMR spectra through the proportional comparison of the peak areas integrated for both the selected signal from the internal standard and from the substance in question:m(x)=P(std)·MW(x)MW(std)·nH(std)nH(x)·m(std)P(x)·A(x)A(std)(1)where m(x)and m(std)are the masses(weights)in g,MW(x)and MW(std)are the molecular weights in g/mol,P(x)and P(std)are the purities,nH(x)and nH(std)are the number of protons generating the selected signals for integration,A(x)and A(std)are the areas for the selected peaks of the analyte and the internal standard,all respectively.2.5.Differential scanning calorimetry(DSC)DSC measurements were performed on a Q1000DSC instrument (TA Instruments,DE,USA)equipped with a refrigerated cooling system and calibrated using an indium metal standard(99.999%). Three samples of each substance(internal standard)were weighed (1.7–2.6mg)in aluminum pans.Melting curves were recorded using encapsulated sample and empty reference pans,a sampling rate of2.0◦C/min,a sampling interval of0.10s/point,and a start temperature∼10◦C below the melting point of the sample.Purity calculations were performed using the purity analysis function as described in TA Instruments Explorer software,that operates according to the ASTM procedure E0928[16].648T.Rundlöf et al./Journal of Pharmaceutical and Biomedical Analysis52 (2010) 645–6513.Results and discussion3.1.The investigated compounds as internal standardsA suitable internal standard should meet the criteria given below:(i)ability of providing unique and stable signals(chemical shifts),(ii)available purity,(iii)solubility in different NMR solvents, (iv)easily weighable,(v)non-volatile,(vi)non-reactive,(vii)long-term stable,and(viii)having optimum molecular weight(small molecular weight compounds require very small amounts).Facing the difficulty offinding a suitable internal standard for a qNMR application,there exist only limited and fragmented information in the literature.There are numerous individual studies where only single type of applications were reported [17–19],whereas papers including several internal standards are rare[5,6].Filling this important gap,the chemical shift(ı) values,assignments,multiplicities and number of protons(for each signal),appropriateness of25compounds in four different deuterated solvents(D2O,DMSO-d6,CD3OD,CDCl3)were stud-ied.Some of these compounds were previously used in NMR quantification,while others are novel.The criteria for the selec-tion/ranking of these compounds were chosen on the basis of needs/requirements in our laboratory.Major criteria were unique chemical shift,sharp signal(preferably one singlet),solubil-ity properties,easy-to-use(weighing).Minor selection criteria were reactivity towards the analyte/solvent(inertness),protolytic properties,purity,and toxicity.Criteria such as complexation potential,long-term stability,and extraction behavior were,how-ever,not included in the selection/ranking procedure in this study.The suitability of the individual compounds as internal stan-dards was examined using different solvents.The spectral properties of the15highest ranked compounds were summarized (Table1),and the individual suitability of each of these compounds based on the criteria given above is discussed below.3,4,5-Trichloropyridine(1)was readily soluble in DMSO-d6, CD3OD,and CDCl3,but almost insoluble in D2O.It was an eas-ily weighable,crystalline compound that shows1H spectra with only one singlet originating from two protons in a normally signal-free region at ca.8.6ppm.The compound is a very weak protolyte, reasonably some orders of magnitude weaker base than pyridine [20],i.e.,the1H NMR chemical shift should not be effected due to protolytic activity in the sample.1,4-Dinitrobenzene(2)was soluble in DMSO-d6,CD3OD,CDCl3, but almost insoluble in D2O.The1H spectrum showed only one sharp singlet,originating from four protons at ca.8.4ppm.The substance is considered toxic and harmful for the environment.1,3,5-Trichloro-2-nitrobenzene(3)was soluble in all solvents except for D2O.The molecule contains only two aromatic protons, which appeared as one sharp singlet at around8.0ppm.Notably, the chemical shift varied much between different solvents.The substance is considered toxic.Dimethyl terephthalate(4)was easily soluble in DMSO-d6, CD3OD,and CDCl3,but almost insoluble in D2O.The proton spec-tra showed two sharp signals as singlets,one at ca.8.1ppm and another at ca.3.9ppm.The signal of the methyl group at around 3.9ppm had an unexceptional chemical shift in a normally signal-crowded area,whereas the low-field signal at around8.1ppm(4H) was of high potential to be employed as reference signal.Maleic acid(5)was soluble in all solvents except CDCl3.Two sig-nals appeared in the proton spectra of maleic acid:one sharp singlet at around6.1ppm,and a broad one for the carboxylic acid protons at around11.0ppm.Although the compound is hygroscopic,maleic acid was a good choice for the quantification analyses giving the credits to its distinct solubility in D2O and easy handling,i.e.,easily weighable crystalline.Maleic acid is a protolyte,i.e.,when mixed with other protolytes,the chemical shift of the signal may change to some extent.2,4,6-Triiodophenol(6)was soluble in all solvents except for D2O. It showed a valuable reference signal at around7.95ppm,being constituted by two protons.The phenolic proton appeared at about 9.8ppm as a broad peak.The compound is a weak protolyte.2,3,5-Triiodobenzoic acid(7)was easily soluble in DMSO-d6and CD3OD;and partly soluble in CDCl3and D2O.The proton spectra showed two doublets and one broad acidic proton signal.One of the doublets showed a unique chemical shift at around8.35ppm,suit-able for quantification,whereas the broad acidic signal was ignored due to its nature.The compound is a protolyte,cf.,maleic acid above.Fumaric acid(8)was soluble in DMSO-d6,CD3OD but not in CDCl3.It required heat and sonication to dissolve in D2O.The pro-ton spectra showed a singlet at around6.6.Only in the spectrum of fumaric acid in DMSO-d6,it was possible to observe the singlet from the carboxyl protons resonating at13.12ppm.Fumaric acid is a protolyte,cf.,maleic acid above.Acetanilide(9)is a white to grey solid that was soluble in DMSO-d6,CD3OD and CDCl3,and sparingly soluble in D2O.It exhibited four signals and three of them were in the region where typically aromatic proton signals are found.Acetanilide was of high purity analytical grade and reasonably prized.Dimethyl sulfone(10)was soluble in all employed solvents.How-ever,the substance was not suitable as internal standard due to low molecular weight and the fact that the signal in the spectrum comprised six protons.Probably the error in quantification will be higher compared to other suitable internal standards.A signal at3.0ppm was not unique and also prone to prospective overlap problems.3,4,5-Trimethoxybenzaldehyde(11)was soluble in DMSO-d6, CD3OD and CDCl3,and partly soluble in D2O.Atfirst glance the spec-tra showed a unique aldehyde signal of one proton at ca.9.8ppm, which seemed to be advantageous.However,being an aldehyde, this compound awakened some concerns about stability and reac-tivity properties,requiring further investigations.Hexamethylcyclotrisiloxane(12)was soluble in all solvents apart from D2O.This moisture sensitive and unstable compound had one signal at ca.0.1ppm,sporting a unique chemical shift outside of the most crowded regions.However,it contained18protons exerting a source of weight error for quantification.2,2-Dimethylmalonic acid(13)was soluble in all solvents apart from CDCl3.Two signals appear in the spectrum:1.3and12.6ppm. The methyl signal at1.3ppm was not unique and the signal of acidic protons at12.6ppm was too broad.The compound is a protolyte, cf.,maleic acid above.2,4,5-Trichloropyrimidine(14)was soluble in DMSO-d6,CD3OD and CDCl3,and partly soluble in D2O.It showed a suitable singlet signal at around9.0ppm.The only drawback was that this com-pound is a liquid,requiring careful handling during weighing.The compound is a protolyte,cf.,3,4,5-trichloropyridine above.Sodium acetate(15)is known to be hygroscopic.It was solu-ble in CD3OD and D2O,partly soluble in DMSO-d6but insoluble in CDCl3.Furthermore,it is well known that NMR tubes as well as other chemical lab ware may contain acetate ions as impurities, which means that a full investigation of blank samples need to be performed.The chemical shift of the signal was around1.8ppm, which was not unique as to avoiding overlap.The compound is a protolyte,cf.,maleic acid above.The above15compounds were found to meet many of the qualities of a useful internal standard.We also studied other compounds(hexamine,uracil,l-leucine,anthracene, acetamide,2,3,4-trifluorobenzamide,2,4,6-trifluorobenzoic acid, 2,4,6-trichlorobenzoyl chloride,2,3,5-tribromothiophene,5-fluorouracil),that showed out not to be particularly suitable as internal standards due to various reasons, e.g.,non-uniqueT.Rundlöf et al./Journal of Pharmaceutical and Biomedical Analysis 52 (2010) 645–651649Table 2Purities of the selected internal standards by NMR,DSC,and as reported by the certificate of pound NMR impurity peaks NMR a purity,std.dev.DSC b purity,std.dev.Certificate of analysis,technique 1–c 99.5±0.3%99.9±0.06%99.9%,GC 2–c98.1±0.6%99.6±0.03%99.9%,GC 3ıH 8.6,area ∼1%97.8±0.1%98.0±0.05%98.7%,GC 4–c 100.0±0.3%99.9±0.02%100.0%,GC 5–c99.6±0.3%–d 100.0%,HPLC 6ıH 1.1,area ∼1%96.5±0.5%98.8±0.14%97.8%,GC 7ıH 7.6,area ∼2%99.8±1.2%99.5±0.03%99.3%,HPLC 8–c 99.2±0.2%–d 100.0%,HPLC 9–c–d99.9±0.03%100.0%ea Weight%,n =6(n =5for compound 3).b mol%,n =3.c No obvious impurity peaks larger than ∼0.1%detected.d Not determined.eAnalytical technique not reported in the certificate.chemical shift(s),broad/heavily “splitted”signals,toxicity,and reactivity/non-stability.Based on these observations on the aptness of the individual compounds as internal standards,compounds 1–8were stud-ied further in order to determine their absolute purity using both differential scanning calorimetry (DSC)and quantitative NMR spectroscopy.The highly pure acetanilide was employed as the reference internal standard.3.2.Acetanilide as control reference for qNMRIn order to perform accurate quantification it is essential to know the actual purity of the used internal standard.Suitable methods for determination of purity are DSC and qNMR.The performance of qNMR has been thoroughly assessed in previous studies [10,21,22].Using qNMR it is necessary to use an estab-lished reference standard of high purity, e.g .,acetanilide.The reference standard itself can advantageously be qualified by 1H NMR spectroscopy,with respect to observed organic impurities,in combination with measurement of the water content by,e.g .,loss-on-drying,and inorganic impurities by,e.g .,sulphated ash.In the current work,acetanilide due to its high level of purity (reported as 100.0%)and renowned stability was selected as the reference standard to be used in purity determination of the eight internal standards chosen above [23].Quantification was per-formed on mixtures of acetanilide and the respective analyte in DMSO-d 6,using integrals of the acetanilide signal at 2.0ppm and the analyte signal of highest chemical shift.In order to exemplify the employment of acetanilide in purity determination,two frequently used internal standards,3-sulfolene and 1,3,5-trimethoxybenzene,were checked for their long-term purity stabilities using the qNMR protocol described in Section2.The compounds were more than 3years old and kept in dry environment in their original containers with tightly closed caps.The observed purity was 98.9%for 3-sulfolene,RSD 0.2%(n =6),and 99.2%for 1,3,5-trimethoxybenzene,RSD 0.2%(n =6).No obvi-ous impurity peaks,except for water,were detected in the 1H NMR spectra.The measured differential scanning calorimetry (DSC)assay at time of delivery was 99.9%for both compounds.The fact that lower assays were obtained after storage of these compounds show on the necessity to implement a quick assay check method for internal standards used in routine work.3.3.Purities of the selected internal standardsThe purities of the eight selected compounds and acetanilide were first determined using DSC.The analyses performed smoothly for compounds 1,2,3,4,6,and 7as well as for acetanilide (9).Unfortunately,the analysis failed for maleic acid (5)and fumaric acid (8).The reason might be conversion of maleic to fumaric acid near themelting point,sublimation and/or the formation of the anhydride during heating.The results from DSC analyses (Table 2)were reported as mol%.The relative standard deviation (RSD)was excellent indicating that the content was homogeneous for all com-pounds.Purity determination by qNMR was performed for each of the eight selected internal standards using the acetanilide method described above (Table 2).In most cases similar results were obtained using NMR and DSC,and the results also correlated well with the purities reported in the certificates.The fact that qNMR purities,unlike the other tech-niques,are reported as weight percentages,influence the reported values.High molecular weight impurities would result in lower qNMR purities as compared to,e.g .,DSC mol percentage purities.ForFig.1.1H NMR spectrum from purity determination of dimethyl terephthalate (B)using 100%pure acetanilide (A)as a primary reference standard.The areas of the signals at 8.1ppm (B)and 2.0ppm (A)were used for purity calculation.Residual solvent peaks from DMSO-d 6and water appear at 2.5and 3.3ppm,respectively.650T.Rundlöf et al./Journal of Pharmaceutical and Biomedical Analysis52 (2010) 645–651low molecular weight impurities,e.g.,residual solvents,the qNMR purity would be higher than the corresponding mol percentage purity.In previous comparative purity studies,determination by the traditional mass-balance HPLC method and the1H NMR method showed similar absolute purities[24,25]for compounds with90% or higher purities.The results(Table2)showed that compounds1,4and5were highly pure and the qNMR assays resulted in purities of99.5%, 100.0%,and99.6%,respectively,similar to the results obtained by DSC purities and the reported value in the product certificates.Only few tiny impurity peaks,much smaller than the13C-satellites,were present in the proton spectra.An illustrative spectrum for dimethyl terephtalate is shown in Fig.1.Compounds2and8showed no obvious impurity peaks and the obtained qNMR purities were98.1%and99.2%,respectively,which were lower compared to purities obtained from DSC and the cer-tificate.The reason may be due to difference in the water content, but this was not further studied.For compounds3and7similar results were obtained using the different techniques,but for compound6the result of the qNMR assay was lower compared to the results from the DSC and certifi-cate assays.Obvious impurity peaks of1–2area%were observed in the proton spectra of3,6and7(Table2).Compared to the other compounds,compound7showed a low precision in the qNMR purity determination.This may be due to problems with hygro-scopicity,poor solution stability,poor substance homogeneity,or other undetermined issues in sample preparation or NMR analysis, and must be considered.3.4.Spin-lattice relaxation times(T1)The proton spin-lattice relaxation times(T1)of the eight selected internal standards were measured on the300MHz spectrometer using a standard inversion recovery experiment[26].The resulting exponential curves have been analyzed,and the T1values of the protons of the selected compounds are reported in Table3.Employing an insufficiently short delay between the repeated NMR experiments(scans)in qNMR would cause incorrect quantifi-cation ually it is accustomed to use a minimum delay time offive times the longest corresponding T1value[15].The longest T111.3s was obtained for3,4,5-trichloropyridine(1)in DMSO-d6.This means that a repetition delay of57s is required in order to ensure reasonable relaxation between90◦pulses.For dimethyl terephthalate(4),on the other hand,at a maximum T1Table31H relaxation times(T1)in seconds of the selected internal standards in various NMR solvents.Compound a D2O(s)DMSO-d6(s)CD3OD(s)CDCl3(s)1–b11.3 6.8 6.62–b 5.2 6.2 5.83–b10.27.37.24–b 1.1c,2.7d 2.4c,4.1d 2.0c,3.8d 5 6.7 2.4 4.0–b6–b 4.4 6.1 6.87–b 4.5e,4.5f 3.7e,4.4f–b810.0 4.4 5.2–ba Concentration2–5mg/ml.b Not determined due to low solubility.cıH3.9–4.0.dıH8.1.eıH7.7–7.9.fıH8.3–8.4.4.1s was observed in CD3OD for the aromatic proton and,accord-ingly,a repetition delay of21s would be sufficient.Consequently, a quickly relaxing standard would result in a shorter measurement time,assuming quick relaxation of the analyte protons.It should be noted that for a smaller pulse angle,e.g.,30◦,a shorter repeti-tion delay can be used in order to maximize sensitivity in afixed amount of instrument time[15].Since the routine qNMR method in our laboratory involves a30◦pulse angle and90s repetition delay, the complete relaxation criterion between scans was fulfilled for all of these eight standards.3.5.Employment of the selected internal standards in a real case testSelected internal standards were used for the quantification of paracetamol(acetaminophen,N-(4-hydroxyphenyl)acetamide)in a500mg paracetamol tablet.All samples were portions taken from pulverized material from one and single tablet,DMSO-d6was usedin order to ensure maximum recovery of paracetamol and the inter-nal standard,and quantification was made by integration of themethyl signal of paracetamol at ca.2.0ppm and a non-overlappingsignal of the respective internal standard.A typical example spec-trum is shown in Fig.2.Different purities of the standards obtained by NMR and DSCand from the certificate of analysis,reported in Table2above,wereused for the assay calculations.The results are reported in Table4.Fig.2.Representative1H NMR spectrum from the determination of paracetamol(A)content in a paracetamol500mg tablet,using dimethyl terephthalate(B)as internal standard.The areas of the signals at8.1ppm(B)and2.0ppm(A)were used for content calculation.Residual solvent peaks from DMSO-d6and water appear at2.5and3.3ppm, respectively.。
两种超声波速度测量方法的比较
价值工程0引言声波是一种在弹性媒质中传播的机械波,频率低于20Hz 的声波称为次声波;频率在20Hz ~20KHz 的声波可以被人听到,称为可闻声波;频率在20KHz 以上的声波称为超声波。
声波在媒质中的传播速度与媒质的特性及状态因素有关。
因而通过媒质中声速的测定,可以了解媒质的特性或状态变化[1-4]。
声速测定在工业生产上具有一定的实用意义。
由于超声波具有波长短、易于定向发射等优点,所以在超声波段进行声速测量是比较方便的。
超声波的发射接收一般通过电磁振动与机械振动的相互转换来实现。
最常见的是利用压电效应和磁致伸缩效应。
本实验就是测量频率为36.90kHz 的超声波在空气中的传播速度。
1实验原理测量声速的方法有两种:时差法和波动法[5-8]。
时差法在工程中得到了泛的应用。
它是将经脉冲调制的电信号加到发射换能器上,声波在介质中传播,经过t 时时间后,到达L 距离处的接收换能器,所以可以用以下公式求出声波在介质中传播的速度。
声波传播的距离与传播的时间存在下列关系:v=L/t 。
在波动过程中波速V 、波长λ和频率f 之间存在着下列关系:V=f λ,实验中可通过测定声波的波长λ和频率f 来求得声速V ,通常情况下声波的频率是已知的,这样只要测出声波在介质中传播的波长即可。
常用的方法有共振干涉法与相位法。
本次实验研究采用的就是利用共振干涉法和相位法展开的。
1.1共振干涉法装置如图1所示,压电陶瓷换能器S 1作为声波发射器,它由信号源供给频率36.90千赫的交流电信号,由逆压电效应发出一平面超声波;而换能器S 2则作为声波的接收器,正压电效应将接收到的声压转换成电信号,压电陶瓷换能器压电效应中压力和电信号之间是正比关系,所以示波器上显示的电信号越强说明作用在压电陶瓷换能器端面上的力越大,从而说明处在S 2接受器端面位置的声压也越大。
由于声波要在S 1和S 2两器件端面之间反射多次,因此在两各端面之间形成的声波场对应的质点位移变化和声压变化不再是简单的驻波,而是行驻波,但在端面距离较小时,接收端面近似处于声压波腹位置,且相邻的两个声压极大值之间距离△L=λ/2[9-11],这样只要测量出一系列相邻的声压级极大位置就可以测出波长。
速测卡法与酶抑制率法快速检测蔬菜中农药残留的对比研究
速测卡法与酶抑制率法快速检测蔬菜中农药残留的对比研究作者:汤彤来源:《安徽农业科学》2017年第01期摘要 [目的]研究蔬菜农药残留快速检测的方法,为保障果蔬类农产品的质量安全提供技术支撑。
[方法]以六大类300份蔬菜样品的检测结果为依据,对速测卡法和酶抑制率法2种快速检测方法中的检测原理、检测步骤、检测结果、检出限、阳性结果符合率进行对比研究。
[结果]速测卡法和酶抑制率法都属于快速检测农药残留的方法,相比较气相色谱法方便简单。
速测卡法便于携带,随用随取,检测速度更快。
酶抑制率法需要使用RP-410型农残速测仪或其他类型分光光度计、恒温培养箱等设备。
[结论]速测卡法易操作,无需仪器和试剂,是市场、车站等场所快速检测蔬菜农药残留的较好方法。
关键词农药残留;快速检测;速测卡法;酶抑制率法中图分类号 S481+.8 文献标识码 A 文章编号 0517-6611(2017)01-0102-03A Comparative Study on Rapid Detection of Pesticide Residues in Vegetables by Measurement Card and Enzyme Inhibition MethodsTANG Tong(Agricultural Products Quality Inspection Center of Haimen City in Jiangsu Province,Haimen, Jiangsu 226100)Abstract [Objective] The aim was to study rapid detection method for pesticide residues in vegetables, and provide technical support for ensuring quality and safety of fruits and vegetables. [Method] Based on the detection results of 300 vegetable samples in 6 major categories, testing principle, procedures, results, detection limit, coincidence rate of positive results of measurement card method and enzyme inhibition method were comparatively studied. [Result] The measurement card method and enzyme inhibition method both are rapid detection methods of pesticide residues, they are convenient and simple compared with the gas chromatography method. The measurement card method is easy to carry, with the use of access, the detection rate is faster. The enzyme inhibition method requires the use of RP-410 type rapid test instrument or other type spectrophotometer, constant temperature incubator and other equipments. [Conclusion] The measurement card method is easy to operate, without of instruments and reagents and is a good way to detect pesticide residues in vegetables from market, station and so on.Key words Pesticide residue;Rapid detection;Measurement card method;Enzyme inhibition method蔬菜作为人们日常生活中不可或缺的食品,其质量安全直接关系到消费者的身体健康及生命安全。
2022年考研考博-考博英语-煤炭科学研究总院考试预测题精选专练VII(附带答案)卷19
2022年考研考博-考博英语-煤炭科学研究总院考试预测题精选专练VII(附带答案)第1套一.综合题(共25题)1.单选题The law can () fathers to make regular payments for their children.问题1选项pelplyplainbine【答案】A【解析】考查动词辨析。
A项compel “强迫、迫使”,B项comply “遵守、顺从”,C项complain “抱怨”,D项combine “联合、结合”;句意:这项法律可强制父亲定期支付子女的费用。
因此A 选项正确。
2.写作题Directions: “Publish or perish” is well-known in the academic world. Do you agree or disagree with this view points. Please express your opinion in about 150 words.【答案】略3.单选题A few months of grooming, mentors and founders can then () hundreds of people to watch their company's official introduction to society.问题1选项A.summonB.uniteC.gatherD.assemble【答案】A【解析】考查动词辨析。
A项summon “召唤”,指运用权威或行使权力指示、命令、吩咐,或要求某人去某处,常用于正式的集会或公务等方面;B项untie “团结、合并”,指将两个或两个以上原本分散或对立的事物联合起来,或者指主动联合自己周围的人或物,使之围绕在自己身旁;C项gather “聚集”,多强调按照一定目的或计划有选择的使人或物聚集在一起;D项assemble “集合、聚集”,更突出聚集或收集的目的;句意:经过几个月的培训后,导师和创始人可以召集数百人观看他们公司向社会的正式介绍。
02-专业学位研究生英语水平自测试题
UNIT 2 Model Test 2Part I Vocabulary1.Although Asian countries are generally more cautious in social customs than Western countries, there havebeen several notable examples of women leaders in both China and India.A) conservative 保守的B) confidential 机密的C) comprehensive 综合的D) consistent 始终的虽然亚洲的国家在社会习俗方面普遍比西方国家保守,但中国和印度仍有好几位著明的女性领导人。
Cautious:谨慎的2.The law prohibits occupancy by more than 250 persons.A) abandons 放弃B) defines 定义C) declare 宣布D) forbids 禁止法律禁止超过250人的占用。
Prohibit:禁止3.One condition of this job is that you must be present at work at weekends.A) available to 可以用来B) capable of 有能力C) acceptable to 可接受D)accessible to 可得到这个工作的一个条件就是你必须周末去工作。
Present at:在场4.The availability of food and probably to a lesser extent, the degree of danger from predators are two basicinfluences in the relations between individuals within a species.A) distribution 分配B) diversity 多样性C) imitation 模仿D) utility 效用食物的可获得性及可能在稍微小的程度上来自捕食者的危险程度是两个影响个体在物种之间的关系基本因素。
《中国白内障认知与诊疗现状调研报告》发布
·药物临床·651-658.[14] Hampel H, Buerger K, Zinkowski R, et al. Measurement ofphosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study[J].Arch Gen Psychiatry, 2004, 61(1): 95-102.[15] Lee RC, Feinbaum RL, Ambros V. The C. Elegansheterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993, 75(5): 843-854. [16] Fineberg SK, Kosik KS, Davidson BL. MicroRNAs potentiateneural development[J]. Neuron, 2009, 64(3): 303-309. [17] Millan MJ. Linking deregulation of non-coding RNA to thecore pathophysiology of Alzheimer’s disease: an integrative review[J]. Prog Neurobiol, 2017, 156: 1-68.[18] Swarbrick S, Wragg N, Ghosh S, et al. Systematic reviewof miRNA as biomarkers in Alzheimer’s disease[J]. Mol Neurobiol, 2019, 56(9): 6156-6167.[19] Slota JA, Booth SA. MicroRNAs in neuroinflammation:implications in disease pathogenesis, biomarker discovery and therapeutic applications[J]. Noncoding RNA, 2019, 5(2): 35.[20] Moradifard S, Hoseinbeyki M, Ganji SM, et al. Analysisof microRNA and gene expression profiles in Alzheimer’s disease: a meta-analysis approach[J]. Sci Rep, 2018, 8(1): 4767.[21] Nagaraj S, Zoltowska KM, Laskowska-Kaszub K, et al.microRNA diagnostic panel for Alzheimer’s disease and epigenetic trade-off between neurodegeneration and cancer[J].Ageing Res Rev, 2019, 49: 125-143.[22] Cogswell JP, Ward J, Taylor IA, et al. Identification ofmiRNA changes in Alzheimer’s disease brain and CSF yields putative biomarkers and insights into disease pathways[J]. J Alzheimers Dis, 2008, 14(1): 27-41.[23] Burgos K, Malenica I, Metpally R, et al. Profiles ofextracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer’s and Parkinson’s diseases correlate with disease status and features of pathology[J]. PLoS One, 2014, 9(5): e94839.[24] Lusardi TA, Phillips JI, Wiedrick JT, et al. MicroRNAs inhuman cerebrospinal fluid as biomarkers for Alzheimer’sdisease[J]. J Alzheimers Dis, 2017, 55(3): 1223-1233.[25] Muller M, Jakel L, Bruinsma IB, et al. MicroRNA-29a isa candidate biomarker for Alzheimer’s disease in cell-freecerebrospinal fluid[J]. Mol Neurobiol, 2016, 53(5): 2894-2899.[26] Dangla-Valls A, Molinuevo JL, Altirriba J, et al. CSFmicroRNA profiling in Alzheimer’s disease: a screening and validation study[J]. Mol Neurobiol, 2017, 54(9): 6647-6654.[27] McKeever PM, Schneider R, Taghdiri F, et al. MicroRNAexpression levels are altered in the cerebrospinal fluid of patients with young-onset Alzheimer’s disease[J]. Mol Neurobiol, 2018, 55(12): 8826-8841.[28] Zendjabil M. Circulating microRNAs as novel biomarkers ofAlzheimer’s disease[J]. Clin Chim Acta, 2018, 484: 99-104. [29] Leidinger P, Backes C, Deutscher S, et al. A blood based12-miRNA signature of Alzheimer disease patients[J].Genome Biol, 2013, 14(7): R78.[30] Tan L, Yu JT, Tan MS, et al. Genome-wide serum microRNAexpression profiling identifies serum biomarkers for Alzheimer’s disease[J]. J Alzheimers Dis, 2014, 40(4): 1017-1027.[31] Li D, Li YP, Li YX, et al. Effect of regulatory network ofexosomes and microRNAs on neurodegenerative diseases[J].Chin Med J (Engl), 2018, 131(18): 2216-2225.[32] Lugli G, Cohen AM, Bennett DA, et al. Plasma exosomalmiRNAs in persons with and without Alzheimer disease: altered expression and prospects for biomarkers[J]. PLoS One, 2015, 10(10): e0139233.[33] Yang TT, Liu CG, Gao SC, et al. The Serum exosome derivedmicroRNA-135a, -193b, and -384 were potential Alzheimer’s disease biomarkers[J]. Biomed Environ Sci, 2018, 31(2): 87-96.[34] Takousis P. Analysis of micro-RNA expression by qPCR ona microfluidics platform for Alzheimer’s disease biomarkerdiscovery[J]. Methods Mol Biol, 2018, 1750: 283-292. [35] Fransquet PD, Ryan J. MicroRNA as a potential blood-based epigenetic biomarker for Alzheimer’s disease[J]. Clin Biochem, 2018, 58: 5-14.(收稿日期:2020-10-29)《中国白内障认知与诊疗现状调研报告》发布据中华医学会眼科学分会统计,我国60至89岁人群白内障发病率约为80%。
f相对质量
f相对质量The concept of relative mass is fundamental in the field of physics and chemistry. It refers to the ratio of the mass of an atom or molecule to a standard mass, typically the mass of one-twelfth of a carbon-12 atom. This ratio allows us to compare the masses of different atoms and molecules on a relative scale.相对质量在物理学和化学领域是一个基本概念。
它指的是一个原子或分子的质量与一个标准质量的比值,通常是以碳-12原子质量的十二分之一为标准。
这个比值使我们能够在一个相对尺度上比较不同原子和分子的质量。
The relative mass is not an absolute measurement of mass but rather a comparative measure. It is useful in a variety of contexts, including the study of atomic structure, chemical reactions, and isotopic analysis. By understanding the relative masses of atoms and molecules, scientists can gain insights into their properties and behaviors.相对质量并不是质量的绝对测量,而是一种比较性的度量。
它在多种情境下都很有用,包括原子结构的研究、化学反应和同位素分析等。
森林碳汇计量方法的比较研究
森林碳汇计量方法的比较研究李笑笑,潘家坪(南京林业大学经济管理学院,南京210037)摘要:森林碳汇对降低大气中二氧化碳的浓度、减缓全球气候变暖具有十分重要的作用,森林碳汇的会计计量问题也越来越受到人们的重视。
从从实物计量和货币计量两个层面阐述了森林碳汇量的5种计量方法,着重介绍了其原理和分析了其优缺点,以期为实际计量中的方法选择提供参考。
关键词:森林碳汇;实物计量;货币计量;比较研究中图分类号:F307.2文献标识码:A文章编号:1673-5919(2020)04-0096-02DOI:10.13691/23-1539/f.2020.04.028Comparative Study on Measurement Methods of Forest Carbon SinkLI Xiao-xiao,PAN Jia-ping(College of Economics and Management,Nanjing Forestry University,Nanjing210037,China)Abstract:Forest carbon sinks play a very important role in reducing the concentration of carbon dioxide inthe atmosphere and slowing down global warming.The accounting measurement of forest carbon sinks is al⁃so gaining more and more attention.This paper expounded five measurement methods of forest carbon se⁃questration from two aspects of physical measurement and monetary measurement.It analyzed the advan⁃tages and disadvantages of the five measurement methods,aiming at providing a reference for the actual measurement method selection.Key words:forest carbon sinks;physical measurement;monetary measurement;comparative study近年来,生态系统和人类社会经济系统一直受全球气候变暖的气候变化影响,而人类活动更是大气温室气体增加的主要因素[1]。
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1 A Comparative Measurement Study of the Workload of Wireless Access Points in Campus NetworksF´e lix Hern´a ndez-Campos Maria PapadopouliEmails:fhernand,maria@Abstract—Our goal is to perform a system-wide character-ization of the workload of wireless access points(APs)in a production802.11infrastructure.The key issues of this study are the characterization of the traffic at each access point(AP), its modeling,and a comparison among APs of different wireless campus-wide infrastructures.Unlike most other studies,we compare two networks using similar data acquisition techniques and analysis methods.This makes the results more generally applicable.We analyzed the aggregate traffic load of APs and found that the log normality is prevalent.The distributions of the wireless received and sent traffic load for these infrastructures are similar.Furthermore,we discovered a dichotomy of APs:there are APs with the majority of clients that are uploaders and APs in which the majority of their clients are downloaders.Also,the number of non-unicast wireless packets and the percentage of roaming events is large.Finally,there is a correlation between the number of associations and traffic load in the log-log scale.I.I NTRODUCTIONWireless networks are increasingly being deployed and expanded in airports,universities,corporations,hospitals,res-idential,and other public areas to provide wireless Internet access.It is interesting to observe its evolution both in the spatial and temporal domain.While there is a rich literature characterizing traffic in wired networks(e.g.,[9],[8],[13], [3]),there are only a few studies available that examined and modeled wireless traffic load.Furthermore,there is no study that compares the different wireless infrastructures to generalize the models and characteristics of the traffic load. Access points(APs)are a critical element of the wireless infrastructure in campus network.The key issues of this study are the characterization of the traffic at each AP,its modeling,and a comparison among APs of two different wireless campus-wide infrastructures.Unlike most other stud-ies,we compare two networks using similar data acquisition techniques and analysis methods.This makes the result more generally applicable.In this paper,we study two large wireless infrastructures of the University of North Carolina at Chapel Hill(UNC) and Dartmouth College using a lightweight data acquisi-tion methodology.The data was collected using the Simple Network Management Protocol(SNMP),the most widely available monitoring service in wireless platforms.Any AP in the market supports monitoring using SNMP,so it is important to understand how much operators and researchers can learn from SNMP data.Other types of data,such as packet orflow a.Department of Computer Science,University of North Carolina at Chapel Hill,USA.b.ICS-FORTH,Greece.level data,are generally too detailed for this purpose,and their acquisition is much more resource-intensive.This paper makes use of SNMP data for analyzing traffic characteristics, such as the total number of bytes and packets that each access points sent and received during the monitoring period.We also discuss some of the challenges of analyzing this type of data accurately.Our study considers three dimensions of the workload an AP:number of bytes sent and received,number of packets sent and received,and number of associations and roaming operations.In addition,we have also consider how the building types(e.g.,academic,residential,etc.)affect the characteristics of the AP workloads.While previous works have partially considered some of these aspects,our focus on access points is rather unique.Furthermore,we performed system-wide characterization,rather than focusing only the most utilized areas of the studied networks.We believe this type of analysis provides a useful view of the entire utilization of a wireless network,at least from the point of the access points that form the backbone of the wireless infrastructure.In general,we found a surprising degree of similarity in the characteristics of the UNC and Dartmouth wireless networks. Our results therefore provide strong evidence in support of the development of parsimonious workload models of campus wireless networks.This type of modeling would make it possible to develop more realistic simulations and testbed experiments.We can summarize our contributions as follows.We ana-lyzed the aggregate traffic load of APs across the two campus networks and found a wide range of workloads.Our analysis reveals that log normality is prevalent in both UNC and Dartmouth traces.In general,the traffic load in both wireless infrastructures is light,although there are long tails.There is no clear dependency with the type of building at which the AP is located,although some stochastic ordering in present in the tail of the distributions.An interesting dichotomy among APs is prominent in both the two infrastructures,namely,APs dominated by uploaders and APs dominated by downloaders. Specifically,we observed that as the total wireless received traffic of an AP increases,there is also an increase in its total sent traffic and at the same time a decrease in the sent to received ratio.The number of of non-unicast wireless packets is substantial.Furthermore,the number of unicast received packets is strongly correlated in the log-log scale with the number of unicast sent packets.We have also studied average packet sizes.While the majority of APs send and receive packets of relative small size,a significant number of APs2show rather very asymmetric packet sizes,i.e.,,APs with an average large sent and small receive packets,and APs with small sent and large receive packets.Furthermore,we studied the distribution of the associations and roaming operations and found them quite heavy.We found a correlation of the traffic load and number of associations in the log-log scale. Section III describes briefly the wireless infrastructure at UNC,and data acquisition process.In Section IV,we focus on analysis.Section II discusses previous related research.In Section V,we summarize our main results and discuss future work.II.R ELATED W ORKThere is only a small number of measurements studies that have examined the workload of802.11APs in production environments.In general,these studies have considered a wider range of issues,such as overall usage of a wireless infrastructure,and client mobility patterns,providing only a limited picture of the utilization of APs.Our work character-izes the workload of APs in a more systematic manner,and the results should have implications for the design of new wireless equipment and its evaluation.Tang and Baker[12]used tcpdump traces and SNMP data to study a building WLAN with12APs and74users.Their only AP-specific results have to do with the variability in the maximum number users(between3and12),and small number of handoffs(at mostfive within afive-minute period). Balazinska and Castro[2]used SNMP to characterize a much larger wireless network in three IBM buildings(177APs). The study examined the maximum number of simultaneous users per AP(mostly between5and15),total load and throughput distributions.Two interesting observation found in this paper are that offered load and number of users are weakly correlated,and that user transfer rates are dependent on the location of the AP.Balachandran et al.[1]performed measurements in a three-day conference setting,also focusing on the offered network load and global AP utilization.They characterized wireless users and their workload and addressed the network capacity planning problem.The overall bursty behavior and peaks and troughs are similar at all APs,though the absolute peak throughout at each AP varies.They observed that offered load is more sensitive to individual client traffic characteristics rather than just the total number of clients. Kotz et al.[7],[5]studied the wireless network at Dart-mouth College using syslog,SNMP,and tcpdump traces.Their first study[7]reported the distribution of average daily traffic for451APs,which ranged from39MB to more than2GB, and observed that maximum daily traffic was far larger than the average daily traffic.In their follow-up study[5],they reported the average number of active cards per active AP per day(2-3in2001,and6-7in2003/2004),and average daily traffic per AP by category(2-3times higher in2003/2004; twice or thrice more inbound than outbound traffic).A subset of the same data(syslog messages and tcpdump traces from31 APs in5buildings)was revisited by Meng et al.[10]forflow modeling purposes.The authors proposed a two-tier(Weibull regression)model for the arrival offlows at APs and a Weibull model forflow residing times,and they also observed high spatial similarity within the same building.This paper makes a compelling case against Poisson modeling of wirelessflows (at least for busy APs).The authors also study the modeling offlow size,and suggest that a log-normal model provides the best approximation.This is consistent with the large body of work on this topic for wired networks andfile systems(e.g., [11],[6],[4]).III.D ATA A CQUISITIONThe data comes from the large campus wireless networks deployed at UNC and Dartmouth.UNC’s network provides coverage for729-acre campus and a number of off-campus administrative offices.The university has26,000students, 3,000faculty members,and9,000staff members.Undergrad-uate students(16,000)are required to own laptops,which are generally able to communicate using the campus wireless network.A total of488APs were part of the campus network at the start of our study.These APs belong to three different series of the Cisco Aironet platform:the state-of-the-art1200 Series(269APs),the widely deployed350Series(188APs) and the older340Series(31APs).The1200s and350s ran Cisco IOS while the340s ran VxWorks.Dartmouth’s network serves190buildings in a200-acre campus.The university population includes5,500students and1,200faculty members. Laptops are also required in this institution,and almost all of them are equipped with a wireless interface.During the period of time considered in this study,the infrastructure had557 Cisco Aironet350APs running VxWorks.The data in this paper was collected using SNMP for polling every AP on campus everyfive minute.We collected the UNC trace using a custom data collection system,being careful to avoid the pitfalls described in[5].The system was imple-mented using a non-blocking SNMP library for polling each AP precisely everyfive minutes in an independent manner. This eliminates any extra delays due to the slow processing of SNMP polls by some of the slower APs.The system ran in a multiprocessor system and the CPU utilization in each of the three processors we employed never exceeded70%.The UNC trace was collected between9:09AM,September29th,2004 and12AM,November25th,2004.The monitoring system did not suffer any problems during this period.The Dartmouth trace corresponds to the most recent dataset studied in[5].It was collected between November1st,2003, and February28,2004,so the duration of this trace is twice the duration of the UNC one.The data was acquired using a similar approach,although the data collection system has some shortcomings that are described in section IV-A.This trace includes6875unique MAC addresses which were associated with one or more APs during the data collection period.This number is larger for the UNC trace,which reports on the activity of14,712unique MAC address.In summary,while the number of access points in both campus networks is similar, the population of wireless clients is more than twice larger for the UNC trace.3T o t a l W i r e l e s s T r a f f i c S e n t B y A P i n G i g a b y t e sTotal Wireless Traffic Received By AP in GigabytesA P S e n t /R e c e i v e d R a t i oTotal Wireless Traffic Received By AP in GigabytesA P S e n t /R e c e i v e d R a t i oTotal Wireless Traffic Sent By AP in GigabytesFig.1.Total traffic load in Dartmouth trace.T o t a l W i r e l e s s T r a f f i c S e n t B y A P i n G i g a b y t e sTotal Wireless Traffic Received By AP in GigabytesA P S e n t /R e c e i v e d R a t i oTotal Wireless Traffic Received By AP in GigabytesA P S e n t /R e c e i v e d R a t i oTotal Wireless Traffic Sent By AP in GigabytesFig.2.Total traffic load in UNC trace.IV.A NALYSISA.Traffic LoadThe first dimension of the workload of the wireless infras-tructure that we examine in this study is the total traffic load in terms of bytes.Most of the APs considered in this study made use of the 802.11b wireless LAN standard.This limited the bandwidth that could be used by an AP to communicate to its wireless client to 11Mbps.All of the APs in the Dartmouth trace and the majority of the ones in the UNC trace used 802.11b.A higher capacity standard is 802.11a,which can reach a bandwidth of 54Mbps.At the start of the our tracing of the UNC infrastructure,802.11a was used in 152APs,while 802.11b was used in 335APs.A number of the APs were upgraded during the tracing period,so at end of the trace were observed 169using 802.11a and 311using 802.11b.The SNMP traces for UNC and Dartmouth consists of samples of cumulative counters.For example,one of the counters reports on the total number of bytes sent by an access point using its wireless interface since its last reboot.These cumulative counters are encoded using only 32bits,so wrap-arounds are frequent and they must be properly handled to reconstruct cumulative values above bytes.In this section,we first consider the total number of bytes observed by each wireless puting this quantity is straight-forward,but it requires to walk through the entire sequence of values for each counter to detect wrap-arounds.Given our sampling rate,5minutes,we expected that wrap-around could be detected simply by looking for values of the cumulative counters below their previous values.In practice,the analysis is far more complicated.First,every time an AP reboots,its counters are reset.It is possible to distinguish this case by examining the up time SNMP counter,which keeps track of the timesince the last reboot in each AP.Each reboots makes this counter decrease below the sampling interval,and this fact can be used to detect a reboot between two consecutive SNMP samples.Second,the firmware in the APs is not bug-free,and this has to be taken into account when computing the total number of bytes.One frequent problem is an off-by-one error in which the counter is decreased by one byte between two consecutive samples 1.Third,the Dartmouth trace was collected using an SNMP polling system which sometimes suffered long delays to the extend that there is a significant number of samples that are in the wrong order 2.This problem can be detected by checking for decreases in the up time not due to reboots.Fourth,the byte/packet counters of the Cisco Aironet 340s sometimes get reset for no apparent reason.We apply a heuristic to detect and correct this case.In summary,obtaining precise load information from this type of data requires extreme care.A single spurious wrap-around can skew the result significantly by adding Gigabytes of inexistent load.Figures 1and 2provide an overview of the total traffic loads in the Dartmouth and UNC infrastructures.Since we are interested in studying the heterogeneity in the load of different APs due to their different uses,we consider here only those APs that remained operational for the majority of the tracing period.This means that the number of APs studied was 499for Dartmouth (out of 557present in the trace),and 447for UNC (out of 488).The left scatter-plots in the two figures shows one symbol for each AP,comparing the total number of bytes that each access point received from its clients (x-axis)to the total number of bytes that it sent (y-axis).The1Weknow this is a bug because the corresponding SNMP counters forpackets do not increase accordingly.2The researchers that collected this trace have confirmed the presence of this problem.4plots illustrate the wide range of loads in the infrastructure. Some APs had extremely light loads(a few Megabytes during months of operations)while others were used much more heavily(hundreds of Gigabytes).This is consistent for both campus wireless networks.We can also observe in both plots a clear linear trend with a positive slope.This shows that while byte loads were generally asymmetric,no extreme cases were present.The scatter-plots in Figures1and2use different symbols for the APs located in different types of campus buildings. The building classification is based on main purpose of the building(e.g.,residential buildings are inhabited year-round by students).For both datasets,the majority of APs were located in academic or residential buildings.The left scatter-plots of Figure1and2show a wide range of traffic loads for each type of building.However,in both cases,the types of the most loaded APs were residential or library.Further analysis of this data using cumulative distribution funtions revealed that the tails of the distributions of loads exhibit significant stochastic ordering in their tails.The tails of the distributions of loads in residential buildings are heavier than those of the academic buildings,which are themselves heavier than those in administrative,athletic and business buildings.We must note that the building type classifications,while interesting,are not completely reliable.Buildings may have areas dedicated to a different purpose and APs may serve some rooms in nearby buildings.The middle and right plots in Figure1and2show an interestingfinding.These plots use the y-axis for the ratio of bytes sent to bytes received.This quantity characterizes the symmetry in the load of APs.The smaller the ratio,the more dominated the load of the APs was by data sent from its own clients.As the two middle plots illustrate,there is a clear downward trend when the ratio of sent to receive bytes is plotted against the total number of received bytes. This implies that APs with more bytes sent from their clients tend to send less data to them.We can say that these access points are dominates by uploaders,i.e.,clients that mostly serve data rather than download it from the Internet.We conjecture that this is due to peer-to-peer applications,which are fairly popular in both campus networks.The building type breakdown reveals some structure,although there is again a wide variety among the buildings of each type.Most social and dining buildings had a ratio above one,so uploading behavior was not very significant in them.Residential buildings account for a large fraction of the buildings with a ratio below1. The right plots in Figures1and2do not show the prominent linear trend found in the middle plots.This is most clear for the Dartmouth data.Rather than a positive trend,which would indicate that the APs with more bytes sent were dominated by downloaders,wefind no trend(Dartmouth)or a slight downward trend(UNC).Since most clients are downloaders, this indicated that the total number of bytes sent by an AP increased as the number of clients increased,rather than as the clients become heavier downloaders.This is sharp contrast to the structure found for total received bytes,which increased as the APs became more dominated by uploaders.The left plot of Figure3shows the cumulative distribution functions,,for sent and received bytes.Dart-mouth is heavier in both cases,as one would expect from a longer monitoring period.We also found that in general the distribution of AP aggregate loads can be well-approximated with a log-normal model.This is illustrated in the middle and left plots of Figure3.These quantile-quantile plots compare the quantiles of an empirical distribution with the theoretical quantiles of afitted model.Quantiles are represented using dots,with their theoretical value as the x-coordinate and their empirical value as their y-coordinate.In addition,the solid45-degree lineflanked by dashed confidence interval curves represents the area where the quantiles should appear in the case of a goodfit.The middle plots,which correspond to the distribution of the total number of bytes sent by UNC APs,show an excellent match with the log-normal model.Note the theoretical quantiles correspond to those of a normal distribution,since the data has been transformed by taking the logarithm.Therefore,the system-wide distribution of sent bytes can be modeled accurately with a log-normal distribution.This is also true for the Dartmouth APs.On the contrary,thefit is not as good for received bytes.The highest quantiles show a systematic deviation above the upper confidence interval curve.This suggests that the empirical distribution has a tail that is significantly heavier than that of thefitted log normal model.Given the linearity of this deviation,we believe that a bimodalfit(e.g.,two log-normals with different parameters)would provide a goodfit3.This is also true for the Dartmouth received bytes distribution.This finding is consistent with the results in Figures1and2,which show two types of APs workloads(uploader vs.downloader dominated).Uploader dominated APs made the tails of the received bytes distributions heavier than captured by log-normal models.It is important to note that this conclusions cannot be extrapolated from the log-normality offlow sizes observed in previous studies4[10](except,of course,in extreme cases of APs with only oneflow in total).The previous plots examined the total load of the APs over the tracing period.It is also interesting to study the load during shorter intervals of time.Our SNMP data was sampled every five minutes,so it seemed natural to study AP loads using such interval of time.This analysis required to handle irregularities in the SNMP polling rate.We can distinguish two types of irregularities.Thefirst types of irregularity is the presence of gaps in the polling sequence.When an APs is very busy,it may not reply to the polling request from the SNMP collector. In this case,the trace shows polling samples separated by a multiple of the sampling interval.We used linear interpolation to reconstruct the values of the missing samples(i.e.,obtained 5-minute samples by splitting the load of a longer sample).The second type of irregularity is due the scheduling inaccuracies in the polling process.In the case of the UNC trace,the3See[6]for a successful application of this approach in a similar context. 4APs handled many thousands offlows during the tracing periods.By the central limit theorem,the sum of many thousands of samples from a log-normal distribution is normally distributed(not log-normally distributed).The phenomenon we observed is due to the spacial distributions of loads across large campus networks,and not just to the distributional properties offlow sizes.C u m u l a t i v e P r o b a b i l i t yTotal Number of Gigabytes2122232425S a m p l e Q u a n t i l e s (L o g B y t e s S e n t B y A P)212223242526S a m p l e Q u a n t i l e s (L o g B y t e s R e c v . B y A P )Fig.3.Cumulative distribution functions for total traffic loads (left),and Q-Q plots for the distributions of total traffic sent (middle)and received (left)by UNC APs.C u m u l a t i v e P r o b a b i l i t yWireless Traffic in Megabytes during 5-Minute IntervalC u m u l a t i v e P r o b a b i l i t y P e r B y t eWireless Traffic in Megabytes during 5-Minute IntervalC o m p l e m e n t a r y C u m u l a t i v e P r o b a b i l i t yWireless Traffic in Megabytes during 5-Minute IntervalFig.4.Three different visualizations of the distributions 5-minute traffic loads for UNC and Dartmouth.SNMP collector polled each access points precisely every five minutes.However,if the request was lost or the APs did not respond to it,the collector tried up to three more times,spacing each request by 5seconds.This meant that the polling may have been late by at most 20seconds.As in the previous case,we used linear interpolation to correct the measured values,and obtain the total number of bytes in a five minute interval.In the case of the Dartmouth trace,polling can be delayed much longer,and even be performed after the next scheduled poll.We ignored any polling not spaced at least 250seconds from the previous poll,and made use of linear interpolation to adjust values and fill gaps.The cumulative distribution functions shown in the left plot of Figure 4study the load of the APs during 5-minute intervals.Note that we only report intervals with non-zero loads,and our analysis was performed for all the APs in both traces,rather than those APs that were on-line for most of the tracing period as in previous figures.This plot shows that the distributions of sent bytes are surprisingly similar for both networks.APs sent between 500KB and 2MB during most active intervals.In contrast,the distributions of bytes received from clients are quite different.The distribution for Dartmouth has a very light body,with less than 100KB sent in 75%of the intervals.The UNC distribution shows two different regions:a very light one with 40%of the intervals;and a heavier one which is quite close to the distribution of sent bytes.This difference may seem at odds with the similarity between the two sites in Figures 1and 2.However,the total bytes sent shown in those Figures are dominated by the largest values.As the middle plot in the Figure shows,the distributions of sent bytes for Dartmouth and UNC are similar when we consider the probability per byte rather than per interval.While the numberof intervals with very small loads was large,their impact was small in terms of the total bytes (e.g.,only 15-20%of the bytes came from the lower 95%of the intervals).Finally,the tails of these distributions are shown in the right plot of Figure 4using a complementary cumulative distribution function,.The plot shows that the most utilized intervalsfollow similar distributions for both sent and received bytes.The sharp decrease around 1000Megabytes is not surprising given the bandwidth limits in 802.11.The similarity,and linearity,of the curves between 1and 100Megabytes is more remarkable.B.Packet LoadA scatter-plot of the total number of unicast packets ob-served in UNC APs are shown in the left plot of Figure 5.The plots for Dartmouth is very similar and is not included here.The range of packets loads is very variable,with APs that handled only a few tends of thousands of packets during months of operation,while others handled tends of millions of packets.It is interesting to note that there is a far stronger correlation between the numbers of sent and received packets that between the corresponding numbers of bytes (see Figures 1and 2).The byte plots showed a large variability around the linear trend which was due to the variable degree to which APs were dominated by more or less asymmetric communications (e.g.,lighter or heavier downloaders).On the contrary,when the total number of packets is examined,this heterogeneity is ameliorated by the ubiquitous use of TCP,which requires at least one acknowledgment packets for every two data packets.This severely limits the degree of asymmetry in packet load,and this observation can have implications for the design of APs and the improvement of the 802.11protocols.100001000001e+061e+071e+081e+09100001000001e+061e+071e+081e+09T o t a l N u m b e r o f U n i c a s t P a c k e t s S e n t B y A PTotal Number of Unicast Packets Received By APUNC Sep 29 to Nov 25, 20041000001e+061e+071e+081000100001000001e+061e+07T o t a l N u m b e r o f M c a s t /B c a s t P a c k e t s S e n t B y A PTotal Number of Multicast/Broadcast Packets Received By APUNC Sep 29 to Nov 25, 2004A v e r a g e S i z e o f P a c k e t s S e n t b y A P i nB y t e sAverage Size of Packets Received by AP in BytesFig.5.Unicast (left)and non-unicast packets loads for UNC APs,and average packet sizes for UNC APs.00.10.20.30.40.50.60.70.80.911101001000100001000001e+06C u m u l a t i v e P r o b a b i l i t yTotal Number of AssociationsUNCAssociations Roamed-In Roamed-Away5010015020025030035040045001000020000300004000050000600007000080000T o t a l W i r e l e s s T r a f f i c i n G i g a b y t e sNumber of Client AssociationsDartmouth Nov 1, 2003 to Feb 28, 20040.11101001000101001000100001000001e+06T o t a l W i r e l e s s T r a f f i c i n G i g a b y t e sNumber of Client AssociationsDartmouth Nov 1, 2003 to Feb 28, 2004Fig.6.Distributions of client associations for UNC APs (left)and correlation between total traffic load and number of associations for Dartmouth APs (middle and right).The middle plot in Figure 5shows packets load for UNC access points due to non-unicast packets.The numbers are rather large,suggesting that this type of packet are quite significant in this type of infrastructures.Unfortunately,no similar data was collected for Dartmouth.Our preliminary analysis shows that these non-unicast packets mostly came from Net-Bios and ARP.The right plot shows the average packet sizes for the APs in the UNC campus.Most average packets sizes are sizes are below 600bytes,although we observe some degree of axis-hugging ,where a small average received packet size corresponds to a large average sent packet size.This con-firms the previous observation that some APs are dominated by highly asymmetric client behaviors (mostly uploading or mostly downloading),which sent mostly large (data)packets in one direction and mostly small (acknowledgment)packets in the other direction.Note that this plot was created by dividing the total number of bytes by the total number of packets (both unicast and non-unicast).A similar plot for Dartmouth using total bytes divided by total unicast packets results in average packet sizes well above the Maximum Transfer Unit of 802.11b,so it is clear that the number of non-unicast packets was also rather significant for Dartmouth.C.Client AssociationsClient association dynamics represent another important aspect of the workload of wireless APs.The SNMP counters in the Dartmouth and UNC trace include cumulative counts of the number of client that associated with each APs,number of clients that roamed into each access points,and number of clients that roamed away from each AP.The left plot in Figure 6shows the cumulative distribution function forthese three parameters for UNC.As in previous cases,we find distributions that are quite heavy.One third of the APs received between 10,000associations and 250,000association during the monitored period.This represents daily averages between 170and 4,310,which should be considered rather high.In addition,the distributions for roaming operations are also rather heavy.It is unlikely that this is purely due to client mobility,so we conjecture that associations instabilities are common,i.e.,clients that roamed to a nearby APs due to interferences and poor signal strength.Previous studies [2]observed no correlation between the number of associations and the total traffic per AP.We have also studied this question and found only weak correlations for the Dartmouth and UNC traces (Pearson’s correlation of 0.30and 0.41respectively).The middle plot of Figure 6illustrates the absence of any clear trend in the Dartmouth data.However,when the data is examined in a log-log scale as in the right plot,it is clear that a linear upward trend is present.The correlation between the logarithm of the total bytes and the logarithm of the number of associations was 0.80for Dartmouth and 0.74for UNC.This means thatwhere is the total traffic and is thenumber of associations.Therefore ,and the total amount of traffic grows very quickly with the total number of associations.In our further analysis,we have plotted (not shown here)the total traffic against the average association size,and found a upward trend.This implies that higher loads in APs with more associations are not only due a greater number of associations but also to “bigger”associations,i.e.,associations that transfer a greater number of bytes in average.。