国产奎硫平或利培酮合并碳酸锂治疗伴有精神病性症状的女性躁狂发作的对照研究

国产奎硫平或利培酮合并碳酸锂治疗伴有精神病性症状的女性
躁狂发作的对照研究
卓子禄;刘君;夏小露
【期刊名称】《四川医学》
【年(卷),期】2011(32)7
【摘要】目的比较国产奎硫平和利培酮合并碳酸锂治疗伴有精神病性症状的女性蹂狂发作的效果及安全性.方法以80例入院治疗,符合ICD-10伴有精神病性症状的蹂狂发作标准,Bech-Rafaelsen躁狂量表(BRMS)评分≥16分,精神病阴性/阳性症状评定量表(PANSS)分≥60分的女性患者作为研究对象.随机分为两组,分别以碳酸锂合并奎硫平和利培酮治疗8周.采用BRMS、PANSS总分及因子分评定治疗前,治疗后2、4、8周减分差异.疗效按治疗8周时减分率评定,以痊愈+显效作为有效率评价.用副反应量表(TESS)评定治疗过程中的不良反应发生率.结果两组各40例均完成8周治疗,使用碳酸锂(1.2±0.3)g/d和(1.33±0.24)g/d.奎硫平组剂量(500±150)mg/d,利培酮组剂量(4.2±1.5)mg/d.8周有效率为72.5%和80%,两组疗效经Ridit分析,P=0.59.治疗2周后两组BRMS、PANSS总分及因子分均呈现同步下降趋势,但8周时利培酮组PANSS阴性症状因子分明显高于奎硫平组
(P=0.03).TESS评定中两组均有头晕、头痛、恶心、呕吐、便秘、心动过速、体重增加等现象.但奎硫平组更多出现困倦嗜睡,利培酮组则以静坐不能、肌张力增高,特别是催乳素增高率显著(P＜0.05～0.01).结论奎硫平虽有困倦嗜睡,但较少引起锥体外系反应和高催乳素血症.因此从治疗风险/效益比评价,奎硫平较利培酮更适合于伴有精神病性症状的女性躁狂症,特别是年青女性的治疗.%Objective To explore the efficacy and safety between domestic quetiapine and risperidone
comhined with lithium in the treatment of female manic episode with psychotic symptoms. Methods A total of 80 female manic episode patients with psychotic symptoms by ICD-10 ( BPRS≥ 16 , PANSS≥ 60 ) were randomly divided into quetiapine comhined with lithium group and risperidone combined with lithium group to treat for 8 weeks. BechRafaelsen Mania Rating Scale ( BRMS) , Positive and Negative Syndrome Scale ( PANSS) and Treatment Emergent Symptom Scale (TESS) were used to assess the efficacy and side effects before and after
2,4,8weeks in the treatment. Results All of the patients completed the 8 weeks treatment. the use of lithium carbonate (1. 2 ± 0.0 3) g/ day and (1.
33 ± 0. 24) g/ day. Quetiapine dose (500 ± 150) mg / day, and risperidone dose ( 4. 2 ± 1. 5) mg / day. The effective rate after 8 weeks were 72. 5％ and 80％ , by Ridit efficacy analysis,P = 0. 59. After 2 weeks of treatment the BRMS, PANSS total scores and factor scores both showed a downward trend in sync , hut after 8 weeks, the PANSS negative symptom factor scores m risperidone group were significantly higher than the quetiapine group ( P = 0. 03) . Assessed by the TESS hoth of the two groups had dizziness. headache , nausea, vomiting, constipation, tachycardia, weight gain and so on , but more often quetiapine group brought drowsiness. and risperidone group hrought akathisia. increased muscular tension ,especially prolactin increased significantly ( P ＜ 0. 05 ～0. 01 ) . Conclusion Although there were more sleepy in the quetiapine group, hut less likely to cause extra pyramidal reactions and hyperprolactinemia. Therefore , from treatment of risk / benefit ratio
evaluation of quetiapine compared with risperidone is more suitable for women with psychotic symptoms of mania, especially in the treatment of young women.
【总页数】4页(P1075-1078)
【作者】卓子禄;刘君;夏小露
【作者单位】自贡市精神卫生中心,四川自贡643020;自贡市精神卫生中心,四川自贡643020;自贡市精神卫生中心,四川自贡643020
【正文语种】中文
【中图分类】R749.4+1
【相关文献】
1.奎硫平单用与联合碳酸锂治疗女性躁狂发作患者的对照研究 [J], 刘浩志;马智文
2.碳酸锂联合利培酮与奎硫平治疗急性躁狂发作对照研究 [J], 杜贵平
3.国产奎硫平联合碳酸锂治疗急性躁狂发作对照研究 [J], 李爱凤;阳琼;邓良华;严文群
4.齐拉西酮与奎硫平合并碳酸锂治疗双相情感障碍躁狂发作对照研究 [J], 高五军;黑燕子;王桢桢;陈延会;徐娅
5.奎硫平与利培酮合并丙戊酸钠治疗躁狂发作的临床对照研究 [J], 张富松
因版权原因，仅展示原文概要，查看原文内容请购买。