Scalable production of standardized extracellular

专利名称：Scalable production of standardized
extracellular vesicles, extracellular vesicle
preparations and uses thereof
发明人：Darwin J. Prockop,Dong-Ki Kim,Hidetaka Nishida,Askok K. Shetty
申请号：US15570316
申请日：20160428
公开号：US11160834B2
公开日：
20211102
专利内容由知识产权出版社提供
摘要：Preparations comprising an enriched population of extracellular vesicles (nEVs) having a negatively charged surface, and that are CD81+ and CD9−, are provided. Improved processes and methods for producing an enriched population of nEVs from non-murine cells, especially human origin cells and/or tissues, are disclosed. Therapeutic methods for using the preparations, including for reducing brain inflammation and treatment of various pathologies associated with brain inflammation, such as by intravenous or intranasal administration, are also described. Methods and preparations for reducing brain inflammation associated with traumatic brain injury (TBI) are also disclosed. A method for treating a patient having suffered a mild traumatic injury (mTMI), or concussion, such as a sports-related head injury, is also disclosed. The nEVs are also demonstrated to reduce the expression level of IL-Iβ in brain tissue of an animal having had traumatic brain injury. Methods for improving cognitive function and performance in animals after a traumatic brain injury is also demonstrated using the preparations of nEVs disclosed herein.
申请人：THE TEXAS A&M UNIVERSITY SYSTEM 地址：College Station TX US
国籍：US
代理机构：Husch Blackwell LLP
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