尿酸转运蛋白与血清尿酸平衡

尿酸转运蛋白与血清尿酸平衡
丁雪东;彭成璐;李曼曼;李锦春;吴金节
【期刊名称】《国际药学研究杂志》
【年(卷),期】2018(0)9
【摘要】During the uric acid production, excretion and reabsorption in the liver, kidney and intestine, several uric acid transporter proteins are involved in these processes. A large number of studies have shown that glucose transporter 9 plays an important role in the uric acid transport in the liver, kidney and intestine, and participates in the uric acid reabsorption. The ATP-binding cassette superfamily G member 2 is mainly expressed in the apical membrane of the proximal tubular epithelial cells of the kidney, which is involved in the uric acid secretion. The multidrug resistant protein 4 is expressed in the apical membrane of the renal tubular epithelial cells, which transfers uric acid from the renal tubular epithelial cells into the renal tubular lumen. The urate-anion transporter 1 as well as the organic anion transporters 1 and 3 are all the organic anion transporters belonging to the SLC22 A family of transmembrane transporters, and all participate in the uric acid transport in the kidney, especially the uric acid secretion and excretion. In this review, we summarize the research progress of these uric acid transporters, focusing on their effects on the regulation of the serum uric acid balance.%尿酸在肝生成到肾和肠道的排泄、重吸收这一过程有多种尿酸转运蛋白参与.现有研究表明
葡萄糖转运体9在肝、肾和肠道的尿酸跨膜转运中起着重要作用, 参与尿酸的重吸收;三磷酸腺苷结合盒转运蛋白G2主要表达在肾近端小管上皮细胞顶膜, 参与尿酸的分泌作用;多药耐药蛋白4表达于肾小管上皮细胞顶端膜, 可将尿酸从肾小管上皮细胞转运到肾小管腔内;尿酸盐阴离子转运体1、有机阴离子转运体1和3均属于有机阴离子转运蛋白, 是SLC22A家族跨膜转运蛋白的成员, 参与肾的尿酸转运, 尤其是尿酸的分泌和排泄.本文综述了这些尿酸转运蛋白参与调控血清尿酸平衡相关的研究进展.
【总页数】5页(P665-669)
【作者】丁雪东;彭成璐;李曼曼;李锦春;吴金节
【作者单位】安徽农业大学动物科技学院 230061 合肥;安徽农业大学动物科技学院 230061 合肥;安徽农业大学动物科技学院 230061 合肥;安徽农业大学动物科技学院 230061 合肥;安徽农业大学动物科技学院 230061 合肥
【正文语种】中文
【中图分类】Q493.9
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